scholarly journals Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

2020 ◽  
Vol 21 (3) ◽  
pp. 950 ◽  
Author(s):  
Nittiya Suwannasom ◽  
Ijad Kao ◽  
Axel Pruß ◽  
Radostina Georgieva ◽  
Hans Bäumler
Keyword(s):  
Protective Effect ◽  
Toxic Effect ◽  
Biological Effects ◽  
Health Benefits ◽  
Water Soluble ◽  
Medical Conditions ◽  
Protective Properties ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
B Vitamin

Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely studied for their anti-oxidant, anti-aging, anti-inflammatory, anti-nociceptive and anti-cancer properties. Moreover, the combination of RF and other compounds or drugs can have a wide variety of effects and protective properties, and diminish the toxic effect of drugs in several treatments. Research has been done in order to review the latest findings about the link between RF and different clinical aberrations. Since further studies have been published in this field, it is appropriate to consider a re-evaluation of the importance of RF in terms of its beneficial properties.

scholarly journals Experimental eva luation of the protective properties of the original chewing compositions in relation to the toxic effect of water soluble nicotos-containing substances of the tobacco on an immature organism

2019 ◽  
pp. 13-24
Author(s):  
Anna V. Adamovich ◽  
Vitalii V. Shevlyakov ◽  
Tamara M. Yuraha
Keyword(s):  
Young People ◽  
Protective Effect ◽  
Toxic Effect ◽  
Aqueous Extract ◽  
Water Soluble ◽  
Daily Consumption ◽  
Tobacco Products ◽  
Protective Properties ◽  
Total Alkaloids ◽  
White Rats

On the experimental model of subchronic oral alkaloidization of immature white rats with their 59-daily consumption of aqueous extract from tobacco products in cyclically increasing concentrations of the total alkaloids, the potential protective properties of the developed original prophylactic chewable compositions (based on mexidol, glycine, vitamin complex and phytocomponents) in relation to toxic effect of the complex of soluble substances of tobacco were studied. The results of the study testify to the protective effect of prophylactic chewable compositions with their 2-week consumption of alkaloidized animals on models of continuing consumption of aqueous extract from tobacco products and its termination, which was reflected in the normalization or significant improvement of morphofunctional indicators of the organism of intoxication genesis in alkaloidized animals. The developed formulations of prophylactic chewable compositions are promising for drug support in the prevention and cessation of tobacco use by young people and are recommended for further study for this purpose.

Medicinal Properties of Cinchona Alkaloids - A Brief Review

2021 ◽  
Vol 11 (3) ◽  
pp. 224-228
Author(s):  
Anubhav Dubey ◽  
Yatendra Singh
Keyword(s):  
Toxic Effect ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Folk Medicine ◽  
Modern Medicine ◽  
Cinchona Alkaloids ◽  
Literature Study ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties

Cinchona which belongs to family Rubiaceae, got its importance from the centuries because of its anti- malarial activity. Alkaloids present in this herb, Quinine, Chichonine, Quinidine and Cinchonidine are the main, but percentage may vary in species to species. Since the early 17th century, these alkaloid are frequently used in Indian ayurvedic, sidha and traditional folk medicine to treating fever and Still now in modern medicine cinchona alkaloids are used for the treatment of malaria as well as for other diseases and became the well-known drug after the treatment of malaria caused by Plasmodium Sp. Literature study revealed that along with the antimalarial activity the cinchona alkaloids has other potentiality like anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity. These article reviews the biological activities of cinchona alkaloids along with its toxic effect.

Preventive Intra Oral Treatment of Sea Cucumber Ameliorate OVA-Induced Allergic Airway Inflammation

2016 ◽  
Vol 44 (08) ◽  
pp. 1663-1674 ◽  
Author(s):  
Da-In Lee ◽  
Mi-Kyung Park ◽  
Shin Ae Kang ◽  
Jun-Ho Choi ◽  
Seok-Jung Kang ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Sea Cucumber ◽  
Cell Activation ◽  
Biological Effects ◽  
Oral Treatment ◽  
Allergic Airway Inflammation ◽  
Treg Cells ◽  
Mesenteric Lymph Nodes ◽  
Anti Cancer ◽  
Anti Oxidant

Sea cucumber extracts have potent biological effects, including anti-viral, anti-cancer, antibacterial, anti-oxidant, and anti-inflammation effects. To understand their anti-asthma effects, we induced allergic airway inflammation in mice after 7 oral administrations of the extract. The hyper-responsiveness value in mice with ovalbumin (OVA)-alum-induced asthma after oral injection of sea cucumber extracts was significantly lower than that in the OVA-alum-induced asthma group. In addition, the number of eosinophils in the lungs of asthma-induced mice pre-treated with sea cucumber extract was significantly decreased compared to that of PBS pre-treated mice. Additionally, CD4[Formula: see text]CD25[Formula: see text]Foxp3[Formula: see text]T (regulatory T; Treg) cells significantly increased in mesenteric lymph nodes after 7 administrations of the extract. These results suggest that sea cucumber extract can ameliorate allergic airway inflammation via Treg cell activation and recruitment to the lung.

