Computer-aided Design Techniques for Flow-based Microfluidic Lab-on-a-chip Systems

2021 ◽  
Vol 54 (5) ◽  
pp. 1-29
Author(s):  
Xing Huang ◽  
Tsung-Yi Ho ◽  
Wenzhong Guo ◽  
Bing Li ◽  
Krishnendu Chakrabarty ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Large Scale ◽  
Fault Tolerant ◽  
Point Of Care ◽  
Lab On A Chip ◽  
Future Research ◽  
Enzyme Linked Immunosorbent Assay ◽  
Full Potential ◽  
Computer Aided ◽  
Aided Design

As one of the most promising lab-on-a-chip systems, flow-based microfluidic biochips are being increasingly used for automatically executing various laboratory procedures in biology and biochemistry, such as enzyme-linked immunosorbent assay, point-of-care diagnosis, and so on. As manufacturing technology advances, the characteristic dimensions of biochip systems keep shrinking, and tens of thousands of microvalves can now be integrated into a coin-sized microfluidic platform, making the conventional manual-based chip design no longer applicable. Accordingly, computer-aided design (CAD) of microfluidics has attracted considerable research interest in the EDA community over the past decade. This review article presents recent advances in the design automation of biochips, involving CAD techniques for architectural synthesis, wash optimization, testing, fault diagnosis, and fault-tolerant design. With the help of these CAD tools, chip designers can be released from the burden of complex, large-scale design tasks. Meanwhile, new chip architectures can be explored automatically to open new doors to meet requirements from future large-scale biological experiments and medical diagnosis. We discuss key trends and directions for future research that are related to enable microfluidics to reach its full potential, thus further advancing the development and progression of the microfluidics industry.

A Multi-User Computer-Aided Design Competition: Experimental Findings and Analysis of Team-Member Dynamics

2017 ◽  
Vol 17 (3) ◽  
Author(s):  
Brett Stone ◽  
John Salmon ◽  
Keenan Eves ◽  
Matthew Killian ◽  
Landon Wright ◽  
...  
Keyword(s):  
Computer Aided Design ◽  
Value Added ◽  
Future Research ◽  
Calendar Time ◽  
Competition Analysis ◽  
Computer Aided ◽  
Design Competition ◽  
Purdue Spatial Visualization Test ◽  
Experimental Findings ◽  
Aided Design

A competition for teams of three students using a prototype multi-user computer-aided design (MUCAD) tool was held to investigate various hypotheses regarding the performance of teams in such a setting. By comparing models from the competition to the same model in a single-user CAD environment, it is seen that use of a MUCAD system can significantly increase the value-added per unit of calendar time for a modeling effort. An investigation was also made into the causes of the performance differences among the various MUCAD teams which participated in the competition. Analysis of the results shows that teams that encouraged effective forms of communication and teams whose members scored similarly on the Purdue Spatial Visualization Test: Visualization of Rotations (PSVT:R) performed better than other teams. Areas of future research in analyzing teams in MUCAD environments are suggested.

The CAD/CAM Interface: A 25-Year Retrospective

2005 ◽  
Vol 5 (3) ◽  
pp. 188-197 ◽  
Author(s):  
J. Corney ◽  
C. Hayes ◽  
V. Sundararajan ◽  
P. Wright
Keyword(s):  
Computer Aided Design ◽  
Future Research ◽  
Manufacturing Processes ◽  
Sheet Metal Parts ◽  
Multiaxis Machining ◽  
Computer Aided ◽  
Cad Cam ◽  
Feature Based ◽  
Manufacturing Applications ◽  
Aided Design

The vision of fully automated manufacturing processes was conceived when computers were first used to control industrial equipment. But realizing this goal has not been easy; the difficulties of generating manufacturing information directly from computer aided design (CAD) data continued to challenge researchers for over 25 years. Although the extraction of coordinate geometry has always been straightforward, identifying the semantic structures (i.e., features) needed for reasoning about a component’s function and manufacturability has proved much more difficult. Consequently the programming of computer controlled manufacturing processes such as milling, cutting, turning and even the various lamination systems (e.g., SLA, SLS) has remained largely computer aided rather than entirely automated. This paper summarizes generic difficulties inherent in the development of feature based CAD/CAM (computer aided manufacturing) interfaces and presents two alternative perspectives on developments in manufacturing integration research that have occurred over the last 25 years. The first perspective presents developments in terms of technology drivers including progress in computational algorithms, enhanced design environments and faster computers. The second perspective describes challenges that arise in specific manufacturing applications including multiaxis machining, laminates, and sheet metal parts. The paper concludes by identifying possible directions for future research in this area.

