Aluminum phthalocyanine and gold nanorod conjugates: the combination of photodynamic therapy and photothermal therapy to kill cancer cells

2012 ◽  
Vol 16 (07n08) ◽  
pp. 802-808 ◽  
Author(s):  
J. Wang ◽  
H. Yan Tang ◽  
W. Li Yang ◽  
J. Yao Chen
Keyword(s):  
Photodynamic Therapy ◽  
Cell Viability ◽  
Cancer Cells ◽  
White Light ◽  
Photothermal Therapy ◽  
Red Light ◽  
Carcinoma Cells ◽  
Light Irradiation ◽  
Surface Plasmon Coupling ◽  
Electrostatic Binding

The sulfonated aluminum phthalocyanines (AlPcSs), popularly used photosensitizers, were linked on the surfaces of gold nanorods (AuNRs) by the electrostatic binding to form AlPcS–AuNRs conjugates, in order to improve the photo-therapy efficiency of cancer cells by combining the photodynamic therapy (PDT) of AlPcSs and the photothermal therapy (PTT) of AuNRs . The AlPcS's fluorescence is two-fold enhanced when they adhered on the surfaces of AuNRs probably due to the surface Plasmon coupling, which would facilitate the AlPcS detection. The fluorescence images show that AuNRs can carry loaded AlPcSs to penetrate into human nasopharyngeal carcinoma cells with a fast speed, achieving the effective intracellular delivery of AlPcSs . The PTT effect of cellular AuNRs alone under the white light irradiation of 50 minutes decreased the cell viability to 77%, and the PDT effect of cellular AlPcS–AuNRs with filtered red light (670–710 nm) irradiation of 50 min lowered the cell viability to 79%. However, with the same white light irradiation of 50 min, the AlPcS–AuNRs destroyed most cells leaving the cell viability to 28%, reflecting a typical synergistic effect on cell killing. These results suggest that the combination of PTT and PDT with AlPcS–AuNRs is a promising strategy for improving the phototherapy of cancers.

Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy

2020 ◽  
Vol 56 (17) ◽  
pp. 2630-2633 ◽  
Author(s):  
Jiabao Zhuang ◽  
Hanxiao Yang ◽  
Yue Li ◽  
Bing Wang ◽  
Nan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
White Light ◽  
Light Irradiation ◽  
Emission Characteristics ◽  
Gram Positive ◽  
Aggregation Induced Emission ◽  
Gram Positive Bacteria ◽  
Targeted Photodynamic Therapy

Efficient photosensitizers with aggregation-induced emission effects were reported to selectively stain lysosome and Gram-positive bacteria, which further triggered the ablation of cancer cells and bacteria under white light irradiation.

scholarly journals LED and UV Light Utilizing Flavonoids and Limonoids to Investigate the Effect of Post-harvest Light Irradiation

2020 ◽  
Author(s):  
Shengyu Liu
Keyword(s):  
White Light ◽  
Uv Light ◽  
Light Emitting Diode ◽  
Red Light ◽  
Principal Component ◽  
Experimental Period ◽  
Light Irradiation ◽  
Flavonoid Glycosides ◽  
Clear Correlation ◽  
Post Harvest

To investigate the effect of post-harvest light irradiation on the accumulation of flavonoids and limonoids, harvestedNewhall navel oranges were continuously exposed to light-emitting diode (LED) and ultraviolet (UV) light irradiationfor 6 days, and the composition and content of flavonoids and limonoids in the segments were determined usingUPLC-qTOF-MS at 0, 6, and 15 days after harvest. In total, six polymethoxylated flavonoids (PMFs), fiveflavoneO/C-glycosides, seven flavanone-O-glycosides, and three limonoids were identified in the segments. Theaccumulation of these components was altered by light irradiation. Red and blue light resulted in higher levels ofPMFs during exposure periods. The accumulation of PMFs was also significantly induced after white light, UVBand UVC irradiation were removed. Red and UVC irradiation induced the accumulation of flavone and flavanoneglycosides throughout the entire experimental period. Single light induced limonoid accumulation during exposureperiods, but limonoid levels decreased significantly when irradiation was removed. Principal component analysisshowed a clear correlation between PMFs and white light, between flavonoid glycosides and red light and UVC,and between limonoids and UVC. These results suggest that the accumulation of flavonoids and limonoids in citrusis regulated by light irradiation. White light, red light and UVC irradiation might be a good potential method forimproving the nutrition and flavor quality of post-harvest citrus.

