Background: Opioid medications are frequently used effectively for analgesia in acute settings,
however, they are associated with dependence and addiction, and were implicated in 47,600
American fatalities in 2017. Evidence suggests that despite guidelines and professional body
recommendations, acute prescribing remains highly variable. Educational interventions targeting
prescribers have potential to optimize prescribing in-line with evidence-based best practice.
Objectives: To identify the objective impacts of education interventions on opioid prescribing in
the acute care setting.
Study Design: A systematic literature review.
Setting: The electronic databases MEDLINE, Embase, and Cochrane for works published until
December 31, 2018. Bibliographies of relevant studies and the gray literature were also searched.
Methods: Databases were searched for interventional studies (clinical trials and pre- and
poststudies). Studies describing an educational intervention delivered to clinicians and reporting at
least one objective measure of opioid use in the acute care setting were included. Studies reporting
only subjective outcomes and those focused on chronic pain or set in primary care were excluded.
Two reviewers (RB, TB) extracted data and assessed the quality of included studies using the Downs
and Black Tool.
Results: Nine studies met inclusion criteria; all used pre- and postdesigns. Three studies described
stand-alone education, and the others described multifaceted interventions. All 9 interventions
significantly reduced at least one of the following: high-risk agent use including meperidine
use by up to 71%; total or daily dosage of opioids at discharge, including median morphine
milligram equivalence (MME) from 90 mg to 45 mg per patient; and quantity of medications such
as oxycodone supplied to patients, halved in one study from 6,170 expected to 2,932 supplied
tablets. No increase in pain complaints or prescription refill requests were reported in those studies
assessing these outcomes. The longest study examined prescribing 15 months after education
delivery, reporting sustained practice changes.
Limitations: Overall study quality was fair to poor. Significant heterogeneity in settings,
patient groups, methodologies, and outcomes prevented pooled quantitative analysis. No studies
examined all available opioid agents or formulations.
Conclusions: These findings support prescriber education as an effective strategy to reduce
opioid use and optimize prescribing in acute settings. Further research, particularly high quality
randomized studies, describing the impact of education on all available opioid formulations and
total MME is required. Reviewing the existing literature has offered useful models that can be
implemented to improve care with opioid prescribing in acute settings.
Key words: Opioids, education, physician education, prescriber education, opioid education,
opioid prescribing, systematic review, prescriptions, prevention