Introductory remarks

1971 ◽  
Vol 321 (1545) ◽  
pp. 145-146
Keyword(s):  
Engineering Design ◽  
Computer Aided Design ◽  
Mechanical Engineering ◽  
Future Research ◽  
Design Work ◽  
Computer Aided ◽  
Hidden Line ◽  
Multi Access ◽  
Aided Design ◽  
Design And Manufacture

From time to time the Royal Society organizes meetings for the discussion of some new development in engineering and applied science. It seemed possible to the organizers of this meeting that it would be profitable to bring together workers in industry and in the universities to discuss some aspect of computer-aided design. As you will see we have chosen the application of computer aids to mechanical engineering design and manufacture. This restriction to mechanical engineering was deliberate, partly because the application of computer aids to mechanical engineering design is somewhat behind similar activities in electrical and civil engineering. Another reason is that the development of such applications has reached a particularly interesting stage, and it is now perhaps appropriate to review progress and to discuss the directions in which future research should proceed. Although some examples of computer-aided design in mechanical engineering can be found from the earliest days of computing, the development really started in the late fifties with early experiments in the use of graphic displays and with the introduction of multi-access computing. Some may date the beginning of the developments which we are going to discuss today, from the work at M. I. T. on automated programmed drawing started in 1958. This has led to a concentration of effort on graphics and computer-aided drafting. Much research has been done on the mathematical description of curves, surfaces and volumes in a form suitable for engineering design. Work has been done on the automatic dimensioning of drawings, hidden line removal, the prob­lems of lofting, etc.

MCAD-ECAD Integration: Overview and Future Research Perspectives

2007 ◽  
Author(s):  
Kenway Chen ◽  
Dirk Schaefer
Keyword(s):  
Computer Aided Design ◽  
Electrical Engineering ◽  
Rapid Change ◽  
Background Information ◽  
Future Research ◽  
Product Modeling ◽  
Directional Information ◽  
Research Perspectives ◽  
Computer Aided ◽  
Aided Design

The domain of Electrical Computer-Aided Design and Engineering (ECAD/ECAE) has been subject to major and rapid change over the past couple of years. Electrical Engineering Computer-Aided Design (CAD) tools developed in the early to mid-1990s no longer meet future requirements. Consequently, a new generation of Electrical Engineering CAD systems has been under development for about a decade now. An overview of advances in this field is presented in the introductory part of this paper. This overview also sets the context and provides background information for the main topic, MCAD-ECAD-integration, to be addressed in the remainder of this paper. Many complex engineered systems encompass mechanical as well as electrical engineering components. Unfortunately, contemporary CAE environments do not provide a sufficient degree of integration in order to allow for multi-disciplinary product modeling and bi-directional information flow (i.e. automated design modifications on either side) between mechanical and electrical CAD domains. Overcoming this barrier of systems integration would release a tremendous efficiency potential with regard to the efficient development of multidisciplinary product platforms and configurations. An overview of the state-of-the-art in MCAD-ECAD integration is presented. In addition, associated research questions are postulated and potential future research perspectives discussed.

Computer Aided Design of Chinese College English Teaching Materials Based on COCA Corpus

2014 ◽  
Vol 590 ◽  
pp. 916-919
Author(s):  
Yan Juan Huo
Keyword(s):  
Computer Aided Design ◽  
Large Scale ◽  
English Language ◽  
English Language Teaching ◽  
Teaching Material ◽  
Teaching Resources ◽  
College English ◽  
English Teaching ◽  
Computer Aided ◽  
Aided Design

As the flourishing of computer technology and the appearing of lots of large-scale and well-designed corpora and concordance software, corpus-based approach, an advanced teaching resources, has been widely employed in language researches of various fields and perspectives. English teaching material, the main source of language input, has the quality and authority in Chinese English language teaching classes. The present study attempts to bring about some innovations in construction and designing of teaching material on the basis of the Corpus of Contemporary American English (COCA). Moreover, the research is intended to effectively improve teacher’s input and introducing data-driven learning (DDL), and to effectively stimulate the motivations of students by using this computer-aided and COCA-based designing.

scholarly journals Three Out of Two

2001 ◽  
Vol 123 (09) ◽  
pp. 60-63 ◽  
Author(s):  
Jean Thilmany
Keyword(s):  
Computer Aided Design ◽  
Tool Design ◽  
Software Systems ◽  
Full Potential ◽  
Drawing Tool ◽  
Cad Systems ◽  
3D Cad ◽  
Computer Aided ◽  
General Contractors ◽  
Aided Design

This article reviews computer-aided design (CAD) software that is meant to function as more than a drawing tool; design offices and general contractors are still learning how to take advantage of its full potential even as the software systems mature. CAD systems are used to sell products before they are produced, to warehouse past designs in a central library, and to describe an intended design to a parts supplier. Traditional wisdom holds that 2D CAD systems are best suited to products with simple geometries that can be easily represented without considerable interpretive errors, products such as the nozzles. Often, 2D drawings can be ambiguous and are open to errors in interpretation, especially in cases of complex designs, according to the Queensland Manufacturing Institute (QMI) report. Century Tool wanted to use the 3D CAD software to check for interferences in the design of a part a customer had charged Century Tool with building.

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