Prevalence of neonatal hyperbilirubinaemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood-type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

BackgroundHyperbilirubinaemia is a silent cause of newborn disease and death worldwide. However, studies of the disease in sub-Saharan Africa are highly variable with respect to its prevalence. Hence, this study aimed to estimate the overall magnitude of neonatal hyperbilirubinaemia and its association with glucose-6-phosphate dehydrogenase (G6PD) deficiency and blood-type incompatibility in sub-Saharan Africa.MethodsPubMed, Scopus, Google Scholar and the Cochrane Review were systematically searched online to retrieve hyperbilirubinaemia-related articles. All observational studies reported the prevalence of hyperbilirubinaemia in sub-Saharan Africa were included for analysis and excluded if the study failed to determine the desired outcome. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Heterogeneity across the included studies was evaluated using the inconsistency index (I2). Subgroup and meta- regression analysis were also done. Publication bias was examined by funnel plot and the Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of neonatal hyperbilirubinaemia. The meta-analysis was performed using the STATA V.14 software.ResultsA total of 30 486 studies were collected from the different databases and 10 articles were included for the final analysis. The overall magnitude of neonatal hyperbilirubinaemia was 28.08% (95% CI20.23 to 35.94, I2=83.2) in sub-Saharan Africa. Neonates with G6PD deficiency (OR 2.42, 95% CI 1.64 to 3.56, I2=37%) and neonates that had a blood type that was incompatible with their mother’s (OR 3.3, (95% CI 1.96 to 5.72, I2=84%) were more likely to develop hyperbilirubinaemia.ConclusionThe failure to prevent and screen G6PD deficiency and blood-type incompatibility with their mother’s results in high burden of neonatal hyperbilirubinaemia in sub-Saharan Africa. Therefore, early identification and care strategies should be developed to the affected neonates with G6PD deficiency and blood-type incompatibility with their mother’s to address long-term medical and scholastic damages among those exposed to hyperbilirubinaemia

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Prevalence of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis

10.21203/rs.3.rs-29475/v1 ◽

2020 ◽

Author(s):

Yared Asmare Aynalem ◽

Getaneh Baye Mulu1 ◽

Tadesse Yirga Akalu ◽

Wondimeneh Shibabaw Shiferaw

Keyword(s):

Systematic Review ◽

G6pd Deficiency ◽

Meta Analysis ◽

Cochrane Review ◽

Neonatal Hyperbilirubinemia ◽

Blood Type ◽

Sub Saharan Africa ◽

Inconsistency Index ◽

Sub Saharan ◽

Glucose 6 Phosphate Dehydrogenase

Abstract Background: Severe indirect hyperbilirubinemia is a silent cause of newborn disease and death worldwide. However, studies of the disease in sub-Saharan Africa are highly variable with respect to its prevalence. Hence, this study aimed to estimate the overall magnitude of neonatal hyperbilirubinemia and its association with glucose-6-phosphate dehydrogenase (GP6D) deficiency and blood type incompatibility in sub-Saharan Africa.Methods: PubMed, Scopus, Google Scholar, and the Cochrane Review were systematically searched online to retrieve hyperbilirubinemia-related articles. All observational studies reported the prevalence of hyperbilirubinemia in sub-Saharan Africa were included for analysis and excluded if the study failed to determine the desired outcome. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were followed. Heterogeneity across the included studies was evaluated using the inconsistency index (I2). Publication bias was examined by funnel plot and the Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of neonatal hyperbilirubinemia among patients in Sub Saharan Africa. The meta-analysis was performed using the STATA™ version 14 software.Results: A total of 30,486 studies were collected from the different databases and 10 articles were included for the final analysis. The overall magnitude of neonatal hyperbilirubinemia was 28.08 % (95% CI: (20.23, 35.94)) in sub-Saharan Africa. Neonates with G6PD deficiency were 2.42 times (95% CI: 1.64, 3.56) more likely to develop hyperbilirubinemia as compared to infants with normal G6PD levels. Moreover, the risk of developing hyperbilirubinemia was 3.3 times (95% CI: 1.96, 5.72) higher among neonates that had a blood type that was incompatible with their mother’s.Conclusion: The failure to prevent and screen G6PD deficiency and blood type incompatibility with their mother’s results in high burden of neonatal hyperbilirubinemia in sub-Saharan Africa. Therefore, early identification and care strategies should be developed to the affected neonates with G6PD deficiency and blood type incompatibility with their mother’s to address long-term medical and scholastic damages among those exposed to severe hyperbilirubinemia

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Prevalence of HIV Sero-discordance among Couples in Sub Saharan Africa, 2019, Systematic Review and Meta Analysis

