Preventive Intra Oral Treatment of Sea Cucumber Ameliorate OVA-Induced Allergic Airway Inflammation

2016 ◽  
Vol 44 (08) ◽  
pp. 1663-1674 ◽  
Author(s):  
Da-In Lee ◽  
Mi-Kyung Park ◽  
Shin Ae Kang ◽  
Jun-Ho Choi ◽  
Seok-Jung Kang ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Sea Cucumber ◽  
Cell Activation ◽  
Biological Effects ◽  
Oral Treatment ◽  
Allergic Airway Inflammation ◽  
Treg Cells ◽  
Mesenteric Lymph Nodes ◽  
Anti Cancer ◽  
Anti Oxidant

Sea cucumber extracts have potent biological effects, including anti-viral, anti-cancer, antibacterial, anti-oxidant, and anti-inflammation effects. To understand their anti-asthma effects, we induced allergic airway inflammation in mice after 7 oral administrations of the extract. The hyper-responsiveness value in mice with ovalbumin (OVA)-alum-induced asthma after oral injection of sea cucumber extracts was significantly lower than that in the OVA-alum-induced asthma group. In addition, the number of eosinophils in the lungs of asthma-induced mice pre-treated with sea cucumber extract was significantly decreased compared to that of PBS pre-treated mice. Additionally, CD4[Formula: see text]CD25[Formula: see text]Foxp3[Formula: see text]T (regulatory T; Treg) cells significantly increased in mesenteric lymph nodes after 7 administrations of the extract. These results suggest that sea cucumber extract can ameliorate allergic airway inflammation via Treg cell activation and recruitment to the lung.

scholarly journals Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma

2021 ◽  
Vol 25 (4) ◽  
pp. 2279-2284
Author(s):  
Yimin Guo ◽  
Jianting Shi ◽  
Qiujie Wang ◽  
Luna Hong ◽  
Ming Chen ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Treg Cells

scholarly journals Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhidan Li ◽  
Wei Zhang ◽  
Fang Luo ◽  
Jian Li ◽  
Wenbin Yang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protective Effect ◽  
Airway Inflammation ◽  
Lung Tissue ◽  
Immunoglobulin E ◽  
Allergic Airway Inflammation ◽  
Treg Cells ◽  
Protective Effects ◽  
Novel Therapy ◽  
Allergen Sensitization

Schistosoma japonicum infection showed protective effects against allergic airway inflammation (AAI). However, controversial findings exist especially regarding the timing of the helminth infection and the underlying mechanisms. Most previous studies focused on understanding the preventive effect of S. japonicum infection on asthma (infection before allergen sensitization), whereas the protective effects of S. japonicum infection (allergen sensitization before infection) on asthma were rarely investigated. In this study, we investigated the protective effects of S. japonicum infection on AAI using a mouse model of OVA-induced asthma. To explore how the timing of S. japonicum infection influences its protective effect, the mice were percutaneously infected with cercaria of S. japonicum at either 1 day (infection at lung-stage during AAI) or 14 days before ovalbumin (OVA) challenge (infection at post–lung-stage during AAI). We found that lung-stage S. japonicum infection significantly ameliorated OVA-induced AAI, whereas post–lung-stage infection did not. Mechanistically, lung-stage S. japonicum infection significantly upregulated the frequency of regulatory T cells (Treg cells), especially OVA-specific Treg cells, in lung tissue, which negatively correlated with the level of OVA-specific immunoglobulin E (IgE). Depletion of Treg cells in vivo partially counteracted the protective effect of lung-stage S. japonicum infection on asthma. Furthermore, transcriptomic analysis of lung tissue showed that lung-stage S. japonicum infection during AAI shaped the microenvironment to favor Treg induction. In conclusion, our data showed that lung-stage S. japonicum infection could relieve OVA-induced asthma in a mouse model. The protective effect was mediated by the upregulated OVA-specific Treg cells, which suppressed IgE production. Our results may facilitate the discovery of a novel therapy for AAI.

