Aging, evolution and individual health span: introduction

Genome ◽  
1989 ◽  
Vol 31 (1) ◽  
pp. 361-367 ◽  
Author(s):  
B. Cinader
Keyword(s):  
Life Span ◽  
Old Age ◽  
Reverse Genetics ◽  
Inbred Mice ◽  
Sandhoff Disease ◽  
Demographic Changes ◽  
Degenerative Diseases ◽  
Health Span ◽  
Age Related ◽  
Starting Point

The effect of autologous and environmental wear and tear on genes and gene products will be considered in systems renewed by self-replicating stem and precursor cells as well as in systems that do not have the capacity for self-renewal. Aging will be discussed in terms of speciation and in terms of health-span differences between individuals of the same species. The analysis of speciation involves early as well as late-acting genes. The intraspecies analysis is primarily concerned with the second half of life and thus is not affected by selective pressures. Analysis of individual aging is concerned with health span, qualified by identification of the particular system that is responsible for the limit of health span in subpopulations; it depends on a subset of allelic products of many genes and their relative functional capacity. The identification of such alleles can provide the starting point for reverse genetics. Results will be presented, which have been obtained by analysis of age-related events in inbred mice, where regulation, involved in degenerative disease of old age, can be studied in groups of individuals with a relatively constant genetic background. It should be possible to identify appropriate probes for degenerative diseases of old age that can be used for detection of corresponding human genes. Worldwide demographic changes have created the need for a new type of public health policy. To respond to this need, we should learn how to identify individuals at risk from degenerative diseases of old age and how to treat them preventively.Key words: evolution of aging – demographic changes, life-span – health span, chromosome fragility, muscular dystrophy, Sandhoff disease, end cell and aging, hibernation and life-span, degenerative diseases of old age.

Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention

2007 ◽  
Vol 32 (5) ◽  
pp. 954-966 ◽  
Author(s):  
Christy S. Carter ◽  
Tim Hofer ◽  
Arnold Y. Seo ◽  
Christian Leeuwenburgh
Keyword(s):  
Life Span ◽  
Calorie Restriction ◽  
Aging Process ◽  
Molecular Mechanisms ◽  
Geriatric Medicine ◽  
Functional Decline ◽  
Intervention Strategies ◽  
Health Span ◽  
Structural Deterioration ◽  
Age Related

The aging process results in a gradual and progressive structural deterioration of biomolecular and cellular compartments and is associated with many pathological conditions, including cardiovascular disease, stroke, Alzheimer’s disease, osteoporosis, sarcopenia, and liver dysfunction. Concomitantly, each of these conditions is associated with progressive functional decline, loss of independence, and ultimately disability. Because disabled individuals require care in outpatient or home care settings, and in light of the social, emotional, and fiscal burden associated with caring for an ever-increasing elderly population, research in geriatric medicine has recently focused on the biological mechanisms that are involved in the progression towards functional decline and disability to better design treatment and intervention strategies. Although not completely understood, the mechanisms underlying the aging process may partly involve inflammatory processes, oxidative damage, mitochondrial dysfunction, and apoptotic tissue degeneration. These hypotheses are based on epidemiological evidence and data from animal models of aging, as well as interventional studies. Findings from these studies have identified possible strategies to decrease the incidence of age-related diseases and delay the aging process. For example, lifelong exercise is known to extend mean life-span, whereas calorie restriction (CR) increases both mean and maximum life-span in a variety of species. Optimal application of these intervention strategies in the elderly may positively affect health-related outcomes and possibly longevity. Therefore, the scope of this article is to (i) provide an interpretation of various theories of aging from a “health-span” perspective; (ii) describe interventional testing in animals (CR and exercise); and (iii) provide a translational interpretation of these data.

scholarly journals Increasingly capable at the ripe old age? Cognitive abilities from 2004 to 2013 in Germany, Spain, and Sweden