International Journal of Women’s Health Care ◽

10.33140/ijwhc.05.01.04 ◽

2020 ◽

Vol 5 (1) ◽

Keyword(s):

Data Extraction ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Sub Saharan Africa ◽

Pooled Prevalence ◽

Study Heterogeneity ◽

Discordant Couples ◽

Data Extraction Tool ◽

Sub Saharan

Background: HIV/AIDS ranks among the world’s most devastating diseases because it spreads rapidly through sexual intercourse (90-95%) and mainly affects young people in their most productive years especially discordant couples are at continuous risk for acquiring the infection. But many individuals are unaware of their partner’s and their own Sero status. So this Meta-analysis aimed to assess the prevalence of HIV Sero discordance among adult discordant couples in Sub Saharan Africa, 2019. Methods: published and unpublished studies were searched systematically using electronic databases such as Google scholars, Medline, hennery, Scopes and Pub Med. All observational studies, which were assessing and reporting the prevalence of HIV sero discordance were identified and included in analysis. Investigators using a data extraction tool did data extraction. STATA statistical software version 14 was used for data analysis. The I2 test was used to evaluate study heterogeneity, the random effect model was used to estimate the pooled association, and the Egger test was used to check for publishing bias. Results: Ten studies met the inclusion criteria and were included in the Meta - analysis. The findings of these 10 studies revealed that there was 23.77 (95 percent CI: 10.48, 37.09) pooled prevalence of sero discordance. The highest prevalence of HIV sero discordance was found in Uganda and SSA OR: 49.2 (95% CI = (47, 50.9) and OR: 43 (95% CI = (41, 45) respectively. Conclusion: In this Meta-analysis the pooled prevalence of HIV sero discordant was high in Africa.

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Non-prescription dispensing of antibiotic agents among community drug retail outlets in Sub-Saharan African countries: a systematic review and meta-analysis

Antimicrobial Resistance and Infection Control ◽

10.1186/s13756-020-00880-w ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Sewunet Admasu Belachew ◽

Lisa Hall ◽

Linda A. Selvey

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Acute Diarrhoea ◽

Upper Respiratory Tract ◽

Cross Sectional ◽

Retail Outlets ◽

Sub Saharan ◽

Tract Infections ◽

Ssa Countries

Abstract Background The development of antimicrobial resistance, which is partially attributable to the overuse and/or misuse of antibiotics in health care, is one of the greatest global public health challenges. In Sub-Saharan African (SSA) countries, non-prescribed dispensing of antibiotics in community drug retail outlets (CDROs) has been flagged as one of the contributing factors for the widespread misuse of antibiotics in the community. Objective The current review aimed to estimate the proportion of non-prescription antibiotics requests or consultations that resulted in provision of antibiotics without a valid prescription among CDROs in SSA region, and describe the type of antibiotics dispensed. Methods A literature search was conducted using PubMed, CINAHL, Scopus and Google Scholar. We also searched reference lists of relevant articles. Random effect model meta-analysis was employed to determine the pooled proportion of over the counter sale of antibiotics. Subgroup and meta-regression was undertaken to explore the potential cause of heterogeneity in effect size across studies. Results Of 671 total citations retrieved, 23 met the inclusion criteria (seven cross-sectional questionnaire-based surveys and 16 cross-sectional client-based studies). The overall pooled proportion of non-prescription antibiotics requests or consultations that resulted in supply of antibiotics without prescription was 69% (95% CI 58–80). Upper respiratory tract infections and/or acute diarrhoea were the most frequently presented case scenarios, and amoxicillin and co-trimoxazole were the most frequently dispensed antibiotics to treat those symptoms. Conclusions Non-prescribed dispensing of antibiotics was found to be a common practice among CDROs in several SSA countries. Ease of access to and overuse of antibiotics can potentially accelerate the emergence of resistance to antibiotics available in the region. Our review highlights the need for a stringent enforcement of existing policies and/or enacting new regulatory frameworks that would regulate antibiotic supply, and training and educational support for pharmacy personnel (e.g. pharmacists, pharmacy assistants) regarding judicious use of antibiotics and the importance of antimicrobial stewardship.

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A systematic review and meta-analysis reveal that Campylobacter spp. and antibiotic resistance are widespread in humans in sub-Saharan Africa

PLoS ONE ◽

10.1371/journal.pone.0245951 ◽

2021 ◽

Vol 16 (1) ◽

pp. e0245951

Author(s):

Delfina F. Hlashwayo ◽

Betuel Sigaúque ◽

Emília V. Noormahomed ◽

Sónia M. S. Afonso ◽

Inácio M. Mandomando ◽

...

