Testosterone and exercise: Effects on fitness, body composition and strength in middle-to-older aged men with low-normal serum testosterone levels.

2021 ◽  
Author(s):  
Lauren C. Chasland ◽  
Bu B Yeap ◽  
Andrew J. Maiorana ◽  
Yi X Chan ◽  
Barbara A Maslen ◽  
...  
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Aerobic Capacity ◽  
Lean Mass ◽  
Visceral Fat ◽  
Serum Testosterone ◽  
Normal Serum ◽  
Testosterone Treatment ◽  
Leg Strength ◽  
Therapeutic Doses

As men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L−1). Participants (n=80) were randomised to AndroForte5® (Testosterone 5.0%w/v, 100mg/2mL) cream (T), or matching placebo (P), applied transdermally daily, and supervised centre-based exercise (Ex) or no additional exercise (NEx), for 12-weeks. Exercise increased VO2peak and strength vs non-exercise (VO2peak: T+Ex:+2.5, P+Ex:+3.2mL·kg−1·min−1, P<0.001; leg press: T+Ex:+31, P+Ex:+24kg, P=0.006). T treatment did not affect VO2peak or strength. Exercise decreased total (T+Ex:-1.7, P+Ex-2.3kg, P<0.001) and visceral fat (T+Ex:-0.1, P+Ex:-0.3kg, P=0.003), and increased total (T+Ex:+1.4, P+Ex:+0.7kg, P=0.008) and arm lean mass (T+Ex:+0.5, P+Ex:+0.3kg, P=0.024). T treatment did not affect total or visceral fat, but increased total (T+Ex:+1.4, T+NEx:+0.7kg, P=0.015), leg (T+Ex:+0.3, T+NEx:+0.2kg, P=0.024) and arm lean mass (T+Ex:+0.5, T+NEx:+0.2kg, P=0.046). T+Ex increased arm lean mass (T+Ex:+0.5kg vs P+NEx:-0.0kg, P=0.001) and leg strength (T+Ex:+31 vs P+NEx:+12kg, P=0.032) compared to P+NEx, with no other additive effects. Exercise training was more effective than T treatment in increasing aerobic capacity and decreasing total and visceral fat mass. T treatment at therapeutic doses increased lean mass but conferred limited additional benefit when combined with exercise. Exercise should be evaluated as an anti-ageing intervention in preference to testosterone treatment in men.

Abstract 075: Differences In Body Composition At Baseline And In Response To Exercise Training By Metabolic Health And Weight Status

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Alexis Jones ◽  
Jacob L Barber ◽  
James S Skinner ◽  
Claude Bouchard ◽  
Mark A Sarzynski
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Visceral Fat ◽  
Weight Status ◽  
Normal Weight ◽  
Metabolic Health ◽  
Fat Free Mass ◽  
Obese Adults ◽  
Change Models ◽  
Metabolically Healthy

Background: Body composition is known to differ across metabolic health and weight phenotypes. Regular exercise improves body composition, yet little is known about differences in exercise response across metabolic health and weight phenotypes. Methods: Normal weight (n=376) and overweight/obese (OWOB) adults (n=456) from the HERITAGE Family Study (56% female, 38% Black) completed a 20-week endurance training program. Four groups based on baseline BMI and metabolic risk were created: metabolically healthy normal weight, MHNW; metabolically unhealthy normal weight, MUNW; metabolically healthy OWOB, MHO; and metabolically unhealthy OWOB, MUO. Unhealthy was defined as having ≥2 metabolic syndrome components. General linear models tested for differences in baseline and change in measures of body composition (fat mass [FM], fat-free mass [FFM], % body fat [%BF], visceral fat) after adjusting for age, sex, and ethnicity (and baseline value in change models). Results: Table 1 shows adjusted mean baseline and change in body composition values by group. Baseline body composition tended to track with weight status, with NW adults having lower FM, %BF, and visceral fat compared to obese adults (p<0.05), regardless of metabolic health. However, the MHO group had lower baseline values of these traits compared to MUO (p<0.05). Body composition measures significantly improved with exercise training in all groups, however, the magnitude of change differed between groups. For example, both NW groups had larger decreases in %BF compared to the obese groups, with MUNW showing the largest decrease. Conversely, MHNW showed the largest decrease in visceral fat, which was greater than both obese groups, but change in visceral fat was similar between MHO and MUNW. Conclusions: Normal weight adults tended to have better body composition profiles at baseline and larger improvements with exercise compared to obese adults, regardless of metabolic health. Within weight groups, body composition improved regardless of metabolic health status.

