Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine

2009 ◽  
Vol 297 (4) ◽  
pp. R978-R987 ◽  
Author(s):  
Aurélien Pichon ◽  
Bai Zhenzhong ◽  
Fabrice Favret ◽  
Guoen Jin ◽  
Han Shufeng ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Respiratory Pattern ◽  
Whole Body ◽  
Plateau Pika ◽  
Ventilatory Parameter ◽  
Species Effect ◽  
Oxide Synthase ◽  
And Control

We assessed ventilatory patterns and ventilatory responses to hypoxia (HVR) in high-altitude (HA) plateau pikas, repetitively exposed to hypoxic burrows, and control rats. We evaluated the role of neuronal nitric oxide synthase (nNOS) and dopamine by using S-methyl-l-thiocitrulline (SMTC) inhibitor and haloperidol antagonist, respectively. Ventilation (V̇i) was measured using a whole body plethysmograph in conscious pikas ( n = 9) and low-altitude (LA) rats ( n = 7) at different PiO2 (56, 80, 111, 150, and 186 mmHg) and in HA acclimatized rats ( n = 9, 8 days at 4,600 m) at two different PiO2 (56 and 80 mmHg). The effects of NaCl, SMTC, and haloperidol on ventilatory patterns were assessed in pikas at PiO2 = 56 and 80 mmHg. We observed a main species effect with larger V̇i, tidal volume (VT), inspiratory time/total time (Ti/Ttot), and a lower expiratory time in pikas than in LA rats. Pikas had also a larger VT and lower respiratory frequency compared with HA rats in hypoxia. HVR of pikas and rats were not statistically different. In pikas, SMTC induced a significant increase in V̇i and VT for a PiO2 of 56 mmHg, but had no effect for a PiO2 of 80 mmHg, i.e., the living altitude of pikas. In pikas, haloperidol injection had no effect on any ventilatory parameter. Long-term ventilatory adaptation in pikas is mainly due to an improvement in respiratory pattern (VT and Ti/Ttot) with no significant improvement in HVR. The sensitivity to severe acute hypoxia in pikas seems to be regulated by a peripheral nNOS mechanism.

Cognitive Treatment for OCD

2012 ◽  
Author(s):  
Maureen L. Whittal ◽  
Melisa Robichaud
Keyword(s):  
Term Treatment ◽  
Future Directions ◽  
Cognitive Treatment ◽  
Long Term Treatment ◽  
Inflated Responsibility ◽  
And Control ◽  
The Relationship ◽  
Control Of Thoughts

The cornerstone of cognitive treatment (CT) for OCD is based upon the knowledge that unwanted intrusions are essentially a universal experience. As such, it is not the presence of the intrusion that is problematic but rather the associated meaning or interpretation. Treatment is flexible, depending upon the nature of the appraisals and beliefs, but can include strategies focused on inflated responsibility and overestimation of threat, importance and control of thoughts, and the need for perfectionism and certainty. The role of concealment and the relationship to personal values are important maintaining and etiological factors. The short-term and long-term treatment outcome is reviewed, along with predictors of treatment response and mechanisms of action, and the chapter concludes with future directions regarding CT for OCD.

Selected Contribution: Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nosgene-deficient mice

2003 ◽  
Vol 94 (6) ◽  
pp. 2534-2544 ◽  
Author(s):  
Wieslaw Kozak ◽  
Anna Kozak
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Corn Oil ◽  
Normal Male ◽  
Wild Type ◽  
Oxide Synthase ◽  
And Control ◽  
Nos Isoforms ◽  
Deficient Mice

