Therapeutic Effects of Moxibustion on Experimental Tumor

1999 ◽  
Vol 27 (02) ◽  
pp. 157-166 ◽  
Author(s):  
Dou-Mong Hau ◽  
I-Hsin Lin ◽  
Jaung-Geng Lin ◽  
Yung-Hsich Chang ◽  
Ching-Ha Lin
Keyword(s):  
Therapeutic Response ◽  
Subcutaneous Tissue ◽  
Tumor Therapy ◽  
Radioactive Tracer ◽  
Control Group ◽  
Therapeutic Effects ◽  
Experimental Tumor ◽  
Mean Survival Time ◽  
Reliable Model ◽  
Experimental Group

This work investigated the therapeutic effects of the improved form of moxibustion (MT) on experimental tumor. Sarcoma 180 cells (1 × 107) were transplanted into the subcutaneous tissue in the breast area of female ICR mice. Mice bearing a tumor were divided into one control and four experimental groups. The experimental groups were treated with MT for 1, 2, 3 and 4 times (abbreviated as MT1, MT2, MT3, MT4, respectively). This study showed that the experimental group treated with MT3 displayed the optimal therapeutic response. The longest mean survival time (87.8 days) within 120 days after treatment of MT3 significantly differed from the control group (60.2 days). In addition, uptake of 86Rb-radioactive tracer significantly decreased in tumors treated with MT3. The improved form of moxibustion used in this study is a reliable model of localized hyperthermia in tumor therapy.

scholarly journals Direct pulp capping with novel nanostructural materials based on calcium silicate systems and hydroxyapatite

2016 ◽  
Vol 63 (4) ◽  
pp. 183-192 ◽  
Author(s):  
Marijana Popović Bajić ◽  
Violeta Petrović ◽  
Vanja Opačić Galić ◽  
Vesna Danilović ◽  
Vukoman Jokanović ◽  
...  
Keyword(s):  
Calcium Silicate ◽  
Healing Process ◽  
Glass Ionomer Cement ◽  
Control Group ◽  
Therapeutic Effects ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Nanostructural Material ◽  
Experimental Group

Summary Introduction Direct pulp capping is an important therapeutic method that has goal to provide formation of dentin bridge and healing process of the pulp. The aim of this study was to investigate the effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite on exposed dental pulp in Vietnamese pigs. Material and Methods The study was conducted on 30 teeth of two Vietnamese pigs (Sus scrofa verus). On buccal surfaces of incisors, canines and first premolars, class V cavities were prepared with a small round bur and pulp horn was exposed. In the first experimental group (10 teeth) the perforation was covered with new nanostructural material based on calcium silicate systems (CS). In the second experimental group, the perforation was covered with compound of calcium silicate systems and hydroxyapatite (HA-CS) (10 teeth). In the control group, exposed pulp was covered with Pro Root MTA® (Dentsply Tulsa Dental, Johnson City, TN, USA) (10 teeth). All cavities were restored with glass ionomer cement (GC Fuji VIII, GC Corporation, Tokyo, Japan). Observation period was 28 days. After sacrificing the animals, histological preparations were done to analyze the presence of dentin bridge, inflammatory reaction of the pulp, pulp tissue reorganization and the presence of bacteria. Results Dentin bridge was observed in all teeth (experimental and control groups). Inflammation of the pulp was mild to moderate in all groups. Neoangiogenesis and many odontoblast like cells responsible for dentin bridge formation were detected. Necrosis was not observed in any case, neither the presence of Gram-positive bacteria in the pulp. Conclusion Histological analysis indicated favorable therapeutic effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite for direct pulp capping in teeth of Vietnamese pigs.

scholarly journals Clinical Study of Acupotomy Trinity Lysis on Cervical Spondylotic Myelopathy with Liver and Kidney Deficiency Syndrome

