Muscle metaboreflex control is diminished in normotensive obese women

2001 ◽  
Vol 281 (2) ◽  
pp. H469-H475 ◽  
Author(s):  
Carlos Eduardo Negrão ◽  
Ivani C. Trombetta ◽  
Luciana T. Batalha ◽  
Maurício Maltez Ribeiro ◽  
Maria Urbana P. Brandão Rondon ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Vascular Resistance ◽  
Muscle Sympathetic Nerve Activity ◽  
Circulatory Arrest ◽  
Isometric Exercise ◽  
Voluntary Contraction ◽  
Obese Women ◽  
Muscle Metaboreflex ◽  
Forearm Vascular Resistance

There is no information about the muscle metaboreflex control in obese individuals. In 40 normotensive obese women (OW; body mass index 33.5 ± 0.4 kg/m2, age 32.4 ± 1.1 yr) and 15 age-matched, normotensive lean women (LW; body mass index 22.7 ± 0.8 kg/m2, age 34.4 ± 1.4 yr), we measured muscle sympathetic nerve activity (MSNA) and forearm blood flow (FBF) in the nonexercising forearm during static exercise at 10 and 30% of maximal voluntary contraction (MVC). Baseline MSNA (38 ± 2 vs. 31 ± 1 bursts/min, P = 0.001) and mean blood pressure were significantly higher in OW compared with LW. FBF was significantly lower, whereas forearm vascular resistance was significantly higher in OW. During 10% MVC, MSNA increased similarly in both groups, but during 30% MVC, MSNA was higher in LW. FBF and forearm vascular resistance responses during both 10 and 30% MVC were similar between groups. During posthandgrip circulatory arrest, MSNA remained significantly elevated compared with baseline in both groups, but this increase was significantly lower in OW (3.8 ± 0.82 vs. 9.4 ± 1.03 bursts/min, P = 0.002). In conclusion, muscle metaboreflex control of MSNA is blunted in OW. MSNA responses are not augmented during selective activation of central command/mechanoreceptors and metaboreceptors, despite increased MSNA levels in OW. Muscle vasodilatory response during graded handgrip isometric exercise is preserved in OW.

scholarly journals Weight loss improves neurovascular and muscle metaboreflex control in obesity

2003 ◽  
Vol 285 (3) ◽  
pp. H974-H982 ◽  
Author(s):  
Ivani Credidio Trombetta ◽  
Luciana T. Batalha ◽  
Maria Urbana P. B. Rondon ◽  
Mateus Camaroti Laterza ◽  
Fátima H. S. Kuniyoshi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Loss ◽  
Body Mass ◽  
Muscle Sympathetic Nerve Activity ◽  
Circulatory Arrest ◽  
Hypocaloric Diet ◽  
Obese Women ◽  
Vascular Conductance ◽  
Muscle Metaboreflex ◽  
Forearm Vascular Conductance

We studied the effects of a hypocaloric diet (D, n = 24, age: 32.2 ± 1.4 yr, body mass index: 34.7 ± 0.5 kg/m2) and a hypocaloric diet associated with exercise training (D + T, n = 25, age: 32.3 ± 1.3 yr, body mass index: 32.9 ± 0.4 kg/m2) on muscle metaboreflex control, muscle sympathetic nerve activity (MSNA, microneurography), blood pressure, and forearm blood flow (plethysmography) levels during handgrip exercise at 10% and 30% of maximal voluntary contraction in normotensive obese women. An additional 10 women matched by age and body mass index were studied as a nonadherent group. D or D + T significantly decreased body mass index. D or D + T significantly decreased resting MSNA (bursts/100 heartbeats). The absolute levels of MSNA were significantly lower throughout 10% and 30% exercise after D or D + T, although no change was found in the magnitude of response of MSNA. D + T, but not D, significantly increased resting forearm vascular conductance. D + T significantly increased the magnitude of the response of forearm vascular conductance during 30% exercise. D or D + T significantly increased MSNA levels during posthandgrip circulatory arrest when muscle metaboreflex is isolated. In conclusion, weight loss improves muscle metaboreflex control in obese women. Weight loss reduces MSNA, which seems to be centrally mediated. Weight loss by D + T increases forearm vascular conductance at rest and during exercise in obese individuals.

