Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies

2019 ◽  
Vol 76 (9) ◽  
pp. 611-616
Author(s):  
Francesco Barone-Adesi ◽  
Daniela Ferrante ◽  
Elisabetta Chellini ◽  
Enzo Merler ◽  
Venere Pavone ◽  
...  
Keyword(s):  
Epidemiological Studies ◽  
Pooled Analysis ◽  
External Exposure ◽  
Multistage Model ◽  
Peritoneal Cancer ◽  
Long Term Trends ◽  
Over Time ◽  
Better Than

ObjectivesModels based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis.MethodsWe used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time.ResultsRates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer.ConclusionsRates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.

scholarly journals CTNI-01. EFFECT OF STEREOTACTIC RADIOSURGERY COMPARED TO WHOLE-BRAIN RADIOTHERAPY FOR LIMITED BRAIN METASTASIS ON LONG TERM COGNITION AND QUALITY OF LIFE: A POOLED ANALYSIS OF RANDOMIZED CLINICAL TRIALS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii40-ii41
Author(s):  
Joshua Palmer ◽  
Brett Klamer ◽  
Karla Ballman ◽  
Paul Brown ◽  
Jane Cerhan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Randomized Clinical Trials ◽  
Whole Brain Radiotherapy ◽  
Pooled Analysis ◽  
Cognitive Outcomes ◽  
Phase Iii ◽  
Brain Radiotherapy ◽  
Over Time

Abstract PURPOSE We investigated the long term impact of SRS and WBRT in two large prospective phase III trials. METHODS Patients with 1–4 BMs +/- resection were randomized to SRS or WBRT. Cognitive deterioration was a drop of >1 standard deviation from baseline in >2/6 cognitive measures (CM). Quality of life (QOL) scores were scored 0–100 point scale. CM and QOL scores were modeled using baseline adjusted Linear Mixed Models (LMM) with uncorrelated random intercept for subject and random slopes for time. Differences over time between groups and the effect of >2 cognitive scores with >2 SD change from baseline were assessed. RESULTS 88 patients were included with median follow up of 24 months. We observed decreasing CM over time (SRS: 4/6; WBRT: 5/6). Mean CM was significantly higher in SRS for Total recall and Delayed Recall at 3, 6, 9, 12 months. More patients in WBRT arm declined 1 SD in >1 and >2 CM at the 3, 6, 9, and 12 months. A 1 SD decline in >3 CM at 1 year was 21% SRS vs 47% WBRT (p=0.02). SRS had fewer patients with a 2 SD decline in >1 CM at every time point. SRS had fewer patients with a 2 SD decline at >2 and >3 CM. WBRT had lower QOL at 3 months, but switched to SRS having lower QOL at 24 months for PWB, EWB, FWB, FactG, BR, and FactBR (p< 0.05). A 2 SD decline in cognition decreased mean FWB by 6.4 units (95% CI: -11, -1.75; p=0.007) and decreased QOL by 5.1 units (95% CI: -7.7, -2.5; p< 0.001). CONCLUSIONS We report the first pooled prospective study demonstrating the long term outcomes of patients with BMs after cranial radiation. WBRT was associated with worse cognitive outcomes. Impaired cognition is associated with worse QOL.

scholarly journals Long-Term Trends in News Content

2019 ◽  
Author(s):  
Edda Humprecht ◽  
Linards Udris
Keyword(s):  
International Comparisons ◽  
Organizational Level ◽  
Steady Increase ◽  
Theoretical Concepts ◽  
News Content ◽  
National Differences ◽  
Long Term Trends ◽  
Over Time ◽  
The Way

