46 A NEW MODEL FOR THE ROLE OF INDIVIDUAL PREDISPOSITION IN ORTHOSTATIC INTOLERANCE BEFORE AND AFTER EXPOSURE TO SIMULATED MICROGRAVITY.

Recent studies have suggested that microgravity-induced arterial remodelling contributes to post-flight orthostatic intolerance and that multiple mechanisms are involved in arterial remodelling. However, the initial mechanism by which haemodynamic changes induce arterial remodelling is unknown. Focal adhesions (FAs) are dynamic protein complexes that have mechanotransduction properties. This study aimed to investigate the role of FAs in simulated-microgravity-induced basilar and femoral arterial remodelling. A 4-week hindlimb-unweighted (HU) rat model was used to simulate the effects of microgravity, and daily 1-hour intermittent artificial gravity (IAG) was used to prevent arterial remodelling. After 4-week HU, wall thickness, volume of smooth muscle cells (SMCs) and collagen content were increased in basilar artery but decreased in femoral artery (P < 0.05). Additionally, the expression of p-FAK Y397 and p-Src Y418 was increased and reduced in SMCs of basilar and femoral arteries, respectively, by HU (P < 0.05). The number of FAs was increased in basilar artery and reduced in femoral artery by HU (P < 0.05). Furthermore, daily 1-hour IAG prevented HU-induced differential structural adaptations and changes in FAs of basilar and femoral arteries. These results suggest that FAs may act as mechanosensors in arterial remodelling by initiating intracellular signal transduction in response to altered mechanical stress induced by microgravity.

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Changes in size and compliance of the calf after 30 days of simulated microgravity

Journal of Applied Physiology ◽

10.1152/jappl.1989.66.3.1509 ◽

1989 ◽

Vol 66 (3) ◽

pp. 1509-1512 ◽

Cited By ~ 75

Author(s):

V. A. Convertino ◽

D. F. Doerr ◽

S. L. Stein

Keyword(s):

Simulated Microgravity ◽

Orthostatic Intolerance ◽

Bed Rest ◽

Calf Muscle ◽

Venous Compliance ◽

Cross Sectional ◽

Percent Change ◽

Long Duration ◽

Before And After ◽

Muscle Compartment

Increased leg venous compliance may contribute to postflight orthostatic intolerance in astronauts. We reported that leg compliance was inversely related to the size of the muscle compartment. The purpose of this study was to test the hypothesis that reduced muscle compartment after long-duration exposure to microgravity would cause increased leg compliance. Eight men, 31–45 yr old, were measured for vascular compliance of the calf and serial circumferences of the calf before and after 30 days of continuous 6 degrees head-down bed rest. Cross-sectional areas (CSA) of muscle, fat, and bone compartments in the calf were determined before and after bed rest by computed tomography. From before to after bed rest, calculated calf volume (cm3) decreased (P less than 0.05) from 1,682 +/- 83 to 1,516 +/- 76. Calf muscle compartment CSA (cm2) also decreased (P less than 0.05) from 74.2 +/- 3.6 to 70.6 +/- 3.4; calf compliance (ml.100 ml-1.mmHg-1.100) increased (P less than 0.05) from 3.9 +/- .7 to 4.9 +/- .5. The percent change in calf compliance after bed rest was significantly correlated with changes in calf muscle compartment CSA (r = 0.72, P less than 0.05). The increased leg compliance observed after exposure to simulated microgravity can be partially explained by reduced muscle compartment. Countermeasures designed to minimize muscle atrophy in the lower extremities may be effective in ameliorating increased venous compliance and orthostatic intolerance after spaceflight.

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Effects of simulated microgravity on closed-loop cardiovascular regulation and orthostatic intolerance: analysis by means of system identification

Journal of Applied Physiology ◽

10.1152/japplphysiol.00602.2003 ◽

2004 ◽

Vol 96 (2) ◽

pp. 489-497 ◽

Cited By ~ 20

Author(s):

Xinshu Xiao ◽

Ramakrishna Mukkamala ◽

Natalie Sheynberg ◽

S. Marlene Grenon ◽

Michael D. Ehrman ◽

...

