Effects of vasoactive drugs on hepatic and intestinal circulation and intestinal barrier in patients with septic shock

In this study, 60 patients with septic shock were selected over the course of 1 year, and the effects of dopamine and norepinephrine combined with dobutamine on hepatic and intestinal circulation and intestinal barrier in patients with septic shock were studied by comparison between the control group and the experimental group. All patients received mechanical ventilation to maintain breathing at 14 to 20 times/min. The experimental group was treated with vascular active drugs after adequate rehydration, and the control group only received adequate rehydration. There were extremely significant differences (p<0.01) in the total effective rate of each group. There were significant differences in the hemodynamic indexes in each group (p<0.05). There was a significant difference in total 24-hour bile output (p<0.01). There were significant differences in liver function and blood lipid values in patients (p<0.01). There were significant differences in the repair of epithelial injury at 0 hour, 48 hours and 96 hours (p<0.01). There were significant differences in the transmembrane resistance of monolayer cells (p<0.01). The expression differences of three proteins ZO-1, occludin and β-actin were also significant, among which the three proteins in the control group were weak, while those in groups A and B were strong. The expression of tight junction protein in monolayer cells was weakly positive in expression and strong in other proteins. In conclusion, vasoactive drugs had significant effects on hepatic and intestinal circulation and intestinal barrier in patients with septic shock.

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Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v2i6.671 ◽

2018 ◽

Vol 2 (6) ◽

Author(s):

Xiaoye Wang

Keyword(s):

Blood Pressure ◽

Coronary Heart Disease ◽

Heart Disease ◽

Elderly Patients ◽

Adverse Reactions ◽

Effective Rate ◽

Control Group ◽

Significant Difference ◽

Pre Treatment ◽

Experimental Group

ã€Abstractã€‘Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

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Microvascular decompression for the treatment of neurogenic hypertension with trigeminal neuralgia

BMC Neurology ◽

10.1186/s12883-019-1569-y ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Wenchao Lu ◽

Hui Wang ◽

Zhongnan Yan ◽

Yuangang Wang ◽

Hongmin Che

Keyword(s):

Blood Pressure ◽

Trigeminal Neuralgia ◽

Trigeminal Nerve ◽

Microvascular Decompression ◽

Effective Rate ◽

Ventrolateral Medulla ◽

Control Group ◽

Hypertensive Patients ◽

Significant Difference ◽

Experimental Group

Abstract Background To evaluate the efficacy of microvascular decompression (MVD) in reducing hypertension (HTN) in hypertensive patients with trigeminal neuralgia (TN). Methods The clinical data of 58 cases of neurogenic HTN with TN treated in our hospital were retrospectively reviewed. Preoperative MR revealed abnormal blood pressure in the left rostral ventrolateral medulla (RVLM) and the posterior cranial nerve root entry zone (REZ). The patients were divided into control group: only trigeminal nerve was treated with MVD; experimental group: trigeminal nerve, RVLM and REZ were treated with MVD at the same time. The patients were followed up for 6 months to 1 year to observe the changes of blood pressure. Results There was no significant difference in gender, age, course of TN, course of HTN, grade of HTN and preoperative blood pressure between the two groups. After operation, the effective rate of HTN improvement with MVD was 32.1% in the control group. There was no significant difference in the preoperative and post operative blood pressure. (P△SBP = 0.131; P△BDP = 0.078). In the experimental group, the effective rate was 83.3%. The postoperative blood pressure was significantly lower than preoperative values. (P△SBP < 0.001; P△DBP < 0.001). Conclusions MVD is an effective treatment for neurogenic HTN. However, the criteria for selecting hypertensive patients who need MVD to control their HTN still needs to be further determined. Possible indications may include: left trigeminal neuralgia, neurogenic HTN; abnormal blood pressure compression in the left RVLM and REZ areas on MR; and blood pressure in these patients can not be effectively controlled by drugs.