scholarly journals Serum estradiol is associated with lean mass in elderly Swedish men

2010 ◽  
Vol 162 (4) ◽  
pp. 737-745 ◽  
Author(s):  
Liesbeth Vandenput ◽  
Dan Mellström ◽  
Magnus K Karlsson ◽  
Eric Orwoll ◽  
Fernand Labrie ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Lean Mass ◽  
Association Studies ◽  
Serum Testosterone ◽  
Fat Distribution ◽  
Free Testosterone ◽  
Elderly Men ◽  
Central Fat ◽  
Free Serum

ObjectiveAssociation studies in men have shown that androgens are inversely related to fat measures, while the relation between sex steroids and lean mass remains unclear. We, therefore, investigated the associations between serum sex steroid levels and body composition in elderly men with a main focus on lean mass measures.Design and methodsA cross-sectional survey of a population-based cohort of 3014 elderly men, aged 69–80 years (Osteoporotic Fractures in Men study, Sweden). Serum levels of testosterone and estradiol (E2) were measured by mass spectrometry, sex hormone-binding globulin (SHBG) levels were measured by IRMA, and measures of body composition were obtained by dual-energy X-ray absorptiometry.ResultsTotal as well as free serum testosterone associated independently inversely (P<0.001), while total as well as free serum E2associated independently directly (P<0.001) with total body fat mass and trunk fat mass. Serum SHBG associated independently inversely with central fat distribution. Serum E2and free E2but not serum testosterone or free testosterone levels associated positively with lean mass (P<0.01). Elderly men within the lowest quartile of free E2had 0.5 kg less lean mass in the legs than subjects within the highest quartile, while the subjects in the different quartiles of free testosterone did not differ in lean mass.ConclusionsSerum E2, but not serum testosterone, is directly associated with lean mass in this large study of elderly Swedish men. In addition, serum SHBG is associated with central fat distribution and we confirmed that serum testosterone is inversely associated with fat mass.

scholarly journals Evidence of Hypertension in Healthy Children and Its Association with Body Composition and Aerobic Capacity

2020 ◽  
Vol 9 (2) ◽  
pp. 116-121
Author(s):  
Aaron Azzu Tetteh ◽  
Monday Omoniyi Moses
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Heart Rate ◽  
Body Composition ◽  
Bone Mass ◽  
Body Mass ◽  
Aerobic Capacity ◽  
Visceral Fat ◽  
Fat Free Mass ◽  
Healthy Children

Hypertension is mostly associated with adulthood and old age with little attention on children. This study provided evidence of hypertension in healthy children and its association with body composition and aerobic capacity (VO2max). 266 healthy children aged 8-11 years were recruited for the study. Blood pressure, heart rate, body mass index (BMI), basal metabolic rate (BMR), fat free mass, bone mass, visceral fat, total body water (TBW), and VO2max were measured. 18.79% were pre-hypertensive and 9.40% overweight at least, while 65.42% underweight. Correlation between blood pressure and maxVO2 was significant (P < 0.05). VO2max significantly correlate with body mass index (r = -.415, P < 0.05), fat mass (r = -.385, P < 0.05) negatively and visceral fat (r = -.267, P < 0.05) and positive with fat free mass (r =.385, P < 0.05) and bone mass (r =.077, P < 0.05). Gender differences were significant in BMR, TBW, VO2max and heart rate (P < 0.05). Evidence of hypertension in relatively healthy children is a clarion call to avert unprecedented decline in future life expectancy rate. Physical activity interventions are suggested antidotes to avert the risk factors of hypertension and excess body fat in children

scholarly journals The effects of an exercise training program on body composition and aerobic capacity parameters in Tunisian obese children

2013 ◽  
Vol 17 (6) ◽  
pp. 1040 ◽  
Author(s):  
Mahdi Kamoun ◽  
Sameh Ghroubi ◽  
Haithem Rebai ◽  
Habib Elleuch ◽  
MounaMnif Feki ◽  
...  
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Training Program ◽  
Aerobic Capacity ◽  
Obese Children ◽  
Exercise Training Program

