scholarly journals PO-478 Prognostic significance of E-cadherin and beta-catenin expression in HPV-negative oropharyngeal squamous cell carcinomas

2018 ◽  
Author(s):  
R Granda ◽  
F Hermida-Prado ◽  
N Del Rio-Ibisate ◽  
MA Villaronga ◽  
S Álvarez-Teijeiro ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Beta Catenin ◽  
E Cadherin

Prognostic significance of E-cadherin and β-catenin expression in HPV-negative oropharyngeal squamous cell carcinomas

Head & Neck ◽  
2017 ◽  
Vol 39 (11) ◽  
pp. 2293-2300 ◽  
Author(s):  
Juana M. García-Pedrero ◽  
Patricia García-Cabo ◽  
M. Ángeles Villaronga ◽  
Francisco Hermida-Prado ◽  
Rocío Granda-Díaz ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
E Cadherin

Outcome and molecular features of head and neck squamous cell carcinomas (HNSCC) bearing a p16 high phenotype

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 6031-6031
Author(s):  
D. Psyrri ◽  
E. Pectasides ◽  
P. Weinberger ◽  
C. Sasaki ◽  
B. Burtness ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Protein Expression ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Beta Catenin ◽  
Class Iii ◽  
Molecular Features ◽  
P16 Expression ◽  
E Cadherin

6031 Background: We have previously demonstrated that p16 expression defines a biologically distinct subgroup of oropharyngeal squamous cell cancers (OSCC). Thus, OSCC can be Class I: human papillomavirus (HPV)-, Class II: HPV16+/p16-, or Class III: HPV16+/p16+. Tumors bearing a high p16 phenotype were associated with superior outcome. Using in situ automated quantitative protein expression analysis (AQUA) to explore the biomarker signatures of these 3 classes we found that beta-catenin, epidermal growth factor receptor (EGFR) and Met were upregulated in class III tumors. Our aim was to validate these findings using an independent cohort. Methods: A tissue microarray composed of 122 specimens from primary HNSCC cases treated with either external beam radiotherapy (EBRT) or gross total surgical resection and EBRT was constructed. Protein expression levels for a panel of 13 markers (EGFR, MET, STAT 3, ERK 1/2, pAkt, PI3Kp85, PI3Kp110, PTEN, p53, Bcl-2, E-cadherin, β-catenin, NFκB) were analyzed using AQUA. P16 protein levels were correlated with progression-free (PFS) and overall survival (OS). Survival analysis was performed by Kaplan-Meier method with log-rank test for assessing statistical significance.Comparison of expression between the p16 positive and p16 negative groups was done using unpaired t-tests. Results: Mean follow-up time for the cohort was 40 months. AQUA scores were divided into quartiles. Survival analysis showed that patients in the top quartile had a significantly better DFS (p = 0.01) and OS (p = 0.002). In multivariable analysis, adjusting for well-characterized prognostic variables, p16 expression retained its prognostic significance. Expression of E-cadherin and β-catenin was significantly higher in the p16 positive versus the p16 negative group (p = 0.014 and p = 0.006, respectively). p16 positive tumors also expressed higher levels of PTEN (p = 0.0009), PI3Kp110 (p = 0.03), NFκB (p = 0.007), and Bcl-2 (p = 0.005). Conclusions: These results validate p16 as a favorable prognostic marker in HNSCC. They also validate beta-catenin as a distinct biomarker in HNSCC bearing high p16 phenotype. Given that HPV+ tumors are p16+, beta-catenin is a candidate biomarker that distinguishes HPV+ versus HPV- HNSCC. No significant financial relationships to disclose.

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

2002 ◽  
Vol 6 (3) ◽  
pp. 207-209 ◽  
Author(s):  
D. Czarnecki ◽  
C. J. Meehan ◽  
F. Bruce ◽  
G. Culjak
Keyword(s):  
Family History ◽  
Squamous Cell ◽  
Retrospective Studies ◽  
Prognostic Significance ◽  
Squamous Cell Carcinomas ◽  
Histological Features ◽  
Actinic Keratoses ◽  
Skin Cancers ◽  
History Of ◽  
A Prospective Study

Background: Retrospective studies have given conflicting results with respect to how many cutaneous squamous cell carcinomas (SCCs) arise in actinic keratoses (AK). Objective: This study was conducted to determine what percentage of SCCs arise in AKs and to obtain more information about two histological features of SCCs, namely, thickness and ulceration. Methods: A prospective study was done of all SCCs treated by the authors during one calendar year. Results: Two hundred eight patients with SCC were entered into the study. An AK was contiguous with an SCC in 72% of the cases. This was taken as evidence that the SCC arose in the AK. Men presented with thicker and more ulcerated SCCs than women, but these were not statistically significant: p = 0.06 for thickness and p = 0.07 for ulceration. Ulcerated SCCs were more likely to arise on the head and neck (p = 0.02), on patients who had multiple skin cancers ( p = 0.005), and on patients who had a family history of skin cancer ( p = 0.03). Conclusion: Actinic keratoses need to be removed before they turn into SCCs. The prognostic significance of ulceration of cutaneous SCCs needs to be determined.

Wnt5a Expression Is Associated With the Tumor Proliferation and the Stromal Vascular Endothelial Growth Factor—An Expression in Non–Small-Cell Lung Cancer

2005 ◽  
Vol 23 (34) ◽  
pp. 8765-8773 ◽  
Author(s):  
Cheng-long Huang ◽  
Dage Liu ◽  
Jun Nakano ◽  
Shinya Ishikawa ◽  
Keiichi Kontani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Proliferation Index ◽  
Beta Catenin ◽  
Vascular Endothelial ◽  
Small Cell Lung ◽  
Ki 67 ◽  
Wnt5a Expression ◽  
Endothelial Growth Factor

Purpose The Wnt gene family encodes the multifunctional signaling glycoproteins. We performed the present study to investigate the clinical significance of Wnt5a expression in non–small-cell lung cancer (NSCLC). Patients and Methods One hundred twenty-three patients with NSCLC who had undergone resection were investigated. Real-time quantitative reverse transcriptase polymerase chain reaction was performed to evaluate the Wnt5a gene expression. Immunohistochemistry was performed to investigate the Wnt5a protein expression, the Ki-67 proliferation index, tumor angiogenesis, and the expression of beta-catenin and vascular endothelial growth factor-A (VEGF-A). Results Wnt5a gene expression in squamous cell carcinoma was significantly higher than that in adenocarcinoma (P < .0001). There was a significant correlation between the normalized Wnt5a gene expression ratio and the intratumoral Wnt5a protein expression (r = 0.729; P < .0001). The intratumoral Wnt5a expression was significantly correlated with the Ki-67 proliferation index (r = 0.708; P < .0001). In contrast, no correlation was observed between the intratumoral Wnt5a expression and tumor angiogenesis. Furthermore, the intratumoral Wnt5a expression was significantly correlated with the stromal expression of beta-catenin (r = 0.729; P < .0001) and VEGF-A (r = 0.661; P < .0001). In addition, the stromal VEGF-A expression was also correlated with Ki-67 proliferation (r = 0.627; P < .0001). Cox regression analyses demonstrated Wnt5a status to be a significant prognostic factor for NSCLC patients (P = .0193), especially for patients with squamous cell carcinomas (P = .0491). Conclusion The present study revealed that an overexpression of Wnt5a could produce more aggressive NSCLC, especially in squamous cell carcinomas, during tumor progression.

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