Keyword(s):

System Identification ◽

Simulated Microgravity ◽

Closed Loop ◽

Orthostatic Intolerance ◽

Bed Rest ◽

Model Parameters ◽

Primary Concern ◽

Loop Model ◽

Before And After ◽

Coupling Mechanisms

Microgravity-induced orthostatic intolerance (OI) continues to be a primary concern for the human space program. To test the hypothesis that exposure to simulated microgravity significantly alters autonomic nervous control and, thus, contributes to increased incidence of OI, we employed the cardiovascular system identification (CSI) technique to evaluate quantitatively parasympathetic and sympathetic regulation of heart rate (HR). The CSI method analyzes second-to-second fluctuations in noninvasively measured HR, arterial blood pressure, and instantaneous lung volume. The coupling mechanisms between these signals are characterized by using a closed-loop model. Parameters reflecting parasympathetic and sympathetic responsiveness with regard to HR regulation can be extracted from the identified coupling mechanisms. We analyzed data collected from 29 human subjects before and after 16 days of head-down-tilt bed rest (simulated microgravity). Statistical analyses showed that parasympathetic and sympathetic responsiveness was impaired by bed rest. A lower sympathetic responsiveness and a higher parasympathetic responsiveness measured before bed rest identified individuals at greater risk of OI before and after bed rest. We propose an algorithm to predict OI after bed rest from measures obtained before bed rest.

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Child and Adolescent Suicides in Bosnia and Herzegovina Before and After the War (1992–1995)

Crisis ◽

10.1027/0227-5910/a000021 ◽

2010 ◽

Vol 31 (3) ◽

pp. 160-164 ◽

Cited By ~ 3

Author(s):

Almir Fajkic ◽

Orhan Lepara ◽

Martin Voracek ◽

Nestor D. Kapusta ◽

Thomas Niederkrotenthaler ◽

...

Keyword(s):

Bosnia And Herzegovina ◽

Age Differences ◽

Suicide Risk ◽

Child And Adolescent ◽

Youth Suicide ◽

Southeastern Europe ◽

Suicide Rates ◽

Before And After ◽

Sex And Age Differences

Background: Evidence on youth suicides from Southeastern Europe is scarce. We are not aware of previous reports from Bosnia and Herzegovina, which experienced war from 1992 to 1995. Durkheim’s theory of suicide predicts decreased suicide rates in wartime and increased rates afterward. Aims: To compare child and adolescent suicides in Bosnia and Herzegovina before and after the war. Methods: Data on youth suicide for prewar (1986–90) and postwar (2002–06) periods were analyzed with respect to prevalence, sex and age differences, and suicide methods. Suicide data from 1991 through 2001 were not available. Results: Overall youth suicide rates were one-third lower in the postwar than in the prewar period. This effect was most pronounced for girls, whose postwar suicide rates almost halved, and for 15–19-year-old boys, whose rates decreased by about a one-fourth. Suicides increased among boys aged 14 or younger. Firearm suicides almost doubled proportionally and were the predominant postwar method, while the most common prewar method had been hanging. Conclusions: The findings from this study indicate the need for public education in Bosnia and Herzegovina on the role of firearm accessibility in youth suicide and for instructions on safe storage in households. Moreover, raising societal awareness about suicide risk factors and suicide prevention is needed.

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Strategic Role of Zakat in Multidimensional Quality of Life in Sijunjung, Indonesia

The Journal of Muamalat and Islamic Finance Research ◽

10.33102/jmifr.v15i1.101 ◽

2018 ◽

Vol 15 (1) ◽

pp. 55-72

Author(s):

Herlin Hamimi ◽

Abdul Ghafar Ismail ◽

Muhammad Hasbi Zaenal

Keyword(s):

