scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid  patients: a cross-sectional study in China

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Min Wang ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Cross Sectional ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion : The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Rui Zhai ◽  
HongMei Liu ◽  
Dongmei Pan
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Total Iodine ◽  
Normal Thyroid Function ◽  
The Mean

Abstract Background: The aim of this study was to investigate the correlation of the dual energy CT measured iodine concentration and total iodine content with blood measured thyroid parameters. Methods: 43 patients with normal thyroid function at our hospital from August 2017 to October 2019 were included in this retrospective study. Dual energy CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of the thyroid. Relevant tests of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of the thyroid mean iodine concentration and total iodine content with blood-measured thyroid function was analysed. Result: The total iodine content in the thyroid was positively correlated with FT3 but negatively correlated with TSH. The mean iodine concentration of the thyroid was positively correlated with both FT3 and TT3. Conclusion: The thyroid iodine content measured by dual energy CT can be used to determine the human iodine nutritional status and evaluate thyroid function, which will facilitate the diagnosis and treatment of thyroid diseases.

scholarly journals Studies of the correlation between dual-source CT measured thyroid iodine concentrations, contents and thyroid function

2019 ◽  
Author(s):  
ZhengTeng Li ◽  
Dongmei Pan ◽  
Rui Zhai ◽  
Min Wang
Keyword(s):  
Thyroid Function ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Source Ct ◽  
Total Iodine ◽  
Total Triiodothyronine ◽  
Total Thyroxine ◽  
Dual Source ◽  
The Mean

Abstract Background The aim of this study is to investigate the correlation between dual-source CT measured iodine concentration, total iodine content and blood measured thyroid parameters.Methods Dual-source CT was used to scan the neck of thyroid patients. The mean iodine concentration and thyroid tissue volume were measured to calculate the total iodine content of thyroid. Relevant test of triiodothyronine (FT3), total triiodothyronine (TT3), total thyroxine (TT4), free thyroxine (FT4), and thyroid hormone (TSH) were conducted. The correlation of thyroid mean iodine concentration and total iodine content with blood measured thyroid function was analyzed.Result The total iodine content in thyroid was positively correlated with FT3, but negatively correlated with TSH. The mean iodine concentration of thyroid was positively correlated with both FT3 and TT3.Conclusion The thyroid iodine content measured by dual-source CT can be used to determine the human iodine nutritional status and evaluate thyroid functions, which will provide help for the diagnosis and treatment of thyroid diseases.

scholarly journals Iodine and iodothyronine content in human neonate thyroid gland

2002 ◽  
Vol 54 (3-4) ◽  
pp. 69-74 ◽  
Author(s):  
Svetlana Savin-Zegarac ◽  
Dubravka Cvejic ◽  
Olgica Nedic ◽  
R. Radosavljevic ◽  
Ivana Petrovic
Keyword(s):  
Thyroid Gland ◽  
Gestational Age ◽  
Thyroid Tissue ◽  
Iodine Content ◽  
Postnatal Life ◽  
Total Iodine ◽  
Mean Values ◽  
Human Neonate ◽  
The Mean ◽  
Human Neonates

A few years after the iodine content of salt in Serbia was increased from 7 to 15 mg/kg NaCI, iodine, thyroxine (T4) and triiodothyronine (T3) concentrations were measured in thyroid tissue obtained at autopsy from 21 human neonates who died within 30 days after birth. The thyroidal iodine as well as T4 and T3 content per gland in?creased progressively with gestational age of human neonates (r = 0.73, 0.70 and 0.67 respectively, p < 0.001). In seven newborns (gestational age 36 to 41 weeks) the mean values for total iodine, T4 and T3 per gland were 109.1 ?g, 52.2 ?g and 4.4 ?g respectively. The results of iodine and iodothyroninc content found in neonatal thyroid gland, particularly at the end of gestation and a few days of postnatal life, indicates that the iodine supply was satisfactory.

scholarly journals Quantitative Assessment of Thyroid Nodules Using Dual-Energy Computed Tomography: Iodine Concentration Measurement and Multiparametric Texture Analysis for Differentiating between Malignant and Benign Lesions

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Hayato Tomita ◽  
Hirofumi Kuno ◽  
Kotaro Sekiya ◽  
Katharina Otani ◽  
Osamu Sakai ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Texture Analysis ◽  
Thyroid Nodules ◽  
Texture Features ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Concentration Measurement ◽  
Cross Sectional ◽  
Dual Energy Computed Tomography