Assessing the utility of cardiorespiratory fitness, visceral fat, and liver fat in predicting changes in insulin sensitivity beyond simple changes in body weight after exercise training in adolescents

2021 ◽  
Vol 46 (1) ◽  
pp. 55-62
Author(s):  
Jennifer L. Kuk ◽  
SoJung Lee
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Weight Change ◽  
Visceral Fat ◽  
Liver Fat ◽  
Body Weight Change ◽  
Sensitivity Changes

To examine the utility of changes in cardiorespiratory fitness (CRF) and body composition in response to exercise training in adolescents with obesity beyond simple measures of body weight change. This is a secondary analysis of our previously published randomized trials of aerobic, resistance, and combined training. We included 104 adolescents (body mass index (BMI) ≥85th percentile) who had complete baseline and post-intervention data for CRF, regional body fat, insulin sensitivity, and oral glucose tolerance. Associations between changes in body composition and CRF with cardiometabolic variables were examined adjusted for age, sex, Tanner stage, race, exercise group, and weight loss. At baseline, CRF, visceral fat and liver fat were correlated with insulin sensitivity with and without adjustment for BMI percentile. Training-associated changes in CRF, visceral fat, and liver fat were also correlated with insulin sensitivity changes, but not independent of body weight change. After accounting for body weight change, none of the body composition or CRF were associated with changes in insulin sensitivity, glucose tolerance, systolic blood pressure, or high-density lipoprotein cholesterol. Although CRF and body composition were strong independent correlates of insulin sensitivity at baseline, changes in CRF and visceral fat were not associated with changes in insulin sensitivity after accounting for body weight change. Clinicaltrials.gov registration nos.: NCT00739180, NCT01323088, NCT01938950. Novelty With exercise training, changes in body weight, CRF, visceral fat, and liver fat were correlated with changes in insulin sensitivity. Changes in body composition or CRF generally did not remain significant correlates of changes in insulin sensitivity after adjusting for body weight changes.

scholarly journals Effect of Exercise Training Intensity on Abdominal Visceral Fat and Body Composition

2008 ◽  
Vol 40 (11) ◽  
pp. 1863-1872 ◽  
Author(s):  
BRIAN A. IRVING ◽  
CHRISTOPHER K. DAVIS ◽  
DAVID W. BROCK ◽  
JUDY Y. WELTMAN ◽  
DAMON SWIFT ◽  
...  
Keyword(s):  
Body Composition ◽  
Exercise Training ◽  
Visceral Fat ◽  
Training Intensity ◽  
Abdominal Visceral Fat

scholarly journals Effects of Exercise Training on Fat Loss and Lean Mass Gain in Mexican-American and Korean Premenopausal Women

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Shenghui Wu ◽  
Kyung-Shin Park ◽  
Joseph B. McCormick
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
Exercise Training ◽  
Fat Mass ◽  
Visceral Adipose Tissue ◽  
Lean Mass ◽  
Mexican American ◽  
Fat Percentage ◽  
Tissue Area ◽  
Visceral Adipose

We investigated the effect of exercise training on body composition change in women. Nineteen Mexican-American and 18 Korean premenopausal overweight/obese women were randomized into one of the following groups: control, low-intensity training group (LI), and high-intensity training group (HI). Subjects completed 12 weeks of training at 50–56% maximal oxygen consumption (LI) or 65–70% maximal oxygen consumption (HI). Body composition components were measured at baseline and after training using dual-energy X-ray absorptiometry for Mexican-Americans, while whole-body composition was measured by the direct segmental multifrequency bioelectrical impedance analysis and abdominal fat was measured by single-slice computed tomography for Koreans. Data were analyzed using mixed-model repeated measures independent of age, ethnicity, and body mass index (BMI). Exercise training showed a significant effect on BMI, fat percentage, fat mass, lean mass, and visceral adipose tissue area. HI significantly decreased fat mass and fat percentage but increased lean mass (all P<0.05). LI significantly reduced BMI, fat mass, fat percentage, and visceral adipose tissue area but increased lean mass (all P<0.05). Exercise training had a beneficial effect on reducing BMI, fat percentage, fat mass, and visceral adipose tissue area but had no effect on increasing lean mass for Mexican-American and Korean premenopausal overweight/obese women.

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