Effect of Cantharidins in Chemotherapy for Hepatoma: A Retrospective Cohort Study

2014 ◽  
Vol 42 (03) ◽  
pp. 561-567 ◽  
Author(s):  
Wei Zhang ◽  
Yu-Zhen Ma ◽  
Lei Song ◽  
Chen-Hua Wang ◽  
Tong-Gang Qi ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Symptoms ◽  
Control Group ◽  
Karnofsky Score ◽  
Improvement Rate ◽  
Wbc Count ◽  
Transcatheter Hepatic Arterial Chemoembolization ◽  
Arterial Chemoembolization

This study aimed to evaluate the effects of cantharidins, a traditional Chinese medicine, in chemotherapy for the treatment of hepatoma. From August 2011 to December 2012, 96 patients with hepatoma, who were eligible for transcatheter hepatic arterial chemoembolization and received cantharidins, were selected for comparison with the control group of 95 patients without cantharidins. The treatment effect, clinical symptoms and adverse effects were analyzed. The results of the study showed that the cantharidins group had a higher overall efficient rate than the control group (p < 0.001). The improvement rate of the Karnofsky score in the cantharidins group was significantly higher than that of the control group (p = 0.014). In the cantharidins group, there was a decrease in white blood cell (WBC) count and gastrointestinal response rates were lower than those of the control group (p < 0.05). Therefore, the traditional Chinese medicine cantharidins showed effects of easing the progress of liver cancer, relieving side effects of chemotherapy and improving the quality of life in the treatment of hepatoma.

scholarly journals Aidi Injection, a Traditional Chinese Medicine Injection, Could Be Used as an Adjuvant Drug to Improve Quality of Life of Cancer Patients Receiving Chemotherapy: A Propensity Score Matching Analysis

2018 ◽  
Vol 18 ◽  
pp. 153473541881079 ◽  
Author(s):  
Gang Xie ◽  
Zhihua Cui ◽  
Kai Peng ◽  
Xiehai Zhou ◽  
Quan Xia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Propensity Score ◽  
Cancer Patients ◽  
Control Group ◽  
Tumor Type ◽  
Improvement Rate ◽  
Aidi Injection

Background: Clinical research has paid increasing attention to quality of life (QoL) in recent years, but the assessment of QoL is difficult, hampered by the subjectivity, complexity, and adherence of patients and physicians. According to previous studies, QoL in cancer patients is related to performance status (PS) and influenced by chemotherapy-related toxicity. Aidi injection, a traditional Chinese medicine injection, is used as an adjuvant drug to enhance effectiveness of chemotherapy. The study aims to investigate whether Aidi injection could improve QoL by improving PS and reducing toxicity caused by chemotherapy. Methods: A retrospective cohort study was performed at the First Affiliated Hospital of Anhui Medicine University. Data of consecutive patients diagnosed with cancers between January 2014 and June 2017 were retrieved from the electronic medical record system. After a 1:1 propensity score match, patients were then divided into 2 groups based on the therapies used, that is, Aidi injection combined with chemotherapy and chemotherapy alone, and the PS, chemotherapy-related toxicity, and combined medication information were compared. The effect of different dosages of Aidi injection on patients was further explored. Results: A total of 3200 patients were included in this study. Aidi injection combined with chemotherapy exhibited significantly benefit in PS ( P < .001, odds ratio [OR] 3.4, 95% confidence interval [CI] 2.4-4.8) compared with chemotherapy alone after adjusting for the factors that affect PS. The improvement rate of PS in the Aidi group was significantly higher than in the control group across the stratification of gender, age, tumor type, TNM stage, body mass index, nodal metastasis, prior chemotherapy, chemotherapy regimens, other Chinese tradition medicines, and chemotherapy cycle. Meanwhile, Aidi injection used synchronously with chemotherapeutic drugs could decrease the incident rate of damage to liver and kidney function, myelosuppression, and gastrointestinal reactions caused by chemotherapy. Conclusion: It was indicated that the integrative approach combining chemotherapy with Aidi injection, especially with the conventional dosage of Aidi injection, had significant benefit on QoL in cancer patients.

scholarly journals Functional fitness and quality of life of elderly Lian Gong, Tai Chi, and Qigong practitioners

2020 ◽  
Author(s):  
Márcia Regina Martinez Tedeschi ◽  
Tatiane Assone ◽  
Mauro Ferreira ◽  
Káren Mendes Jorge de Souza
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
The Body ◽  
Control Group ◽  
Case Group ◽  
Functional Fitness ◽  
And Control ◽  
Body Practices