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Jianyong Gao ◽  
Yi Zhao ◽  
Tinglan Sun ◽  
Weike Liu ◽  
Zhenguo Wang
Keyword(s):  
Treatment Group ◽  
Cervical Spondylotic Myelopathy ◽  
Deficiency Syndrome ◽  
Control Group ◽  
Therapeutic Effects ◽  
Kidney Deficiency ◽  
Significant Difference ◽  
Before And After ◽  
Liver And Kidney ◽  
Experimental Group

Objective: To compare the therapeutic effects of acupotomy trinity lysis and traditional acupotomy on cervical spondylotic myelopathy. Methods: A total of 205 patients with cervical spondylotic myelopathy of liver and kidney deficiency syndrome were randomly divided into the experimental group (105 cases) and the control group (100 cases). The experimental group was relaxed with acupotomy in three positions: Heaven (tian), Human (ren) and Earth (di). Traditional acupotomy was used to relax Ashi acupoints of the affected vertebra in the control group. One treatment was conducted in one week, and the duration of one course of treatment was three weeks. The VAS, JOA score and NDI index were observed after treatment.  Results: Before and after treatment, the total treatment efficiency of the treatment group was 95.23%, and that of the control group was 80.00%, there was significant difference between the two groups, P<0.05; Before operation, there was no significant difference in JOA score, NDI index score, and VAS score between the treatment group and the control group (P>0.05); there was no significant difference after 1 week (P>0.05), but there were significant differences between the two groups 2 weeks and 3 weeks after operation (P<0.05). Conclusion: Acupotomy trinity lysis is a safe, effective and economical treatment for cervical spondylotic myelopathy.

scholarly journals Comparison of two different methods of establishment of canine urethroplasty model: an experimental trial

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jianpo Zhai ◽  
Danhui Zhao ◽  
Guanglin Huang ◽  
Libo Man ◽  
Guoqiang Yan ◽  
...  
Keyword(s):  
Blood Loss ◽  
Urinary Retention ◽  
Operative Time ◽  
Intraoperative Complications ◽  
Control Group ◽  
Therapeutic Effects ◽  
Group 4 ◽  
Random Number Table ◽  
Experimental Group ◽  
Median Operative Time

Abstract Background Graft substitute urethroplasty is recommended for patients with long segment anterior urethral stricture. The therapeutic effects of the grafts need to be validated on the animal models. Therefore the aim of this study was to compared the operative time, blood loss, intra- and post- operative complications of two different methods of establishment of canine urethroplasty model. Methods Twelve Beagle dogs were randomly separated into control and experimental group using a random number table. Six animals in the control group received the conventional urethroplasty, while the other 6 in the experimental group received the modified procedures. Tube cystostomy and urethroplasty were performed in the control group. The cystostomy not the tube cystostomy were performed in the experimental group, and the testes were simultaneously removed with the scrotum. Per- and postoperative outcomes, complications were evaluated. Results The urethroplasty were successfully performed for all dogs and all of these procedures were done by the same surgeon. The median operative time in the control and experimental groups was 186.8 min and 188.7 min respectively. The blood loss in the control and experimental groups was 40.8 ml and 45.8 ml respectively. No intraoperative complications occurred. 3 animals in the control group developed acute urinary retention after the accidental removal of suprapubic bladder tube and the cystostomy was done again. There was no occurrence of urinary retention in the experimental group. 4 animals in the control group developed the perineal hematoma, in which one animal had the urine leakage and incision infection. Perineal hematoma occurred in only one animal in the experimental group. Conclusion The occurrence of urinary retention and perineal hematoma decreased in the modified group, in which the cystostomy not the tube cystostomy were performed and the testes with the scrotum were simultaneously removed.

scholarly journals Balance Training as an Adjunct to Methylphenidate: A Randomized Controlled Pilot Study of Behavioral Improvement Among Children With ADHD in China

2021 ◽  
Vol 11 ◽  
Author(s):  
Lei Feng ◽  
Yuanchun Ren ◽  
Jia Cheng ◽  
Yufeng Wang
Keyword(s):  
Behavioral Problems ◽  
Balance Training ◽  
Control Group ◽  
Therapeutic Effects ◽  
Children With Adhd ◽  
Hyperactivity Disorder ◽  
And Behavior ◽  
Core Symptoms ◽  
And Control ◽  
Experimental Group