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Effect of Huoxuejiangu Decoction on Osteoarthritis

E3S Web of Conferences ◽

10.1051/e3sconf/202018503017 ◽

2020 ◽

Vol 185 ◽

pp. 03017

Author(s):

Zike He ◽

Kaifei He ◽

Shangzeng Wang

Keyword(s):

Clinical Symptoms ◽

Research Work ◽

Sodium Hyaluronate ◽

Effective Rate ◽

Clinical Treatment ◽

Control Group ◽

Clinical Value ◽

Improvement Rate ◽

Significant Difference ◽

Experimental Group

Objective: To explore the clinical intervention effect of applying Huoxue Jiangu Decoction in the treatment of patients with osteoarthritis. Methods: Research work was carried out in our hospital from December 2018 to December 2019. A total of 100 patients with osteoarthritis received treatment during this period were selected and divided into two groups using random number method. One group was given sodium hyaluronate injection for treatment, which was the control group, and the other group was given Huoxuejiangu Decoction combined with sodium hyaluronate injection, which was the experimental group. The clinical treatment of the two groups of patients was compared and analyzed. Results: The patients' pain levels were compared. There was no significant difference between the groups before the intervention treatment. After treatment, the experimental group score was (3.05±0.55), which was lower than the control group, the improvement effect was more significant, and the difference between the groups was significant (P< 0.05), the experimental group had a better effect. The clinical treatment of the two groups of patients was compared and analyzed. There was no significant difference in the WOMAS index between the two groups before treatment. After treatment, the score of the experimental group was (34.33±6.98), and the improvement rate was (37.45±13.22). After treatment, the score was lower and the improvement rate was higher, which was significantly higher than the control group (P <0.05), which was significant. The treatment effective rate of the patients in the experimental group was 80.00%, and the treatment effective rate of the patients in the control group was 64.00%. When comparing, the effective rate of the experimental group was higher, and the data comparison between the groups was significantly different. Conclusion: For the patients with osteoarthritis, the application of Huoxue Jiangu Decoction has a significant clinical effect, which can reduce the patient's pain level, improve the patient's clinical symptoms, have high clinical value, and it can be promoted.

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Effect of Buyang Huanwu Decoction Combined with Acupuncture on Sequelae of Cerebral Stroke

E3S Web of Conferences ◽

10.1051/e3sconf/202018503018 ◽

2020 ◽

Vol 185 ◽

pp. 03018

Author(s):

Jian Guo ◽

Deqi Ren ◽

Xuehui Chang

Keyword(s):

Barthel Index ◽

Clinical Effect ◽

Effective Rate ◽

Control Group ◽

Cerebral Stroke ◽

Clinical Effects ◽

Buyang Huanwu Decoction ◽

Nihss Score ◽

Significant Difference ◽

Experimental Group

Objective: To explore the clinical effect of the combined use of Buyang Huanwu Decoction and acupuncture in the treatment of patients with sequelae of stroke. Methods: The research work was carried out in our hospital. The study started from September 2018 to September 2019. A total of 100 patients were selected and randomly grouped into experimental group and control group, both groups were given Buyang Huanwu Decoction for intervention, the experimental group were added acupuncture treatment methods on this basis to explore the clinical effects of different intervention methods. Results: There were 4 patients with ineffective treatment in the experimental group, the effective rate was 92.00%, and the effective rate in the control group was 74.00%. The effective rate of the experimental group was higher, and the data was significantly different (P<0.05). After treatment, the FMA, NIHSS score and Barthel index of the patients in the experimental group were (32.66±6.51), (7.11±3.54) and (90.34±9.87) respectively. The FMA score and Barthel index were significantly higher than the control group, and the NIHSS score was lower than the control group, data differences are significant (P<0.05). At the same time, before treatment, there was no significant difference in the scores of TCM syndromes. After treatment, the patients in the experimental group had less hemiplegia, skewed eyes and mouth, eccentric sensation abnormality and consciousness coma scores than that of the control group. The data difference is quite large (P<0.05), the experimental group had better effect. Conclusion: The combined treatment of Buyang Huanwu Decoction and acupuncture in the treatment of patients with sequelae of stroke has a significant clinical effect, which can improve the quality of life of patients, improve the nerve function of patients, and have a positive effect on clinical development.

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Systematic Analysis of Clinical Curative Effect of Acupuncture on Children with Cerebral Palsy Movement Disorder

E3S Web of Conferences ◽

10.1051/e3sconf/202018503010 ◽

2020 ◽

Vol 185 ◽

pp. 03010

Author(s):

Yujin Hou ◽

Xiaosu Jie ◽

Xin Guo ◽

Yingying Zhang ◽

Hua Shi ◽

...