Vascular responses in forearm and calf to contralateral static exercises

1989 ◽  
Vol 66 (2) ◽  
pp. 669-674 ◽  
Author(s):  
D. A. Duprez ◽  
L. K. Essandoh ◽  
P. M. Vanhoutte ◽  
J. T. Shepherd
Keyword(s):  
Vascular Resistance ◽  
Isometric Exercise ◽  
Normal Subjects ◽  
Quadriceps Muscle ◽  
Progressive Increase ◽  
Voluntary Contraction ◽  
Flexor Muscle ◽  
Arterial Blood ◽  
The Right ◽  
Forearm Vascular Resistance

Ten normal subjects performed a 90-s isometric exercise [20, 30, and 40% of maximal voluntary contraction (MVC) of the flexor muscle of the right index finger or quadriceps muscle of the right leg. Contralateral forearm and calf blood flows (strain gauge plethysmography) and arterial blood pressure (auscultation) were measured simultaneously. Each exercise caused a decrease in forearm vascular resistance and a progressive increase in calf resistance. These changes were greatest with the 40% MVC. With finger exercise at 20 and 40% MVC, the percentage decreases in forearm vascular resistance from control were 12.3 and 22.7%, respectively (P less than 0.01). Similar decreases (9.5 and 24.9%, respectively; P less than 0.01) were noted with exercise of the quadriceps muscle. By contrast, the corresponding increases in calf vascular resistance were greater (P less than 0.01) with quadriceps exercise (13.3 and 55.4%, respectively) than with finger exercise (6.0 and 36.0%). Arrest of the circulation to the exercising muscles just before the exercise ended caused an abrupt increase in forearm vascular resistance and a decrease in calf resistance. These studies provide further evidence of the heterogeneity of responses of forearm and calf resistance vessels to certain cardiovascular stimuli.

Muscle cooling delays activation of the muscle metaboreflex in humans

1997 ◽  
Vol 273 (5) ◽  
pp. H2436-H2441 ◽  
Author(s):  
Chester A. Ray ◽  
Keith M. Hume ◽  
Kathryn H. Gracey ◽  
Edward T. Mahoney
Keyword(s):  
Heart Rate ◽  
Muscle Sympathetic Nerve Activity ◽  
Isometric Exercise ◽  
Voluntary Contraction ◽  
Muscle Temperature ◽  
Isometric Handgrip ◽  
Local Cooling ◽  
Muscle Metaboreflex ◽  
Muscle Cooling ◽  
Exercise Induced

Elevation of muscle temperature has been shown to increase muscle sympathetic nerve activity (MSNA) during isometric exercise in humans. The purpose of the present study was to evaluate the effect of muscle cooling on MSNA responses during exercise. Eight subjects performed ischemic isometric handgrip at 30% of maximal voluntary contraction to fatigue followed by 2 min of postexercise muscle ischemia (PEMI), with and without local cooling of the forearm. Local cooling of the forearm decreased forearm muscle temperature from 31.8 ± 0.4 to 23.1 ± 0.8°C ( P = 0.001). Time to fatigue was not different during the control and cold trials (156 ± 11 and 154 ± 5 s, respectively). Arterial pressures and heart rate were not significantly affected by muscle cooling during exercise, although heart rate tended to be higher during the second minute of exercise ( P = 0.053) during muscle cooling. Exercise-induced increases in MSNA were delayed during handgrip with local cooling compared with control. However, MSNA responses at fatigue and PEMI were not different between the two conditions. These findings suggest that muscle cooling delayed the activation of the muscle metaboreflex during ischemic isometric exercise but did not prevent its full expression during fatiguing contraction. These results support the concept that muscle temperature can play a role in the regulation of MSNA during exercise.

Sympathetic neural discharge and vascular resistance during exercise in humans

1989 ◽  
Vol 66 (5) ◽  
pp. 2472-2478 ◽  
Author(s):  
D. R. Seals
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Vascular Resistance ◽  
Sympathetic Nerve ◽  
Muscle Sympathetic Nerve Activity ◽  
Isometric Exercise ◽  
Lower Leg ◽  
Voluntary Contraction ◽  
Isometric Handgrip ◽  
Exercise In Humans

