Chemical Constituents and Pharmacological Activities of Family Flacourtiaceae: A Class of Important Phytomedicine

2020 ◽  
Vol 48 (02) ◽  
pp. 287-328
Author(s):  
Yu Zhang ◽  
Jing Kong ◽  
Jin-Hua Zhang ◽  
Lu Wang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Chemical Constituents ◽  
Chemical Diversity ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Pharmacological Studies ◽  
Phytochemical Studies ◽  
Further Development

Flacourtiaceae plants are widely used as folk medicines in traditional medicine systems for its chemical diversity and pharmacological activities. In many different areas, Flacourtiaceae plants are used as traditional medicines for the treatment of ulcers, malaria, rheumatism. The Flacourtiaceae plants contain a very plentiful chemical composition, and phytochemical studies show that the Flacourtiaceae plants contained terpenoids, aromatic glycosides, flavnoids, phenylpropanoids, alkaloids, fatty hydrocarbon, and other compounds. In pharmacological studies, various extract and isolated individual compounds exhibited antitumor, anti-oxidation, and anti-inflammatory activities. In this review, the literature data on the chemical constituents and pharmacological investigations of the Flacourtiaceae plants are summarized, to provide information about a more comprehensive chemical composition and detailed pharmacological activities of Flacourtiaceae plants, with a view of further development of clinical medication. However, research on quantitative analysis, toxicity, and drug safety in vitro and in vivo is still insufficient, and further research is required.

scholarly journals Imperata cylindrica: A Review of Phytochemistry, Pharmacology, and Industrial Applications

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1454
Author(s):  
Young-Kyung Jung ◽  
Dongyun Shin
Keyword(s):  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Industrial Applications ◽  
Imperata Cylindrica ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Pharmacological Studies

Imperata cylindrica is a medicinal plant native to southwestern Asia and the tropical and subtropical zones. To date, 72 chemical constituents have been isolated and identified from I. cylindrica Among these compounds, saponins, flavonoids, phenols, and glycosides are the major constituents. Investigations of pharmacological activities of I. cylindrica revealed that this edible medicinal herb exhibits a wide range of therapeutic potential including immunomodulatory, antibacterial, antitumor, anti-inflammatory, and liver protection activities both in vivo and in vitro. The purpose of this review is to provide an overview of I. cylindrica studies until 2019. This article also intends to review advances in the botanical, phytochemical, and pharmacological studies and industrial applications of I. cylindrica, which will provide a useful bibliography for further investigations and applications of I. cylindrica in medicines and foods.

scholarly journals Cocculus hirsutus (L.) W.Theob. (Menispermaceae): A Review on Traditional Uses, Phytochemistry and Pharmacological Activities

Medicines ◽  
2020 ◽  
Vol 7 (11) ◽  
pp. 69
Author(s):  
Rajan Logesh ◽  
Niranjan Das ◽  
Anjana Adhikari-Devkota ◽  
Hari Prasad Devkota
Keyword(s):  
Skin Diseases ◽  
Chemical Constituents ◽  
Scientific Information ◽  
Bibliographic Databases ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
Plant Parts ◽  
Traditional Uses

Background:Cocculus hirsutus (L.) W.Theob. (Menispermaceae) is a perennial climber distributed mostly in tropical and subtropical areas. The main aim of this article is to collect and analyze the scientific information related to traditional uses, bioactive chemical constituents and pharmacological activities. Methods: Scientific information on C. hirsutus was retrieved from the online bibliographic databases (e.g. MEDLINE/PubMed, SciFinder, Web of Science, Google Scholar and Scopus). Information regarding traditional uses was also acquired from secondary resources including books and proceedings. Results: Different plant parts of C. hirsutus were reported to be used for the treatment of fever, skin diseases, stomach disorders and urinary diseases. Alkaloids such as jasminitine, hirsutine, cohirsitine and their derivatives along with a few flavonoids, triterpene derivatives and volatile compounds were reported from whole plant or different plant parts. Extracts were evaluated for their antimicrobial, antidiabetic, immunomodulatory and hepatoprotective activities among others. Conclusion: Although widely used in traditional medicines, only a few studies have been performed related to chemical constituents. Most of the biological activity evaluations were carried out using in vitro evaluation methods and only a few studies were carried out in animal models. In the future, properly designed in vivo and clinical studies are necessary to evaluate the pharmacological activities of C. hirsutus along with bioassay-guided studies to isolate and identify the active constituents.