Keyword(s):

Cerebral Palsy ◽

Acupuncture Treatment ◽

Research Work ◽

Effective Rate ◽

Control Group ◽

Systematic Analysis ◽

Significant Difference ◽

Children With Cerebral Palsy ◽

Improvement Effect ◽

Experimental Group

Objective: To explore the effect of applying acupuncture on children with cerebral palsy dyskinesia. Methods: Research work was carried out in our hospital. The work was carried out from November 2018 to November 2019. A total of 100 patients were selected, all of whom were children with cerebral palsy, accompanied by dyskinesia. They were randomly divided into two groups, and were given conventional rehabilitation training and acupuncture treatment respectively, named the control group and the experimental group, and the clinical efficacy of the two groups of patients was analyzed. Results: There was no significant difference in the MAS scores of the two groups of children before treatment, which was expressed as P> 0.05. After treatment intervention, the scores of the two groups of children were improved, in contrast, the improvement effect is more significant for the experimental group, the data difference is large, P <0.05, which is significant. The treatment effective rate of the children in the experimental group was 92.00%, and the treatment effective rate of the children in the control group was 76.00%, there is a big difference between the two groups of data, P <0.05, which is significant. Conclusion: The application of acupuncture and moxibustion therapy in children with cerebral palsy movement disorders can improve the adverse symptoms of children and promote the recovery of patients, which has positive significance for clinical development.

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Effect of Huatan Quyu Decoction on Patients with Cerebral Infarction

E3S Web of Conferences ◽

10.1051/e3sconf/202127103080 ◽

2021 ◽

Vol 271 ◽

pp. 03080

Author(s):

Yanyong Miao ◽

Xiaolei Han ◽

Liuyang Meng

Keyword(s):

Cerebral Infarction ◽

Research Work ◽

Neurological Impairment ◽

Effective Rate ◽

Control Group ◽

Treatment Intervention ◽

Number Of Patients ◽

Significant Difference ◽

The Difference ◽

Experimental Group

The objective is to explore the clinical methods and effects of applying Huatan Quyu Decoction in the treatment of patients with cerebral infarction. The research work was carried out in our hospital, and the research was carried out from November 2019 to November 2020. Patients with cerebral infarction were selected as the research object, and the number of patients was 80. They were randomly divided into two groups and one group was given conventional rehabilitation therapy as the control group, the other group was given Huatan Quyu Decoction as the experimental group, and the effects of different treatments on patients were compared and analyzed. Before treatment intervention, there was no significant difference in the scores of neurological impairment, limb motor ability and ability of daily living between the two groups of patients, P>0.05. After treatment intervention, the CSS score of the experimental group decreased and the BI score increased, which has significant differences compared with the control group, and the experimental group has higher scores for sensory and motor function. In addition, the effective rate of treatment in the experimental group was 95.00%, which was significantly higher than the 77.50% in the control group. The difference between the two groups was significant and meaningful. The treatment effect was better in the experimental group.The application of Huatan Quyu Decoction in the process of treating patients with cerebral infarction can effectively promote the recovery of patients and improve the quality of life of patients. The clinical application is significant.

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Is perioperative antibiotic necessary in straightforward implant placement procedures?

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00282 ◽

2020 ◽

Author(s):

Elçin Bedeloğlu ◽

Mustafa Yalçın ◽

Cenker Zeki Koyuncuoğlu

Keyword(s):