Background and Objectives. Thyroid nodules are increasingly being detected during cross-sectional imaging of the neck and chest. The purpose of this study is to investigate the efficacy of dual-energy computed tomography (DECT) using iodine concentration measurement and multiparametric texture analysis of monochromatic images for differentiating between benign and malignant thyroid nodules. Materials and Methods. This retrospective study included 34 consecutive patients who presented with thyroid nodules and underwent noncontrast DECT between 2015 and 2016. Manual segmentation of each thyroid nodule by monochromatic imaging (40, 60, and 80 keV) was performed, and an in-house developed MATLAB-based texture analysis program was used to extract 41 textures. Iodine material decomposition and CT attenuation slopes were also measured. Histopathologic findings of ultrasound-guided biopsies over a follow-up period of at least one year were used as reference standards. Basic descriptive statistics and areas under receiver operating characteristic curves (AUCs) were evaluated. Results. The 34 nodules comprised 14 benign nodules and 20 malignant nodules. Iodine content and Hounsfield unit curve slopes did not differ significantly between benign and malignant thyroid nodules (P=0.480–0.670). However, significant differences in the texture features of monochromatic images were observed between benign and malignant nodules: histogram mean and median, co-occurrence matrix contrast, gray-level gradient matrix (GLGM) skewness, and mean gradients and variance of gradients for GLGM at 80 keV (P=0.014–0.044). The highest AUC was 0.77, for the histogram mean and median of images acquired at 80 keV. Conclusions. Texture features extracted from monochromatic images using DECT, specifically acquired at high keV, may be a promising diagnostic approach for thyroid nodules. A further large study for incidental thyroid nodules using DECT texture analysis is required to validate our results.

THE INFLUENCE OF THE PLASMA INORGANIC IODINE CONCENTRATION ON THYROID FUNCTION IN DEHALOGENASE DEFICIENCY

1967 ◽  
Vol 55 (2) ◽  
pp. 361-368 ◽  
Author(s):  
R. McG. Harden ◽  
W. D. Alexander ◽  
S. Papadopoulos ◽  
M. T. Harrison ◽  
S. Macfarlane
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Iodine Concentration ◽  
Rapid Rise ◽  
Normal Range ◽  
Hormone Synthesis ◽  
Thyroid Hormone Synthesis ◽  
Iodine Metabolism ◽  
Inorganic Iodine ◽  
Circulating Levels

ABSTRACT Iodine metabolism and thyroid function were studied in a patient with hypothyroidism and goitre due to dehalogenase deficiency. Initially the plasma inorganic iodine (PII) level was within the normal range but circulating levels of hormone were low and the thyroid clearance and absolute uptake of iodine (AIU) by the thyroid were high. Administration of iodide supplements resulted in a rapid rise in the plasma thyroxine concentration and restoration of the euthyroid state. Thyroid hormone synthesis appeared to proceed normally when the PII exceeded 1.0 μg/100 ml. This was achieved by increasing the intake of iodide by 612 μg per day. At PII levels around 10 μg/100 ml there was evidence of increased levels of circulating thyroid hormone.

scholarly journals People's Knowledge and Practice of Salt Iodization, as Well as the Assessment of Iodine Content in Salt in the Cumilla Region of Bangladesh

2021 ◽  
pp. 12-24
Author(s):  
Sadia Jahan ◽  
Md. Saddam Hossain ◽  
Md. Anisur Rahman Bhuiyan ◽  
Susmita Roy Lisa ◽  
Somaia Haque Chadni
Keyword(s):  
Iodine Deficiency ◽  
Rural Areas ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Salt Iodization ◽  
Knowledge And Practice ◽  
Urban And Rural Areas ◽  
And Behavior

Aim: To evaluate the household iodine content and knowledge, attitude, and behavior regarding salt iodization among the residents of Cumilla, Bangladesh. Subjects and Methods: We conducted a cross-sectional survey of 700 inhabitants in Cumilla's urban and rural areas to determine the iodine concentration of salt they consume. The participants were asked about what they know about iodine deficiency and salt iodization as well as how their salt was packaged and stored. Among them, 338 people provided a sample of salt to be tested of its iodine content by the titrimetric method. Results: 46.57% of people knew that iodization was the best way to prevent iodine deficiency while 35.14% considered salt iodization during purchasing. Most people stored salt in plastic boxes (89.7%) and closed containers (84.14%).Among all participants, only 37.14% of people were aware of the iodine requirement during pregnancy. In urban regions, the median iodine content was 36.76 ppm (OR=0.658, 95% CI, 0.469-0.925), while in rural areas, the median iodine content was 40.92 ppm (OR=1.188, 95% CI, 1.022-1.380). Iodine levels were less than 15 ppm (minimum limit) in 6.8% of samples and greater than 40 ppm (maximum limit) in 56.5%. Only 36.7% of the salt samples contained adequate iodine. Conclusion: An effective and consistent approach for controlling iodine concentration in distributed salt is required at Cumilla, Bangladesh.

