Calcium and metabolism of I131 in rats and homogenates of rat thyroid

1961 ◽  
Vol 200 (5) ◽  
pp. 1023-1026 ◽  
Author(s):  
Yaro Ribeiro Gandra ◽  
John G. Coniglio
Keyword(s):  
Thyroid Tissue ◽  
Iodine Content ◽  
In Vitro Studies ◽  
Iodine Uptake ◽  
Total Iodine ◽  
Organic Iodine ◽  
Free Iodine ◽  
Inorganic Iodine ◽  
Rat Thyroid

The goitrogenic effect of calcium was studied by the use of I131 in intact rats and in rat thyroid slices. Rats receiving excess dietary calcium had larger thyroids than controls. Enlargement of the thyroid was accompanied by increased content of inorganic iodine and decreased content of organic iodine. In vitro studies showed that thyroid enlargement was associated with greater total iodine uptake. Addition of calcium to the incubation medium decreased the total iodine uptake of thyroid slices. The reduction occurred as a consequence of interference with the conversion of inorganic iodine to organic iodine. No decrease in inorganic iodine content was observed. The ratios of bound iodine to free iodine were constantly smaller in the thyroid groups receiving calcium supplement. The results of the in vitro studies suggest that calcium interference is due, at least in part, to a direct effect on thyroid tissue.

scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

Rat Thyroid Peroxidase (Tpo) Biosynthesis in Vitro: Studies Using Antiserum to Porcine Tpo

1987 ◽  
Vol 13 (1) ◽  
pp. 15-29 ◽  
Author(s):  
David S. Cooper ◽  
Farahe Maloof ◽  
E. Chester Ridgway
Keyword(s):  
In Vitro Studies ◽  
Thyroid Peroxidase ◽  
Rat Thyroid

STUDIES OF IODINE METABOLISM IN ICELAND

1964 ◽  
Vol 46 (4) ◽  
pp. 679-683 ◽  
Author(s):  
W. D. Alexander ◽  
Th. Veiger Gudmundsson ◽  
M. M. Bluhm ◽  
R. McG. Harden
Keyword(s):  
Thyroid Gland ◽  
Iodine Content ◽  
Iodine Uptake ◽  
Hormone Production ◽  
High Iodine ◽  
Iodine Level ◽  
Iodine Metabolism ◽  
Inorganic Iodine

ABSTRACT The relation between plasma inorganic iodine level, thyroid clearance and absolute iodine uptake of the thyroid gland has been studied in Iceland and compared with results obtained in Glasgow using identical methods. In Iceland the plasma inorganic iodine (PII) is higher than in Glasgow due to the high iodine content of the diet and the thyroid clearance lower. This adjustment is, however, incomplete, relatively high PII levels being associated with a low thyroid clearance and a raised absolute uptake by the thyroid. There was no evidence of increased hormone production as reflected in the serum PBI.

scholarly journals Biochemical and Microstructural Profile of the Thyroid Gland from Lambs Raised on Experimental Diets

2020 ◽  
Vol 50 (4) ◽  
pp. 670-680
Author(s):  
Tatyana Giro ◽  
Andrey Kulikovsky ◽  
Alexandra Knyazeva ◽  
Ivan Domnitsky ◽  
Anna Giro
Keyword(s):  
Thyroid Tissue ◽  
Reproductive Function ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Essential Elements ◽  
Feed Additives ◽  
Control Group ◽  
Organic Iodine ◽  
Thyroid Glands ◽  
Negative Effect

Introduction. The present research featured biochemical and microstructural features of thyroid glands obtained from lambs raised on various feeds enriched with essential elements. The article focuses on iodine as the most important physiologically active microelement. Iodine participates in the synthesis of thyroid hormones, namely thyroxine and triiodothyronine, which are known to regulate metabolic processes. Iodine deficiency may impair reproductive function and cause such diseases as endemic goiter. Study objects and methods. The study involved thyroid glands from lambs of the Edilbaev breed aged seven months. The lambs were divided into four experimental groups, ten animals in each. The lambs received several feed additives. Ioddar-Zn and DAFS-25 had a balanced protein and carbohydrate content, while the mineral feed of Coretron brand contained such trace elements and minerals as iodine, selenium, and silicon. Results and discussion. The experiment made it possible to describe the microstructural profile of the thyroid glands extracted from seven-month-old lambs raised on feeds enriched with iodine and selenium. Ioddar-Zn and DAFS-25 did not harm the structure of the thyroid tissue, while causing its functional activation in some cases. The morphological parameters of the thyroid glands indicated some breed differences. The iodine concentration in the thyroid glands obtained from the experimental animals was five or six times higher than that in the control group. The content of mono- and diiodotyrosine depended on the accumulation profile of organic iodine. Conclusion. Diets enforced with DAFS-25, Ioddar-Zn, silicon, and a protein-carbohydrate complex produced no negative effect on the structure of the thyroid tissue. It fact, the diet increased the organic iodine content in the thyroid glands in the form of iodotyrosines. The gland structure revealed some cubic epithelium or follicular cells. The mass spectrometric studies confirmed the presence of covalently bound iodine in the form of mono- and diiodotyrosine. Thus, the abovementioned feed additives can be recommended for industrial use.