Keyword(s):

Antibiotic Resistance ◽

Meta Analysis ◽

Random Effect ◽

Research Priorities ◽

Sub Saharan Africa ◽

Cochrane Library ◽

African Countries ◽

Pooled Prevalence ◽

Sub Saharan ◽

The Impact

Introduction Campylobacter spp. are zoonotic bacteria that cause gastroenteritis in humans worldwide, whose main symptom is diarrhea. In certain cases, extra intestinal manifestations may occur, such as Guillain Barré syndrome. The bacteria cause severe diarrhea mostly in children and in immunocompromised individuals. This review aims to address the prevalence of Campylobacter spp. in humans in sub-Saharan Africa. It also aims to understand the impact of HIV in the prevalence, as well as to report data on antibiotic resistance and propose research priorities. Methods We followed PRISMA guidelines to find studies on the occurrence of Campylobacter spp. in humans in all countries from sub-Saharan Africa. Studies published between 2000 and 2020 were searched in PubMed, Cochrane Library, CINAHL, African Index Medicus, African Journals Online, Google Scholar and Science Direct. We have conducted a random-effect meta-analysis and calculated the proportion of resistant isolates to different antibiotics. Results and discussion We found 77 studies that described such occurrence in humans in 20 out of 53 sub-Saharan African countries. Campylobacter jejuni was the most prevalent species. Pooled prevalence was 9.9% (CI: 8.4%–11.6%). No major variations within the different sub-regions were found. Most studies reported Campylobacter spp. as the cause of diarrhea, mainly in children. Some studies reported the bacteria as a possible etiologic agent of acute flaccid paralysis and urinary tract infection. Campylobacter spp. presented a higher pooled prevalence in HIV infected patients, although not statistically significant. High proportions of resistant strains were reported for many antibiotics, including erythromycin and tetracycline. Conclusion Campylobacter spp. occur in sub-Saharan Africa, although information is scarce or inexistent for many countries. Research priorities should include investigation of the understudied species; extra intestinal manifestations; the impact of HIV infection and associated risk factors. Control strategies should be reinforced to contain the spread of this pathogen and drug resistance.

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Gender Based Violence against Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis of Cross-Sectional Studies

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17030903 ◽

2020 ◽

Vol 17 (3) ◽

pp. 903 ◽

Cited By ~ 6

Author(s):

Muluken Dessalegn Muluneh ◽

Virginia Stulz ◽

Lyn Francis ◽

Kingsley Agho

Keyword(s):

Partner Violence ◽

Meta Analysis ◽

Random Effect ◽

Regional Analysis ◽

Sub Saharan Africa ◽

Mitigation Measures ◽

Gender Based Violence ◽

Pooled Prevalence ◽

Sub Saharan ◽

Gender Based

This study aimed to systematically review studies that examined the prevalence of gender based violence (GBV) that included intimate partner violence (IPV) and non-IPV among women in sub-Saharan Africa (SSA). This evidence is an important aspect to work towards achieving the Sustainable Development Goals (SDG’s) target of eliminating all forms of violence in SSA. The Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines were followed. Ovid Medline, CINAHL, Cochrane Central, Embase, Scopus and Web of Science were used to source articles with stringent eligibility criteria. Studies on GBV in SSA countries that were published in English from 2008 to 2019 were included. A random effect meta-analysis was used. Fifty-eight studies met the inclusion criteria. The pooled prevalence of IPV among women was 44%, the past year-pooled prevalence of IPV was 35.5% and non-IPV pooled prevalence was 14%. The highest prevalence rates of IPV that were reported included emotional (29.40%), physical (25.87%) and sexual (18.75%) violence. The sub-regional analysis found that women residing in Western (30%) and Eastern (25%) African regions experienced higher levels of emotional violence. Integrated mitigation measures to reduce GBV in SSA should focus mainly on IPV in order to achieve the SDG’s that will lead to sustainable changes in women’s health.

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G6PD variant distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19

10.1101/2020.05.27.20114066 ◽

2020 ◽

Author(s):

Jorge da Rocha ◽

Houcemeddine Othman ◽

Caroline T. Tiemessen ◽

Gerrit Botha ◽

Michèle Ramsay ◽

...

