scholarly journals Cognitive impairment and psychopathology in out-of-hospital cardiac arrest survivors in Denmark: The REVIVAL cohort study protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e038633
Author(s):  
Mette Kirstine Wagner ◽  
Selina Kikkenborg Berg ◽  
Christian Hassager ◽  
Sophia Armand ◽  
Jacob Eifer Møller ◽  
...  
Keyword(s):  
Mental Health ◽  
Cardiac Arrest ◽  
Cohort Study ◽  
Cognitive Impairment ◽  
Verbal Learning ◽  
Screening Tools ◽  
Primary Study ◽  
Hospital Cardiac Arrest

IntroductionCognitive impairment and psychopathology caused by brain hypoxia and the traumatic impact of critical illness are common in cardiac arrest survivors and can lead to negative consequences of everyday life functioning, and further impact mental health in relatives. Most studies have dealt with the mere survival rate after cardiac arrest and not with long-term consequences to mental health in cardiac arrest survivors. Importantly, we face a gap in our knowledge about suitable screening tools in the early post-arrest phase for long-term risk prediction of mental health problems. This study aims to evaluate the efficacy of a novel screening procedure to predict risk of disabling cognitive impairment and psychopathology 3 months after cardiac arrest. Furthermore, the study aims to evaluate long-term prevalence of psychopathology in relatives.Methods and analysesIn this multicentre prospective cohort study, out-of-hospital cardiac arrest survivors and their relatives will be recruited. The post-arrest screening includes the Montreal Cognitive Assessment (MoCA), the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R) and the Acute Stress Disorder Interview (ASDI) and is conducted during hospitalisation. In a subsample of the patients, functional MRI is done, and cortisol determination collected. At 3-month follow-up, the primary study outcomes for 200 survivors include the Danish Affective Verbal Learning Test-26 (VAMT-26), Delis-Kaplan Executive Function System tests (trail making, colour-word interference, word and design fluency), Rey’s Complex Figure and Letter-number sequencing subtest of Wechsler Adult Intelligence Scale-IV, HADS and IES-R. For the relatives, they include HADS and IES-R.Ethics and disseminationThe study is approved by the local regional Research Ethics Committee (H-18046155) and the Danish Data Protection Agency (RH-2017-325, j.no.05961) and follows the latest version of the Declaration of Helsinki. The results will be published in peer-reviewed journals and may impact the follow-up of cardiac arrest survivors.

scholarly journals Long-term follow-up for Psychological stRess in Intensive CarE (PRICE) survivors: study protocol for a multicentre, prospective observational cohort study in Australian intensive care units

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023310
Author(s):  
Sumeet Rai ◽  
Rhonda Brown ◽  
Frank van Haren ◽  
Teresa Neeman ◽  
Arvind Rajamani ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Family Members ◽  
Psychological Outcomes ◽  
Observational Cohort Study ◽  
Screening Tools ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort

IntroductionThere are little published data on the long-term psychological outcomes in intensive care unit (ICU) survivors and their family members in Australian ICUs. In addition, there is scant literature evaluating the effects of psychological morbidity in intensive care survivors on their family members. The aims of this study are to describe and compare the long-term psychological outcomes of intubated and non-intubated ICU survivors and their family members in an Australian ICU setting.Methods and analysisThis will be a prospective observational cohort study across four ICUs in Australia. The study aims to recruit 150 (75 intubated and 75 non-intubated) adult ICU survivors and 150 family members of the survivors from 2015 to 2018. Long-term psychological outcomes and effects on health-related quality of life (HRQoL) will be evaluated at 3 and 12 months follow-up using validated and published screening tools. The primary objective is to compare the prevalence of affective symptoms in intubated and non-intubated survivors of intensive care and their families and its effects on HRQoL. The secondary objective is to explore dyadic relations of psychological outcomes in patients and their family members.Ethics and disseminationThe study has been approved by the relevant human research ethics committees (HREC) of Australian Capital Territory (ACT) Health (ETH.11.14.315), New South Wales (HREC/16/HNE/64), South Australia (HREC/15/RAH/346). The results of this study will be published in a peer-reviewed medical journal and presented to the local intensive care community and other stakeholders.Trial registration numberACTRN12615000880549; Pre-results.

The importance of long-term follow-up after an out-of-hospital cardiac arrest. The experience of Pavia CARe

Resuscitation ◽  
2018 ◽  
Vol 130 ◽  
pp. e89
Author(s):  
Enrico Baldi ◽  
Aurora Ilaria Danza ◽  
Stefano Buratti ◽  
Alessandra Palo ◽  
Fabrizio Canevari ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Long Term Follow Up ◽  
Hospital Cardiac Arrest

Long-Term Functional Outcome and Quality of Life Following In-Hospital Cardiac Arrest—A Longitudinal Cohort Study

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gemma M. Pound ◽  
Daryl Jones ◽  
Glenn M. Eastwood ◽  
Eldho Paul ◽  
Carol L. Hodgson
Keyword(s):  
Quality Of Life ◽  
Cardiac Arrest ◽  
Cohort Study ◽  
Functional Outcome ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Hospital Cardiac Arrest

P2829Arrhythmia burden during long-term follow-up in a large cohort of patients surviving out-of-hospital cardiac arrest

