Newer generation antidepressants and withdrawal effects: reconsidering the role of antidepressants and helping patients to stop

2021 ◽  
pp. dtb-2020-000080
Author(s):  
Mark Horowitz ◽  
Michael Wilcock
Keyword(s):  
Short Term ◽  
Ongoing Debate ◽  
Prescribing Practice ◽  
Antidepressant Use ◽  
Clinically Significant ◽  
Symptom Measures ◽  
Withdrawal Effects

In England, the prescribing of antidepressants, primarily the newer generation antidepressant classes, has steadily increased over recent years. There is ongoing debate about how the efficacy of these drugs is viewed, their place in therapy and the harms associated with stopping them. Much of the evidence of their efficacy comes from short-term placebo-controlled trials which tend not to include outcomes that are of greatest relevance to patients, such as social functioning or quality of life, but rather restrict outcomes narrowly to symptom measures. On such measures these studies do not demonstrate clinically significant differences from placebo for depression. A range of adverse effects are also recognised, often greater in naturalistic studies of long-term antidepressants users than those measured in short-term efficacy studies, including emotional numbing, sexual difficulties, fatigue and weight gain. There is increasing recognition that withdrawal symptoms from antidepressants are common and that these symptoms can be severe and long-lasting in some patients. Recent guidance on how to stop antidepressants in a tolerable way has been presented by the Royal College of Psychiatrists. We believe that increasing awareness about the difficulty that some patients have in stopping antidepressants should lead to more cautious prescribing practice, with antidepressants given to fewer patients and for shorter periods of time. This article discusses the perceived benefits and harms of antidepressant use.

scholarly journals WHAT IS THE ROLE OF IMPACT ASSESSMENT IN THE LONG TERM?

2015 ◽  
Vol 17 (01) ◽  
pp. 1550006 ◽  
Author(s):  
ALAN BOND
Keyword(s):  
Sustainable Development ◽  
Impact Assessment ◽  
Short Paper ◽  
Research Focus ◽  
Short Term ◽  
Stated Goal ◽  
Generational Equity

This short paper makes the case that most impact assessment (IA) has sustainable development as the stated goal, but that it doesn't deliver sustainable outcomes. A key pillar of sustainable development is equity, both intra-generational (defined after Lamorgese and Geneletti (2013, p.119) as ensuring "equity of opportunity for everyone, particularly the poorest and most vulnerable members of the community and seek to create a good quality of life for everyone") and inter-generational equity (defined after Gibson et al. (2005, p. 235) as favouring "present options and actions that are most likely to preserve or enhance the opportunities and capabilities of future generations to live sustainably"). Notwithstanding the importance of intra-generational equity, this paper focuses on the problem that inter-generational equity presents to IA both because of the prevalence of short-term planning, and because approaches developed to deal with inherent uncertainty associated with impacts considered in the long term are overly resource intensive and therefore impractical. A research focus on IA processes that can deal with inter-generational impacts cost effectively might provide the basis on which to develop an IA tool that actually delivers on its stated goal and fits in with current decision-making norms.

The role of education in the accumulation and transmission of social experience

2021 ◽  
Author(s):  
Andrey Yakovlevich Flier
Keyword(s):  
Social Cost ◽  
Social Experience ◽  
Point Of View ◽  
Community Members ◽  
Life Activity ◽  
Short Term ◽  
Communicative Acts

It is demonstrated that social experience is accumulated in the process of real joint life activity of people in the course of satisfying their group and individual interests and needs, in which there is a constant spontaneous rejection of those forms (technologies and results) of their actions, conduct, communicative acts, the used means, ideological and value foundations, etc. that are recognized as harmful or potentially dangerous for the existing level of social integration of the team and turn out to be unacceptable in terms of their social cost and consequences. Some of these undesirable forms eventually fall under institutional taboo (legislative, religious and other prohibitions, sanctions, etc.), while others remain condemned within the framework of customs (morality, virtue). The forms that in the short term, and especially in the long term, prove to be quite acceptable or even desirable from the point of view of maintaining, reproducing, and sometimes increasing the level of social consolidation of community members, their tolerance, the quality of their mutual understanding and interaction, both spontaneously and over time institutionally selected as recommended, are accumulated and consolidated in social norms, standards, values, rules, laws, and ideological principles. Education is one of these most effective forms. The article shows what functions are performed by education at all levels and stages.

