scholarly journals P306 Public policies for syphilis in pregnancy and congenital syphilis in Brazilian border strip

2021 ◽  
Author(s):  
L Lannoy ◽  
A Santos ◽  
P Gaspar ◽  
R Coelho ◽  
A Guarabyra ◽  
...  
Keyword(s):  
Congenital Syphilis ◽  
Public Policies ◽  
Border Strip ◽  
In Pregnancy

Syphilis and pregnancy: Review

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Samaniego Haro VJ ◽  
Keyword(s):  
Pregnant Woman ◽  
Congenital Syphilis ◽  
Neonatal Morbidity ◽  
Sexual Partners ◽  
Cure Rate ◽  
Chronic Complications ◽  
Drug Of Choice ◽  
Recurrent Abortions ◽  
Penicillin Treatment ◽  
In Pregnancy

Syphilis is a disease that has not been eradicated in part due to inadequate management of antibiotic therapy which is selected according to the stage of the disease and to the misuse of the type of penicillin. Treatment of this disease should be done to prevent it´s chronic complications, to avoid infecting sexual partners and the fetus in a pregnant woman. Syphilis in pregnancy causes increase in the rate of recurrent abortions and neonatal morbidity and mortality, that´s the main reason why early detection and treatment without delay is extremely important. Pregnancy alters immunity, so the serological diagnosis can provide false positives, with the use of inverse algorithms these results may decrease, by increasing the sensitivity of the tests. Today, after 69 years since the advent of penicillin, it has become the drug of choice for any stage of syphilis and in pregnant women; if the patient has allergy, desensitization is indicated either orally or intravenously and other antibiotic shouldn´t be used because of the security offered by penicillin in the cure rate and in the reduction of congenital syphilis. Keywords: Syphilis; Pregnancy; Inverse algorithms.

Infections Caused by Spirochetes: Syphilis, Lyme Disease, Leptospirosis

2018 ◽  
Author(s):  
Patrick Duff
Keyword(s):  
Lyme Disease ◽  
Latent Infection ◽  
Congenital Syphilis ◽  
Ixodes Scapularis ◽  
Severe Disease ◽  
Erythema Migrans ◽  
Treponema Pallidum ◽  
Mild Disease ◽  
Drug Of Choice ◽  
In Pregnancy

Syphilis is caused by the spirochete Treponema pallidum. It is classified as primary, secondary, tertiary, and latent infection. If left untreated, syphilis can cause devastating injury to the fetus. The drug of choice for treatment of syphilis in pregnancy is penicillin. Lyme disease is caused by Borrelia burgdorferi and is transmitted by the Ixodes scapularis tick. The principal clinical manifestation of Lyme disease is erythema migrans, but patients may also develop arthritis and cardiac and neurologic abnormalities. Congenital Lyme disease has not been reported. The drug of choice for treatment of Lyme disease in pregnancy is amoxicillin. Leptospirosis is usually acquired from direct contact with urine of infected animals or through contaminated water, soil, or vegetation. Pregnant women with mild disease should be treated with oral amoxicillin. Patients with severe disease should be hospitalized and treated with intravenous penicillin or ampicillin. This review contains 5 figures, 5 tables, and 19 references. Key Words: clinical infection, congenital syphilis, latent infection, leptospirosis, Lyme disease, syphilis

scholarly journals Retrospective analysis of burden of maternal syphilis and the outcome in the fetus in a tertiary care centre

2018 ◽  
Vol 4 (2) ◽  
pp. 181
Author(s):  
M. Manimegalai ◽  
P. Elangovan ◽  
V.A. Kayalvizhi ◽  
D. Mithra Rangapriya
Keyword(s):  
Congenital Syphilis ◽  
Single Case ◽  
Tertiary Care ◽  
Routine Screening ◽  
Care Centre ◽  
Perinatal Complications ◽  
Tertiary Care Centre ◽  
Maternal Syphilis ◽  
Common Association ◽  
In Pregnancy

