scholarly journals Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism

2011 ◽  
Vol 300 (3) ◽  
pp. F801-F810 ◽  
Author(s):  
Xiaoxin X. Wang ◽  
Tao Jiang ◽  
Yan Shen ◽  
Hannah Santamaria ◽  
Nathaniel Solis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Extracellular Matrix ◽  
Growth Factors ◽  
Fatty Acid ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
Proinflammatory Cytokines ◽  
Cholesterol Synthesis ◽  
Mesangial Expansion

Diet-induced obesity (DIO) and insulin resistance in mice are associated with proteinuria, renal mesangial expansion, accumulation of extracellular matrix proteins, and activation of oxidative stress, proinflammatory cytokines, profibrotic growth factors, and the sterol regulatory element binding proteins, SREBP-1 and SREBP-2, that mediate increases in fatty acid and cholesterol synthesis. The purpose of the present study was to determine whether treatment of DIO mice with the vitamin D receptor (VDR) agonist doxercalciferol (1α-hydroxyvitamin D2) prevents renal disease. Our results indicate that treatment of DIO mice with the VDR agonist decreases proteinuria, podocyte injury, mesangial expansion, and extracellular matrix protein accumulation. The VDR agonist also decreases macrophage infiltration, oxidative stress, proinflammatory cytokines, and profibrotic growth factors. Furthermore, the VDR agonist also prevents the activation of the renin-angiotensin-aldosterone system including the angiotensin II type 1 receptor and the mineralocorticoid receptor. An additional novel finding of our study is that activation of VDR results in decreased accumulation of neutral lipids (triglycerides and cholesterol) and expression of adipophilin in the kidney by decreasing SREBP-1 and SREBP-2 expression and target enzymes that mediate fatty acid and cholesterol synthesis and increasing expression of the farnesoid X receptor. This study therefore demonstrates multiple novel effects of VDR activation in the kidney which prevent renal manifestations of DIO in the kidney.

Vitamin D receptor gene FokI variant in diabetic foot ulcer and its relation with oxidative stress

Gene ◽  
2017 ◽  
Vol 599 ◽  
pp. 87-91 ◽  
Author(s):  
Negin Soroush ◽  
Mania Radfar ◽  
Armita Kakavand Hamidi ◽  
Mohammad Abdollahi ◽  
Mostafa Qorbani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Diabetic Foot ◽  
Receptor Gene ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Vitamin D Receptor Gene

Role of vitamin D in oxidative stress modulation in end‐stage renal disease patients: A double‐blind randomized clinical trial

2020 ◽  
Vol 24 (3) ◽  
pp. 367-373
Author(s):  
Leila Malekmakan ◽  
Zeinab Karimi ◽  
Afshin Mansourian ◽  
Maryam Pakfetrat ◽  
Jamshid Roozbeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Vitamin D ◽  
Renal Disease ◽  
Randomized Clinical Trial ◽  
End Stage Renal Disease ◽  
Double Blind ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Apa I polymorphism in the vitamin D receptor gene may affect the parathyroid response in Japanese with end-stage renal disease

1998 ◽  
Vol 53 (2) ◽  
pp. 454-458 ◽  
Author(s):  
Keitaro Yokoyama ◽  
Takashi Shigematsu ◽  
Toshihiko Tsukada ◽  
Yousuke Ogura ◽  
Fumi Takemoto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
End Stage Renal Disease ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Vitamin D receptor genetic variants among patients with end-stage renal disease

Renal Failure ◽  
2010 ◽  
Vol 32 (8) ◽  
pp. 969-977 ◽  
Author(s):  
Gaurav Tripathi ◽  
Richa Sharma ◽  
Raj K. Sharma ◽  
Sushil Kumar Gupta ◽  
Satya Narayan Sankhwar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Renal Disease ◽  
Vitamin D Receptor ◽  
Genetic Variants ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Effects of acute doxorubicin treatment on oxidative stress markers and expression of the vitamin D receptor in liver of fasted animals

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Amie Jeanette Dirks‐Naylor ◽  
Joseph D. Bero ◽  
Raean Mabolo ◽  
Ngan T.K. Tran ◽  
Sendra Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Oxidative Stress Markers ◽  
Doxorubicin Treatment ◽  
Stress Markers

scholarly journals Interaction Effects of Vitamin D Receptor Polymorphisms and Vitamin D3 Supplementation on Plasma Oxidative Stress and Apoptotic Biomarkers Among Breast Cancer Survivors (P05-027-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Elham Kazemin ◽  
Yasaman Jamshidi-naeini ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Vitamin D ◽  
Linear Regression ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Multiple Testing ◽  
Breast Cancer Survivors ◽  
Vitamin D3 Supplementation