Information and Self-Enforcing Democracy: The Role of International Election Observation

2014 ◽  
Vol 68 (2) ◽  
pp. 329-359 ◽  
Author(s):  
Susan D. Hyde ◽  
Nikolay Marinov
Keyword(s):  
Short Term ◽  
Election Observation ◽  
Election Fraud ◽  
Credible Information ◽  
Democratic Elections

AbstractThis article argues that when democracy is not yet institutionalized, leaders have little incentive to push for clean elections, in part because they are likely to face accusations of fraud from domestic opposition groups regardless of their true behavior. Reputable international election observers can facilitate self-enforcing democracy by providing credible information about the quality of elections, thus increasing citizens’ ability to coordinate against the regime when election fraud occurs, and discrediting “sore loser” protests. Patterns of postelection protests are consistent with the argument, including that postelection protests are more likely and last longer following negative reports from international observers. International election observers help promote democracy by making postelection protest more accurate in the short term, thereby increasing incentives for leaders to hold democratic elections in the long term.

Considerations of the technological quality assessment of sugarbeet

2011 ◽  
pp. 85-89 ◽  
Author(s):  
Giorgio Pezzi
Keyword(s):  
Quality Parameters ◽  
Northern Italy ◽  
Glucose Content ◽  
Long Term Storage ◽  
Interesting Correlation ◽  
Technological Quality ◽  
Thick Juice

No real improvement in the technological quality of beet has been recorded over the last 15 years in Northern Italy. Among the possible explanations for the quality stagnation is that the traditional formulae cannot correctly differentiate between sugarbeet varieties which produce thick juice of very high purity. This seems to be connected with the role of potassium. The use of a standard purification procedure gives reliable and accurate data which is immediately comparable with the factory data. Research projects on medium/long term storage are currently being performed by Co.Pro.B., Italy, in cooperation with Syngenta and Beta. Up to now the results have shown that storage of sugarbeet in autumn time in northern Italy is possible provided that suitable varieties and proper handling of the roots are employed. Results obtained in the storage trials are reported. Correlations have been found between quality parameters (purity, color and lime salts) of the purified juice with the glucose content of the raw juice. An interesting correlation is reported between purified juice purity and raw juice purity.

Impact of FII’s and FDI’s on Indian Stock Market

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Dr. Kamlesh Kumar Shukla
Keyword(s):  
Stock Market ◽  
Financial Markets ◽  
Global Economy ◽  
Short Term ◽  
Earnings Growth ◽  
The Past ◽  
Bull Market ◽  
Indian Stock Market

FIIs are companies registered outside India. In the past four years there has been more than $41 trillion worth of FII funds invested in India. This has been one of the major reasons on the bull market witnessing unprecedented growth with the BSE Sensex rising 221% in absolute terms in this span. The present downfall of the market too is influenced as these FIIs are taking out some of their invested money. Though there is a lot of value in this market and fundamentally there is a lot of upside in it. For long-term value investors, there’s little because for worry but short term traders are adversely getting affected by the role of FIIs are playing at the present. Investors should not panic and should remain invested in sectors where underlying earnings growth has little to do with financial markets or global economy.

Thrombopoietin Receptor Agonists in Children with Immune Thrombocytopenia: A New Therapeutic Era

2020 ◽  
Vol 20 ◽  
Author(s):  
Giuseppe Lassandro ◽  
Valentina Palladino ◽  
Giovanni Carlo Del Vecchioa ◽  
Viviana Valeria Palmieri ◽  
Paola Carmela Corallo ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Treatment Options ◽  
Thrombopoietin Receptor Agonists ◽  
Receptor Agonists ◽  
Thrombopoietin Receptor ◽  
Related Quality ◽  
Health Related

Background and Objective: Immune thrombocytopenia (ITP) is a common bleeding disorder in childhood. The management of ITP in children is controversial, requiring personalized assessment of patients and therapeutic choices. Thrombopoietin receptor agonists (TPO-RAs), eltrombopag and romiplostim, have been shown to be safety and effective for the treatment of pediatric ITP. The aim of our research is defining the role of thrombopoietin receptor agonists in the management of pediatric ITP. Method: This review focuses on the use of TPO-RAs in pediatric ITP, in randomized trials and in clinical routine, highlighting their key role in management of the disease. Results: Eltrombopag and romiplostim appear effective treatment options for children with ITP. Several clinical studies have assessed that the use of TPO-RAs increases platelet count, decreases bleeding symptoms and improves health-related quality of life. Moreover, TPO-RAs are well tolerated with minor side effects. Conclusion: Although TPO-RAs long term efficacy and safety still require further investigations, their use is gradually expanding in clinical practice of children with ITP.