Objective: This study aimed to compare the therapeutic effects of two different approaches to attention deficit hyperactivity disorder (ADHD): (1) methylphenidate (MPH) treatment combined with balance training, and (2) MPH monotherapy.Methods: The study was based on a randomized, single-blind trial involving 27 ADHD patients. An experimental group received the treatment combining MPH and balance training, while a control group were administered just MPH. After 40 sessions of training at the 6-month mark, patients' improvement as observed in their core symptoms and behavioral problems were compared between the experimental and control group.Results: A total of 27 patients underwent randomization, with 13 assigned to the experimental group and 14 to the control group. After the 6-month trial, the experimental group outperformed the control group in terms of teachers' scores for inattention on the ADHD-RS-IV (19.38 ± 2.96 vs. 23.21 ± 3.91, t = −2.854, P = 0.009). The experimental group also showed greater improvement on the items involving behavior (3.14 ± 1.46 vs. 5.24 ± 1.04, t = 1.463, P = 0.026) and hyperactivity (1.92 ± 1.19 vs. 3.86 ± 2.32, t = −2.697, P = 0.012).Conclusion: In children with ADHD, the experimental group displayed a significant improvement in the symptoms and behavior associated with inattention than did the group whose treatment consisted of only MPH.

scholarly journals Observation on the Therapeutic Effects of Wenjing Decoction on Menstrual Disorders

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Diancui Zhang ◽  
Junxia Cui ◽  
Shuwen Gai ◽  
Tongzhen Zhao ◽  
Liqiang Wu
Keyword(s):  
Quality Of Life ◽  
Control Group ◽  
Therapeutic Effects ◽  
Research Subjects ◽  
Menstrual Disorders ◽  
Treatment Methods ◽  
Number Of Cycles ◽  
And Control ◽  
Experimental Group

Objective?To treat patients with menstrual disorders with Wenjing Decoction and analyze its therapeutic effects. Methods?80 patients with menstrual disorders were selected as the research subjects, and they were divided into two groups (experimental group and control group), with each group given different treatment methods. The control group was given conventional Western medical treatment while the experimental group was given Wenjing Decoction treatment, and the effects of different treatment methods on the patients were compared. Results: The total number of effectively treated patients in the experimental group (39 cases, 97.50%) was more than the that of the control group (25 cases, 62.50%), and the quality of life score of the experimental group (91.56±4.44 points) was higher that of the control group (81.72±3.19 points), and the number of menstrual recovery cycles (1.11±0.41) was less than that of the control group patients (2.42±1.25 times), P<0.05. Conclusion: The application of Wenjing Decoction for patients with menstrual disorders can significantly improve the treatment efficacy and is beneficial to improve the quality of life of the patients and shorten the number of cycles that menstruation starts to return to normal.

scholarly journals Efficacy and Safety of Tirofiban in Thrombolytic Therapy for Ischemic Stroke

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Ruixian Wang ◽  
Lishun Yang ◽  
Jianhui Zhang ◽  
Qingping Yao ◽  
Zihuan Zhang
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Platelet Glycoprotein ◽  
Control Group ◽  
Therapeutic Effects ◽  
Efficacy And Safety ◽  
Improvement Rate ◽  
Stroke Thrombolysis ◽  
Experimental Group ◽  
Receptor Inhibitor

Objective: To evaluate the efficacy and safety of tirofiban hydrochloride in the treatment of ischemic stroke with thrombolytic therapy. Method: Two hundred patients with acute ischemic stroke thrombolysis were randomly divided into the experimental group and the control group. The experimental group was given tirofiban with the addition of rtpa in the control group and the therapeutic effects of the two groups were compared. Results: In comparison with the control group, the NIHSS improvement rate was 98% in the experimental group within 14 days. The platelet aggregation rate and efficacy in the experimental group were significantly reduced than the control group (P < 0.01). The major adverse reaction in the two groups was hemorrhage with an incidence rate of 3%. Conclusion: Tirofiban hydrochloride is a highly effective and selective platelet glycoprotein IIb/IIIa receptor inhibitor, which is safe and effective in combination with heparin and aspirin.

