54Mn Uptake by the Ovaries and Reproductive Tract of Cycling and Anestrous Ewes

The uptake of 54Mn by the ovaries and reproductive tract of cycling and anestrous ewes has been investigated following intravenous injection of a single dose of S4Mn Cl2 and sacrifice of the ewes 6 h later. The uptake of 54Mn was greater in the Graafian follicle and the corpus luteum (CL) of the cycle than in the other components of the ovary. An increased uptake of radioactivity was recorded in the CL of the 11th day of the cycle when compared with that of the 4th day. The uptake of 54Mn was lower in the corpus albicans and follicles. A low uptake of radio manganese was found also in the various tissues of the reproductive tract. These findings indicate that manganese may play a role in the normal functioning of ovarian activity in the ewe.

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INFLUENCE OF POSTWEANING GROWTH RATE ON PUBERTY AND OVARIAN ACTIVITY IN HEIFERS

Canadian Journal of Animal Science ◽

10.4141/cjas75-012 ◽

1975 ◽

Vol 55 (1) ◽

pp. 93-100 ◽

Cited By ~ 14

Author(s):

J. J. DUFOUR

Keyword(s):

Growth Rate ◽

Corpus Luteum ◽

Follicular Fluid ◽

Initial Phase ◽

Follicular Development ◽

The Other ◽

Ovarian Activity ◽

Final Phase ◽

Feeding Regime ◽

Feeding Regimes

Thirty-six Holstein heifers were randomly assigned at the weight of 136 kg to two groups: a fast-growing (FR) and a moderate-growing (MR) feeding regime for an initial phase of 100 days, followed by a final phase ending with ovariectomy after puberty, during which half of each group was subjected to the other feeding regime. The effect at puberty of the FR was a nonsignificant reduction of 16.3 days in age, and a significant increase (P < 0.01) of 26.2 kg in weight when considering the feeding regimes of the initial phase of growth. When the same treatments were imposed during the final phase of growth, heifers on FR were 52.0 days younger at puberty (P < 0.01) and 10.0 kg lighter (P > 0.05) than heifers on MR. Follicular development, in terms of follicular fluid weight, and diameters of the largest and second largest follicles 15 days after estrus, was greater in the ovary bearing the corpus luteum than in the other ovary. The diameter of the second largest follicle was greater in heifers on FR when imposed in the final phase of growth. Injection of Vetrophin at the estrus preceding ovariectomy did not change the ovulation rate, but increased the percentage of small-sized follicles and decreased the percentage of medium-sized follicles. The number of corpora albicantia observed at ovariectomy indicated that 76.5% of the heifers ovulated prior to puberty without exhibiting a standing estrus. Of those exhibiting an estrus at first ovulation, 33.3% had a first estrous cycle of less than 10.0 days in length.

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PROGESTERONE IN THE HUMAN PERIPHERAL BLOOD IN THE PREOVULATORY PERIOD OF THE MENSTRUAL CYCLE

Acta Endocrinologica ◽

10.1530/acta.0.0550091 ◽

1967 ◽

Vol 55 (1) ◽

pp. 91-96 ◽

Cited By ~ 9

Author(s):

Benno Runnebaum ◽

Josef Zander

Keyword(s):

Menstrual Cycle ◽

Corpus Luteum ◽

Peripheral Blood ◽

Human Peripheral Blood ◽

Progesterone Concentration ◽

Plasma Progesterone ◽

Progesterone Secretion ◽

Graafian Follicle ◽

The Mean ◽

Mean Concentration

ABSTRACT Progesterone was determined and identified in human peripheral blood during the preovulatory period of the menstrual cycle, by combined isotope derivative and recrystallization analysis. The mean concentration of progesterone in 1.095 ml of plasma obtained 9 days before ovulation was 0.084 μg/100 ml. However, the mean concentration of progesterone in 1.122 ml of plasma obtained 4 days before ovulation was 0.279 μg/100 ml. These data demonstrate a source of progesterone secretion other than the corpus luteum. The higher plasma-progesterone concentration 4 days before ovulation may indicate progesterone secretion of the ripening Graafian follicle of the ovary.