Introduction: Kinship Bereavement in Later Life

1997 ◽  
Vol 35 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Brian De Vries
Keyword(s):  
Adult Child ◽  
Later Life ◽  
Short Term ◽  
Traumatic Grief ◽  
Death Of A Parent ◽  
De Vries ◽  
Longitudinal Effects ◽  
Analysis Of Variation

This article introduces a volume devoted to the examination of later-life bereavement: an analysis of variation in cause, course, and consequence. Six articles address and represent this variation and comprise this volume: 1) Prigerson et al. present case histories of the traumatic grief of spouses; 2) Hays et al. highlight the bereavement experiences of siblings in contrast to those spouses and friends; 3) Moss et al. address the role of gender in middle-aged children's responses to parent death; 4) Bower focuses on the language adopted by these adult children in accepting the death of a parent; 5) de Vries et al. explore the long-term, longitudinal effects on the psychological and somatic functioning of parents following the death of an adult child; and 6) Fry presents the short-term and longitudinal reactions of grandparents to the death of a grandchild. A concluding article is offered by de Vries stressing both the unique and common features of these varied bereavement experiences touching on some of the empirical issues and suggesting potential implications and applications.

scholarly journals Shades between Black and Green Investment: Balance or Imbalance?

2021 ◽  
Vol 13 (9) ◽  
pp. 5024
Author(s):  
 Vítor Manuel de Sousa Gabriel ◽  
María Mar Miralles-Quirós ◽  
José Luis Miralles-Quirós
Keyword(s):  
Risk Factor ◽  
Oil Prices ◽  
Oil Price ◽  
Short Term ◽  
Environmental Indices ◽  
Long Run ◽  
Green Investment ◽  
Bounds Test

This paper analyses the links established between environmental indices and the oil price adopting a double perspective, long-term and short-term relationships. For that purpose, we employ the Bounds Test and bivariate conditional heteroscedasticity models. In the long run, the pattern of behaviour of environmental indices clearly differed from that of the oil prices, and it was not possible to identify cointegrating vectors. In the short-term, it was possible to conclude that, in contemporaneous terms, the variables studied tended to follow similar paths. When the lag of the oil price variable was considered, the impacts produced on the stock market sectors were partially of a negative nature, which allows us to suppose that this variable plays the role of a risk factor for environmental investment.

scholarly journals The key role of contact time in elucidating the mechanisms of enhanced decontamination by Fe0/MnO2/sand systems

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Viet Cao ◽  
Ghinwa Alyoussef ◽  
Nadège Gatcha-Bandjun ◽  
Willis Gwenzi ◽  
Chicgoua Noubactep
Keyword(s):  
Contact Time ◽  
Diffusive Transport ◽  
Iron Hydroxides ◽  
Iron Corrosion ◽  
Short Term ◽  
Batch Studies ◽  
Water Decontamination ◽  
Co Precipitation

AbstractMetallic iron (Fe0) has shown outstanding performances for water decontamination and its efficiency has been improved by the presence of sand (Fe0/sand) and manganese oxide (Fe0/MnOx). In this study, a ternary Fe0/MnOx/sand system is characterized for its discoloration efficiency of methylene blue (MB) in quiescent batch studies for 7, 18, 25 and 47 days. The objective was to understand the fundamental mechanisms of water treatment in Fe0/H2O systems using MB as an operational tracer of reactivity. The premise was that, in the short term, both MnO2 and sand delay MB discoloration by avoiding the availability of free iron corrosion products (FeCPs). Results clearly demonstrate no monotonous increase in MB discoloration with increasing contact time. As a rule, the extent of MB discoloration is influenced by the diffusive transport of MB from the solution to the aggregates at the bottom of the vessels (test-tubes). The presence of MnOx and sand enabled the long-term generation of iron hydroxides for MB discoloration by adsorption and co-precipitation. Results clearly reveal the complexity of the Fe0/MnOx/sand system, while establishing that both MnOx and sand improve the efficiency of Fe0/H2O systems in the long-term. This study establishes the mechanisms of the promotion of water decontamination by amending Fe0-based systems with reactive MnOx.

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