Use of Electrical Currents to Delay Intravascular Thrombosis in Experimental Animals

1956 ◽  
Vol 187 (3) ◽  
pp. 473-478 ◽  
Author(s):  
Philip N. Sawyer ◽  
Bernhard Deutch

Previous studies on the relationship of electric phenomena to intravascular thrombosis have been discussed. On the basis of these studies, canine experiments were designed to determine whether or not a negatively charged electrode could by means of its oriented current prevent formation of a thrombus in an injured vessel. Using electrodes of several types a series of controlled experiments were performed which demonstrate that a current created by the technique used would delay intravascular thrombosis for periods up to 12 hours.

2022 ◽  
Vol 2022 (1) ◽  
pp. 013403
Author(s):  
Liping Lian ◽  
Xu Mai ◽  
Weiguo Song ◽  
Jun Zhang ◽  
Kwok Kit Richard Yuen ◽  
...  

Abstract Merging pedestrian flow can be observed often at public intersections and locations where two or more channels merge. Because of restrictions on the flow, pedestrian congestion, or even crowd disasters (e.g. Hajj crush 2015) happen easily at these junctions. However, studies on merging behaviors in large crowds remain rare. This paper investigates the merging characteristics of the pedestrian flow with controlled experiments under laboratory conditions. The formation of lanes is observed, and the lane separation width can vary for different density levels. Shannon entropy is used to analyze the utilization of the passage. The space usage in the merging area is most efficient when the width of the two branches is half that of the main corridor. Furthermore, the branch and main channel can mutually bottleneck each other in the large crowds and the flowrates for the upstream, downstream and branches are investigated. This study uses spatiotemporal diagrams to explore the clogging propagation of the merging flow as well as the relationship of the velocity and position. The results can be used as references for the design of public infrastructure and human safety management.


Lipar ◽  
2021 ◽  
Vol 22 (75) ◽  
pp. 49-72
Author(s):  
Časlav Nikolić ◽  

/ The paper examines the image of Paris in Miloš Crnjanski’s A Novel of Lon- don: at first as a space of memory of the main character, and then as a figure of urban semiology. Paris is reflected in the situations, faces and conditions that determine the Russian emigrant in London, so we see it as a city in a relationship of doubling. As a double to London, Paris represents an urban ambience that participates in building the story of Ryepnin and Nadya. It is not a current existential space, but a city of memories of events, performances and accidents that will be repeated and magnified in London. Paris is an important mnemotope in Crnjanski’s book, which articulates the relationship between memory and oblivion as a framework for the dramatic manifestation of the existence of the modern subject and the poetics of modernist narration. Although it is not the only place of such orientation, Paris is marked as that figure of the urban through which Ryepnin passes into the game of signs and thus irrevocably eludes others, London, Russia, himself. Paris and the French legion of foreigners are signs whose effects enable the hero to hide his disappearance from others when he leaves London.


Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.


Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.


Author(s):  
Leon Dmochowski

Electron microscopy has proved to be an invaluable discipline in studies on the relationship of viruses to the origin of leukemia, sarcoma, and other types of tumors in animals and man. The successful cell-free transmission of leukemia and sarcoma in mice, rats, hamsters, and cats, interpreted as due to a virus or viruses, was proved to be due to a virus on the basis of electron microscope studies. These studies demonstrated that all the types of neoplasia in animals of the species examined are produced by a virus of certain characteristic morphological properties similar, if not identical, in the mode of development in all types of neoplasia in animals, as shown in Fig. 1.


Author(s):  
J.R. Pfeiffer ◽  
J.C. Seagrave ◽  
C. Wofsy ◽  
J.M. Oliver

In RBL-2H3 rat leukemic mast cells, crosslinking IgE-receptor complexes with anti-IgE antibody leads to degranulation. Receptor crosslinking also stimulates the redistribution of receptors on the cell surface, a process that can be observed by labeling the anti-IgE with 15 nm protein A-gold particles as described in Stump et al. (1989), followed by back-scattered electron imaging (BEI) in the scanning electron microscope. We report that anti-IgE binding stimulates the redistribution of IgE-receptor complexes at 37“C from a dispersed topography (singlets and doublets; S/D) to distributions dominated sequentially by short chains, small clusters and large aggregates of crosslinked receptors. These patterns can be observed (Figure 1), quantified (Figure 2) and analyzed statistically. Cells incubated with 1 μg/ml anti-IgE, a concentration that stimulates maximum net secretion, redistribute receptors as far as chains and small clusters during a 15 min incubation period. At 3 and 10 μg/ml anti-IgE, net secretion is reduced and the majority of receptors redistribute rapidly into clusters and large aggregates.


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