IDDF2019-ABS-0230 Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of trigonella foenum graecum and vanadate

Aim: This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of Asteriscus graveolens. Background: Asteriscus graveolens (Asteraceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Objective: This work aimed to assess the capacity of flavonoids extracted from Asteriscus graveolens (FEE) to improve diabetes mellitus and dyslipidemia in normal and STZ-induced diabetic rats. Methods: Flavonoids were extracted from A. graveolens using the Soxhlet apparatus and using different organic solvents. Normal and streptozotocin-induced diabetic rats were treated orally by the extract of A. graveolens at a dose of 10 mg/kg. The oral treatment during 15 days was used to evaluate the effect of the flavonoids extracted from A. graveolens on blood glucose level and lipid profile in normal and diabetic rats. The oral glucose tolerance test as well as the analysis of histopathological examination of liver was performed. The antioxidant activity of FEE was also assessed by the method of trapping of free radical 2,2-diphenyl-1 picrylhydrazyl (DPPH), in order to estimate the mechanisms of action involved by FEE to improve hyperglycemia and lipid profile in normal and diabetic rats. Results: FEE reduced serum glucose concentrations in both normal and diabetic rats and exhibited in the last group lowering total cholesterol and triglycerides effects as well as improvement of the HDL-cholesterol serum level. In addition, a remarkable influence on glucose tolerance was also noticed after FEE treatment. Moreover, FEE was able to improve histopathological status of liver and possess a potential antioxidant effect in vitro. Conclusion: In conclusion, this study demonstrates the hypoglycemic and antihyperlipidemic effects of FEE in rats supporting then its traditional use for the management of diabetes.

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Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666181113124727 ◽

2019 ◽

Vol 19 (4) ◽

pp. 503-510 ◽

Cited By ~ 2

Author(s):

Mohamed Eddouks ◽

Farid Khallouki ◽

Robert W. Owen ◽

Morad Hebi ◽

Remy Burcelin

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Oral Administration ◽

Lipid Profile ◽

Plasma Cholesterol ◽

Diabetic Rats ◽

Lipid Lowering ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

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Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats

Pharmacological Research ◽

10.1016/j.phrs.2005.08.008 ◽

2006 ◽

Vol 53 (1) ◽

pp. 69-74 ◽

Cited By ~ 15

Author(s):

S ELBATRAN ◽

O ABDELSALAM ◽

S NOFAL ◽

A BAIUOMY

Keyword(s):

Lipid Profile ◽

Serum Glucose ◽

Diabetic Rats

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Amelioration of histological changes and associated metabolic abnormalities by a combination of Morinda lucida and metformin in diabetic rats

The Journal of Phytopharmacology ◽

10.31254/phyto.2018.7304 ◽

2028 ◽

Vol 7 (3) ◽

pp. 253-256

Author(s):

Atanu FO ◽

◽

Momoh S ◽

Ugwu CE ◽

Ameh O ◽

...

Keyword(s):

Body Weight ◽

Lipid Profile ◽

Diabetic Complications ◽

Combined Treatment ◽

Diabetic Rats ◽

Atherogenic Index ◽

Positive Outcomes ◽

Metabolic Abnormalities ◽

Histological Changes ◽

Histological Studies

This work investigates the ability of Morinda lucida and co-administration of Morinda lucida/metformin in the control of biochemical and histological changes in alloxan-induced diabetic rats. Alloxan diabetic rats were treated with 200 mg/Kg body weight of Morinda lucida leaves extract, 1 mg/Kg BW of metformin or a combination of the two treatments for 28 days. Results of the studies revealed that Morinda lucida leaves extract significantly improved lipid profile and kidney function in diabetic rats. These positive outcomes were enhanced by combined treated with Morinda lucida leaves extract and metformin. Furthermore, the calculated atherogenic index of treated animals were close to those of normal rats as opposed to diabetic rats. Similarly, histological studies showed that Morinda lucida leaves extract and metformin administered together or singly, ameliorated damages in pancreas and kidneys from alloxan diabetic rats. It can therefore be inferred that combined treatment with Morinda lucida leaves extract and merformin could improve the potency of Morinda lucida leaves used in the management of diabetic complications

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Comparative effect of Nauclea latifolia leaf fractions on blood glucose and lipid profile parameters of alloxan induced-diabetic rats

Journal of Medicinal Plants Research ◽

10.5897/jmpr2017.6355 ◽

2017 ◽

Vol 11 (24) ◽

pp. 387-392

Author(s):

Sylvester Effiong Grace ◽

Emmanuel Essien Grace

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Diabetic Rats ◽

Comparative Effect ◽

Nauclea Latifolia

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Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0592 ◽

2017 ◽

Vol 42 (8) ◽

pp. 816-828 ◽

Cited By ~ 13

Author(s):

Seetur R. Pradeep ◽

Krishnapura Srinivasan

Keyword(s):

Oxidative Stress ◽

Beneficial Effect ◽

Allium Cepa ◽

Diabetic Rats ◽

Dietary Interventions ◽

Fenugreek Seeds ◽

Soluble Fibre ◽

Trigonella Foenum Graecum ◽

Allium Cepa L ◽

Trigonella Foenum Graecum L

Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p < 0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p < 0.05), especially from low-density lipoprotein−associated fraction by 43%, 35%, and 54%, respectively. Elevated concentrations of cholesterol and triglycerides in the liver and heart under diabetic conditions were significantly counteracted by these dietary interventions, with the additive combination resulting in greater effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when consumed together.

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Effect of Pericampylus glaucus on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

Bangladesh Journal of Pharmacology ◽

10.3329/bjp.v11i1.24593 ◽

2016 ◽

Vol 11 (1) ◽

pp. 200 ◽

Cited By ~ 1

Author(s):

Muhammad Kifayatullah ◽

Pinaki Sengupta

Keyword(s):

Lipid Profile ◽

Plasma Glucose ◽

Glucose Concentration ◽

Ethanolic Extract ◽

Diabetic Rats ◽

Plasma Glucose Concentration ◽

Short And Long Term ◽

Different Doses ◽

Long Term Studies

The purpose of this study was to evaluate the effects of Pericampylus glaucus extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. The ethanolic extract were administered orally at three different doses (400, 600 and 800 mg/kg) and glibenclamide (20 mg/kg p.o.) for 21 days after 72 hours of streptozotocin injection. During the short- and long-term studies, the extract was found to possess significant (p<0.01, p<0.001) anti-diabetic activity in normal and diabetic rats compared with untreated normal and untreated diabetic group. It also caused reduction in the level of total cholesterol, triglyceride, and LDL etc. and improvement in the HDL level compared with untreated diabetic rats. Reduction in the fasting blood sugar, cholesterol, triglyceride, urea, LDL, creatinine levels and improvement in the HDL by P. glaucus indicates that plant has anti-diabetic activity along with anti hyperlipidemic efficacy and provides a scientific rationale for the use.

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