Thyroid function of subjects with goitre and cretinism in an endemic goitre area of rural China after use of iodized salt

1988 ◽  
Vol 118 (3) ◽  
pp. 444-448 ◽  
Author(s):  
Xuan-Ping Pang ◽  
An Ouyang ◽  
Tian-Sue Su ◽  
Jerome M. Hershman
Keyword(s):  
Thyroid Function ◽  
Rural China ◽  
Public Health Problem ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Epidemiological Survey ◽  
Iodized Salt ◽  
Endemic Goitre ◽  
Serum Thyroglobulin ◽  
Serum Free

Abstract. Endemic goitre and cretinism are still a public health problem in China. An epidemiological survey showed that about 5% of the inhabitants in Daxin village, Henan province, had goitre or cretinism after an iodized salt prevention programme had been carried out for two decades. The main food for the inhabitants of this area has an iodine content <30 nmol/kg and the water for cooking and drinking has an iodine concentration between 7–12 nmol/l. We studied thyroid function in subjects of this village. There were 42 with grade 0 goitre (males 29, females 13), 42 grade I (males 23, females 19), 27 grade II (males 9, females 18), 31 grade III (males 14, females 17) and 34 cretinism patients (males 30, females 4) diagnosed and classified according to WHO criteria. Serum T4, free T4, T3, free T3, T3 uptake, TSH and thyroglobulin were measured in these subjects. The patients with goitre or cretinism had significantly decreased serum free T4 and increased serum T3 and free T3 levels compared with those of controls. Thyroid size was positively correlated with age and serum thyroglobulin concentrations. Serum thyroglobulin was significantly increased even in the grade 0 goitre subjects. The percentages of subjects with serum free T4 < 12 nmol/l, T3 >2.5 nmol/l, free T3 >5.2 pmol/l, TSH >3.5 mU/l, T3/T4 ratio >0.03 and free T3/free T4 ratio >0.36 were significantly higher among goitre and cretinism patients than among controls. The data suggest that there is partial compensation for a marginal deficiency of iodine in the inhabitants of this village.

scholarly journals Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

2018 ◽  
Vol 6 (3) ◽  
pp. 488-492
Author(s):  
Imad R. Musa ◽  
Duria A. Rayis ◽  
Mohmamed A. Ahmed ◽  
Ammar H. Khamis ◽  
Abubakr M. Nasr ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Function ◽  
Early Pregnancy ◽  
Cross Sectional Study ◽  
The Body ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
The Mean ◽  
25 Oh Vitamin D

AIM: A cross-sectional study was conducted at Saad Abualila Hospital (Khartoum, Sudan) to evaluate the vitamin D levels and thyroid function among pregnant Sudanese women (132) in early pregnancy.METHODS: A cross-sectional study was conducted at Saad Abualila hospital (Khartoum, Sudan) during the period from March to July 2015. Women who were in early pregnancy with a singleton pregnancy were approached to participate in the study after signing informed consent. A sample size of 132 participants was calculated guided by the normal interval of thyroid function in Sudanese women in the first trimester and not the level of 25(OH) vitamin D. The 25 - hydroxyvitamin D (25 (OH) vitamins levels were measured using an electrochemiluminescence immunoassay on an Elecsys 2010 Analyzer (Roche Diagnostics, Mannheim, Germany).RESULTS: The mean (SD) of age, gravidity and gestational age was 27.6 (5.5) years, 2.2 (1.6) and 10.4 (2.2) weeks, respectively. The mean (SD) of the body mass index (BMI) and haemoglobin was 27.1 (5.2) kg/m2 and 10.8 (1.1) g/dl, respectively. Median (interquartile) values of TSH, FT3, and FT4 were 1.164 IU/ml (0.079 -2.177 IU/ml), 4.639 nmol/l (3.843 - 6.562 nmol/l), and 16.86 pmol/l (13.02 - 31.48 pmol/l), respectively. There was no significant correlation between vitamin D levels and TSH, FT3 and FT4CONCLUSION: There is no correlation between 25 (OH) vitamin D levels and thyroid function during early pregnancy among Sudanese pregnant women, despite prevalent vitamin D deficiency among these women.

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