Truncated vitamin B12 derivative with the phosphate group retained
2019 ◽
Vol 23
(04n05)
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pp. 554-560
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Keyword(s):
Cobyric acid and cobinamide are valuable building blocks for the synthesis of artificial cobalamins modified at the nucleotide loop. However, truncated vitamin B[Formula: see text] derivatives are devoid of the phosphate group. We have found that 2-iodoxy benzoic acid-mediated phosphorolysis leads to the cleavage of only one of the phosphodiester bond giving a vitamin B[Formula: see text] analogue with the phosphate moiety preserved. Subsequent alkylation with an organic halide establishes its role as a precursor for the synthesis of vitamin B[Formula: see text] mimics modified at the nucleotide loop.
2016 ◽
Vol 20
(01n04)
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pp. 1-20
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Keyword(s):
2013 ◽
Vol 17
(01n02)
◽
pp. 104-117
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Keyword(s):
1954 ◽
Vol 9
(8)
◽
pp. 509-513
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2015 ◽
Vol 7
(9)
◽
pp. 709-711
2010 ◽
Vol 63
(14-16)
◽
pp. 2431-2439
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Keyword(s):
1954 ◽
Vol 11
(4)
◽
pp. 355-361
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Keyword(s):
Keyword(s):
1958 ◽
Vol 13
(9)
◽
pp. 605-610
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