scholarly journals Effect of Post-Harvest LED and UV Light Irradiation on the Accumulation of Flavonoids and Limonoids in the Segments of Newhall Navel Oranges (Citrus sinensis Osbeck)

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1755 ◽  
Author(s):  
Shengyu Liu ◽  
Linping Hu ◽  
Dong Jiang ◽  
Wanpeng Xi
Keyword(s):  
White Light ◽  
Uv Light ◽  
Light Emitting Diode ◽  
Red Light ◽  
Principal Component ◽  
Light Irradiation ◽  
Flavonoid Glycosides ◽  
Clear Correlation ◽  
Post Harvest ◽  
Uv Light Irradiation

To investigate the effect of post-harvest light irradiation on the accumulation of flavonoids and limonoids, harvested Newhall navel oranges were continuously exposed to light-emitting diode (LED) and ultraviolet (UV) light irradiation for 6 days, and the composition and content of flavonoids and limonoids in the segments were determined using UPLC-qTOF-MS at 0, 6, and 15 days after harvest. In total, six polymethoxylated flavonoids (PMFs), five flavone-O/C-glycosides, seven flavanone-O-glycosides, and three limonoids were identified in the segments. The accumulation of these components was altered by light irradiation. Red and blue light resulted in higher levels of PMFs during exposure periods. The accumulation of PMFs was also significantly induced after white light, UVB and UVC irradiation were removed. Red and UVC irradiation induced the accumulation of flavone and flavanone glycosides throughout the entire experimental period. Single light induced limonoid accumulation during exposure periods, but limonoid levels decreased significantly when irradiation was removed. Principal component analysis showed a clear correlation between PMFs and white light, between flavonoid glycosides and red light and UVC, and between limonoids and UVC. These results suggest that the accumulation of flavonoids and limonoids in citrus is regulated by light irradiation. White light, red light and UVC irradiation might be a good potential method for improving the nutrition and flavor quality of post-harvest citrus.

scholarly journals TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro

2020 ◽  
Vol 13 (7) ◽  
pp. 137 ◽  
Author(s):  
Sarah Chamberlain ◽  
Houston D. Cole ◽  
John Roque ◽  
David Bellnier ◽  
Sherri A. McFarland ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Cell Viability ◽  
Light Propagation ◽  
Residual Disease ◽  
Red Light ◽  
Optical Surface ◽  
Light Fluence ◽  
532 Nm

Intra-operative photodynamic therapy (IO-PDT) in combination with surgery for the treatment of non-small cell lung cancer and malignant pleural mesothelioma has shown promise in improving overall survival in patients. Here, we developed a PDT platform consisting of a ruthenium-based photosensitizer (TLD1433) activated by an optical surface applicator (OSA) for the management of residual disease. Human lung adenocarcinoma (A549) cell viability was assessed after treatment with TLD1433-mediated PDT illuminated with either 532- or 630-nm light with a micro-lens laser fiber. This TLD1433-mediated PDT induced an EC50 of 1.98 μM (J/cm2) and 4807 μM (J/cm2) for green and red light, respectively. Cells were then treated with 10 µM TLD1433 in a 96-well plate with the OSA using two 2-cm radial diffusers, each transmitted 532 nm light at 50 mW/cm for 278 s. Monte Carlo simulations of the surface light propagation from the OSA computed light fluence (J/cm2) and irradiance (mW/cm2) distribution. In regions where 100% loss in cell viability was measured, the simulations suggest that >20 J/cm2 of 532 nm was delivered. Our studies indicate that TLD1433-mediated PDT with the OSA and light simulations have the potential to become a platform for treatment planning for IO-PDT.

Polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposite for combined photodynamic and photothermal therapy

2018 ◽  
Vol 6 (48) ◽  
pp. 8148-8162 ◽  
Author(s):  
Qi Cai ◽  
Jiating Xu ◽  
Dan Yang ◽  
Yunlu Dai ◽  
Guixin Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Light Irradiation ◽  
Nir Light

Under 980 nm light irradiation, polypyrrole-coated UCNPs@mSiO2@ZnO nanocomposites can convert NIR light to achieve both photodynamic therapy (PDT) and photothermal therapy (PTT).

scholarly journals Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

2018 ◽  
Vol 6 (45) ◽  
pp. 7373-7377 ◽  
Author(s):  
Koushambi Mitra ◽  
Montserrat Samsó ◽  
Charles E. Lyons ◽  
Matthew C. T. Hartman
Keyword(s):  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Red Light ◽  
Selective Uptake ◽  
Grafted Nanoparticles ◽  
Targeted Photodynamic Therapy

Hyaluronic acid nanoparticles containing a platinum(ii)–silicon(iv) phthalocyanine conjugate exhibited selective uptake by cancer cells and potent mitochondria-targeted PDT and chemotherapy.

scholarly journals White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9218-9222
Author(s):  
Jiamei Liang ◽  
Pan Wu ◽  
Chunyan Tan ◽  
Yuyang Jiang
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
White Light ◽  
Cell Apoptosis ◽  
Light Irradiation ◽  
Conjugated Polyelectrolyte ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

A conjugated polyelectrolyte PPET3 functions as an efficient photosensitizer for photodynamic therapy and induces cell apoptosis under white light irradiation.

scholarly journals LED and UV Light Utilizing Flavonoids and Limonoids to Investigate the Effect of Post-harvest Light Irradiation

2019 ◽  
Author(s):  
Shengyu Liu ◽  
Linping Hu ◽  
Dong Jiang ◽  
Wanpeng Xi
Keyword(s):  
White Light ◽  
Uv Light ◽  
Light Emitting Diode ◽  
Red Light ◽  
Principal Component ◽  
Experimental Period ◽  
Light Irradiation ◽  
Flavonoid Glycosides ◽  
Clear Correlation ◽  
Post Harvest

To investigate the effect of post-harvest light irradiation on the accumulation of flavonoids and limonoids, harvested Newhall navel oranges were continuously exposed to light-emitting diode (LED) and ultraviolet (UV) light irradiation for 6 days, and the composition and content of flavonoids and limonoids in the segments were determined using UPLC-qTOF-MS at 0, 6, and 15 days after harvest. In total, six polymethoxylated flavonoids (PMFs), five flavone-O/C-glycosides, seven flavanone-O-glycosides, and three limonoids were identified in the segments. The accumulation of these components was altered by light irradiation. Red and blue light resulted in higher levels of PMFs during exposure periods. The accumulation of PMFs was also significantly induced after white light, UVB and UVC irradiation were removed. Red and UVC irradiation induced the accumulation of flavone and flavanone glycosides throughout the entire experimental period. Single light induced limonoid accumulation during exposure periods, but limonoid levels decreased significantly when irradiation was removed. Principal component analysis showed a clear correlation between PMFs and white light, between flavonoid glycosides and red light and UVC, and between limonoids and UVC. These results suggest that the accumulation of flavonoids and limonoids in citrus is regulated by light irradiation. White light, red light and UVC irradiation might be a good potential method for improving the nutrition and flavor quality of post-harvest citrus.

Nanoscaled porphyrinic metal–organic frameworks: photosensitizer delivery systems for photodynamic therapy

2017 ◽  
Vol 5 (9) ◽  
pp. 1815-1821 ◽  
Author(s):  
Daniel Bůžek ◽  
Jaroslav Zelenka ◽  
Pavel Ulbrich ◽  
Tomáš Ruml ◽  
Ivana Křížová ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Visible Light ◽  
Cancer Cells ◽  
Visible Light Irradiation ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Post Treatment ◽  
Light Irradiation ◽  
Attractive Feature ◽  
Metal Organic

PCN-222/MOF-545 nanoparticles cause apoptosis of cancer cells upon visible light irradiation. The phototoxicity of the nanoparticles is deactivated after several hours, which is an attractive feature to avoid post-treatment photosensitization issues.

Sign in / Sign up

Export Citation Format

Share Document