scholarly journals Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

2020 ◽  
Vol 21 (3) ◽  
pp. 950 ◽  
Author(s):  
Nittiya Suwannasom ◽  
Ijad Kao ◽  
Axel Pruß ◽  
Radostina Georgieva ◽  
Hans Bäumler
Keyword(s):  
Protective Effect ◽  
Toxic Effect ◽  
Biological Effects ◽  
Health Benefits ◽  
Water Soluble ◽  
Medical Conditions ◽  
Protective Properties ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
B Vitamin

Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely studied for their anti-oxidant, anti-aging, anti-inflammatory, anti-nociceptive and anti-cancer properties. Moreover, the combination of RF and other compounds or drugs can have a wide variety of effects and protective properties, and diminish the toxic effect of drugs in several treatments. Research has been done in order to review the latest findings about the link between RF and different clinical aberrations. Since further studies have been published in this field, it is appropriate to consider a re-evaluation of the importance of RF in terms of its beneficial properties.

scholarly journals Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells

2013 ◽  
Vol 7 (8) ◽  
pp. e2379 ◽  
Author(s):  
Laura E. Layland ◽  
Kathrin Straubinger ◽  
Manuel Ritter ◽  
Eva Loffredo-Verde ◽  
Holger Garn ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Treg Cells

Sea Cucumber Lipid-Soluble Extra Fraction Prevents Ovalbumin-Induced Allergic Airway Inflammation

2018 ◽  
Vol 21 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Da-In Lee ◽  
Shin Ae Kang ◽  
Anisuzzaman Md ◽  
U-Cheol Jeong ◽  
Feng Jin ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Sea Cucumber ◽  
Allergic Airway Inflammation

Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma

2011 ◽  
Vol 301 (6) ◽  
pp. L975-L984 ◽  
Author(s):  
Guqin Zhang ◽  
Hanxiang Nie ◽  
Jiong Yang ◽  
Xuhong Ding ◽  
Yi Huang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Cell Activation ◽  
Cell Function ◽  
Allergic Airway Inflammation ◽  
Nkt Cells ◽  
Chronic Inflammatory Disease ◽  
Type I ◽  
Type Ii ◽  
Nkt Cell

Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play a crucial role in the development of asthma. However, the roles of type II NKT cells in asthma have not been investigated before. Interestingly, type I and type II NKT cells have been shown to have opposing roles in antitumor immunity, antiparasite immunity, and autoimmunity. We hypothesized that sulfatide-activated type II NKT cells could prevent allergic airway inflammation by inhibiting type I NKT cell function in asthma. Strikingly, in our mouse model, activation of type II NKT cells by sulfatide administration and adoptive transfer of sulfatide-activated type II NKT cells result in reduced-inflammation cell infiltration in the lung and bronchoalveolar lavage fluid, decreased levels of IL-4 and IL-5 in the BALF; and decreased serum levels of ovalbumin-specific IgE and IgG1. Furthermore, it is found that the activation of sulfatide-reactive type II NKT cells leads to the functional inactivation of type I NKT cells, including the proliferation and cytokine secretion. Our data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation.

scholarly journals Anti-oxidant and Anti-inflammatory Effects of Aquatic Exercise in Allergic Airway Inflammation in Mice

2019 ◽  
Vol 10 ◽  
Author(s):  
Boae Lee ◽  
Yeonye Kim ◽  
Young Mi Kim ◽  
Jaehoon Jung ◽  
Taehyung Kim ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Aquatic Exercise ◽  
Anti Oxidant ◽  
Anti Inflammatory

Effects of ZCR-2060 on Allergic Airway Inflammation and Cell Activation in Guinea-pigs

1994 ◽  
Vol 46 (11) ◽  
pp. 876-882 ◽  
Author(s):  
Tooru Abe ◽  
Kenji Yoshida ◽  
Takeshi Omata ◽  
Yoshihide Segawa ◽  
Kazuo Matsuda ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Guinea Pigs ◽  
Cell Activation ◽  
Allergic Airway Inflammation
Sign in / Sign up

Export Citation Format

Share Document