IODINATED PARTICLES IN THE RAT THYROID I. A RAPID SEPARATION METHOD

1971 ◽  
Vol 68 (2) ◽  
pp. 367-376 ◽  
Author(s):  
C. Simon ◽  
J. Dang ◽  
R. Miquelis ◽  
P. Bastiani
Keyword(s):  
Sucrose Solution ◽  
Maximum Yield ◽  
Iodine Content ◽  
Isotopic Equilibrium ◽  
Rapid Separation ◽  
Total Iodine ◽  
Ficoll Gradient ◽  
Group 5 ◽  
Secondary Lysosomes ◽  
Rat Thyroid

ABSTRACT In a first step, the quantitative preparation of the whole population of iodinated particles was reinvestigated in thyroids obtained from rats maintained in an isotopic equilibrium with 125I. The maximum yield in the iodinated particles was obtained for a 0.15 m sucrose solution in 0.1 m Tris-HCl buffer pH 7. This yield was 3.5 % and 1.7 % of the total iodine content of the thyroid for rats adapted to receive 50 (group 50) and 5 μg (group 5) of iodine daily respectively. The iodinated particles of group 50 were found to be more sensitive to pH variations than those of group 5. In a second step, a rapid method was developed to separate the whole population of iodinated particles into physiological populations (tentatively colloid droplets and secondary lysosomes). By centrifuging onto a discontinuous Ficoll gradient, three distinct iodine peaks were regularly obtained for rats of group 5 and 50 and also for other rats receiving a diet rich in iodine. For group 50, the iodine pools (127I) as measured by isotopic equilibrium were found to represent about 16% (peak 1), 25 % (peak 2) and 59 % (peak 3) of the total particulate iodine content of the gland. The possible nature of these three populations of iodinated particles is discussed.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid  patients: a cross-sectional study in China

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Min Wang ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Cross Sectional ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion : The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Normal Thyroid Function ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

THE CONTENT OF THYROID HORMONES AND OTHER IODINATED COMPOUNDS IN THYROID TISSUE IN AUTOIMMUNE THYROIDITIS

1972 ◽  
Vol 69 (2) ◽  
pp. 309-320 ◽  
Author(s):  
B.-A. Lamberg ◽  
J. Mäenpää ◽  
V. Kivikangas ◽  
R. Karlsson ◽  
P. Saarinen
Keyword(s):  
Thyroid Gland ◽  
Autoimmune Thyroiditis ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Distribution Profile ◽  
Surgical Biopsy ◽  
Total Iodine ◽  
Hypothyroid Patients ◽  
Cellulose Column

ABSTRACT The total iodine content and the content of iodocompounds in the thyroid gland were studied in 9 patients with autoimmune thyroiditis. The thyroids were labelled in vivo with radioactive iodine before surgical biopsy. Five grams of tissue were homogenized and the iodocompounds were separated both by paper chromatography and on a cellulose column. The distribution profile of both the radioactive and the stable compounds was determined. The thyroid tissue contained on an average 11.0 ± 8.0 (sd) per cent of radioactive and 15.0 ± 9.4 per cent of stable iodothyronines. The MIT/DIT ratio was 1.16 ± 0.26 for the radioactive and 0.92 ± 0.30 for the stable compounds. Clinically evident hypothyroidism occurred only in patients with a very low iodine content and was not correlated with the proportion of iodothyronines found in the thyroid tissue. For instance, in two hypothyroid patients the iodothyronines corresponded to about 20 per cent of the iodocompounds of the tissue. These findings suggest that iodine depletion of the thyroid gland plays an important role in the development of clinical hypothyroidism in autoimmune thyroiditis and that up to a very late stage of the disease the thyroid is evidently capable of producing iodothyronines in fairly normal proportions.

scholarly journals Inhibition of Iodine Organification and Regulation of Follicular Size in Rat Thyroid Tissue In Vitro

Endocrine ◽  
1999 ◽  
Vol 11 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Christine Glaser ◽  
Ulrich Marti ◽  
Mary Elizabeth Bürgi-Saville ◽  
Charles Ruchti ◽  
Mathias Gebauer ◽  
...  
Keyword(s):  
Thyroid Tissue ◽  
Follicular Size ◽  
Rat Thyroid
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