scholarly journals 215 Transcutaneous Vagus Nerve Stimulation (TVNS) Decreases Sympathetic Nerve Activity in Older Healthy Human Subjects

Heart ◽  
2016 ◽  
Vol 102 (Suppl 6) ◽  
pp. A142.2-A142 ◽  
Author(s):  
Aaron Murray ◽  
Jennifer Clancy ◽  
Susan Deuchars ◽  
Jim Deuchars
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Vagus Nerve Stimulation ◽  
Sympathetic Nerve Activity ◽  
Human Subjects ◽  
Nerve Activity ◽  
Healthy Human ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Healthy Human Subjects

scholarly journals Non-invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity

2014 ◽  
Vol 7 (6) ◽  
pp. 871-877 ◽  
Author(s):  
Jennifer A. Clancy ◽  
David A. Mary ◽  
Klaus K. Witte ◽  
John P. Greenwood ◽  
Susan A. Deuchars ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Vagus Nerve Stimulation ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Non Invasive ◽  
Healthy Humans

Visceral afferent activation-induced changes in sympathetic nerve activity and baroreflex sensitivity

1999 ◽  
Vol 276 (6) ◽  
pp. R1780-R1791 ◽  
Author(s):  
Tarek M. Saleh ◽  
Barry J. Connell ◽  
Gary V. Allen
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Baroreflex Sensitivity ◽  
Sympathetic Nerve Activity ◽  
Parabrachial Nucleus ◽  
Sprague Dawley ◽  
Nerve Activity ◽  
Renal Nerve ◽  
Relative Contribution

The following experiments were done to determine whether changes in baroreflex sensitivity evoked by cervical vagus nerve stimulation are due to sympathoexcitation mediated by the parabrachial nucleus. The relative contribution of cardiopulmonary and general gastric afferents within the cervical vagus nerve to the depression in baroreflex sensitivity are also investigated. Male Sprague-Dawley rats anesthetized with thiobutabarbital sodium (50 mg/kg) were instrumented to measure blood pressure and heart rate or for the continuous monitoring of renal sympathetic nerve activity. Baroreflex sensitivity was measured using bolus injections of phenylephrine. Electrical stimulation of the cervical vagus (with or without the aortic depressor nerve) or the abdominal vagus nerve produced a significant increase in renal nerve activity and a decrease in baroreflex sensitivity. Both of these effects were blocked after the microinjection of lidocaine into the parabrachial nucleus before nerve stimulation. Therefore, we conclude that an increase in the activity of cardiac, pulmonary, or general gastric afferents mediated the increased sympathetic output and decreased baroreflex sensitivity via a pathway involving the parabrachial nucleus.

scholarly journals Direct and Transcutaneous Vagus Nerve Stimulation for Treatment of Tinnitus: A Scoping Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Natalia Yakunina ◽  
Eui-Cheol Nam
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Neural Plasticity ◽  
Vagus Nerve Stimulation ◽  
Human Subjects ◽  
Acoustic Stimulation ◽  
Non Invasive ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Alternative Approach ◽  
Tinnitus Treatment

Recent animal research has shown that vagus nerve stimulation (VNS) paired with sound stimuli can induce neural plasticity in the auditory cortex in a controlled manner. VNS paired with tones excluding the tinnitus frequency eliminated physiological and behavioral characteristics of tinnitus in noise-exposed rats. Several clinical trials followed and explored the effectiveness of VNS paired with sound stimuli for alleviating tinnitus in human subjects. Transcutaneous VNS (tVNS) has received increasing attention as a non-invasive alternative approach to tinnitus treatment. Several studies have also explored tVNS alone (not paired with sound stimuli) as a potential therapy for tinnitus. In this review, we discuss existing knowledge about direct and tVNS in terms of applicability, safety, and effectiveness in diminishing tinnitus symptoms in human subjects. This review includes all existing clinical and neuroimaging studies of tVNS alone or paired with acoustic stimulation in tinnitus patients and outlines the present limitations that must be overcome to maximize the potential of (t)VNS as a therapy for tinnitus.

Effect of Transcutaneous Vagus Nerve Stimulation in Dysphagia After Lateral Medullary Infarction: A Case Report

2019 ◽  
Vol 28 (4) ◽  
pp. 1381-1387
Author(s):  
Ying Yuan ◽  
Jie Wang ◽  
Dongyu Wu ◽  
Dahua Zhang ◽  
Weiqun Song
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Rating Scale ◽  
Tube Feeding ◽  
Nasogastric Feeding ◽  
Lateral Medullary Infarction ◽  
Severe Dysphagia ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Medullary Infarction

Purpose Severe dysphagia with weak pharyngeal peristalsis after dorsal lateral medullary infarction (LMI) requires long-term tube feeding. However, no study is currently available on therapeutic effectiveness in severe dysphagia caused by nuclear damage of vagus nerve after dorsal LMI. The purpose of the present investigation was to explore the potential of transcutaneous vagus nerve stimulation (tVNS) to improve severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Method We assessed the efficacy of 6-week tVNS in a 28-year-old woman presented with persisting severe dysphagia after dorsal LMI who had been on nasogastric feeding for 6 months. tVNS was applied for 20 min twice a day, 5 days a week, for 6 weeks. The outcome measures included saliva spitted, Swallow Function Scoring System, Functional Oral Intake Scale, Clinical Assessment of Dysphagia With Wallenberg Syndrome, Yale Pharyngeal Residue Severity Rating Scale, and upper esophagus X-ray examination. Results After tVNS, the patient was advanced to a full oral diet without head rotation or spitting. No saliva residue was found in the valleculae and pyriform sinuses. Contrast medium freely passed through the upper esophageal sphincter. Conclusion Our findings suggest that tVNS might provide a useful means for recovery of severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Supplemental Material https://doi.org/10.23641/asha.9755438

Effect of vagus nerve stimulation on hepatic secretion of bile in human subjects

1966 ◽  
Vol 111 (1) ◽  
pp. 66-69 ◽  
Author(s):  
John Baldwin ◽  
F. William Heer ◽  
Robert Albo ◽  
Ole Peloso ◽  
Leonard Ruby ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Human Subjects

scholarly journals Transcutaneous Vagus Nerve Stimulation is Associated with Lower Mechanical Ventilation and Mortality in COVID-19 Patients

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Nemechek P ◽  
Antonelli G ◽  
Braida A
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Safety And Efficacy ◽  
Transcutaneous Vagus Nerve Stimulation

Objective: Evaluate the safety and efficacy of transcutaneous vagus nerve stimulation in preventing respiratory failure and improving survival in hospitalized COVID-19 patients.

Sign in / Sign up

Export Citation Format

Share Document