Male C57BL/6J mice deficient in nitric oxide synthase (NOS) genes (knockout) and control (wild-type) mice were implanted intra-abdominally with battery-operated miniature biotelemeters (model VMFH MiniMitter, Sunriver, OR) to monitor changes in body temperature. Intravenous injection of lipopolysaccharide (LPS; 50 μg/kg) was used to trigger fever in response to systemic inflammation in mice. To induce a febrile response to localized inflammation, the mice were injected subcutaneously with pure turpentine oil (30 μl/animal) into the left hindlimb. Oral administration (gavage) of N G-monomethyl-l-arginine (l-NMMA) for 3 days (80 mg · kg−1 · day−1in corn oil) before injection of pyrogens was used to inhibit all three NOSs ( N G-monomethyl-d-arginine acetate salt and corn oil were used as control). In normal male C57BL/6J mice, l-NMMA inhibited the LPS-induced fever by ∼60%, whereas it augmented fever by ∼65% in mice injected with turpentine. Challenging the respective NOS knockout mice with LPS and with l-NMMA revealed that inducible NOS and neuronal NOS isoforms are responsible for the induction of fever to LPS, whereas endothelial NOS (eNOS) is not involved. In contrast, none of the NOS isoforms appeared to trigger fever to turpentine. Inhibition of eNOS, however, exacerbates fever in mice treated with l-NMMA and turpentine, indicating that eNOS participates in the antipyretic mechanism. These data support the hypothesis that nitric oxide is a regulator of fever. Its action differs, however, depending on the pyrogen used and the NOS isoform.

scholarly journals Bridging worlds: community led visual methods amidst climate change related disasters in Australia

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
C Macdougall ◽  
L Gibbs
Keyword(s):  
Climate Change ◽  
Rural Communities ◽  
Service Providers ◽  
Natural Environments ◽  
Visual Methods ◽  
Community Recovery ◽  
Visual Record ◽  
And Control

Abstract Background In February 2009 Victorian rural communities were hit by the worst bushfires in Australian history. Immediately we evaluated community groups preparing residents for bushfires. Ten years on, we are one of the few teams to evaluate medium to long term community recovery using multiple methods. As climate change becomes more visible, the frequency and intensity of disasters will increase so communities, governments and service providers need more evidence based strategies and policies. We explore how participant led visual methods provide new knowledge. Methods In study 1 participants in 3 of 7 focus groups in peoples’ homes spontaneously brought photos for us to examine before the discussions. In another participants spoke of the importance of photos they took at the time. We returned to the field to interview people in their homes about the meaning and role of photos. Results Participants wanted to inform us-as outsiders-of the awe and enormity of the fires. They created a visual record to communicate with key interest groups and ward off complacity as memories receded. Photos helped them construct timelines and meanings of the intense fires. Crucially, they recorded recovery and rebuilding in both the built and natural environments. Over the next ten years we chronicled stories from community led visual methods of communication, recovery and empowerment. We incorporated into qualitative methods participant led tours of their environments, with visual methods. Visual data collected by communities focused more strongly on the natural environment than researcher led verbal methods. Conclusions Visual sociology changes as technology provides participants in research with increased access to, and control over, visual methods. These changes can rebalance power relations between qualitative researchers and participants and bridge visual and verbal methods; crafting striking stories to influence those Australian policies unresponsive to climate change. Key messages Technological change enables participants in qualitative research to initiate visual methods to build bridges between them and researchers. Community led visual methods provide new types of data useful for theory and knowledge translation.

Effect of chronic lithium administration on endothelium-dependent relaxation of rat mesenteric bed: role of nitric oxide

2007 ◽  
Vol 85 (10) ◽  
pp. 1038-1046 ◽  
Author(s):  
Banafsheh Afsharimani ◽  
Leila Moezi ◽  
Hamed Sadeghipour ◽  
Bahareh Rahimzadeh-Rofouyi ◽  
Maliheh Nobakht ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nadph Diaphorase ◽  
Control Group ◽  
No Donor ◽  
Vascular Bed ◽  
Mesenteric Vascular Bed ◽  
Vascular Beds ◽  
Oxide Synthase ◽  
And Control

The mechanism of action of lithium, an effective treatment for bipolar disease, is still unknown. In this study, the mesenteric vascular beds of control rats and rats that were chronically treated with lithium were prepared by the McGregor method, and the mesenteric vascular bed vasorelaxation responses were examined. NADPH-diaphorase histochemistry was used to determine the activity of NOS (nitric oxide synthase) in mesenteric vascular beds. We demonstrated that ACh-induced vasorelaxation increased in the mesenteric vascular bed of rats treated with lithium. Acute Nο-nitro-l-arginine methyl ester (l-NAME) administration in the medium blocked ACh-induced vasorelaxation in the control group more effectively than in lithium-treated rats, while the vasorelaxant response to sodium nitroprusside, a NO donor, was not different between lithium-treated and control groups. Acute aminoguanidine administration blocked ACh-induced vasorelaxation of lithium-treated rats, but had no effect in the control rats. Furthermore, NOS activity, determined by NADPH-diaphorase staining, was significantly greater in the mesenteric vascular beds from chronic lithium-treated rats than in those from control rats. These data suggest that the enhanced ACh-induced endothelium-derived vasorelaxation in rat mesenteric bed from chronic lithium-treated rats might be associated with increased NOS activity, likely via iNOS. Simultaneous acute l-NAME and indomethacin administration suggests the possible upregulation of EDHF (endothelium-derived hyperpolarizing factor) in lithium-treated rats.