scholarly journals Clinical application effect evaluation of Kanglaite combined with DCF chemotherapy program in patients with gastric cancer

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Haibin Ding
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Clinical Application ◽  
Adverse Reactions ◽  
Life Quality ◽  
Effective Rate ◽  
Control Group ◽  
Therapeutic Effects ◽  
Experimental Group

Objective: To evaluate the clinical application effect of Kanglaite combined with DCF chemotherapy program in the patients with gastric cancer. Methods: 86 cases who were all the gastric cancer patients admitted to our hospital from February 2014 to June 2016 were selected, according to randomly divided into two groups, control group and experimental group. The control group was treated with DCF treatment, and the experimental group were treated with Kanglaite combined DCF chemotherapy program, and the therapeutic effects, the quality of life of patients and incidence rate of adverse reactions in two groups were observed and compared. Result: Compared with the control group, the total effective rate and the quality of life score of the experimental group were significantly higher, and the incidence of adverse reactions was less (P < 0.05). Conclusion: In clinic, Kanglaitecombined with DCF chemotherapy program on patients with gastric cancer, can improve the treatment effect and life quality of patients, with less adverse reaction and high application value.

Intravoxel incoherent motion MRI for monitoring the therapeutic response of hepatocellular carcinoma to sorafenib treatment in mouse xenograft tumor models

2016 ◽  
Vol 58 (9) ◽  
pp. 1045-1053 ◽  
Author(s):  
Yedaun Lee ◽  
Seung Soo Lee ◽  
Hyunhee Cheong ◽  
Chang Kyung Lee ◽  
Namkug Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Diffusion Coefficient ◽  
Therapeutic Response ◽  
Post Treatment ◽  
Control Group ◽  
Therapeutic Effects ◽  
Tumor Cell Death ◽  
Mouse Xenograft ◽  
Tumor Periphery

Background With the introduction of targeted therapies, there has been a growing need for non-invasive imaging methods which accurately evaluate therapeutic effects and overcome the limitations of tumor size-based therapeutic response assessments. Purpose To assess diagnostic values of intra-voxel incoherent motion (IVIM) imaging in evaluating therapeutic effects of sorafenib on hepatocellular carcinoma (HCC) using mouse xenograft model. Material and Methods Twenty-four mice bearing Huh-7 were divided into a control group and two treatment groups received sorafenib doses of 5 mg/kg (5 mg-Tx) or 30 mg/kg (30 mg-Tx). IVIM imaging was performed using 10 b-values (0–900 s/mm2). The apparent diffusion coefficient (ADC), diffusion coefficient ( D), and perfusion fraction ( f) were measured for whole tumors and tumor periphery. Changes between baseline and post-treatment parameters ( Δ ADC, Δ D, and Δ f) were calculated, and these parameters were compared with microvessel density (MVD) and area of tumor cell death. Results The post-treatment f and Δ f for tumor periphery were significantly higher in control group, followed by 5 mg-Tx and 30 mg-Tx ( P < 0.001). MVD showed significant positive correlation with post-treatment f ( r = 0.584, P = 0.003) and negative correlation with D ( r = –0.495, P = 0.014) for tumor periphery, while no parameter showed significant correlation with area of tumor cell death. Conclusion The f is significantly correlated with MVD of HCC, and could potentially be used to evaluate the anti-angiogenic effects of sorafenib.

scholarly journals The use of bicyclol in the treatment of severe liver fibrosis: experimental rationale

2021 ◽  
Vol 12 (5) ◽  
pp. 93-100
Author(s):  
K. V. Zhdanov ◽  
A. V. Saulevich ◽  
K. V. Kozlov ◽  
S. M. Zakharenko ◽  
V. S. Sukachev ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Gut Microbiome ◽  
Molecular Genetic ◽  
Laboratory Animals ◽  
Control Group ◽  
Therapeutic Effects ◽  
Clinical Effects ◽  
Protein Levels ◽  
Male Wistar Rats ◽  
Experimental Group