Abstract BACKGROUND Long-term regular physical activity, such as body practices of Traditional Chinese Medicine, seems to be an important habit for maintaining the functional fitness, independence and quality of life of elderly individuals. However, scientific knowledge production concerning assessment of such practices, specifically for the elderly population, focusing on functional fitness and quality of life, is still modest. Moreover, there is a lack of studies with long-term follow-up and control groups. Therefore, this study aims to compare the parameters of functional fitness and the dimensions of quality of life of elderly participants and non-participants in the body practices of Traditional Chinese Medicine. Longer adherence time, shorter adherence time and control group have been considered. METHODS This is an observational epidemiological case-control study carried out with 118 elderly individuals (≥ 60 years). The case group was represented by 59 elderly people practicing the body practices of Traditional Chinese Medicine, and they were subdivided into two groups, according to their median adherence time (< 24 months and ≥ 24 months). The control group was composed of 59 participants who were not participating in physical activity programs or guided body practices. Collection was carried out in four Traditional Medicine Specialized Units of the Municipal Health Office of the city of São Paulo. Sociodemographic and functional variables were collected. Quality of life was measured by Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). For data analysis, a univariate logistic regression and the Kruskal Wallis test have been performed. RESULTS When assessing quality of life, favorable results were found for the case group, with longer (≥ 24 months) adherence time in the domains of bodily pain (p = 0.003), vitality (p = 0.021), role emotional (p = 0.034), and mental health (p = 0.020). A better result was observed in the case group, with longer (≥ 24 months) adherence time in the functional 30-second chair stand test (p = 0.006). CONCLUSIONS The body practices of Traditional Chinese Medicine can contribute to quality of life, functional fitness, and lower limb strength.

scholarly journals Application of Traditional Chinese Medicine Combined with TACE in Patients with Primary Hepatocellular Carcinoma and Its Effect on Liver Function

1970 ◽  
Vol 1 (2) ◽  
Author(s):  
Haibin Ding
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Cancer ◽  
Liver Function ◽  
Recurrence Rate ◽  
Transcatheter Arterial Chemoembolization ◽  
Primary Liver Cancer ◽  
Control Group ◽  
Experimental Group ◽  
Arterial Chemoembolization

Objective: To analyze the effects of Chinese herbal medicine combined with transcatheter arterial chemoembolization (TACE) on liver function in patients with primary hepatocellularCarcinoma (HCC). Methods: 122 patients with primary hepatocellular carcinoma admitted in our hospital from March 2014 to October 2016 were divided into experimental group and control group according to the digital table. The number of each group was the same. The patients in the control group were treated by transcatheter arterial chemoembolization. The experimental group was treated with traditional Chinese medicine on the basis of the control group. SPSS20.0 statistical software for statistical analysis of two groups of patients with short-term effect, follow-up of one year primary liver cancer recurrence rate, before and after treatment WBC count, liver function (alanine aminotransferase), alpha-fetoprotein and Karnofsky index parameters. Results: ①The total effective rate of the experimental group was significantly higher than that of the control group (P <0.05); ②The relapse rate of theexperimental group was significantly lower than that of the control group (P <0.05); ③ Before the treatment, the patients in the two groups had significantly higher recurrence rate than those in the control group (P <0.05). After treatment, the white blood cell count, liver function and alpha-fetoprotein levels in the experimental group were significantly better than those in thecontrol group (P <0.05), but no significant difference was found between the two groups (P<0.05). ④ The Karnofsky score of the experimental group was significantly higher than that of the control group (P<0.05). Conclusion: Chinese medicine combined with transcatheter arterial chemoembolization in patients with primary liver cancer in the application value is relatively high.

scholarly journals Outcomes reported in clinical studies of stable angina pectoris on traditional Chinese medicine: a systematic review towards a core outcome set

2021 ◽  
Author(s):  
Mingyan Zhang ◽  
Hui Zi Chua ◽  
Bohan Niu ◽  
Wenke Zheng ◽  
Fengwen Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Studies ◽  
Clinical Symptoms ◽  
Core Outcome Set ◽  
Core Outcome ◽  
Outcome Reporting ◽  
Outcome Set ◽  
Symptoms And Signs