Clavulanic Acid ◽

Dental Implant ◽

Prophylactic Antibiotic ◽

Antibiotic Use ◽

Implant Failure ◽

Control Group ◽

Implant Placement ◽

Significant Difference ◽

Amoxicillin Clavulanic Acid ◽

Experimental Group

The purpose of this non-random retrospective cohort study was to evaluate the impact of prophylactic antibiotic on early outcomes including postoperative pain, swelling, bleeding and cyanosis in patients undergoing dental implant placement before prosthetic loading. Seventy-five patients (45 males, 30 females) whose dental implant placement were completed, included to the study. Patients used prophylactic antibiotics were defined as the experimental group and those who did not, were defined as the control group. The experimental group received 2 g amoxicillin + clavulanic acid 1 h preoperatively and 1 g amoxicillin + clavulanic acid twice a day for 5 days postoperatively while the control group had received no prophylactic antibiotic therapy perioperatively. Data on pain, swelling, bleeding, cyanosis, flap dehiscence, suppuration and implant failure were analyzed on postoperative days 2, 7, and 14 and week 12. No statistically significant difference was detected between the two groups with regard to pain and swelling on postoperative days 2, 7, and 14 and week 12 ( p >0.05), while the severity of pain and swelling were greater on day 2 compared to day 7 and 14 and week 12 in both groups ( p =0.001 and p <0.05, respectively). Similarly, no significant difference was found between the two groups with regard to postoperative bleeding and cyanosis. Although flap dehiscence was more severe on day 7 in the experimental group, no significant difference was found between the two groups with regard to the percentage of flap dehiscence assessed at other time points. Within limitations of the study, it has been demonstrated that antibiotic use has no effect on implant failure rates in dental implant surgery with a limited number of implants. We conclude that perioperative antibiotic use may not be required in straightforward implant placement procedures. Further randomized control clinical studies with higher numbers of patients and implants are needed to substantiate our findings.

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The Effect of Using Students Peer Teaching on Iraqi EFL Students' Achievement in the Course of Library and Research Work

Journal of Education College Wasit University ◽

10.31185/eduj.vol1.iss33.771 ◽

2019 ◽

Vol 1 (33) ◽

pp. 693-714

Author(s):

. Muntaha Sabbar Jebur

Keyword(s):

Basic Education ◽

Teaching Method ◽

Research Work ◽

Peer Teaching ◽

Control Group ◽

College Of Basic Education ◽

Significant Difference ◽

Post Test ◽

Efl Students ◽

Experimental Group

Peer teaching is a strategy that allows the students to teach the new content to each other, and they must be accurately guided by instructors. The researcher proposes that the use of students peer teaching may promote students' achievement and ensure the engagement of all the students in the learning process. Therefore, the researcher employs it as a teaching method aiming at investigating its effect on Iraqi EFL students' achievement in the course of Library and Research Work . The study hypothesizes that there is no significant difference between the students' achievement who are taught library and research work by students peer teaching and that of the students taught by the traditional way. The experimental design of the study is Parallel Groups, Random Assignment, posttest. Each group consists of 35 students, chosen randomly from the Third Year Students at the Department of English in the College of Basic Education. Both groups were matched in terms of their age and parents' education. The experiment was fulfilled in the first course for 15 weeks during the academic year 2016-2017. The same materials were presented to both groups. This included units from Writing Research Paper by Lester D. . Post-test was constructed and exposed The t-test for independent samples was used to analyze the results and it is found out that there is a statistical difference between the two groups in their achievement because the calculated t- value 2.635 is bigger than the tabulated t- value which is 2.000, and also shown the superiority of the experimental group. The results indicate that the experimental group, who was taught Library and Research Work by peer teaching was better than the control group, who was taught according to the traditional way. So, the null hypothesis is rejected. Finally, some recommendations and suggestions are presented in the light of the study findings. to a jury of experts to verify its validity and it was administered to both groups.

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Optimization of postoperative management of patients undergoing functional endoscopic sinus surgery

OTORHINOLARYNGOLOGY 2-3(2) 2019 - OTORHINOLARYNGOLOGY ◽

10.37219/2528-8253-2018-1-26 ◽

2018 ◽

pp. 26-31

Author(s):

Sergey Bezshapochny ◽

Andrey Loburets ◽

Valery Loburets

Keyword(s):