scholarly journals Inhibition of the Interaction of AGE–RAGE Prevents Hyperglycemia-Induced Fibrosis of the Peritoneal Membrane

2003 ◽  
Vol 14 (8) ◽  
pp. 2109-2118
Author(s):  
An S. De Vriese ◽  
Allan Flyvbjerg ◽  
Siska Mortier ◽  
Ronald G. Tilton ◽  
Norbert H. Lameire
Keyword(s):  
Diabetic Rats ◽  
Vascular Density ◽  
Peritoneal Membrane ◽  
Glycation End Products ◽  
Pathophysiological Role ◽  
Oxide Synthase ◽  
And Control ◽  
Endothelial Nitric Oxide ◽  
E Mail

ABSTRACT. The peritoneal membrane of long-term peritoneal dialysis patients is characterized by a loss of ultrafiltration capacity, associated morphologically with submesothelial fibrosis and neoangiogenesis. Exposure to high glucose concentrations in peritoneal dialysate and the resultant advanced glycation end-products (AGE) accumulation have been implicated in the development of these changes, but their exact pathophysiological role is unknown. We examined the effect of the interaction of AGE with one of their receptors (i.e., RAGE) on the function and structure of the peritoneum exposed to high ambient glucose concentrations. Streptozotocin-induced diabetic rats and control rats were treated during 6 wk with either neutralizing monoclonal anti-RAGE antibodies or control antibodies. The expression of RAGE was strongly enhanced in the peritoneal membrane of the diabetic animals. The diabetic peritonea were characterized by an elevated transport of small solutes, lower ultrafiltration rates, a higher vascular density, and an upregulation of endothelial nitric oxide synthase expression. These parameters were unaffected by treatment with anti-RAGE antibodies. In contrast, anti-RAGE but not control antibodies prevented upregulation of TGF-β, development of submesothelial fibrosis, and fibronectin accumulation in the peritoneum of diabetic animals. In conclusion, binding of AGE to RAGE increases the expression of TGF-β and contributes to the development of submesothelial fibrosis. Neoangiogenesis and the resultant loss of ultrafiltration capacity are mediated by different pathogenetic pathways. E-mail: [email protected]

scholarly journals Effects of the COVID-19 Pandemic on the Urban Water Cycle

2021 ◽  
Vol 02 (03) ◽  
pp. 1-1
Author(s):  
Hadi Heidari ◽  
◽  
Neil S Grigg ◽  
Keyword(s):  
Water Cycle ◽  
Order Effects ◽  
Urban Water ◽  
First Order ◽  
Short And Long Term ◽  
Water Scarce ◽  
And Control ◽  
Urban Water Cycle

The coronavirus disease 2019 (COVID-19) is a global crisis spreading to all countries. This study explains and documents the first-order effects of the new coronavirus on the urban water cycle. Urban water systems play an important role in public health because people rely so heavily on water services. Findings address short- and long-term changes in climate variables; availability and accessibility of clean water to prevent and control the spread of coronavirus in water-scarce cities; shifts in habits, behavior, and lifestyles of people and effects on water demand during lockdowns; and role of wastewater treatment in preventing the spread of coronavirus.

scholarly journals Workplace Inclusion Competence and Employer Engagement

2021 ◽  
Author(s):  
Heidi Enehaug ◽  
Øystein Spjelkavik ◽  
Eivind Falkum ◽  
Kjetil Frøyland
Keyword(s):  
Organizational Management ◽  
Research Field ◽  
Organizational Perspective ◽  
Employer Engagement ◽  
Developmental Opportunities ◽  
Management Orientation ◽  
And Control ◽  
Workplace Inclusion