scholarly journals Effect of Sodium Fluoride (NaF) Exposure on Heart: Protective Effect of Eugenol with Reference to the Lipid Metabolic Profiles

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Srinivas K ◽  
Shanmugam K. R. ◽  
Shanmugam B. ◽  
Venkatasubbaiah G. ◽  
Ravi S. ◽  
...  
Keyword(s):  
Protective Effect ◽  
Effective Treatment ◽  
Sodium Fluoride ◽  
Review Article ◽  
Metabolic Profiles ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Compounds ◽  
Anti Oxidant ◽  
Cancer Activity

Flavonoids are phytochemical compounds found in a variety of plants, fruits, vegetables, leaves, and barks, it offers a wide range of health benefits. Quercetin is a polyphenolic flavonoid that is found in onions, apples, berries, broccoli, grapes, nuts, cherries and many other food products. Pharmacologically, quercetin has been examined for various disorders and is reported to possess the ability to prevent as well as treat them. It possesses anti-oxidant, anti-allergic, anti-inflammatory, anti-viral and anti-cancer activity as well. Developing suitable formulation for the delivery of quercetin to specific site leads to better compliance and effective treatment of the disease. This review article highlights the beneficiary activities exhibited by quercetin along with the mechanism behind its activity, followed by reporting the different quercetin formulations developed in last few years.

scholarly journals Coffee: Constituents and Health Benefits

2020 ◽  
pp. 22-38
Author(s):  
Shreya Shah ◽  
Anil Kumar
Keyword(s):  
Degradation Products ◽  
Health Benefits ◽  
Protective Effects ◽  
Chlorogenic Acids ◽  
Cholesterol Levels ◽  
Anti Cancer ◽  
The World ◽  
Anti Oxidant ◽  
Ancient Times ◽  
Skeletal Bone

Since ancient times, coffee has been one of the widely consumed beverages all over the world. It is renowned for its refreshing, body stimulating effect and unique taste. It belongs to the genus Coffea, class Dicotyledoneae, order Rubiales and family Rubiaceae. Coffee is a natural complex chemical mixture constituted of several compounds. It is accountable for numerous bioactivities and a number of compounds exhibit these effects. Some of the significant bioactivities documented are anti-oxidant, anti-mutagenic, anti-carcinogenic and anti-obesity properties. The varying constituents of coffee responsible for the chemo-protective effects are mainly polyphenols including chlorogenic acids and their degradation products. Others include caffeine, diterpenoid alcohols such as kahweol, cafestol and other phenolics. Coffee has been reported to exhibit both protective and adverse effects on various body systems such as skeletal (bone), reproductive, nervous and cardiovascular systems; homocysteine and cholesterol levels and so on. The present review provides an overview of the coffee and its constituents; and their relationship with various diseases.  Recent investigations on its health benefits, with focus on their anti-cancer, anti-obesity properties and effect on cardiovascular diseases have also been discussed.

scholarly journals Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of Alnus sibirica

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1938 ◽  
Author(s):  
Hye Soo Wang ◽  
Yoon Jeong Hwang ◽  
Jun Yin ◽  
Min Won Lee
Keyword(s):  
Enzymatic Hydrolysis ◽  
Biological Activities ◽  
Biological Effects ◽  
No Production ◽  
Anti Cancer ◽  
Geographically Distributed ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Hydrolysis Of

Alnus sibirica (AS) is geographically distributed in Korea, Japan, Northeast China, and Russia. Various anti-oxidant, anti-inflammation, anti-atopic dermatitis and anti-cancer biological effects of AS have been reported. Enzymatic hydrolysis decomposes the sugar bond attached to glycoside into aglycone which, generally, has a superior biological activity, compared to glycoside. Enzymatic hydrolysis of the extract (EAS) from AS was processed and the isolated compounds were investigated—hirsutanonol (1), hirsutenone (2), rubranol (3), and muricarpon B (4). The structures of these compounds were elucidated, and the biological activities were assessed. The ability of EAS and the compounds (1–4) to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and Nitroblue tetrazolium (NBT) superoxide, and to inhibit NO production was evaluated in vitro. EAS showed more potent antioxidant and anti-inflammatory activity than AS. All investigated compounds showed excellent antioxidant and anti-inflammatory activities.

scholarly journals Flavonoids: isolation, characterization, and health benefits

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Abiche Ekalu ◽  
James Dama Habila
Keyword(s):  
Secondary Metabolites ◽  
Health Benefits ◽  
The Body ◽  
Pharmacological Activities ◽  
Potential Health ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Plant Families ◽  
Anti Fungal