The way news is produced and consumed has changed dramatically during the first two decades of the 21st century due to digitalization and economic pressures. In a globalized world, current events are reported in almost real time in various countries and are diffused rapidly via social media. Thus much scholarly attention is devoted to determining whether these developments have changed news content. Comparative research in the area of journalism focuses on whether news content across countries converges over time and to what degree national differences persist across countries. When studying the research on long-term trends in news content, three main observations can be made. First, theoretical assumptions are often rooted in different models of democracies, but they are rarely explicitly discussed. Second, many studies focus on the organizational level using theoretical concepts related to increased market orientation of news outlets, such as personalization, emotionalization, or scandalization. Furthermore, commercialization is associated with the effects of digitalization and globalization, namely, decreased advertising revenues and increased competition. A commonly expressed fear is that these changes have consequences for democracy and informed citizenship. Third, in recent years, there has been a steady increase of studies employing international comparisons as well as a growing standardization for measurements. These developments lead to more multicountry studies based on large samples but come at the expense of more fine-grained analysis of the way news content changes over time. Finally, the vast majority of cross-national and single-country studies focus on Western democracies. Thus our knowledge about recent changes in news content is limited to a small set of countries. Overall, many studies provide evidence for constant changes of news content driven by social, political, and economic developments. However, different media systems exhibit a sustained resilience toward transnational pressures reflected in a persistence of national differences in news content over time.

scholarly journals The Long-term Effects of Instruction on EFL Learners' Use of Complaining Formulas

10.29007/5xsb ◽  
2018 ◽  
Author(s):  
Alicia Martínez-Flor ◽  
Esther Usó-Juan
Keyword(s):  
Foreign Language ◽  
Language Learners ◽  
Future Research ◽  
Long Term Effects ◽  
Positive Role ◽  
Efl Learners ◽  
Foreign Language Learners ◽  
Over Time

Studies analysing the positive role of pragmatic instruction in formal settings have increased over the last decades. Within this area of interventional pragmatics, some studies have particularly examined whether the effectiveness of the instruction implemented is sustained over time. In order to shed more light on the long-term effects of instruction, this research investigates English as a Foreign Language learners’ use of complaining formulas not only after immediately receiving instruction, but also two months later. Results show that learners keep using a variety of appropriate complaining formulas two months after having participated in the instructional period. These findings are discussed and directions for future research suggested.

Temperament and Coping Activity Under Stress of Changing Intensity Over Time

2012 ◽  
Vol 17 (4) ◽  
pp. 326-336 ◽  
Author(s):  
Irena Heszen
Keyword(s):  
Stress Intensity ◽  
Emotional Reactivity ◽  
Self Report ◽  
Sensory Sensitivity ◽  
And Coping ◽  
First Myocardial Infarction ◽  
Different Levels ◽  
Over Time

Temperament is probably an important factor that influences coping activity. The framework of the study was the Regulative Theory of Temperament by Strelau, where six temperamental traits are distinguished: emotional reactivity, perseveration, activity, briskness, sensory sensitivity, and endurance. These traits were hypothesized to be connected to coping activity in accordance with their psychological characteristics. It was also expected that the associations between temperament and coping activity should depend on stress intensity. Participants were 278 diabetics and 232 patients after first myocardial infarction (MI). The study was longitudinal and two diseases had been purposely selected so as to represent stress intensity either increasing (in diabetes) or decreasing (after MI) over time. Temperamental traits as well as coping activity components: cognitive appraisal, affect, and coping strategies were measured using self-report questionnaires. As hypothesized, temperamental traits were connected to coping activity. Phase-related changes in coping activity confirmed an increase in stress levels in diabetics, while cardiac patients tended to experience the situation as more challenging. While the expectation referring to the differential role of temperament under different levels of stress intensity was not confirmed, the connections of temperament with coping activity were found to decrease under long-term stress.

scholarly journals Long-term trends in the chemistry of atmospheric deposition in Northwestern Italy: the role of increasing Saharan dust deposition

Tellus B ◽  
2004 ◽  
Vol 56 (5) ◽  
pp. 426-434 ◽  
Author(s):  
M. Rogora ◽  
R. Mosello ◽  
A. Marchetto
Keyword(s):  
Atmospheric Deposition ◽  
Saharan Dust ◽  
Dust Deposition ◽  
Long Term Trends

The Role of Pensions in the Labor Market: A Survey of the Literature

ILR Review ◽  
1994 ◽  
Vol 47 (3) ◽  
pp. 417-438 ◽  
Author(s):  
Alan L. Gustman ◽  
Olivia S. Mitchell ◽  
Thomas L. Steinmeier
Keyword(s):  
Labor Market ◽  
Pension Plans ◽  
Employee Compensation ◽  
Employment Relationships ◽  
Over Time

Because employer-sponsored group pension plans entail agreements between workers and their employers explicitly linking future payment and employment, they offer an unusual window into long-term employment relationships. This review of recent research on pensions explores how pensions influence employee compensation, retirement, turnover, and other matters central to the determination of labor's price and quantity over time. The authors also outline some unanswered questions and difficult-to-reconcile findings.

