Effect of temperature on transition and transversion mutagenesis: characterization of wild type and a mutator T4 DNA polymerase mutant
1984 ◽
Vol 26
(3)
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pp. 386-389
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Keyword(s):
The effect of temperature on genetically well-defined mutational pathways was examined in the bacteriophage T4. The mutational site was a T4 rII ochre mutant which could revert to rII+ via a transversion or to the amber convertant via a transition. Temperature did not strongly affect any of the pathways examined in a wild-type background; however, increased temperature reduced the mutational activity of a mutator DNA polymerase mutant. Possible models to explain the role of temperature in mutagenesis are discussed as well as the significance of low temperatures for in vitro mutagenesis reactions.Key words: bacteriophage T4, mutator, transition, transversion, temperature effects.
2001 ◽
Vol 29
(2)
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pp. 183-187
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Keyword(s):
2001 ◽
Vol 69
(6)
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pp. 3916-3923
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Keyword(s):
The Conserved Poxvirus L3 Virion Protein Is Required for Transcription of Vaccinia Virus Early Genes
2005 ◽
Vol 79
(23)
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pp. 14719-14729
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Keyword(s):
1989 ◽
Vol 264
(11)
◽
pp. 6447-6458
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1991 ◽
Vol 266
(3)
◽
pp. 1830-1840
Keyword(s):
2014 ◽
Vol 307
(3)
◽
pp. H337-H345
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Keyword(s):