scholarly journals Lepidium sativum: A potential functional food

2021 ◽  
Vol 7 (2) ◽  
pp. 140-149
Author(s):  
Mamta B. Shah ◽  
◽  
Vinisha A. Dudhat ◽  
Krupa V. Gadhvi ◽  
◽  
...  
Keyword(s):  
Chemical Constituents ◽  
In Vivo Studies ◽  
Lepidium Sativum ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Pharmacological Studies ◽  
Pharmacology And Toxicology ◽  
Physicochemical Characterisation

Lepidium sativum Linn. (family Cruciferae) is an edible herb that is botanically related to watercress and mustard, having their peppery, tangy taste and odour. Traditionally L. sativum seeds are used to treat wounds, sprains, asthma, bronchitis, cough and is considered useful as abortifacient, aphrodisiac, antibacterial, diuretic, expectorant, gastrointestinal stimulant, gastroprotective, laxative and stomachic. Many of these traditional uses have been scientifically validated using different in vitro and in vivo studies and in this review are compiled in an inclusive manner. Seeds are reported to be rich in carbohydrates, vitamins, amino acids, proteins, triterpenoids, steroids and saponin glycosides possessing different pharmacological activities. Aim of the study: This study is an effort to collate complete scientific literature published till March 2021 in order to generate a succinct summation on the distribution, traditional beneficial potential, chemical constituents, phytochemistry, pharmacology and toxicology of this coveted species of genus Lepidium. Materials and Methods: Exploring assorted scientific databases. Results: The present methodically compiled review article accentuates medicinal and nutritional significance of this highly valued plant by focusing on various aspects of the plant such as the, physicochemical characterisation and pharmacological studies that validates folklore uses. Thus, this annotated script on L. sativum would be a handy tool to explore the future prospective of research on this traditional plant.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

scholarly journals The Genus Lagochilus (Lamiaceae): A Review of Its Diversity, Ethnobotany, Phytochemistry, and Pharmacology

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 132
Author(s):  
Nilufar Z. Mamadalieva ◽  
Davlat Kh. Akramov ◽  
Ludger A. Wessjohann ◽  
Hidayat Hussain ◽  
Chunlin Long ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Chemical Constituents ◽  
Iridoid Glycosides ◽  
Herbal Medicines ◽  
Future Research ◽  
South Central ◽  
Pharmacological Studies ◽  
Central South

The genus Lagochilus (Lamiaceae) is native to Central, South-Central, and Eastern Asia. It comprises 44 species, which have been commonly used as herbal medicines for the treatments of various ailments for thousands of years, especially in Asian countries. This review aims to summarize the chemical constituents and pharmacological activities of species from the genus Lagochilus to unveil opportunities for future research. In addition, we provide some information about their traditional uses, botany, and diversity. More than 150 secondary metabolites have been reported from Lagochilus, including diterpenes, flavonoids, phenolic compounds, triterpenoids, iridoid glycosides, lignans, steroids, alkaloids, polysaccharides, volatile, non-volatile and aromatic compounds, lipids, carbohydrates, minerals, vitamins, and other secondary metabolites. In vitro and in vivo pharmacological studies on the crude extracts, fractions, and isolated compounds from Lagochilus species showed hemostatic, antibacterial, anti-inflammatory, anti-allergic, cytotoxic, enzyme inhibitory, antispasmodic, hypotensive, sedative, psychoactive, and other activities.

scholarly journals Bioactivities of extracts and phytochemicals of Indigofera aspalathoides Vahl ex DC.