Quality Of Life ◽

Positive Impact ◽

Wealth Distribution ◽

Absolute Poverty ◽

Before And After ◽

The Status ◽

Being There ◽

The Impact

Zakat is one of the five pillars of Islam which has a function of faith, social and economic functions. Muslims who can pay zakat are required to give at least 2.5 per cent of their wealth. The problem of poverty prevalent in disadvantaged regions because of the difficulty of access to information and communication led to a gap that is so high in wealth and resources. The instrument of zakat provides a paradigm in the achievement of equitable wealth distribution and healthy circulation. Zakat potentially offers a better life and improves the quality of human being. There is a human quality improvement not only in economic terms but also in spiritual terms such as improving religiousity. This study aims to examine the role of zakat to alleviate humanitarian issues in disadvantaged regions such as Sijunjung, one of zakat beneficiaries and impoverished areas in Indonesia. The researcher attempted a Cibest method to capture the impact of zakat beneficiaries before and after becoming a member of Zakat Community Development (ZCD) Program in material and spiritual value. The overall analysis shows that zakat has a positive impact on disadvantaged regions development and enhance the quality of life of the community. There is an improvement in the average of mustahik household incomes after becoming a member of ZCD Program. Cibest model demonstrates that material, spiritual, and absolute poverty index decreased by 10, 5, and 6 per cent. Meanwhile, the welfare index is increased by 21 per cent. These findings have significant implications for developing the quality of life in disadvantaged regions in Sijunjung. Therefore, zakat is one of the instruments to change the status of disadvantaged areas to be equivalent to other areas.

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The role of adenosinergic system in patients with orthostatic intolerance

Endocrine Abstracts ◽

10.1530/endoabs.63.p1030 ◽

2019 ◽

Author(s):

Zora Lazurova ◽

Peter Mitro ◽

Marta Jakubova ◽

Milos Simurda ◽

Eva Durovcova ◽

...

Keyword(s):

Orthostatic Intolerance

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Gender at Stake: The Role of Eighteenth-Century London Clubs in Shaping A New Model of English Masculinity

Culture Society and Masculinities ◽

10.3149/csm.0401.13 ◽

2012 ◽

Vol 4 (1) ◽

pp. 13-32

Author(s):

Valérie Capdeville

Keyword(s):

Eighteenth Century ◽

New Model

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SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

International Journal of Clinical and Biomedical Research ◽

10.31878/ijcbr.2019.54.05 ◽

2019 ◽

pp. 18-20

Author(s):

Sanjeeva Kumar Goud T ◽

Rahul Kunkulol

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Serum Vitamin ◽

Cross Sectional ◽

Serum Vitamin D ◽

Significant Difference ◽

Before And After

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual route

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Arthroscopy in Arthrosis: Is It Worth it? A case Presentation

Revista de Chimie ◽

10.37358/rc.18.8.6506 ◽

2018 ◽

Vol 69 (8) ◽

pp. 2232-2235

Author(s):

Marius Moga ◽

Mark Edward Pogarasteanu ◽

Antoine Edu

Keyword(s):

Clinical Status ◽

Loose Body ◽

Point Of View ◽

The Other ◽

Joint Range Of Motion ◽

Objective Evidence ◽

Before And After ◽

Total Knee ◽

Joint Range

The role of arthroscopy in incipient and mild arthrosis, even combined with proximal tibial ostetomy, is well known and well documented. On the other hand, its role in the treatment of advanced arthrosis of the large joints, especially the knee, is a subject of controversy. The proponents of the use of arthroscopy in advanced arthrosis claim that meniscectomy, synovectomy, ostophytectomy, chondral lesion stabilization, arthroscopic release, plica and loose body removal greatly improve the quality of life for most patients, especially if followed by the use of viscoelastic injection, by diminishing pain and improving joint range of motion. The opponents claim that, even though the advantages are clear in the cases that refuse arthroplasty, in all the other cases the surgical indication should be total knee arthroplasty, as the clinical relief is temporary, but with all the risks of a surgical intervention. We have conducted an overview of the recent literature, in order to find objective evidence to sustain either point of view. We focused on articles published that included an objective measurement of before and after clinical status through clinical scores and objective measurements. We also focused on the follow-up period and on the evolution of the pathology after arthroscopy.

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