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254038
Author(s):  
Julia Grasshoff ◽  
Johannes Beller ◽  
Beatrice G. Kuhlmann ◽  
Siegfried Geyer
Keyword(s):  
Old Age ◽  
Cognitive Abilities ◽  
Cognitive Aging ◽  
Age Groups ◽  
Good Health ◽  
Cohort Effects ◽  
Educational Systems ◽  
Age Related ◽  
Life Years ◽  
Starting Point

Background Life expectancy is increasing in most high-income countries, but gains in life years are maximized if spent in good health and if cognitive abilities are maintained until old age. Age-related decline of cognitive abilities does nevertheless occur, but the pace of decline is decisive. This was the starting point for our study that aims to examine cohort effects of cognitive aging in women and men in Germany, Spain and Sweden by analyzing changes from 2004 to 2013 by estimating cohort effects within age groups starting from the age of 50 years. Methods A cohort study was conducted that was based on data of the surveys 2004 (N = 6,081) and 2013 (N = 8,650) from the Survey of Health, Ageing and Retirement in Europe (SHARE). The analyses were based on data of female and male respondents aged 50 years and older. Age-specific means of verbal fluency and delayed recall from the German, Spanish and Swedish samples were the cognitive domains considered in the study. Results In both domains of cognitive ability the achievements in the later surveys were higher than in the earlier ones. This was found in all countries, abut achievement levels increased markedly in the German and the Spanish samples, while the scores of the Swedish samples were not significantly different. While the highest scores were found for Sweden, Germany ranked in the middle and the lowest scores were found in the Spanish samples. Over time, the scores of the German samples approached those of Sweden. Conclusions From the first to the second survey, improvements of older adults’ cognitive abilities were found for all countries considered. This may indicate improvements of the underlying educational systems, but also increasingly stimulating general living conditions.

Preparation for old age in different life domains

2013 ◽  
Vol 38 (3) ◽  
pp. 228-238 ◽  
Author(s):  
Anna E. Kornadt ◽  
Klaus Rothermund
Keyword(s):  
Life Span ◽  
Old Age ◽  
Life Domains ◽  
Personality Profiles ◽  
Large Sample ◽  
Domain Specific ◽  
Age Related ◽  
Financial Arrangements ◽  
Age Related Changes

We investigated preparation for age-related changes from a multidimensional, life span perspective and administered a newly developed questionnaire to a large sample aged 30–80 years. Preparing for age-related changes was organized by life domains, with domain-specific types of preparation addressing obstacles and opportunities in the respective domains. Preparing for a third (focusing on activities, leisure, work, fitness, appearance) and a fourth age (focusing on emergencies, dependence/independence, housing, financial arrangements) emerged as superordinate categories of preparation. Different age gradients were obtained for the factors, the former peaking around the age of 65, whereas the latter increased linearly up to the age of 80. Furthermore, preparation factors were characterized by distinct personality profiles. The findings attest to the importance of a differentiated view on preparation for age-related changes and its relevance across the life span.

scholarly journals Education on Old Age and Ageing in School: An Analysis of Students’ Conceptions of Old Age and Ageing and Implications for Teaching

2020 ◽  
Vol 10 (11) ◽  
pp. 307
Author(s):  
Franziska Ginschel ◽  
Kirsten Schlüter
Keyword(s):  
Old Age ◽  
Ninth Graders ◽  
Teaching Approaches ◽  
Individual Interviews ◽  
Age Related ◽  
Starting Point ◽  
Negative Images ◽  
Perceptions Of Students ◽  
Age Cohort ◽  
Images Of Old Age

Issues related to old age and ageing are an imperative topic in a society of long life, concerning everyone. Wherever possible, the age-related issues should also be adequately addressed and integrated into school education. This article gives an overview of perceptions of students in regard to external and self-images of old age, as conceptions from students are an important starting point for the development of teaching approaches. So far, there is an insufficient research situation in Germany regrading images of old age of children and adolescents. Guideline-supported individual interviews with 10 ninth graders (Mage = 15.2 years) were conducted and analyzed in order to get an insight into prevalent conceptions of old age and ageing in this age cohort. The students’ ideas result in a comprehensive category system. In summary, our investigation has shown that students do not hold one-sided positive or negative images of old age in general, although some aspects like the physical condition and exercise capacity are seen more negatively than for example the characteristics of older persons. Teaching approaches for biology lessons and other subjects, deducted from the students’ perceptions, are given in the discussion.