Nasal Cavity ◽

Postoperative Period ◽

Sodium Hyaluronate ◽

Sinus Surgery ◽

Control Group ◽

Nasal Breathing ◽

Traditional Therapy ◽

Significant Difference ◽

Water Salt ◽

Experimental Group

Topicality: The result of surgical treatment depends largely on the chosen method of management of the postoperative period, the main purpose of which is to reduce the effects of surgical trauma. Despite the wide variety of drugs for local and systemic use, the question of pharmacotherapy of the operated sinus remains open to this day. The main properties that a modern drug should possess are safety and high clinical efficacy. Aim: to study the clinical efficacy of topical application of a complex preparation based on a saline solution containing sodium hyaluronate and dexpanthenol in patients with chronic sinusitis after functional endoscopic sinus surgery (FESS). Materials and Methods: Clinical and laboratory studies were conducted on 47 patients with chronic rhinosinusitis who underwent surgery using the FESS technique. Patients were divided into 2 groups according to the principle of the postoperative period. Patients of research group (n=21), except for traditional therapy, was used locally NASOMER (a preparation based on a water-salt solution containing sodium hyaluronate and dexpanthenol); to the control group (n=26) patients entered, in the postoperative period received traditional therapy. Traditional therapy included a toilet of the nasal cavity, the use of short-course topical decongestants, irrigation of the nasal cavity with water-salt solutions. Criteria of clinical effectiveness: data of endoscopy of the nasal cavity, rhinomanometry, activity of the mucociliary transport system. The effectiveness of functional research methods in the postoperative period was determined on the 7th and 14th day of treatment. Results: On the 3rd day of the study, an increase in the swelling of the nasal cavity was observed in patients of both clinical groups, correlated with difficulty in nasal breathing. On the 7th day, a decrease in edema was observed in patients of both groups, but in the experimental group, the index of nasal breathing, according to rhinomanometry, was significantly (p<0.05) different from the control group, and was respectively 1.54±0.14 and 2.04±0.19 kPa/l*s. On the 14th day of the study, no significant difference was observed between these indicators. When studying the activity of the ciliated epithelium of the mucous membrane of the nasal cavity, it was proved that patients of the experimental group on day 7 after surgery showed a statistically significant difference in this indicator compared to the control group (17.8±1.0 and 22.7±2.1 min. respectively). Conclusions: The use of NASOMER after surgical intervention in patients with chronic rhinosinusitis contributes to more effective treatment compared with traditional therapy, as evidenced by the rapid recovery of the main functional parameters according to active posterior rhinomanometry and mucociliary clearance. Based on the results of the studies performed, the use of NASOMER for pharmacotherapy in the postoperative period is recommended for patients who have undergone rhinosurgical interventions with the aim of reducing the period of postoperative rehabilitation as an effective anti-inflammatory and wound-healing agent.

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Effect of Levetiracetam on Cognitive Function and Clonic Seizure Frequency in Children with Epilepsy

Current Molecular Medicine ◽

10.2174/1566524019666190729113321 ◽

2019 ◽

Vol 19 (9) ◽

pp. 699-703

Author(s):

Shihao Zhou ◽

Qiong Zhan ◽

Xiaomei Wu

Keyword(s):

Cognitive Function ◽

Effective Rate ◽

Clonic Seizure ◽

Conventional Group ◽

Significant Difference ◽

Random Number Table ◽

Clonic Seizures ◽

The Difference ◽

Experimental Group ◽

Executive Ability

Background: This study aimed to explore the clinical effect of levetiracetam in the treatment of children with epilepsy. Methods: 136 children with epilepsy were selected from January 2017 to December 2017. According to the random number table method, they were divided into the experimental group and the conventional group, with 68 cases in each group. The conventional group was treated with valproate, while the experimental group was treated with levetiracetam. The effective rate, the cognitive function and the frequency of clonic seizures in the two groups were compared. Results: There was no significant difference in the total effective rate between the two groups (P>0.05). There was no significant difference in attention, executive ability, abstract and orientation scores between the two groups before treatment (P>0.05). After treatment, the focus of attention (106.54±6.56), executive ability (105.76±6.77), abstract and directional score (106.65±6.57) were significantly higher than that of the conventional group. The difference in the two groups was statistically significant (P<0.05). After 3 months of treatment, the frequency of myoclonic seizures (9.22±0.95) and the frequency of tonic-clonic seizures (11.68±1.36) were found to be significantly lower than those of the conventional group, and the difference between the two groups was statistically significant (P<0.05). Conclusion: Levetiracetam is effective in the treatment of children with epilepsy. It can effectively improve the cognitive function of the patients, reduce the frequency of myoclonic seizures and tonic-clonic seizures, and has a high promotion value.

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