Existing active labor market policy (ALMP) measures have been unsuccessful in establishing long- term employment for vulnerable groups.This paper contributes to further development of the role of the employer engagement perspective in ALMP. We introduce the term workplace inclusion competence and explore its association to two distinct work-organizational categories: participa tion- and control-oriented management. We operationalize workplace inclusion competence as inclusion opportunity and inclusion capability. We argue that such competence is dynamic and processual, and find that organizational management-orientation, as well as work pace, employees’ developmental opportunities, financial situation and OSH, have an impact on workplace inclusion competence. Survey data among a sample of managers is analyzed regarding workplaces’ capabilities and opportunities in work inclusion processes. We present two sets of indexes to measure organizational management-orientation and inclusion skills competence. As such, we contribute to the research field by providing new and more specific concepts with adherent question indexes, and by connecting them to a work-organizational perspective.

scholarly journals Angiotensin Converting Enzyme 2 in COVID-19 infections and the implications of COVID-19 on major body systems

2020 ◽  
Vol 9 (2) ◽  
pp. 78-85
Author(s):  
Malyn M.L.K. Antoine ◽  
Yancheng Xu ◽  
Rimanatou Seyni-Boureima ◽  
Chrystal Deniza Antoine-Frank ◽  
Coumba Aicha Thiam ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Uncertain Information ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Modes Of Transmission ◽  
Novel Virus ◽  
And Control ◽  
The Relationship

COVID-19, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), was first identified in China in late 2019 and since then, this disease has become a pandemic affecting many countries across the globe. Due to this outbreak, many researchers have been diligently investigating this disease for the establishment of better methods of its treatment and control. Evidence from research has led to a plethora of valuable but uncertain information on the modes of transmission of COVID-19 and the mechanisms by which SARS-CoV-2 establishes infections in targeted tissues. It is now better understood that in this disease, SARS-CoV-2 gains entrance into cells by specifically binding ACE-2 (angiotensin-converting enzyme 2); ACE-2 serves as a potential receptor for the virus. The lungs, in addition to many other organs and tissues, express ACE-2 in varying degrees. Therefore, this review will examine the role of ACE-2 in COVID-19 and the secondary effects that COVID-19 has on organs that express ACE-2. To this end, it will assist in establishing the relationship between the ACE-2 receptor and SARS-CoV-2, bringing to the forefront the correlation between the symptomatology presentation, as well as the severity of infections experienced with COVID-19. Given this, it may even provide an avenue for the generation of treatment, or create a platform for the enhanced knowledge of this novel virus, and therefore, control, and maybe unravel the mystery for long term complications.  

scholarly journals Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide

1997 ◽  
Vol 82 (1) ◽  
pp. 111-117 ◽  
Author(s):  
T. S. E. Albert ◽  
V. L. Tucker ◽  
E. M. Renkin
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Acute Hypoxia ◽  
Whole Body ◽  
Abdominal Muscles ◽  
Rat Serum ◽  
Alveolar Hypoxia ◽  
Atrial Natriuretic

Albert, T. S. E., V. L. Tucker, and E. M. Renkin. Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide. J. Appl. Physiol. 82(1): 111–117, 1997.—Plasma immunoreactive atrial natriuretic peptide (irANP) and blood-to-tissue clearance of 131I-labeled rat serum albumin (CRSA) were examined in anesthetized rats during hypoxic ventilation ( n = 5–7/group). Hypoxia (10 min) increased irANP from 211 ± 29 (room air) to 229 ± 28 (15% O2, not significant), 911 ± 205 (10% O2), and 4,374 ± 961 pg/ml (8% O2), respectively. Graded increases in CRSA were significant at 8% O2 in fat (3.6-fold), ileum (2.2-fold), abdominal muscles (2.0-fold), kidney (1.8-fold), and jejunum (1.4-fold). CRSA was decreased in back skin and testes; heart, brain, and lungs were unaffected. The increases in CRSAwere related to irANP and not to arterial[Formula: see text]. Circulating plasma volume was negatively correlated with whole body CRSA. Graded increases in extravascular water content (EVW) were found in the kidney, left heart, and cerebrum and were positively related to CRSA in the kidney. EVW decreased in gastrointestinal tissues; the magnitude was inversely related to CRSA. We conclude that ANP-induced protein extravasation contributes to plasma volume contraction during acute hypoxia.

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