Aim. To evaluate the antifibrotic effect of bicyclol with promising clinical effects on diffuse parenchymal liver diseases.Materials and methods: We have included 40 adult male Wistar rats (weight, 180 to 200g) with experimentally inducted toxic F3 stage liver fibrosis. Control group consisted of 16 rats that received standart chow, experimental group of 24 rats also received 30-day bicyclol supply. To evaluate the results we used histological, biochemical, molecular genetic and statistical methods.Results. In experimental group interlobular fibrosis was maintained in 4,16% (p<0,001) of cases after the end of the therapy, stromal fibrosis of portal tracts was observed in 62,5% (p<0,001) of cases. Periportal fibrosis detection rate in experimental group was 66,7% (p<0,001). Rats from experimental group showed regression of liver fibrosis to F1- F2 stage in 16,6% (METAVIR) whereas control group had F3 stage liver fibrosis in 62,5% (p <0,05). Statistically significant increase in ALT activity and decreased total protein levels in control group were observed. No changes in gut microbiome profile in experimental animals were found.Conclusion. Use of bicyclol led to pronounced suppression of liver fibrotic changes in laboratory animals and temporary decreased serum ALT level. Our study showed no link between therapeutic effects of the drug and gut microbiome status.

scholarly journals Effect of PCSK9 Inhibitor on Lipoprotein Particles in Patients With Acute Coronary Syndromes

2020 ◽  
Author(s):  
Tingting Li ◽  
Yingyi Zhang ◽  
Hongliang Cong
Keyword(s):  
Combination Treatment ◽  
Therapeutic Target ◽  
Acute Coronary Syndromes ◽  
Control Group ◽  
Therapeutic Effects ◽  
Lipoprotein Particles ◽  
Pcsk9 Inhibitor ◽  
Coronary Syndromes ◽  
Lipid Control ◽  
Experimental Group

Abstract Backgrounds: To assess the effects of proprotein convertase subtilisin/kexin type 9 inhibitor (evolocumab) on lipoprotein particles subfractions with Nuclear Magnetic Resonance spectroscopy in patients with acute coronary syndromes.Methods: A total of 99 consecutive patients with ACS and poor lipid control were enrolled and assigned to either the experimental group (n = 54) or the control group (n = 45). The combination therapy of PCSK9 inhibitor (Repatha®, 140mg, q2w) and moderate statin (rosuvastatin, 10 mg, qn) was administered in the experimental group, with statin monotherapy (rosuvastatin, 10 mg, qn) in the control group. The therapeutic effects on lipoprotein particle subfractions were assessed with NMR spectroscopy after eight weeks treatment, and the achievement of LDL-C therapeutic target in both groups were analyzed.Results: In the experimental group, after eight weeks of evolocumab combination treatment, the concentrations of blood lipids (TC, LDL-C and its subfractions [LDL-1 to 6], VLDL-C and its subfractions [VLDL-1 to 5], IDL-C, and HDL-C), lipoprotein particles, and their subfractions (VLDL-P, IDL-P, LDL-P, and its subfractions [LDL-P1 to 6], apoB, and LP(a)) demonstrated therapeutic benefits with statistical significance (P < 0.05). The decrease in total LDL-P concentrations was mainly due to a decreased concentration of small-sized LDL particles (LDL 5+6), which was significantly more prominent than the decrease in medium-sized LDL-P (LDL-P3+4) and large-sized LDL-P (LDL-P1+2) (P < 0.001). According to lipid control target recommended by the latest China Cholesterol Education Program Expert Consensus in 2019, after eight weeks treatment, 96.3% patients in the experimental group and 13.3% in the control group had achieved the LDL-C therapeutic target(P < 0.01).Conclusions: Evolocumab combination treatment for 8 weeks could significantly improve the plasma lipid profiles in ACS patients with poor lipid control, and significantly decrease the concentration of lipoprotein particles which could result in atherosclerosis.

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