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Caro Codon ◽  
L Rodriguez Sotelo ◽  
J R Rey Blas ◽  
O Gonzalez Fernandez ◽  
S O Rosillo Rodriguez ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Hospital Admission ◽  
Hospital Discharge ◽  
Atrial Arrhythmias ◽  
Coronary Syndrome ◽  
Long Term Follow Up ◽  
Index Hospital ◽  
Hospital Cardiac Arrest

Abstract Background Data regarding incidence of ventricular (VA) and atrial arrhythmias (AA) in survivors after out-of-hospital cardiac arrest (OHCA) are scarce. Purpose To assess incidence of VA and AA in OHCA patients during long-term follow-up and to identify relevant predictive factors during the index hospital admission. Methods All consecutive patients admitted to the Acute Cardiac Care Unit after OHCA from August 2007 to January 2019 and surviving until hospital discharge were included. Cox proportional hazard models and logistic regression analysis were used to investigate clinical variables related to the incidence of VA and AA. Results The final analysis included 201 patients. Mean age was 57.6±14.2 years and 168 (83.6%) were male. The majority of patients experienced witnessed arrests related to shockable rhythms (176, 87.6%). Thirty-six patients (17.9%) died after a median follow-up of 40.3 months (18.9–69.1), but only 4 presented another cardiac arrest. Eighteen patients (9.0%) suffered new VA and 37 (18.4%) developed atrial fibrillation/atrial flutter. History of coronary heart disease [HR 3.59 (1.37–9.42), p=0.010] and non-acute coronary syndrome-related arrhythmia [HR 5.17 (1.18–22.60), p=0.029] were independent predictors of VA during follow-up. The optimal predictive model for atrial arrhythmias included age at the time of OHCA, LVEF at hospital discharge and non-acute coronary syndrome-related arrhythmias (p<0.001). Table 1 Variable Without VA With VA p value Age, mean ± DS, years 57.4±14.2 60.8±14.7 0.336 Male sex, n (%) 150 (83.3) 15 (83.3) 1.000 Coronary heart disease, n (%) 36 (20.0) 11 (61.1) <0.001 Cardiomyopathy, n (%) 27 (15.0) 8 (44.4) 0.006 Shockable rhythm, n (%) 157 (87.2) 16 (88.9) 1.000 ACS-related arrhythmia (Primary VF), n (%) 83 (46.1) 2 (11.1) 0.004 LVEF at hospital discharge (%) 47.5±13.9 38.3±16.5 0.010 Death during follow-up 32 (17.8) 3 (16.7) 0.603 Cardiac arrest during follow-up 2 (1.1) 2 (11.1) 0.042 CV hospital admission during follow-up 39 (21.7) 14 (77.8) <0.001 Atrial arrhythmias during follow-up 28 (15.6) 9 (50.0) <0.001 Figure 1 Conclusions Despite low incidence of recurrent cardiac arrest, OHCA survivors face a high incidence of VA and AA. Several clinical characteristics during index hospital admission may be useful to identify patients at high risk.

scholarly journals Neuropsychological outcome after cardiac arrest: a prospective case control sub-study of the Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest trial (TTM2)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Erik Blennow Nordström ◽  
Gisela Lilja ◽  
Susanna Vestberg ◽  
Susann Ullén ◽  
Hans Friberg ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cognitive Impairment ◽  
Neuropsychological Test ◽  
Cognitive Domain ◽  
Temperature Management ◽  
Control Group ◽  
Detailed Knowledge ◽  
Screening Battery ◽  
Hospital Cardiac Arrest

Abstract Background This study is designed to provide detailed knowledge on cognitive impairment after out-of-hospital cardiac arrest (OHCA) and its relation to associated factors, and to validate the neurocognitive screening of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2-trial), assessing effectiveness of targeted temperature management after OHCA. Methods This longitudinal multi-center clinical study is a sub-study of the TTM2-trial, in which a comprehensive neuropsychological examination is performed in addition to the main TTM2-trial neurocognitive screening. Approximately 7 and 24 months after OHCA, survivors at selected study sites are invited to a standardized assessment, including performance-based tests of cognition and questionnaires of emotional problems, fatigue, executive function and insomnia. At 1:1 ratio, a matched control group from a cohort of acute myocardial infarction (MI) patients is recruited to perform the same assessment. We aim to include 100 patients per group. Potential differences between the OHCA patients and the MI controls at 7 and 24 months will be analyzed with a linear regression, using composite z-scores per cognitive domain (verbal, visual/constructive, working memory, episodic memory, processing speed, executive functions) as primary outcome measures. Results from OHCA survivors on the main TTM2-trial neurocognitive screening battery will be compared with neuropsychological test results at 7 months, using sensitivity and specificity analyses. Discussion In this study we collect detailed information on cognitive impairment after OHCA and compare this to a control group of patients with acute MI. The validation of the TTM2 neurocognitive screening battery could justify its inclusion in routine follow-up. Our results may have a potential to impact on the design of future follow-up strategies and interventions after OHCA. Trial registration ClinicalTrials.gov, NCT03543371. Registered 1 June 2018

Long-term follow-up after an out-of-hospital cardiac arrest: An important challenge that should be addressed. The results of the first year of Pavia CARe

Resuscitation ◽  
2016 ◽  
Vol 106 ◽  
pp. e16
Author(s):  
Simone Savastano ◽  
Enrico Baldi ◽  
Maurizio Raimondi ◽  
Manuela Guerci ◽  
Fabrizio Canevari ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
First Year ◽  
Long Term Follow Up ◽  
Important Challenge ◽  
Hospital Cardiac Arrest
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