Abstract Background Traditional Chinese medicine (TCM) plays an important role in contributing to the public health in China. However, non-standardized outcomes in TCM related studies posed great difficulty in data synthesis for healthcare decisions. An agreed set of standardized outcomes, or termed as a core outcome set (COS), can solve this existing problem of outcome heterogeneity. This review aimed to analyze outcome heterogeneity, assess the quality of outcome reporting and providing a list of potential outcomes for COS development of SAP using TCM. Methods 8 literature databases were searched to identify clinical studies about TCM for SAP (SAP-TCM) of yearly samples of 2005, 2010, 2015, 2016, 2018 and 2019. 2 clinical registry databases were searched from inception to October 2020. Outcomes definition, measurement methods and time-point were extracted and categorized into 7 themes which include clinical symptoms and signs, physical and chemical examination, TCM-related outcomes, adverse events, quality of life, long-term prognosis and economic evaluation. Timing and quality assessment of the outcomes reported were analyzed and evaluated. Results A total of 1166 studies were included from 12962 potential studies, involving 111426 patients. 231 outcomes were identified and a total of 89 outcomes reported at least twice in the studies. The most commonly reported theme was clinical symptoms and signs. The most frequently reported outcomes were total rate of ECG efficiency and angina attack in clinical studies of published literature and clinical registries databases respectively. Outcomes reported in a single study ranged from 1 to 15, and 5 outcomes on average per study. 80% of the studies lack reporting of primary outcomes. A wide variation of measurement instruments or methods was used. A range of 1–17 measurement time-points were recorded. Quality assessment of outcome reporting was generally low, with 65.6% of the studies scoring 3 to 4 points. Conclusion Outcomes reported in studies on SAP-TCM are heterogeneous. A lack of standardization complicates comparisons of outcomes across studies. Developing a COS for SAP-TCM could contribute to the standardization of outcome reporting and offer a stronger evidence for health decision-making.

scholarly journals Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-23
Author(s):  
Lin Wang ◽  
Xiao-Fei Zhang ◽  
Xue Zhang ◽  
Dong-Yan Guo ◽  
Yu-Wei Duan ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Effect ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Effective Rate ◽  
Control Group ◽  
Inflammatory Factor ◽  
Pain Symptoms ◽  
Experimental Group

Background. Osteoarthritis (OA) is a common degenerative disease of bone and joint characterized by the damage of articular cartilage and hypertonia, which often occurs in the middle-aged and elderly. Traditional Chinese medicine (TCM) therapy, including acupuncture (ACU), oral administration, and external use of traditional Chinese medicines (TCMs), can significantly improve the therapeutic effect on OA and reduce the occurrence of side effects. We provide a latest meta-analysis on the treatment of OA with TCM. Materials and Methods. In the electronic database, appropriate articles without language restrictions on keywords were selected until August 1, 2019. All trajectories are screened according to certain criteria. The quality of qualified research was also assessed. We have made a detailed record of the results of the measurement. Meta-analysis was carried out with Revman 5.3 software. Results. Forty-four articles involving 4014 patients (2012 cases in the experimental group and 2002 cases in the control group) with OA were selected. This article focuses on the study of the treatment of OA by using the general mode of TCM. The quality evaluation included in the study was evaluated independently according to the Cochrane intervention system evaluation manual. In this meta-analysis, 68.18% of the literature correctly described the conditions for the generation of random assignment sequences, only 6.82% of the literature correctly mentioned the hidden details of allocation, and all studies mentioned randomly assigned participants. Compared with Western medicine, the total effective rate (TER) of OA treatment in TCM was significantly increased and the recurrence rate (RR) was significantly decreased ( P < 0.00001 ). In addition, the experimental group was also superior to the control group in terms of the indicators of joint activity function, inflammatory factor content, and various indicators affecting bone metabolism. It can be showed by the network analysis diagram that Aconiti Radix, Achyranthis Bidentatae Radix, and other TCMs can inhibit inflammatory stimulation and relieve the pain symptoms of patients with OA. ACU at Yinlingquan, Xiyan, and other acupoints can effectively improve the clinical symptoms of patients with OA. Conclusion. TCM therapy in treatment of patients with OA could effectively restore joint function, enhance the TER, and reduce RR. However, the results of this study should be handled with care due to the limitations existing. Some rigorous randomized controlled trials (RCTs) are needed to confirm these findings.

scholarly journals The Application Effect of Traditional Chinese Medicine Nursing on General Anesthesia Combined with Epidural Anesthesia and Electric Resection for the Treatment of Bladder Cancer and Its Influence on Tumor Markers

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Yan Wu ◽  
Zhenna Zhang ◽  
Yangfan Liu ◽  
Guangwen Shi ◽  
Xuehai Ding
Keyword(s):  
Quality Of Life ◽  
Bladder Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
General Anesthesia ◽  
Tumor Markers ◽  
Epidural Anesthesia ◽  
Control Group ◽  
Study Group

