Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats
2020 ◽
Vol 319
(6)
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pp. H1459-H1473
Keyword(s):
Using a novel loss-of-function mutation in estrogen receptor-α (ERα), we demonstrate that female, but not male, ERα mutant rats display right ventricular (RV)-vascular uncoupling, diastolic dysfunction, and fibrosis following pressure overload, indicating a sex-dependent role of ERα in protecting against adverse RV remodeling. TIMP metallopeptidase inhibitor 1 (Timp1), matrix metalloproteinase 9 (Mmp9), kallikrein-related peptidase 10 ( Klk10), and Jun Proto-Oncogene ( Jun) were identified as potential mediators in ERα-regulated pathways in RV pressure overload.
2012 ◽
Vol 230
(1)
◽
pp. 11-20
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Keyword(s):
2015 ◽
Vol 28
(7)
◽
pp. 828-843
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2005 ◽
Vol 288
(2)
◽
pp. H469-H476
◽
2005 ◽
Vol 26
(S 1)
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Keyword(s):