The purpose of this study was to determine the relationship between changes in efferent muscle sympathetic nerve activity (MSNA) to the lower leg and calf vascular resistance (CVR) during isometric exercise in humans. We made intraneural (microneurographic) determinations of MSNA in the right leg (peroneal nerve) while simultaneously measuring calf blood flow to the left leg, arterial pressure, and heart rate in 10 subjects before (control), during, and after (recovery) isometric handgrip exercise performed for 2.5 min at 15, 25, and 35% of maximal voluntary contraction (MVC). Heart rate and arterial pressure increased above control within the initial 30 s of handgrip at all levels, and the magnitudes of the increases at end contraction were proportional to the intensity of the exercise. In general, neither MSNA nor CVR increased significantly above control levels during handgrip at 15% MVC. Similarly, neither variable increased above control during the initial 30 s of handgrip at 25 and 35% MVC; however, during the remainder of the contraction period, progressive, parallel increases were observed in MSNA and CVR (P less than 0.05). The correlation coefficients relating changes in MSNA to changes in CVR for the individual subjects averaged 0.63 +/- 0.07 (SE) (range 0.30–0.91) and 0.94 +/- 0.06 (range 0.80–0.99) for the 25 and 35% MVC levels, respectively. During recovery, both MSNA and CVR returned rapidly toward control levels. These findings demonstrate that muscle sympathetic nerve discharge and vascular resistance in the lower leg are tightly coupled during and after isometric arm exercise in humans. Furthermore, the exercise-induced adjustments in the two variables are both contraction intensity and time dependent.

Hyperoxia enhances metaboreflex sensitivity during static exercise in humans

2006 ◽  
Vol 291 (1) ◽  
pp. H210-H215 ◽  
Author(s):  
Anne Houssière ◽  
Boutaina Najem ◽  
Nicolas Cuylits ◽  
Sophie Cuypers ◽  
Robert Naeije ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sympathetic Nerve ◽  
Animal Studies ◽  
Muscle Sympathetic Nerve Activity ◽  
Circulatory Arrest ◽  
Lactic Acid Production ◽  
Isometric Exercise ◽  
Lactate Production ◽  
Voluntary Contraction ◽  
Isometric Handgrip

Peripheral chemoreflex inhibition with hyperoxia decreases sympathetic nerve traffic to muscle circulation [muscle sympathetic nerve activity (MSNA)]. Hyperoxia also decreases lactate production during exercise. However, hyperoxia markedly increases the activation of sensory endings in skeletal muscle in animal studies. We tested the hypothesis that hyperoxia increases the MSNA and mean blood pressure (MBP) responses to isometric exercise. The effects of breathing 21% and 100% oxygen at rest and during isometric handgrip at 30% of maximal voluntary contraction on MSNA, heart rate (HR), MBP, blood lactate (BL), and arterial O2 saturation (SaO2) were determined in 12 healthy men. The isometric handgrips were followed by 3 min of postexercise circulatory arrest (PE-CA) to allow metaboreflex activation in the absence of other reflex mechanisms. Hyperoxia lowered resting MSNA, HR, MBP, and BL but increased SaO2 compared with normoxia (all P < 0.05). MSNA and MBP increased more when exercise was performed in hyperoxia than in normoxia (MSNA: hyperoxic exercise, 255 ± 100% vs. normoxic exercise, 211 ± 80%, P = 0.04; and MBP: hyperoxic exercise, 33 ± 9 mmHg vs. normoxic exercise, 26 ± 10 mmHg, P = 0.03). During PE-CA, MSNA and MBP remained elevated (both P < 0.05) and to a larger extent during hyperoxia than normoxia ( P < 0.05). Hyperoxia enhances the sympathetic and blood pressure (BP) reactivity to metaboreflex activation. This is due to an increase in metaboreflex sensitivity by hyperoxia that overrules the sympathoinhibitory and BP lowering effects of chemoreflex inhibition. This occurs despite a reduced lactic acid production.

scholarly journals Maternal Body Mass Index and Use of Labor Neuraxial Analgesia

2018 ◽  
Vol 129 (3) ◽  
pp. 448-458 ◽  
Author(s):  
Alexander J. Butwick ◽  
Cynthia A. Wong ◽  
Nan Guo
Keyword(s):  
Body Mass Index ◽  
Relative Risk ◽  
Body Mass ◽  
Normal Body Mass Index ◽  
Adjusted Relative Risk ◽  
Obese Women ◽  
Obesity Class ◽  
Normal Body ◽  
Neuraxial Analgesia ◽  
Obese Class

Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background Neuraxial labor analgesia may benefit obese women by optimizing cardiorespiratory function and mitigating complications related to emergency general anesthesia. We hypothesized that obese women have a higher rate of neuraxial analgesia compared with nonobese parturients. Methods Using U.S. natality data, our cohort comprised 17,220,680 deliveries, which accounts for 61.5% of 28 million births in the United States between 2009 and 2015. We examined the relationships between body mass index class and neuraxial labor analgesia, adjusting for sociodemographic, antenatal, pregnancy, and peripartum factors. Results The study cohort comprised 17,220,680 women; 0.1% were underweight, 12.7% were normal body mass index, 37% were overweight, and 28.3%, 13.5%, and 8.4% were obesity class I, II, and III, respectively. Rates of neuraxial analgesia by body mass index class were as follows: underweight, 59.7% (9,030/15,128); normal body mass index, 68.1% (1,487,117/2,182,797); overweight, 70.3% (4,476,685/6,368,656); obesity class I, 71.8% (3,503,321/4,881,938); obesity class II, 73.4% (1,710,099/2,330,028); and obesity class III, 75.6% (1,089,668/1,442,133). Compared to women with normal body mass index, the likelihood of receiving neuraxial analgesia was slightly increased for overweight women (adjusted relative risk, 1.02; 95% CI, 1.02 to 1.02), obese class I (adjusted relative risk, 1.04; 95% CI, 1.04 to 1.04), obese class II (adjusted relative risk, 1.05; 95% CI, 1.05 to 1.05), and obese class III (adjusted relative risk, 1.06; 95% CI, 1.06 to 1.06). Conclusions Our findings suggest that the likelihood of receiving neuraxial analgesia is only marginally increased for morbidly obese women compared to women with normal body mass index.

The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study

Thorax ◽  
2019 ◽  
Vol 74 (10) ◽  
pp. 958-964 ◽  
Author(s):  
Magnus Pär Ekström ◽  
Anders Blomberg ◽  
Göran Bergström ◽  
John Brandberg ◽  
Kenneth Caidahl ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Body Mass ◽  
Lung Volume ◽  
Airflow Obstruction ◽  
Adult Life ◽  
Population Based ◽  
Obese Women ◽  
Adverse Health Outcomes ◽  
Lower Lung

IntroductionBreathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear.MethodsThis population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex.ResultsWe included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness.ConclusionBreathlessness is independently associated with obesity and with weight gain in adult life, and the association is stronger for individuals with lower lung volumes.

scholarly journals Analisis Antimullerian Hormon (AMH) di Dalam Serum pada Berbagai Kategori Indeks Masa Tubuh

2019 ◽  
Vol 5 (1) ◽  
pp. 162-168
Author(s):  
Didik Rio Pambudi ◽  
Ashon Sa�adi ◽  
Sudjarwo Sudjarwo
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Normal Weight ◽  
Uterine Bleeding ◽  
Obese Women ◽  
Height Measurement ◽  
Normality Test ◽  
Laboratory Infection ◽  
Special Hospital ◽  
The Relationship

Obesity-related to the result of decreased reproduction. Obese women are more prone to abnormal anovulation and uterine bleeding, endometrial hyperplasia/cancer, infertility, miscarriage, and pregnancy complications, compared to women of normal weight. This study aims to determine the levels of anti-Mullerian hormone (AMH) in the serum at various BMI (body mass index), also to determine the relationship and correlation between obesity and AMH levels in serum. The population in the study were women aged 20 years to 40 years with less BMI, Normal BMI and Obesity BMI. The study subjects were women between the ages of 20 to 40 years with a BMI less than 17-19.9, obesity BMI = 25 and normal BMI 20-25 as controls. Height measurement, weight weighing, and BMI calculation carried out according to the standard and subject to approval. Taking blood samples for the examination of AMH levels carried out by the RSKI laboratory (Infection Special Hospital) Airlangga University. The results of the data processed with SPSS 25 with the Shapiro-Wilk normality test and Mann Whitney statistical analysis for different tests and Spearman analysis for the correlation test. The results of the study found homogeneous samples, there were no significant differences between the AMH levels of the less and obese groups with, p = 0.832 (p> 0.05). AMH levels in BMI were less (0.459 � 0.112 ng / mL) than obesity BMI (0.432 � 0.058 ng / mL), so it was concluded that AMH levels did not correlate with less BMI with obesity BMI, with a correlation value (r) = -0.105 (p = 0.643; p> 0.05). The results of this study concluded that body mass index not related and does not correlate with the levels of anti-Mullerian hormone in the serum.

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