Adverse childhood events and cardiovascular diseases: the potential role of Sirt1

2021 ◽  
Vol 321 (3) ◽  
pp. H577-H579
Author(s):  
Paula Rodriguez-Miguelez ◽  
Jennifer S. Pollock
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role ◽  
Adverse Childhood Events ◽  
Adverse Childhood

Adverse childhood events, adult distress, and the role of emotion regulation.

2019 ◽  
Vol 25 (2) ◽  
pp. 124-132 ◽  
Author(s):  
Sasha Rudenstine ◽  
Adriana Espinosa ◽  
Andrew Brockbank McGee ◽  
Emma Routhier
Keyword(s):  
Emotion Regulation ◽  
Adverse Childhood Events ◽  
Adverse Childhood

scholarly journals The Role of Uridine Adenosine Tetraphosphate in the Vascular System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Rita C. Tostes ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Smooth Muscle Cells ◽  
Vascular Function ◽  
Purinergic Receptors ◽  
Potential Role ◽  
Vascular System

The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphate (Up4A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). Up4A structurally contains both purine and pyrimidine moieties, which activate purinergic receptors. There is an accumulating body of evidence to show that Up4A modulates vascular function by actions on endothelial and smooth muscle cells. In this paper, we discuss the effects of Up4A on vascular function and a potential role for Up4A in cardiovascular diseases.

scholarly journals The potential role of miRNAs in calcification of cardiovascular diseases

2019 ◽  
pp. 118-125 ◽  
Author(s):  
A. G. Ibragimova ◽  
K. R. Shakhmaeva ◽  
I. E. Stanishevskaya ◽  
A. V. Shindyapina
Keyword(s):  
Cardiovascular Diseases ◽  
Potential Role

scholarly journals MicroRNA-143/-145 in Cardiovascular Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wang Zhao ◽  
Shui-Ping Zhao ◽  
Yu-Hong Zhao
Keyword(s):  
Smooth Muscle ◽  
Cardiovascular Diseases ◽  
Vascular Smooth Muscle Cells ◽  
Essential Role ◽  
Recent Progress ◽  
Potential Role ◽  
Phenotypic Switching ◽  
Diagnostic Biomarkers ◽  
Potential Strategy

MicroRNAs (miRNAs) play an essential role in the onset and development of many cardiovascular diseases. Increasing evidence shows that miRNAs can be used as potential diagnostic biomarkers for cardiovascular diseases, and miRNA-based therapy may be a promising therapy for the treatment of cardiovascular diseases. The microRNA-143/-145 (miR-143/-145) cluster is essential for differentiation of vascular smooth muscle cells (VSMCs) and determines VSMC phenotypic switching. In this review, we summarize the recent progress in knowledge concerning the function of miR-143/-145 in the cardiovascular system and their role in cardiovascular diseases. We discuss the potential role of miR-143/-145 as valuable biomarkers for cardiovascular diseases and explore the potential strategy of targeting miR-143 and miR-145.

Outcomes of COVID-19 on Latinx youth: Considering the role of adverse childhood events and resilience.

2021 ◽  
Author(s):  
Stephanie D'Costa ◽  
Andrea Rodriguez ◽  
Stephanie Grant ◽  
Mayra Hernandez ◽  
Joaquin Alvarez Bautista ◽  
...  
Keyword(s):  
Adverse Childhood Events ◽  
Adverse Childhood ◽  
Latinx Youth

scholarly journals IL-37—a putative therapeutic agent in cardiovascular diseases

QJM ◽  
2021 ◽  
Author(s):  
S McCurdy ◽  
J Yap ◽  
J Irei ◽  
J Lozano ◽  
W A Boisvert
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Potential Role ◽  
Therapeutic Agent ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Orphan Receptor ◽  
Elevated Plasma ◽  
Coronary Syndrome

Summary Although it is a member of the Interleukin (IL)-1 family, IL-37 is unique in that it has wide-ranging anti-inflammatory characteristics. It was originally thought to prevent IL-18-mediated inflammation by binding to the IL-18-binding protein. However, upon discovery that it binds to the orphan receptor, IL-1R8, further studies have revealed an expanded role of IL-37 to include several intracellular and extracellular pathways that affect various aspects of inflammation. Its potential role specifically in cardiovascular diseases (CVD) stemmed initially from the discovery of elevated plasma IL-37 levels in human patients with acute coronary syndrome and atrial fibrillation. Other studies using mouse models of ischemia/reperfusion injury, vascular calcification and myocardial infarction have revealed that IL-37 can have a beneficial role in these conditions. This review will explore recent research on the effects of IL-37 on the pathogenesis of CVD.

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