X-IRRADIATION OF RIBOSE AND DEOXYRIBOSE DERIVATIVES
During X-irradiation of ribosides and deoxyribosides in dilute aqueous solution, purine and sugar moieties were destroyed at approximately the same rate. Pyrimidine moieties, on the other hand, were destroyed more rapidly, resulting in a fairly rapid liberation of free sugar during irradiation of pyrimidine ribosides or deoxyribosides. No marked differences in the rates of destruction of ribose and deoxyribose derivatives were observed in these experiments.Similar reactions were observed during irradiation of blood samples. However, acid-soluble ribonucleotides in the blood proved to be much more sensitive than the nucleic acids or proteins to destruction by X-radiation. The significance of these findings is discussed with relation to the damage produced in cells by X-irradiation.