Abstract 224: Detoxification versus Healthy Aging: Aryl Hydrocarbon Receptor Deficiency Improves Vessel Functionality and Increases Healthy Lifespan

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Joachim Altschmied ◽  
Anna Eckers ◽  
Sascha Jakob ◽  
Christian Heiss ◽  
Christine Goy ◽  
...  
Keyword(s):  
Life Span ◽  
Aryl Hydrocarbon Receptor ◽  
Knockout Mice ◽  
Healthy Aging ◽  
Human Subjects ◽  
Surrogate Marker ◽  
Health Span ◽  
C Elegans ◽  
Aryl Hydrocarbon ◽  
Age Related

Development of age-associated vascular diseases like atherosclerosis depends not only on genetic predisposition but also on environmental influences. Ligands of the aryl hydrocarbon receptor (AhR), a ubiquitously expressed transcription factor upregulating detoxifying enzymes, like dioxin and benzo[a]pyrene (BaP) have been shown to promote atherosclerosis. Furthermore, recovery of the blood flow after hindlimb ischemia is significantly enhanced in AhR-deficient mice demonstrating increased angiogenesis in the absence of AhR. Thus, there seems to be a link between AhR, vessel functionality and age-related cardiovascular diseases. To investigate the role of the AhR in health span and vessel function, we analyzed AhR-deficient Caenorhabditis elegans, vessel stiffness in AhR-knockout mice and human subjects of different age and with varying levels of AhR expression as well as functional parameters in primary human endothelial cells (EC) after AhR activation. AhR-deficient C. elegans showed not only an extended life span, but also enhanced motility. In AhR-knockout mice, we observed a reduced PWV in both old and young animals, suggesting that AhR impairs vessel function already at young age. Concomitantly, eNOS phosphorylation at serine 1178, a surrogate marker for eNOS activation, was enhanced in aortas of knockout animals. In line with this, the AhR agonist BaP increased an inhibitory phosphorylation on eNOS in EC. Moreover, BaP reduced migration of EC without changes in proliferation or apoptosis, an effect that was reversed by addition of the AhR antagonist 3’methoxy-4’nitroflavone. In human subjects we demonstrated not only a positive correlation between age and pulse wave velocity (PWV), a readout for vessel stiffness, but also between AhR expression in blood cells and PWV, again suggesting a negative impact of AhR on vessel functionality. Our data demonstrate that loss of AhR extends life span as well as health span in C. elegans. Knockout of AhR in mice leads to improvement of vessel functionality by decreasing vessel stiffness. Finally, the PWV in humans positively correlates not only with age but also with the expression of AhR. Thus, AhR expression may be useful as a new predictor of healthy aging from nematodes to humans.

scholarly journals Aging in the Digital Age: Using Technology to Increase the Reach of the Clinician Expert and Close the Gap Between Health Span and Life Span

2021 ◽  
Vol 3 ◽  
Author(s):  
Joyce Gomes-Osman ◽  
Javier Solana-Sánchéz ◽  
Emily Rogers ◽  
Gabriele Cattaneo ◽  
William Souillard-Mandar ◽  
...  
Keyword(s):  
Life Span ◽  
Large Scale ◽  
Health Care Systems ◽  
Therapeutic Interventions ◽  
Brain Health ◽  
Health Span ◽  
Personal Connection ◽  
Age Related ◽  
Intelligent Technology ◽  
The Impact