Keyword(s):

Allele Frequency ◽

G6pd Deficiency ◽

Sequence Data ◽

Sub Saharan Africa ◽

Whole Genome Sequence ◽

Interaction Factor ◽

High Prevalence ◽

Potential Risks ◽

Sub Saharan ◽

Glucose 6 Phosphate Dehydrogenase

AbstractChloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs have warning labels for use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole-genome sequence data of 458 individuals from sub-Saharan Africa showed significant G6PD variation across the continent. We identified nine variants, of which four are potentially deleterious to G6PD function, and one (rs1050828) that is known to cause G6PD deficiency. We supplemented data for the rs1050828 variant with genotype array data from over 11,000 Africans. Although this variant is common in Africans overall, large allele frequency differences exist between sub-populations. African sub-populations in the same country can show significant differences in allele frequency (e.g. 16.0% in Tsonga vs 0.8% in Xhosa, both in South Africa, p = 2.4 × 10−3). The high prevalence of variants in the G6PD gene found in this analysis suggests that it may be a significant interaction factor in clinical trials of chloroquine and hydrochloroquine for treatment of COVID-19 in Africans.

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The Acceptance Rate Toward COVID-19 Vaccine in Africa: A Systematic Review and Meta-analysis

Global Pediatric Health ◽

10.1177/2333794x211048738 ◽

2021 ◽

Vol 8 ◽

pp. 2333794X2110487

Author(s):

Addisu Dabi Wake

Keyword(s):

Systematic Review ◽

Subgroup Analysis ◽

Meta Analysis ◽

Random Effect ◽

Cochrane Review ◽

Random Effect Model ◽

Acceptance Rate ◽

The People ◽

Pooled Prevalence ◽

Study Participants

Background: The Coronavirus Disease 2019 (COVID-19) pandemic remains serious public issue. COVID-19 vaccine is a vital strategy to prevent this critical pandemic. However, unwillingness to take this vaccine are key barriers to manage the COVID-19 pandemic. The control of this pandemic will depend principally on the people acceptance of COVID-19 vaccine. Therefore, this systematic review and meta-analysis was intended to determine the acceptance rate toward COVID-19 vaccine in Africa. Methods: African Journals OnLine, PubMed, Cochrane Review, HINARI, EMBASE, Google Scholar, Web of Science, and Scopus were used to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were used for this study. Random-effect model, a funnel plot, Egger’s test, I2 statistic, subgroup analysis was done. The study was performed by using a STATA version 11 statistical software. Results: A total of 22 studies with 33,912 study participants were included in this systematic review and meta-analysis. From this finding, the pooled prevalence of acceptance toward COVID-19 vaccine among adults in Africa was 48.93% (95% CI: [39.49, 58.37]). The subgroup analysis revealed that the pooled prevalence of COVID-19 vaccine acceptance among adults in Africa was highest (66.03%, 95% CI [62.84, 69.22]) in Southern Africa, and Lowest (24.28%, 95% CI [3.26, 45.30]) in Northern Africa. Conclusion: This study showed that the estimate of the pooled prevalence of acceptance toward COVID-19 vaccine among adults in Africa was very low. All concerned bodies should be actively involved to improve the acceptance rate of COVID-19 vaccine.

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Menstrual hygiene practice and its determinants among Adolescent Girls in Sub-Saharan Africa. A systematic review and meta-analysis protocol

10.21203/rs.3.rs-640932/v1 ◽

2021 ◽

Author(s):

Etsay Woldu Anbesu ◽

Setognal Birara Aychiluhm

Keyword(s):

Systematic Review ◽

Adolescent Girls ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect Model ◽

Sub Saharan Africa ◽

Hygiene Practice ◽

Menstrual Hygiene ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background: Poor menstrual hygiene practices can lead to gynecological problems, psychosocial stress, and reduced access to school. Menstrual hygiene has not received adequate attention in Sub-Saharan Africa. Moreover, there were fragmented and inconsistent findings. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of menstrual hygiene practice and identify its associated factors among adolescent girls in Sub-Saharan Africa.Methods: The protocol for this review had registered at PROSPERO with registration number: CRD42020165628. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used. Online electronic databases PubMed, Google Scholar, CINAHL and grey literature will be searched to retrieve available studies. Joanna Briggs Institute checklist will be used to assess the quality of the studies. Heterogeneity among studies will be examined using a chi-squared test and I-squared statistic.To investigate sources of heterogeneity, subgroup analyses and meta-regression will be performed. Sensitivity analysis will be conducted to identify influential studies. Publication bias will be examined by funnel plots and Egger’s test. The statistical analysis will be conducted using STATA version-16 software. A random-effect model will be used to estimate the pooled prevalence, and statistical significance will be determined at a p-value of <0.05.Discussion: Poor menstrual hygiene practice affects the health of millions of adolescent girls in developing countries. Currently, there are no synthesis research findings on the overall pooled prevalence of menstrual hygiene practice and its associated factor in Sub-Saharan Africa. Therefore, this systematic review and meta-analysis will be used to inform policy-makers, programmers, planners, clinicians, and researchers to design appropriate strategies.

