Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers

Ghrelin, produced and secreted by the A-like cells of the stomach, stimulates growth hormone secretion, gastric motility, and food intake. Cysteamine inhibits the release of somatostatin and induces the formation of duodenal ulcers in rats. The present study was conducted to investigate the dynamics of ghrelin secretion in rats treated with cysteamine. Male Wistar rats (7 wk old) were administered three doses of cysteamine (400 mg/kg) orally; at 50 h after the first dose, duodenal ulcers were induced, and the plasma level of somatostatin and gastric density of somatostatin-immunoreactive cells were significantly reduced. The plasma total and active ghrelin levels were significantly higher in the cysteamine-treated rats than in the control rats, whereas the gastric ghrelin levels, number of gastric ghrelin-immunoreactive cells, and preproghrelin mRNA expression levels were significantly lower. Even at the time points of 2 and 10 h after the first dose of cysteamine, at which time no significant ulcer formation or antral neutrophil accumulation was yet noted, a significant increase in the plasma ghrelin level and decrease in the gastric ghrelin level were observed. Furthermore, although lansoprazole treatment attenuated the duodenal ulceration induced by cysteamine, the increase in the plasma level of ghrelin could still be demonstrated. Because an inverse correlation was found between the plasma ghrelin and somatostatin levels, the inhibition of somatostatin secretion may be associated with the increased ghrelin secretion. In conclusion, an increase in the plasma ghrelin level precedes the formation of duodenal ulcers in rats treated with cysteamine.

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Acylated Ghrelin Secretion Is Acutely Suppressed by Oral Glucose Load or Insulin-Induced Hypoglycemia Independently of Basal Growth Hormone Secretion in Humans

Hormone Research in Paediatrics ◽

10.1159/000097098 ◽

2006 ◽

Vol 67 (5) ◽

pp. 211-219 ◽

Cited By ~ 10

Author(s):

Sang Wan Kim ◽

Kyung Won Kim ◽

Chan Soo Shin ◽

Do Joon Park ◽

Kyong Soo Park ◽

...

Keyword(s):

Growth Hormone ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Oral Glucose ◽

Acylated Ghrelin ◽

Oral Glucose Load ◽

Glucose Load ◽

Ghrelin Secretion

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Association of plasma ghrelin levels with diabetic nephropathy

LaboratoriumsMedizin ◽

10.1515/labmed-2017-0050 ◽

2018 ◽

Vol 42 (1-2) ◽

pp. 39-44

Author(s):

Somayeh Rahimi ◽

Faranak Kazerouni ◽

Mehdi Hedayati ◽

Mehr Ali Rahimi ◽

Ali Rahimipour ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Density Lipoprotein ◽

Inverse Correlation ◽

Ghrelin Level ◽

Lipoprotein Cholesterol ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Plasma Ghrelin Level ◽

Type 2 Diabetic

AbstractBackground:Ghrelin is a 28-amino acid peptide hormone which is produced in various tissues such as the kidney. It is proposed that this hormone exerts a broad spectrum of biological functions throughout the body. Ghrelin carries out endocrine and/or paracrine functions in the kidney, which seems to be one of the target tissues of this hormone. Results regarding circulating ghrelin levels in chronic kidney disease (CKD) and diabetic nephropathy (DN) patients are conflicting. We aimed to investigate the plasma ghrelin levels in type 2 diabetic patients with and without nephropathy.Methods:A total of 45 patients with DN and 45 patients with diabetes without diabetic nephropathy (NDN) were recruited for this study. Plasma ghrelin levels were determined using the enzyme-linked immunosorbent assay (ELISA) method. The association of plasma ghrelin with concentrations of fasting glucose (FBS), creatinine (Cr), blood urea nitrogen (BUN), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), triglycerides (TG) and anthropometric parameters was analyzed.Results:Plasma ghrelin concentration in the DN group was 1.16 (1.01–1.38) ng/mL and in the NDN group was 1.16 (0.92–1.41) ng/mL, so there were no significant differences between the two groups (p=0.467). In the NDN group, ghrelin showed an inverse correlation with TG (r=−0.467, p=0.001) and a direct correlation with HDL (r=0.562, p=0.000) but in the DN group these correlations were not found.Conclusions:Our findings implicated no relationship between the plasma ghrelin level and renal dysfunction in type 2 diabetic patients. Therefore, plasma ghrelin level may not be a probable indicator of kidney insufficiency in patients with type 2 diabetes mellitus (T2DM). Furthermore, we also found a positive correlation between ghrelin and HDL and an inverse correlation with TG levels.

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Enhanced plasma ghrelin level reflects ghrelin secretion from the inflamed stomach of H.pylori-Infected mongolian gerbils

Gastroenterology ◽

10.1016/s0016-5085(03)82974-8 ◽

2003 ◽

Vol 124 (4) ◽

pp. A587

Author(s):

Hidekazu Suzuki ◽

Tatsuhiro Masaoka ◽

Hiroshi Hosoda ◽

Takayuki Ota ◽

Yuriko Minegishi ◽

...

Keyword(s):

Ghrelin Level ◽

Mongolian Gerbils ◽

Plasma Ghrelin Level ◽

Ghrelin Secretion

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Altered Ghrelin Secretion Pattern and Sense of Hunger by Providing Low and High Density Breakfast in Obese Female Adolescents

Biomolecular and Health Science Journal ◽

10.20473/bhsj.v1i1.8223 ◽

2018 ◽

Vol 1 (1) ◽

pp. 10

Author(s):

Ni Luh Putu Ayu Putrisari Putri ◽

Elyana Asnar ◽

Purwo Sri Rejeki

Keyword(s):

Energy Density ◽

High Energy ◽

Ghrelin Level ◽

High Energy Density ◽

Major Influence ◽

Food Density ◽

Low Calorie ◽

Plasma Ghrelin Level ◽

Obese Female ◽

Ghrelin Secretion

Introduction: Ghrelin has been recognized to have a major influence on energy balance. Hence, the discovery of various regulatory factors that control ghrelin secretion may have major implications for the development of drugs and diet control. This study aims to analyze differences in ghrelin secretion pattern and prevention of hunger in the provision of breakfast in low-calorie breakfast, low energy density and high energy density in obese female adolescents.Methods: Subjects were female students aged 18-22 years with a BMI=25 kg/m², receiving low-calorie breakfast with low (n=8) and high energy density (n=8). Before the breakfast, subjects fasted for 12 hours and were subjected to plasma ghrelin level and hunger measurement using visual analog scale (VAS). Breakfast was done at 08.00, divided into three parts and each was taken for 5 minutes. Measurement of plasma ghrelin was carried out again post prandial (PP) at 2 hours and 4 hours. VAS filling was done 1 hour PP, 2 hours PP, 3 hours PP, and 4 hours PP.Result: There were differences in plasma ghrelin level, but not significant. VAS 1 analysis of hunger (p=0.040) at 4 hours PP and VAS 3 of satiety (p=0.025) was significantly different at 3 hours PP. Conclusion: Food density did not affect the plasma ghrelin levels. Low density foods are more effective to prevent hunger in 4 hours PP and increases satiety in 3 hours PP.

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