2021 ◽  
pp. 1-16
Keyword(s):  
Plant Species ◽  
Web Of Science ◽  
Scientific Evidence ◽  
Anticancer Compounds ◽  
Traditional Medicines ◽  
Anti Inflammatory ◽  
Phytochemical Studies ◽  
The Web

Indigofera aspalathoides Vahl ex DC. belongs to the Fabaceae family. I. aspalathoides is applied to heal tumors, inflammations, diabetes, leprosy, and kidney illnesses in traditional medicines. Compounds including kaempferol, kaempferol 5-O-β-D-glucopyranoside, 5,4'-dihydroxy 6,8-dimethoxy 7-O-rhamnosyl flavone, indigocarpan, and mucronulatol have isolated from this plant species. Hitherto, there is no comprehensive review available regarding the reported bioactivities of I. aspalathoides. Thus, this article goals to analyze, summarize and document the published bioactivities-related publications. Electronic databases the Web of Science, Scopus, ScienceDirect, and PubMed used to find relevant publications from 1900 to December 2020. Thus far, only in vivo and in vitro scientific evidence levels of bioactivities are available. I. aspalathoides holds such as anti-inflammatory, anticancer, antihepatotoxic, anti-arthritic, immunomodulatory, and antidiabetic properties. Overall, immunomodulatory, anti-inflammatory, and anticancer compounds have been isolated from this plant species Therefore, additional bioactivity and phytochemical-related researches would need to perform to generate more scientific evidence for other applications. This work will be useful for further bioactivity and phytochemical studies using this plant species.

The Genus Patrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies

2017 ◽  
Vol 45 (04) ◽  
pp. 637-666 ◽  
Author(s):  
Xirui He ◽  
Fei Luan ◽  
Zefeng Zhao ◽  
Ning Ning ◽  
Maoxing Li ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
In Vivo Studies ◽  
Positive Effects ◽  
Traditional Uses ◽  
Asian Medicine ◽  
Pharmacological Studies ◽  
Botanical Description ◽  
Pharmacology And Toxicology

The aim of the present review is to comprehensively outline the botanical description, traditional uses, phytochemistry, pharmacology and toxicology of Patrinia, and to discuss possible trends for the further study of medicinal plants from the genus Patrinia. The genus Patrinia plays an important role in Asian medicine for the treatment of erysipelas, conjunctival congestion with swelling and pain, peri-appendicular abscesses, lung carbuncle, dysentery, leucorrhea, and postpartum disease. More than 210 chemical constituents have been isolated and identified from Patrinia plants, especially P. scabiosaefolia Fisch., P. scabra Bunge, P. villosa Juss., P. heterophylla Bunge and P. rupestris(Pall.) Juss[Formula: see text] Of these compounds, triterpenoids and saponins, iridoids, flavonoids, and lignans are the major or active constituents. Both in vitro and in vivo studies have indicated that some monomer compounds and crude extracts from the genus Patrinia possess wide pharmacological activities, including antitumor, anti-inflammatory, antibacterial, and antiviral effects. In addition, they have been shown to have valuable and positive effects on the immune and nervous system in experimental animals. There are also some reports on the clinical uses and toxicity of these species. However, few reports have been published concerning the material identification or quality control of Patrinia species, and the clinical uses and toxic effects of these plants are relatively sparse. More attention must be given to these issues.

scholarly journals Botanical description, phytochemistry, traditional uses, and pharmacology of Crataeva nurvala Buch. Ham.: an updated review

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Dinesh Kumar ◽  
Shivangi Sharma ◽  
Sunil Kumar
Keyword(s):  
Chemical Constituents ◽  
Memory Loss ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Anti Cancer ◽  
Botanical Description ◽  
Ethnomedicinal Uses ◽  
Important Medicinal Plant