Objective. To explore the effects of traditional Chinese medicine nursing on general anesthesia combined with epidural anesthesia and electric resection to treat bladder cancer and its influence on tumor markers. Methods. A total of 160 patients with non-muscle-invasive bladder cancer who underwent general anesthesia combined with epidural anesthesia and resection were included in this study. The patients were divided into control group (n = 80) and study group (n = 80) according to the random number table method. The control group received hydroxycamptothecin bladder perfusion therapy, and the study group received traditional Chinese medicine nursing combined with hydroxycamptothecin bladder perfusion therapy. The clinical efficacy, three-year cumulative survival rate, and postoperative recurrence rate of the two groups of patients were detected. The levels of tumor markers including vascular endothelial growth factor (VECF) and bladder tumor antigen (BTA) before and after treatment were also tested. The immune function, inflammatory factor levels, and quality of life of the two groups before and after treatment were evaluated. Results. The total effective rate of the study group (83.75%) was significantly higher than that of the control group (58.75%). After treatment, the serum VEGF and BTA levels, inflammatory factors interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) levels of the two groups of patients decreased, and the decrease in the study group was more significant than that in the control group P < 0.05 . After treatment, the levels of CD3+, CD4+, and CD4+/CD8+ in the two groups increased P < 0.05 , and the increase in the study group was more significant than that in the control group P < 0.05 . After treatment, the CD8+ levels of the two groups of patients decreased P < 0.05 , and the decrease in the study group was more significant than that in the control group P < 0.05 . After treatment, the quality-of-life scores in both groups increased P < 0.05 , and the increase in the study group was even more significant P < 0.05 . Conclusion. Traditional Chinese medicine nursing has significant clinical effects on the treatment of bladder cancer with general anesthesia combined with epidural anesthesia and electric resection. It can more effectively prevent the risk of recurrence of bladder cancer after surgery, significantly improve the quality of life, improve immune system function, regulate the levels of VECF and BTA, effectively reduce the level of serum inflammatory factors, inhibit tumor progression, and reduce tumor viability.

scholarly journals Efficacy of Traditional Chinese Medicine in Xerostomia and Quality of Life during Radiotherapy for Head and Neck Cancer: A Prospective Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Pei-Yu Hsu ◽  
Sien-Hung Yang ◽  
Ngan-Ming Tsang ◽  
Kang-Hsing Fan ◽  
Chia-Hsun Hsieh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Head And Neck ◽  
Neck Cancer ◽  
Social Contact ◽  
Control Group ◽  
The Impact

Xerostomia is one of the most common acute and late complications of radiotherapy for head and neck cancer, and it affects quality of life. We conducted a prospective study to evaluate the efficacy of traditional Chinese medicine (TCM) in toxicities and quality of life during radiotherapy. Head and neck cancer patients who were scheduled for radiotherapy were checked for inclusion/exclusion criteria before enrollment. Patients in the study group (inpatients) were hospitalized in a Chinese medicine ward and received concomitant TCM intervention during radiotherapy, while those in the control group (outpatients) received only conventional cancer treatments at the Western outpatient department. The primary end point was amelioration of postradiotherapy side effects. The secondary end points were quality of life during the cancer therapy and occurrence of adverse events following the TCM treatments. Thirty inpatients and 50 outpatients completed the study. Compared to the control group, those in the TCM group had decreased severity of xerostomia. There was no treatment-related impairment of renal or hepatic function among TCM group. Although better outcomes of social contact, dyspnea, physical and emotional function, and financial problems were found in the TCM group, we need further confirmation about the impact of hospitalization itself on these results.

scholarly journals Discussion on the Management of Safe Medication in the Treatment of Internal Diseases of Traditional Chinese Medicine

2021 ◽  
Vol 5 (4) ◽  
pp. 38-42
Author(s):  
Xuan Gong ◽  
Liming Zhang ◽  
Lizhi Niu
Keyword(s):  
Quality Of Life ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medication Management ◽  
Compliance Rate ◽  
Clinical Treatment ◽  
Control Group ◽  
Safe Medication ◽  
Experimental Group

Objective: To discuss the management of safe medication in the treatment of internal diseases in traditional Chinese medicine. Methods: 124 patients with medical diseases were divided into experimental group and control group by random number table method, with 62 cases in each group. The experimental group implemented safe medication management, and the control group implemented routine medication management, all of which were treated for 4 consecutive weeks. The comparison of the improvement of the quality of life, the compliance rate of safe medication and the adverse drug reactions of the two groups after clinical treatment were compared. Results: After 8 weeks of treatment, there was a significant difference in clinical efficacy between the two groups of patients. In terms of quality-of-life scores, the scores of the experimental group were better than those of the control group. The living ability, condition, physical strength and other conditions of patients were significantly different. The t-values were 15.3427, 14.0275, and 7.7113, respectively, and P<0.01 was statistically significant. The compliance rates of patients in the experimental group and observation group were 95.16% and 70.96%, respectively, with significant differences (P<0.05). In terms of the incidence of adverse drug events, the experimental group was 3.22%, which was significantly lower than the observation group’s 8.06% (P<0.05). Conclusion: The implementation of safe medication management in the clinical treatment of TCM internal diseases can improve the quality of life of patients to a certain extent, increase their safe medication compliance rate, and reduce the incidence of adverse medication events. The clinical application value is extremely high, and it can be widely promoted and applied.

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