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EFFECT OF FEEDING ETHINYLOESTRADIOL FOR VARIOUS PERIODS BEFORE MATING ON REPRODUCTION IN THE HAMSTER

Acta Endocrinologica ◽

10.1530/acta.0.0700582 ◽

1972 ◽

Vol 70 (3) ◽

pp. 582-590

Author(s):

B. K. Davis ◽

I. Noske ◽

M. C. Chang

Keyword(s):

Single Dose ◽

Pregnancy Rate ◽

Fertility Control ◽

Normal Pregnancy ◽

Oestrous Cycle ◽

The Other ◽

Feeding Schedule ◽

Crown Rump Length ◽

Essentially Normal ◽

Effect Of Feeding

ABSTRACT Ethinyloestradiol (EO) fed for various periods before mating to female hamsters affected the timing of mating and pregnancy rate. Slight effects on ovulation, foetal-crown rump length and resorption may have occurred, but effects on implantation were not apparent among pregnant hamsters. The response observed depended upon the feeding schedule adopted: hamsters fed 2.5 mg EO in a single dose, on day 3 before mating, mated normally but had a significantly lower pregnancy rate; on the other hand, animals fed 2.5 mg EO (0.21 mg/day) over three oestrous cycles, days 14–3 before mating, showed variations in the time of mating but had an essentially normal pregnancy rate; and, a group of hamsters who received the same total amount of EO (0.63 mg/day) over one oestrous cycle, days 6–3 premating, showed untowards effects by the steroid on both the timing of mating and pregnancy rate. The implications of these results are considered in relation to fertility control.

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Intravenous injection of elemental mercury: A report of two cases

Indian Journal of Plastic Surgery ◽

10.1055/s-0039-1699270 ◽

2008 ◽

Vol 41 (02) ◽

pp. 214-218

Author(s):

A. Gopalakrishna ◽

T. V. Pavan Kumar

Keyword(s):

Intravenous Injection ◽

Elemental Mercury ◽

The Other ◽

Surgical Removal

ABSTRACTTwo cases of intravenous injection of elemental mercury are described in this report. One patient succumbed and the other remains asymptomatic two years after the surgical removal of all the injected mercury. Management of intravenous injection of elemental mercury (intended to be an aphrodisiac in these two cases) is discussed here and the need for surgical removal of all accessible mercury has been emphasized

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Ultrastructural studies of the bovine Graafian Follicle and corpus luteum

Cell and Tissue Research ◽

10.1007/bf00455274 ◽

1968 ◽

Vol 91 (4) ◽

pp. 554-573 ◽

Cited By ~ 39

Author(s):

Janis Priedkalns ◽

Alvin F. Weber

Keyword(s):

Corpus Luteum ◽

Ultrastructural Studies ◽

Graafian Follicle

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NO, CO and H2S based pharmaceuticals in the mission of vision (eye health): a comprehensive review

Reviews in Inorganic Chemistry ◽

10.1515/revic-2021-0009 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Jan Mohammad Mir ◽

Ram Charitra Maurya ◽

Mohd Washid Khan

Keyword(s):

Nitric Oxide ◽

Carbon Monoxide ◽

Human Physiology ◽

Hydrogen Sulfide ◽

The Other ◽

Normal Functioning ◽

Comprehensive Review ◽

Molecular Systems ◽

Eye Health ◽

Highly Sensitive

Abstract A set of well defined signaling molecules responsible for normal functioning of human physiology including nitric oxide along with carbon monoxide and hydrogen sulphide are referred as “gasotransmitters”. Due to their involvement in almost every system of a human body, the care of highly sensitive organs using these molecules as drugs represents highly fascinating area of research. In connection with these interesting aspects, the applied aspects of these gaseous molecules in maintaining healthy eye and vision have been targeted in this review. Several examples of eye-droppers including NORMs like latanoprost and nipradiol, CORMs like CORM-3 and CORM-A1, and Hydrogen sulfide releasing system like GYY4137 have been discussed in this context. Therefore the relation of these trio-gasotransmitters with the ophthalmic homeostasis on one hand, and de-infecting role on the other hand has been mainly highlighted. Some molecular systems capable of mimicking gasotransmitter action have also been introduced in connection with the titled theme.

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Seminal vesicle proteins SVS3 and SVS4 facilitate SVS2 effect on sperm capacitation

Reproduction ◽

10.1530/rep-15-0551 ◽

2016 ◽

Vol 152 (4) ◽

pp. 313-321 ◽

Cited By ~ 8

Author(s):

Naoya Araki ◽

Natsuko Kawano ◽

Woojin Kang ◽

Kenji Miyado ◽

Kaoru Yoshida ◽

...