Abstract Background Crataeva nurvala Buch. Ham., an important medicinal plant of the Capparidaceae family, is widely distributed in India and tropical and subtropical parts of the world. It has been reported for its folkloric use in various disorders such as blood purifier, breathing problems, fever, metabolic disorders, wound healing, memory loss, and weak immune system. Results The present review has focused on the botanical description and ethnomedicinal and traditional uses of C. nurvala along with its reported pharmacological activities. Chief chemical constituents and pharmacological aspects of C. nurvala have been deeply explored to unravel the unexplored folklore/ethnomedicinal uses of this plant so that the researchers working on this plant may be able to find new insights to continue further investigation on this plant. The pharmacological aspects like anti-diabetic, anti-inflammatory, anti-nociceptive, anti-diarrheal, anti-fertility, anti-pyretic, and anti-cancer potentials evaluated by various in vitro/in vivo methods on this plant have been reported. Conclusion Various traditional uses have been reported that need to be scientifically investigated in depth and several pharmacological activities have been reported for the C. nurvala, but more detailed and mechanism-based studies linked to a particular lead compound need to be targeted in the future. Moreover, this plant has not been completely assessed on the basis of its safety and efficacy on humans. It is expected that this review will compile and improve the existing knowledge on the potential utilization of C. nurvala in complementary and alternative medicine.

scholarly journals Ethnobotany, Phytochemistry and Pharmacology of Pericopsis laxiflora (Baker) Meeuwen (Leguminosae) – A Review

2021 ◽  
pp. 1-7
Author(s):  
Frederick Sarfo-Antwi ◽  
Christopher Larbie ◽  
Benjamin Obukowho Emikpe ◽  
Regina Appiah–Opong
Keyword(s):  
Web Of Science ◽  
Skin Diseases ◽  
Pain Treatment ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Clinical Evaluations ◽  
Pharmacological Studies ◽  
Tryptamine Derivative

Pericopsis laxiflora (Family Leguminosae) is a medicinal plant that is ubiquitous especially in the tropical and savannah regions. There are many reports on folkloric and traditional medicinal uses that include haemorrhoids, rheumatism, abdominal pain treatment, diarrhoea, and dysentery, fever, skin diseases and jaundice. Peer-reviewed articles were gathered by consulting the databases of Scopus, Medline, Web of Science, PubMed, Science Direct and Google Scholar. Phytochemical investigations have revealed many bioactive compounds such as β-carboline derivative and tryptamine derivative. The plant has been examined on the basis of the in vitro, in vivo or clinical evaluations and shown to possess major pharmacological activities. These include anti-trypanosomal, antimicrobial, antibacterial, antioxidant and anti-malarial activities. In the present review, an attempt has been made to congregate the traditional, phytochemical and pharmacological studies performed on Pericopsis laxiflora. Comprehensive safety and efficacy studies must be conducted on the plant. Generally, there are knowledge gaps that must be filled. Thus this review is intended for practitioners and researchers in the fields of ethnopharmacology, natural product chemistry and drug discovery related research.

scholarly journals Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6249
Author(s):  
Chao Su ◽  
Nan Li ◽  
Ruru Ren ◽  
Yingli Wang ◽  
Xiaojuan Su ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Research Progress ◽  
In Vitro Tests ◽  
Pharmacological Activities ◽  
Gynostemma Pentaphyllum ◽  
Parkinson’S Diseases

Gynostemma pentaphyllum (Thunb.) Makino (GP), also named Jiaogulan in Chinese, was known to people for its function in both health care and disease treatment. Initially and traditionally, GP was a kind of tea consumed by people for its pleasant taste and weight loss efficacy. With the passing of the centuries, GP became well known as more than just a tea. Until now, numbers of bioactive compounds, including saponins (also named gypenosides, GPS), polysaccharides (GPP), flavonoids, and phytosterols were isolated and identified in GP, which implied the great medicinal worth of this unusual tea. Both in vivo and in vitro tests, ranging from different cell lines to animals, indicated that GP possessed various biological activities including anti-cancer, anti-atherogenic, anti-dementia, and anti-Parkinson’s diseases, and it also had lipid-regulating effects as well as neuroprotection, hepatoprotective, and hypoglycemic properties. With the further development and utilization of GP, the research on the chemical constituents and pharmacological properties of GP were deepening day by day and had made great progress. In this review, the recent research progress in the bioactive compounds, especially gypenosides, and the pharmacological activities of GP were summarized, which will be quite useful for practical applications of GP in the treatment of human diseases.

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