scholarly journals P2-259 Cancer risk in children with birth defects: a longitudinal, population-based assessment among 2.7 million births

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A293-A293
Author(s):  
P. A. Romitti ◽  
T. Flood ◽  
M. L. Feldkamp ◽  
S. Krikov ◽  
S. Puzhankara ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Birth Defects ◽  
Population Based

Abstract LB-161: A population-based assessment of cancer risk among children with non-chromosomal birth defects in 10 million live births

2018 ◽  
Author(s):  
Jeremy M. Schraw ◽  
Tania A. Desrosiers ◽  
Wendy N. Nembhard ◽  
Glenn Copeland ◽  
Robert E. Meyer ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Birth Defects ◽  
Population Based ◽  
Live Births

scholarly journals Association Between Birth Defects and Cancer Risk Among Children and Adolescents in a Population-Based Assessment of 10 Million Live Births

JAMA Oncology ◽  
2019 ◽  
Vol 5 (8) ◽  
pp. 1150 ◽  
Author(s):  
Philip J. Lupo ◽  
Jeremy M. Schraw ◽  
Tania A. Desrosiers ◽  
Wendy N. Nembhard ◽  
Peter H. Langlois ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Children And Adolescents ◽  
Birth Defects ◽  
Population Based ◽  
Live Births

scholarly journals Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults

BMJ ◽  
2020 ◽  
pp. m4060
Author(s):  
Dagrun Slettebø Daltveit ◽  
Kari Klungsøyr ◽  
Anders Engeland ◽  
Anders Ekbom ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Nervous System ◽  
Cancer Risk ◽  
Birth Defects ◽  
Odds Ratio ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Chromosomal Anomalies ◽  
Risk Of Cancer ◽  
Control Study

AbstractObjectiveTo examine associations between birth defects and cancer from birth into adulthood.DesignPopulation based nested case-control study.SettingNationwide health registries in Denmark, Finland, Norway, and Sweden.Participants62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014.Main outcome measuresRelative risk of cancer in relation to major birth defects, estimated as odds ratios with 99% confidence intervals from logistic regression models.ResultsAltogether, 3.5% (2160/62 295) of cases and 2.2% (15 826/724 542) of controls were born with major birth defects. The odds ratio of cancer for people with major birth defects compared with those without was 1.74 (99% confidence interval 1.63 to 1.84). For individuals with non-chromosomal birth defects, the odds ratio of cancer was 1.54 (1.44 to 1.64); for those with chromosomal anomalies, the odds ratio was 5.53 (4.67 to 6.54). Many structural birth defects were associated with later cancer in the same organ system or anatomical location, such as defects of the eye, nervous system, and urinary organs. The odds ratio of cancer increased with number of defects and decreased with age, for both non-chromosomal and chromosomal anomalies. The odds ratio of cancer in people with any non-chromosomal birth defect was lower in adults (≥20 years: 1.21, 1.09 to 1.33) than in adolescents (15-19 years: 1.58, 1.31 to 1.90) and children (0-14 years: 2.03, 1.85 to 2.23). The relative overall cancer risk among adults with chromosomal anomalies was markedly reduced from 11.3 (9.35 to 13.8) in children to 1.50 (1.01 to 2.24). Among adults, skeletal dysplasia (odds ratio 3.54, 1.54 to 8.15), nervous system defects (1.76, 1.16 to 2.65), chromosomal anomalies (1.50, 1.01 to 2.24), genital organs defects (1.43, 1.14 to 1.78), and congenital heart defects (1.28, 1.02 to 1.59) were associated with overall cancer risk.ConclusionsThe increased risk of cancer in individuals with birth defects persisted into adulthood, both for non-chromosomal and chromosomal anomalies. Further studies on the molecular mechanisms involved are warranted.

scholarly journals Cancer Risk in Individuals With Major Birth Defects: Large Nordic Population Based Case-Control Study Among Children, Adolescents, and Adults

2021 ◽  
Vol 76 (4) ◽  
pp. 191-193
Author(s):  
Dagrun Slettebø Daltveit ◽  
Kari Klungsøyr ◽  
Anders Engeland ◽  
Anders Ekbom ◽  
Mika Gissler ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Birth Defects ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Adolescents And Adults ◽  
Control Study

scholarly journals Cancer Risk in Children and Adolescents with Birth Defects: A Population-Based Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69077 ◽  
Author(s):  
Lorenzo D. Botto ◽  
Timothy Flood ◽  
Julian Little ◽  
Mark N. Fluchel ◽  
Sergey Krikov ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Children And Adolescents ◽  
Birth Defects ◽  
Population Based

Observed evidence for guideline‐recommended genes in predicting prostate cancer risk from a large population‐based cohort

The Prostate ◽  
2021 ◽  
Author(s):  
Jun Wei ◽  
Wancai Yang ◽  
Zhuqing Shi ◽  
Lucy Lu ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Large Population ◽  
Prostate Cancer Risk ◽  
Population Based

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

scholarly journals Risk of cancer development in patients with keloids

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ying-Yi Lu ◽  
Hung-Pin Tu ◽  
Chieh-Hsin Wu ◽  
Chien-Hui Hong ◽  
Kuo-Chia Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Relative Risk ◽  
Skin Cancer ◽  
Cancer Risk ◽  
Population Based ◽  
Abdominal Ultrasonography ◽  
Cancer Risk Factors ◽  
Oral Cancers ◽  
Cox Proportional Hazard Regression ◽  
Risk Of Cancer

AbstractKeloid is a skin disease characterized by exaggerated scar formation, excessive fibroblast proliferation, and excessive collagen deposition. Cancers commonly arise from a fibrotic microenvironment; e.g., hepatoma arises from liver cirrhosis, and oral cancers arise from submucosal fibrosis. As keloids are a prototypic fibroproliferative disease, this study investigated whether patients with keloids have an increased cancer risk. In a matched, population-based study, first 17,401 patients treated for keloids during 1998–2010 with 69,604 controls without keloids at a ratio of 1:4 were evaluated. The association between keloids and risk of cancer was estimated by logistic regression or Cox proportional hazard regression models after adjustment of covariates. In total, 893 first-time cases of cancer were identified in the 17,401 patients with keloids. The overall cancer risk was 1.49-fold higher in the keloids group compared to controls. Regarding specific cancers, the keloids group, had a significantly higher risk of skin cancer compared to controls (Relative risk = 1.73). The relative risk for skin cancer was even higher for males with keloids (Relative risk = 2.16). Further stratified analyses also revealed a significantly higher risk of developing pancreatic cancer in female patients with keloids compared to controls (Relative risk = 2.19) after adjustment for known pancreatic cancer risk factors. This study indicates that patients with keloids have a higher than normal risk for several cancer types, especially skin cancers (both genders) and pancreatic cancer (females). Therefore, patients with keloids should undergo regular skin examinations, and females with keloids should regularly undergo abdominal ultrasonography.

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