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Menstrual hygiene practice and its determinants among Adolescent Girls in Sub-Saharan Africa. A systematic review and meta-analysis protocol

10.21203/rs.3.rs-640932/v4 ◽

2021 ◽

Author(s):

Etsay Woldu Anbesu ◽

Setognal Birara Aychiluhm

Keyword(s):

Systematic Review ◽

Adolescent Girls ◽

Meta Analysis ◽

Grey Literature ◽

Random Effect Model ◽

Sub Saharan Africa ◽

Hygiene Practice ◽

Menstrual Hygiene ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background: Poor menstrual hygiene practices can lead to gynecological problems, psychosocial stress, and reduced access to school. Menstrual hygiene has not received adequate attention in Sub-Saharan Africa. Despite this, there are fragmented and inconsistent findings in Sub-Saharan Africa. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of good menstrual hygiene practice and identify its associated factors among adolescent girls in Sub-Saharan Africa. Methods: The protocol for this review was registered at PROSPERO with registration number: CRD42020165628. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline will be used to report the protocol. Online electronic databases PubMed, Google Scholar, CINAHL and unpublished grey literature will be searched to retrieve available studies from January 1-May/2021. The selection, data extraction, and quality assessment of studies will be carried by two authors. Joanna Briggs Institute checklist will be used to assess the quality of the studies. Heterogeneity among studies will be examined using a chi-squared test and I-squared statistic. To investigate sources of heterogeneity, subgroup analyses and meta-regression will be done based on region and sample size. Sensitivity analysis will be conducted to identify influential studies. Publication bias will be examined by funnel plots and Egger’s test. The statistical analysis will be conducted using STATA version-14 software. A random-effect model will be used to estimate the pooled prevalence, and statistical significance will be determined at a p-value of <0.05.Discussion: Poor menstrual hygiene practice affects the health of millions of adolescent girls in developing countries. Currently, there are no synthesis research findings on the pooled prevalence of menstrual hygiene practice and its associated factor in Sub-Saharan Africa. Therefore, the findings of this systematic review and meta-analysis will be helpful to inform policy-makers, planners, and researchers to design appropriate interventions.

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Atrial fibrillation among adults with heart failure in sub-Saharan Africa — prevalence, incidence and all-cause mortality: a systematic review and meta-analysis protocol

BMJ Open ◽

10.1136/bmjopen-2018-022320 ◽

2019 ◽

Vol 9 (2) ◽

pp. e022320 ◽

Cited By ~ 1

Author(s):

Valirie Ndip Agbor ◽

Leopold Ndemnge Aminde ◽

Frank-Leonel Tianyi ◽

Clarence Mvalo Mbanga ◽

Saint-Just N Petnga ◽

...

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Communicable Disease ◽

Meta Analysis ◽

Random Effect ◽

Sub Saharan Africa ◽

Published Data ◽

Economic Productivity ◽

All Cause Mortality ◽

Sub Saharan

IntroductionHeart failure (HF) remains a major non-communicable disease in sub-Saharan Africa (SSA) associated with high rates of readmission, mortality and loss of economic productivity as it affects mostly young and economically active adults. Atrial fibrillation (AFib) is a major determinant of mortality among patients with HF in SSA. Meanwhile, the use of anti-arrhythmic medications in the region remains unacceptably low. This review aims to evaluate the prevalence and incidence of AFib in adult patients with HF in SSA, and the all-cause mortality rate among patients with HF and AFib.Methods and analysisThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Protocols 2015 statement was used to prepare this protocol. All eligible studies from database inception to December, 31 2018 in MEDLINE, Embase, Google Scholar, Web of science and Africa-specific databases (AFROLIB, African Index Medicus and African Journals Online) will be included without language restrictions. The process of study screening, selection, data extraction and assessment of risk of bias will be conducted independently by two reviewers. Disagreements will be arbitrated by a third reviewer. Study-specific estimates will be pooled using random-effect meta-analysis and summary measures obtained will be presented in forest plots. The χ2test on Cochrane’s Q and the I2statistics will be used to assess and quantify heterogeneity, respectively. The Egger’s test and funnel plots will be used to assess publication bias.Ethics and disseminationSince our review will be based on already published data, an ethical approval is not required. The findings of this review will be presented in conferences and peer-reviewed journals and shared on social media such as Researchgate, Facebook, WhatsApp and Twitter.PROSPERO registration numberCRD42018087564.

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