<p class="abstract"><strong>Background:</strong> Syphilis in pregnancy has its own significance with regards to the outcome of pregnancy. In the meanwhile, it also reflects the effectiveness of health system in the community.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was carried out in a tertiary care centre in Chennai between January 2014 and July 2015 to determine the seroprevalence of syphilis in pregnant women. A total of 4423 ANC mother attending the hospital were included in the study.<strong></strong></p><p class="abstract"><strong>Results:</strong> Of the 4423 cases studied, 7 cases were found to be positive for RPR accounting to the prevalence of 0.15%. One mother was symptomatic, presenting with condyloma lata. TPHA was positive in 2 cases (28.5%) Most common association was with HIV infection, 2/7 (28.5%). All the RPR positive patients were treated with tablet erythromycin 500 mg qid × 14 days. Epidose for the partner was given. The outcome was uneventful except for one. A single case of congenital syphilis was reported.</p><p class="abstract"><strong>Conclusions:</strong> Though the prevalence of RPR positive in routine screening is less, the outcome of single congenital syphilis is worrisome. To conclude, although the prevalence of syphilis (0.1%) is low, routine screening of asymptomatic ante natal women is recommended to reduce the incidence of congenital syphilis &amp; perinatal complications and it is always better to treat the ANC mothers with syphilis with Penicillin, preferably with a second dose also.</p>

scholarly journals Treatment of Syphilis in Pregnancy and Prevention of Congenital Syphilis

2002 ◽  
Vol 35 (s2) ◽  
pp. S200-S209 ◽  
Author(s):  
George D. Wendel Jr. ◽  
Jeanne S. Sheffield ◽  
Lisa M. Hollier ◽  
James B. Hill ◽  
Patrick S. Ramsey ◽  
...  
Keyword(s):  
Congenital Syphilis ◽  
In Pregnancy

Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis

2017 ◽  
Vol 219 ◽  
pp. 133 ◽  
Author(s):  
Bridie Howe ◽  
Medhat Basta ◽  
Kirsty Foster ◽  
Umo Esen ◽  
Richard Ellis ◽  
...  
Keyword(s):  
Genital Herpes ◽  
Congenital Syphilis ◽  
Primary Syphilis ◽  
In Pregnancy

scholarly journals Maternal HIV and syphilis are not syndemic in Brazil: Hot spot analysis of the two epidemics

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255590
Author(s):  
Mary Catherine Cambou ◽  
Eduardo Saad ◽  
Kaitlyn McBride ◽  
Trevon Fuller ◽  
Emma Swayze ◽  
...  
Keyword(s):  
Hot Spots ◽  
Congenital Syphilis ◽  
Hot Spot ◽  
Z Score ◽  
Hot Spot Analysis ◽  
Southern States ◽  
Maternal Hiv ◽  
Maternal Syphilis ◽  
In Pregnancy ◽  
Spot Analysis

While the annual incidence of HIV diagnosis in pregnancy in Brazil remains relatively stable, rates of maternal syphilis increased over six-fold in the past decade. We hypothesized that maternal HIV and syphilis are two distinct epidemics. Data on all cases of maternal HIV or syphilis detected in pregnancy between January 1, 2010 to December 31, 2018 were requested from the Brazilian Ministry of Health. In order to evaluate how the epidemics evolved over the time period, ArcGIS software was used to generate spatiotemporal maps of annual rates of detection of maternal HIV and syphilis in 2010 and 2018. We utilized Euclidean-distance hot spot analysis to identify state-specific clusters in 2010 and 2018. From 2010 to 2018, there were 66,631 cases of maternal HIV, 225,451 cases of maternal syphilis, and 150,414 cases of congenital syphilis in Brazil. The state of Rio Grande do Sul had the highest rate of maternal HIV detection in both 2010 and 2018. Hot spots of maternal HIV were identified in the three most Southern states in both 2010 and 2018 (99% confidence, z-score >2.58, p <0.01). While syphilis incidence >30 per 1,000 live births in 2018 in four states, only the two coastal states of Rio de Janeiro and Espirito Santo in Southeastern Brazil were significant hot spots (90% confidence, z-score 1.65–1.95, p <0.10). Contrary to the general assumption, HIV and syphilis epidemics in Brazil are not syndemic in pregnant women. There is a spatial cluster of maternal HIV in the South, while syphilis is increasing throughout the country, more recently on the coast. Focusing on maternal HIV hot spots in the Southern states is insufficient to curtail the maternal and congenital syphilis epidemics throughout the country. New strategies, including ongoing hot spot analysis, are urgently needed to monitor, identify and treat maternal syphilis.

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