Abstract Background The unique and vast pharmacological activities of flavonoids have made them of research interest. This led to the use of various techniques to isolate and characterize them, intending to determine their potential health benefits. Main text The medicinal values of plant-based flavonoids that this literature review tends to summarize the pharmacological activities of these secondary metabolites from 22 selected plant families. The pharmacological shreds of evidence reported in the literature have proven that flavonoids have shown anti-cancer, anti-microbial, anti-oxidant, anti-inflammatory, anti-fungal, anti-ulcer, and anti-edematogenic activities. Out of these, 30% showed to have anti-oxidant activity, key in protecting the body against free radicals. Besides, 18% of the references showed anti-microbial and anti-cancer activities. Further literature reports indicated that flavonoids from these families exhibited anti-inflammatory and anti-edematogenic (9%), anti-viral and anti-ulcer (5%), anti-fungal, anti-nociceptive, and anti-histamine (2%). Conclusion The pharmacological activities of flavonoids from the various sources reviewed in this study show that the secondary metabolites could provide a scaffold for the development of potent anti-cancer drugs in the future.

scholarly journals Health Benefits of Fermented Bamboo Shoots: The Twenty-First Century Green Gold of Northeast India

2021 ◽  
Author(s):  
Prapti Behera ◽  
Seetharaman Balaji
Keyword(s):  
Functional Foods ◽  
Health Benefits ◽  
Northeast India ◽  
First Century ◽  
Positive Effects ◽  
Tribal Area ◽  
Bamboo Shoots ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Twenty First Century

AbstractThe word “bamboo” reminds us of “a hollow stick,” but it is filled with a plethora of health benefits. The tribals of northeastern India ferment these beneficial bamboo shoots for the goodness of mankind. Fermentation is an important age-old biotechnological procedure used for the preservation of food products. Fermented bamboo shoots form the niche for many microorganisms, and this confers positive effects and advantages in many ways. These magical shoots have tremendous health benefits like anti-cancer, anti-oxidant, anti-aging, cardioprotective, weight loss, probiotics, to name a few. Apart from health benefits, fermented bamboo shoots form important functional foods and have industrial and economical values. Though these are commonly found and started in the tribal area, and local markets, today, they are valuable all around the world, as popular as gold. Hence, fermented bamboo shoots are referred as “green gold” of India. This review briefs about various health benefits, advantages, disadvantages, future scope, and finally the economic values of fermented bamboo shoots, the “green gold” of the twenty-first century.

scholarly journals An Overview of a Versatile Compound: Quercetin

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Nikita Naidu ◽  
Dr. Dinesh Biyani ◽  
Dr. Milind Umekar ◽  
Vaishnavi Burley
Keyword(s):  
Effective Treatment ◽  
Health Benefits ◽  
Food Products ◽  
Review Article ◽  
Specific Site ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Compounds ◽  
Anti Oxidant ◽  
Cancer Activity

Flavonoids are phytochemical compounds found in a variety of plants, fruits, vegetables, leaves, and barks, it offers a wide range of health benefits. Quercetin is a polyphenolic flavonoid that is found in onions, apples, berries, broccoli, grapes, nuts, cherries and many other food products. Pharmacologically, quercetin has been examined for various disorders and is reported to possess the ability to prevent as well as treat them. It possesses anti-oxidant, anti-allergic, anti-inflammatory, anti-viral and anti-cancer activity as well. Developing suitable formulation for the delivery of quercetin to specific site leads to better compliance and effective treatment of the disease. This review article highlights the beneficiary activities exhibited by quercetin along with the mechanism behind its activity, followed by reporting the different quercetin formulations developed in last few years.

Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury

1984 ◽  
Vol 51 (01) ◽  
pp. 089-092 ◽  
Author(s):  
M A Boogaerts ◽  
J Van de Broeck ◽  
H Deckmyn ◽  
C Roelant ◽  
J Vermylen ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Umbilical Vein ◽  
Endothelial Damage ◽  
Endothelial Injury ◽  
Mediated Effects ◽  
Anti Oxidant ◽  
Endothelial Cell Cultures ◽  
Vitro Model

SummaryThe effect of alfa-tocopherol on the cell-cell interactions at the vessel wall were studied, using an in vitro model of human umbilical vein endothelial cell cultures (HUEC). Immune triggered granulocytes (PMN) will adhere to and damage HUEC and platelets enhance this PMN mediated endothelial injury. When HUEC are cultured in the presence of vitamin E, 51Cr-leakage induced by complement stimulated PMN is significantly decreased and the enhanced cytotoxicity by platelets is completely abolished (p <0.001).The inhibition of PMN induced endothelial injury is directly correlated to a diminished adherence of PMN to vitamin E- cultured HUEC (p <0.001), which may be mediated by an increase of both basal and stimulated endogenous prostacyclin (PGI2) from alfa-tocopherol-treated HUEC (p <0.025). The vitamin E-effect is abolished by incubation of HUEC with the irreversible cyclo-oxygenase inhibitor, acetylsalicylic acid, but the addition of exogenous PGI2 could not reproduce the vitamin E-mediated effects.We conclude that vitamin E exerts a protective effect on immune triggered endothelial damage, partly by increasing the endogenous anti-oxidant potential, partly by modulating intrinsic endothelial prostaglandin production. The failure to reproduce vitamin E-protection by exogenously added PGI2 may suggest additional, not yet elucidated vitamin E-effects on endothelial metabolism.

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