Economic Wood Supply — Problems and Opportunities: Choices for Canada's Forest Industry

1990 ◽  
Vol 66 (1) ◽  
pp. 32-34 ◽  
Author(s):  
Roger A. Sedjo
Keyword(s):  
Forest Resource ◽  
Plantation Forest ◽  
Broad Perspective ◽  
Tropical Regions ◽  
Intensive Forest Management ◽  
Second Growth ◽  
Long Term Trends ◽  
Intensively Managed

This paper examines the role of Canada in world forest resource production. A broad overview of global timber supply is presented together with an overview of likely future sources. The discussion covers both regions of supply as well as the nature of the forest resource — old growth, second growth, and plantation forest. Within this broad perspective some long-term trends and tendencies are identified. The growing role of plantation and intensively managed forestry is discussed. Canada's strengths and liabilities as a forest resource supplier are discussed within this context. It is argued that Canada cannot compete successfully with semi-tropical regions in intensive forest management. Rather, Canada appears to have the features necessary to compete in world wood markets using a strategy of extensive forestry that takes advantage of Canada's vast forest land areas.

scholarly journals The role of transfer in language variation and change: Evidence from contact varieties of French

2005 ◽  
Vol 8 (2) ◽  
pp. 93-98 ◽  
Author(s):  
JEANINE TREFFERS-DALLER ◽  
RAYMOND MOUGEON
Keyword(s):  
Geographical Area ◽  
Demographic Factors ◽  
Institutional Support ◽  
Language Variation ◽  
The Other ◽  
Special Issue ◽  
Language Variation And Change ◽  
Over Time

In this Special Issue, the focus is on contact-induced language variation and change in situations of societal bilingualism that involve long-term contact between French and another language. As is well known, when two or more languages are spoken by groups of speakers in the same geographical area, over time, features from one language can be transferred to the other language, especially when the languages in question are unequal in terms of prestige, institutional support and demographic factors. The process that leads to the adoption of such features in the contact languages is generally known as INTERFERENCE or TRANSFER, and these terms are also used to describe the features in question (i.e. the end product of the process of transfer). In this issue we prefer to use the term TRANSFER over the use of the notion INTERFERENCE, as the former has fewer negative connotations than the latter.

Book Reviews

2019 ◽  
Vol 57 (3) ◽  
pp. 702-704
Keyword(s):  
Cultural Context ◽  
Historical Perspectives ◽  
European Banking ◽  
Country Analysis ◽  
Cross Country ◽  
Over Time

Kim Oosterlinck of Université Libre de Bruxelles reviews “Financial Elites and European Banking: Historical Perspectives,” edited by Youssef Cassis and Giuseppe Telesca. The Econlit abstract of this book begins: “Nine papers look at the role of financial elites in different European societies and markets over time, providing historical comparisons and cross-country analysis of their adaptation and contribution to the transformation of the national and international regulatory/cultural context in the wake of a crisis in a long-term perspective.”

Irregular Migration, Human Smuggling, and the Eastern Enlargement of the European Union

2007 ◽  
Vol 41 (2) ◽  
pp. 291-315 ◽  
Author(s):  
Michael Jandl
Keyword(s):  
Eu Enlargement ◽  
Human Smuggling ◽  
The European Union ◽  
Eastern Enlargement ◽  
Irregular Migration ◽  
Ample Evidence ◽  
Recent Developments ◽  
Long Term Trends

This article examines the consequences of the latest round of EU-Enlargement in May 2004 on irregular migration across Central and Eastern Europe. Drawing on a unique collection of both quantitative and qualitative data related to irregular migration and human smuggling, the article first presents some long-term trends in irregular migration across the region before taking up more recent developments in 2003 and 2004. While border apprehensions have broadly declined since about 2000 there is ample evidence for an increasing role of human smugglers in facilitating irregular migration. In addition, there are noticeable changes in the modus operandi of human smugglers.

Sign in / Sign up

Export Citation Format

Share Document