Keyword(s):

Seminal Vesicle ◽

Reproductive Tract ◽

Female Reproductive Tract ◽

The Other ◽

Sperm Capacitation ◽

Other Hand ◽

Sperm Membrane ◽

Vesicle Secretion ◽

Mammalian Spermatozoa

Mammalian spermatozoa acquire their fertilizing ability in the female reproductive tract (sperm capacitation). On the other hand, seminal vesicle secretion, which is a major component of seminal plasma, inhibits the initiation of sperm capacitation (capacitation inhibition) and reduces the fertility of the capacitated spermatozoa (decapacitation). There are seven major proteins involved in murine seminal vesicle secretion (SVS1-7), and we have previously shown that SVS2 acts as both a capacitation inhibitor and a decapacitation factor, and is indispensable forin vivofertilization. However, the effects of SVSs other than SVS2 on the sperm have not been elucidated. Since mouseSvs2–Svs6genes evolved by gene duplication belong to the same gene family, it is possible that SVSs other than SVS2 also have some effects on sperm capacitation. In this study, we examined the effects of SVS3 and SVS4 on sperm capacitation. Our results showed that both SVS3 and SVS4 are able to bind to spermatozoa, but SVS3 alone showed no effects on sperm capacitation. On the other hand, SVS4 acted as a capacitation inhibitor, although it did not show decapacitation abilities. Interestingly, SVS3 showed an affinity for SVS2 and it facilitated the effects of SVS2. Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2. Therefore, we suggest that separate processes may cause capacitation inhibition and decapacitation, and SVS3 and SVS4 act on sperm capacitation cooperatively with SVS2.

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Intravenous injection of cyclophilin A realizes the transient and reversible opening of barrier of neural vasculature through basigin in endothelial cells

Scientific Reports ◽

10.1038/s41598-021-98163-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Narumi Nakada-Honda ◽

Dan Cui ◽

Satoshi Matsuda ◽

Eiji Ikeda

Keyword(s):

Endothelial Cells ◽

Single Dose ◽

Blood Brain Barrier ◽

Intravenous Injection ◽

Cyclophilin A ◽

Brain Barrier ◽

Blood Brain ◽

Neural Tissues ◽

Neural Diseases

AbstractNeural vasculature forms the blood–brain barrier against the delivery of systemically administered therapeutic drugs into parenchyma of neural tissues. Therefore, procedures to open the blood–brain barrier with minimal damage to tissues would lead to the great progress in therapeutic strategy for intractable neural diseases. In this study, through analyses with mouse in vitro brain microvascular endothelial cells and in vivo neural vasculature, we demonstrate that the administration of cyclophilin A (CypA), a ligand of basigin which is expressed in barrier-forming endothelial cells, realizes the artificial opening of blood–brain barrier. Monolayers of endothelial cells lost their barrier properties through the disappearance of claudin-5, an integral tight junction molecule, from cell membranes in a transient and reversible manner. Furthermore, the intravenous injection of a single dose of CypA into mice resulted in the opening of blood–brain barrier for a certain period which enabled the enhanced delivery of systemically administered doxorubicin into the parenchyma of neural tissues. These findings that the pre-injection of a single dose of CypA realizes an artificial, transient as well as reversible opening of blood–brain barrier are considered to be a great step toward the establishment of therapeutic protocols to overcome the intractability of neural diseases.

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Non-specific Bacterial Profiles in Reproductive Tract of Dairy Cattle during Artificial Insemination

World s Veterinary Journal ◽

10.54203/scil.2021.wvj15 ◽

2021 ◽

Vol 11 (1) ◽

pp. 110-114

Author(s):

Astin Islam Andriani ◽

Sri Pantja Madyawati ◽

Emy Koestanti Sabdoningrum

Keyword(s):

Dairy Cattle ◽

Bacterial Infection ◽

Artificial Insemination ◽

Reproductive Tract ◽

The Other ◽

Reproductive Efficiency ◽

Reproductive Disorders ◽

Bacterial Isolation ◽

Isolation And Identification ◽

Other Hand

One of the causes of low reproductive efficiency in dairy cattle is the presence of reproductive disorders caused by a non-specific bacterial infection. The aim of the present study was to isolate and identify the genus of non-specific bacteria in the reproductive tract of dairy cattle during artificial insemination. A total of 10 samples in the form of mucus attached to the plastic sheath used after artificial insemination in dairy cattle were collected in the study. The samples were subjected to bacterial isolation and identification. The obtained results of the study indicated that Staphylococcus was the dominant genus found (90%). On the other hand, other genera were Escherichia (60%) and Corynebacterium (20%).

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