Age-related cognitive impairment (ARCI) has a profound impact on individuals, families, health care systems, and societies at large. Evidence suggests that ARCI is the consequence of underlying brain pathology. Therefore, efforts to minimize the impact of ARCI and thus closing the gap between health span and life span, which has widened in recent years, requires early detection and timely deployment of targeted, personalized interventions. Access to clinical experts is limited and technology screening and assessment methods are thus appealing. However, as traditionally implemented patients were deprived of the benefit of personalized connection with a clinician, which is particularly critical for the prescription and to ensure the adherence to and ultimate success of therapeutic interventions. We present the concept of Intelligent Technology Therapy Assistant (ITA) as a scalable solution that increases the reach of clinical experts while sustaining the personal connection between each patient and their clinician. We illustrate ITA with the “Guttman Neuro Personal Trainer”®, a tele-rehabilitation platform that provides neuropsychological evaluation and care, and the Barcelona Brain Health Initiative (BBHI) multimodal intervention coaching app, a mobile-based platform that provides lifestyle coaching support in domains related to brain health. In addition, we discuss the translation of these models to a large-scale enterprise with Linus Health. To this end, we conclude with a discussion of challenges and opportunities to move the field forward.

scholarly journals Positive Emodiversity Buffers the Association Between Stress and Depressive Symptoms

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 653-653
Author(s):  
Lizbeth Benson ◽  
Anthony Ong
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Life Span ◽  
Daily Diary ◽  
National Study ◽  
Younger Adults ◽  
Shannon's Entropy ◽  
Daily Experiences ◽  
Age Related ◽  
Optimal Functioning

Abstract Intensive measurements of individuals’ experiences allow for identifying patterns of functioning that may be markers of resilience, and whether such patterns differ across the life span. Using 8 daily diary reports collected in the second burst of the National Study of Daily Experiences (NSDE, n=848, age 34-84; 55%female), we examined whether positive emodiversity (Shannon’s entropy) attenuated the association between cumulative stressor exposure and depressive symptoms, and age-related differences therein. Results indicated age moderated the extent to which positive emodiversity attenuated the association between stress and depressive symptoms (b=0.11, p < .05). The attenuated association was strongest for younger adults with higher positive emodiversity, compared to those with lower positive emodiversity. For older adults, the association between stress and depressive symptoms was relatively similar regardless of their positive emodiversity. Implications pertain to for whom and in what contexts specific types of dynamic emotion experiences may promote optimal functioning and resilience.

scholarly journals Understanding diversity in later life through images of old age

2020 ◽  
pp. 1-20 ◽  
Author(s):  
Friederike Enßle ◽  
Ilse Helbrecht
Keyword(s):  
Qualitative Research ◽  
Old Age ◽  
Public Discourse ◽  
Social Groups ◽  
Later Life ◽  
Older Individuals ◽  
Starting Point ◽  
Conceptual Debate ◽  
Micro Level ◽  
Images Of Old Age

Abstract This article aims to enhance the conceptual debate on diversity in old age by exploring the interplay of diversity in later life and images of old age. We argue that the analysis of images of old age on the micro-level is a fruitful methodology in order to unravel the meaning of diversity in later life. Drawing on findings from qualitative research in Berlin, we explore how new and diverse imaginations, experiences and lifestyles of old age emerge. The conceptual focus on images of old age enables us to investigate further what diversity in later life comprises and how it simultaneously fosters the genesis of new images of old age. The manifold new images we found in our research suggest that prevalent societal discourses about old age on the macro-level are rather deceptive and represent mostly stereotypes such as ‘active agers’ or ‘frail and dependent elders’. We offer three explanations why alternative images of old age are currently barely present in public discourse: (a) the actors transmitting images of age; (b) the institutionalisation of the images; and (c) the challenge to communicate complexity. We conclude by suggesting that images of old age are a promising starting point to explore and make visible both the diversity of social groups within the older generation as well as the heterogeneity of older individuals.

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