Abstract Objectives Interactions of human genes and environmental exposures play a crucial role in cancer etiology and prognosis. We investigated whether response to vitamin D3 supplementation in terms of plasma oxidative stress (OS) and apoptotic biomarkers were mediated by the vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) among breast cancer survivors. Methods Two hundred and fourteen women who were diagnosed with breast cancer (invasive or in situ) and had completed all treatment regimens received 4000 IU of vitamin D3 daily for 12 weeks. Anthropometric, dietary, sun exposure, physical activity, as well as laboratory assessments including plasma superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and Bcl2 were performed at enrolment and post-intervention. VDR genotyping was performed at ApaI, TaqI, FokI, BsmI, and Cdx-2. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was modulated by the selected VDR SNPs. Results Linear regression analysis adjusted for age, BMI, on-study plasma 25(OH)D changes, and baseline circulating 25(OH)D indicated that the AA genotype of the ApaI on VDR was associated with greater increase and decrease in plasma Bcl2 [0.21, 95% Confidence Interval (CI) (0.03, 0.39)] and MDA [−0.68, 95% CI (−1.35, −0.02)] compared to aa respectively. This association did not remain statistically significant after correction for multiple testing. Overall, we found no statistically significant interaction of the VDR SNPs and inferred haplotypes with the circulating OS and apoptotic biomarkers except for the FokI BsmI ApaIhaplotype and circulating MDA (p-value for global score = 0.02) after multiple testing correction. Conclusions Our findings indicate a weak interaction between the VDR haplotypes and responses of plasma OS and apoptotic biomarkers to vitamin D3 supplementation. However, further assessments of additional genes and biomarkers with longer intervention periods may further explain the complex interplay between genes and nutrients. Funding Sources Cancer Research Center, National Nutrition and Food Technology Research Institute, and the Endocrine Research Center of Shahid Beheshti University of Medical Sciences.

Oxidative Stress, Vitamin D Deficiency and Male Infertility: An Under-Looked Aspect

2021 ◽  
pp. 1-3
Author(s):  
Maheen Shahid ◽  
Syeda Amrah Hashmi ◽  
Rehana Rehman ◽  
Admin
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Male Infertility ◽  
Vitamin D Deficiency ◽  
Vitamin D Receptor ◽  
Calcium Supplementation ◽  
Mutant Mice ◽  
Aromatase Activity ◽  
Vitamin D Receptors ◽  
Gonadal Dysfunction

Dear Madam, Infertility is a known source of distress among couples worldwide. This agony significantly stems from the concern of not having an identifiable cause leading to infertility. With male factors accounting for 20-30% of the total causes of infertility (1), a thorough evaluation of both the partners is done. Upon evaluation, Vitamin D deficiency was noticed significantly in males coming to infertility centres. However, its functions and how it impacted reproduction was not known until the research led to the discovery of Vitamin D Receptor (VDR) in many organs of the male reproductive tract. It is now known that vitamin D deficiency decreases male fertility by contributing to oxidative stress and gonadal insufficiency, disrupting spermatogenesis, affecting sperm morphology and normal calcium haemostasis. (2) Oxidative stress, caused by an imbalance between oxidative and antioxidative mechanisms, is believed to be a well-known mechanism underlying idiopathic male infertility. Reproductive health professionals and researchers fittingly started searching for antioxidants to combat this imbalance. A study concluded that adding vitamin D to a cryopreserved semen sample reduced oxidative stress and resulted in better fertility outcomes (3). Animal trials have shown that Vitamin D supplementation reduced oxidative stress and improved semen DNA integrity (4). As Vitamin D exerts its effects by binding to Vitamin D receptors, it was noted that vitamin D receptor null mutant mice had a significant reduction in successful reproductive outcomes due to gonadal insufficiencies. Reduced levels of oestrogen and testosterone were seen along with low sperm count, reduced motility, abnormal spermatogenesis and histological abnormalities in testes of mutant mice. These insufficiencies were attributed to a decreased CYP2R1, CYP27B1 and CYP24A1 expression, lower aromatase activity, secondary to suppression of CYP19 gene and calcium supplementation improved fertility in such cases. (5) There is limited human data available on how Vitamin D deficiency causes gonadal insufficiency, which is important to maintain normal reproductive physiology. More studied are needed to clarify the role of vitamin D in gonadal physiology. Considering the importance of Vitamin D on reproductive functions, its role in causing Oxidative stress and gonadal dysfunction, we suggest randomized control trials in pre-pubertal phase. Continuous....

scholarly journals Monolluma quadrangulaProtects against Oxidative Stress and Modulates LDL Receptor and Fatty Acid Synthase Gene Expression in Hypercholesterolemic Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
May N. Bin-Jumah
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Proinflammatory Cytokines ◽  
Fatty Acid Synthase ◽  
Heart Function ◽  
Ldl Receptor ◽  
Antioxidant Defenses ◽  
Creatine Kinase Mb

Hypercholesterolemia is a metabolic disorder associated with oxidative stress. The present study investigated the protective effect ofMonolluma quadrangulaextract on hypercholesterolemia-induced oxidative stress in the liver and heart of high-cholesterol-diet- (HCD-) fed rats. The experimental animals received HCD for 10 weeks and were concurrently treated with 300 or 600 mg/kgM. quadrangulaextract. HCD-fed rats showed a significant increase in serum triglycerides, total cholesterol, LDL-cholesterol, vLDL-cholesterol, and cardiovascular risk indices along with decreased HDL-cholesterol and antiatherogenic index. TheM. quadrangulaextract significantly improved dyslipidemia and atherogenesis in HCD-fed rats. HCD induced a significant increase in serum transaminases, creatine kinase-MB, and proinflammatory cytokines. In addition, HDC induced a significant increase in hepatic and cardiac lipid peroxidation and decreased antioxidant enzymes. Treatment with theM. quadrangulaextract significantly alleviated liver and heart function markers, decreased proinflammatory cytokines and lipid peroxidation, and enhanced the antioxidant defenses. Also, theM. quadrangulaextract significantly reduced the expression of fatty acid synthase (FAS) and increased the expression of LDL receptor in the liver of HCD-fed rats. In conclusion, theM. quadrangulaextract has a potent antihyperlipidemic and cholesterol-lowering effect on HCD-fed rats. The beneficial effects of theM. quadrangulaextract were mediated through the increased antioxidant defenses, decreased inflammation and lipid peroxidation, and modulated hepatic FAS and LDL receptor gene expression.

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