scholarly journals Functional Consequences of Presynaptic Inhibition During Behaviorally Relevant Activity

2006 ◽  
Vol 96 (4) ◽  
pp. 2139-2143 ◽  
Author(s):  
M. Frerking ◽  
P. Ohliger-Frerking
Keyword(s):  
Presynaptic Inhibition ◽  
Activity Patterns ◽  
Pyramidal Cells ◽  
Neuronal Responses ◽  
Pass Filter ◽  
Behavioral Cues ◽  
Functional Consequences ◽  
Ca3 Pyramidal Cells ◽  
Analytical Approaches ◽  
High Pass

Presynaptic inhibition is a widespread mechanism for regulating transmitter release in the CNS. Presynaptic inhibitors act as a high-pass filter, but the functional consequence of this filtering during the synaptic processing of behaviorally relevant activity remains unknown. Here we use analytical approaches to examine the effects of presynaptic inhibition on synaptic output in response to activity patterns from CA3 pyramidal cells during the performance of a complex behavioral task. We calculate that presynaptic inhibition enhances the contrast between background activity and responses to environmental cues and that neuronal responses to location are subject to stronger contrast enhancement than neuronal responses to olfactory information. Our analysis suggests that presynaptic inhibition also enhances the importance of integrative inputs that respond to many behavioral cues during the task at the expense of specific inputs that respond to only a few of these cues.

scholarly journals Unspecific expression in limited excitatory cell populations in interneuron-targeting Cre-driver lines can have large functional effects

2019 ◽  
Author(s):  
Daniel Müller-Komorowska ◽  
Thoralf Opitz ◽  
Shehabeldin Elzoheiry ◽  
Michaela Schweizer ◽  
Heinz Beck
Keyword(s):  
Fluorescent Proteins ◽  
Pyramidal Cells ◽  
Cell Types ◽  
Mouse Line ◽  
Cell Type Specificity ◽  
Functional Consequences ◽  
Ca3 Pyramidal Cells ◽  
Genetic Constructs ◽  
Mouse Lines

1AbstractTransgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern neuroscience. Particularly, the investigation of interneurons has benefitted from the ability to target genetic constructs to defined cell types. However, the cell type specificity of some mouse lines has been called into questions. Here we show for the first time the functional consequences of unspecific expression in a somatostatin-Cre (SST-Cre) mouse line. We find large optogenetically evoked excitatory currents originating from unspecifically targeted CA3 pyramidal cells. We also used public Allen Brain Institute data to estimate expression specificity in other Cre lines. Another SST-Cre mouse lines shows comparable unspecificity, whereas a Parvalbumin-Cre mouse line shows much less unspecific expression. Finally, we make suggestions to ensure that the results from in-vivo use of Cre mouse lines are interpretable.

A V-Band Two Pole High-Pass Filter for Frequency Quadrupler Design

2016 ◽  
Vol 6 (1) ◽  
pp. 56
Author(s):  
Maryam Abata ◽  
Mahmoud Mehdi ◽  
Said Mazer ◽  
Moulhime El Bekkali ◽  
Catherine Algani
Keyword(s):  
Pass Filter ◽  
High Pass Filter ◽  
V Band ◽  
High Pass

Baseline-free sensor fault detection for piezoelectric array

2021 ◽  
pp. 1045389X2110188
Author(s):  
Qibo Mao ◽  
Yuande Wang ◽  
Shizuo Huang
Keyword(s):  
Prior Knowledge ◽  
Frequency Response Function ◽  
Sensor Array ◽  
Piezoelectric Element ◽  
Piezoelectric Sensor ◽  
Steel Beam ◽  
Sensor Fault ◽  
Pass Filter ◽  
Sensor Fault Detection ◽  
High Pass

In this study, a new methodology is presented to detect the sensor fault for piezoelectric array based on the filtered frequency response function (FRF) shapes. The proposed method does not require prior knowledge about healthy piezoelectric array. First, the imaginary parts of FRFs from the piezoelectric array during vibration are measured and normalized to obtain the FRF shapes in different frequencies. Then the irregularities in these FRF shapes are extracted by using high-pass filter with properly chosen cut-off frequency. These abnormal irregularities on the filtered FRF shape curves indicate the location of the faulty sensor, due to the irregularity of FRF shapes introduced by the faulty piezoelectric element. The proposed sensor fault method is experimentally demonstrated on a clamped-clamped steel beam mounted with piezoelectric buzzer array. Two common piezoelectric sensor fault types including sensor breakage and debonding are evaluated. The experimental results indicate that the proposed method has great potential in the detection of the sensor fault for piezoelectric array as it is simple and does not require the FRF data of the healthy sensor array as a baseline.

Postsynaptic hyperpolarization increases the strength of AMPA-mediated synaptic transmission at large synapses between mossy fibers and CA3 pyramidal cells

2000 ◽  
Vol 39 (12) ◽  
pp. 2288-2301 ◽  
Author(s):  
Nicola Berretta ◽  
Aleksej V Rossokhin ◽  
Alexander M Kasyanov ◽  
Maxim V Sokolov ◽  
Enrico Cherubini ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Mossy Fibers ◽  
Pyramidal Cells ◽  
Ca3 Pyramidal Cells

scholarly journals High-Bandpass Filters in Electrocardiography: Source of Error in the Interpretation of the ST Segment

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
F. Buendía-Fuentes ◽  
M. A. Arnau-Vives ◽  
A. Arnau-Vives ◽  
Y. Jiménez-Jiménez ◽  
J. Rueda-Soriano ◽  
...  
Keyword(s):  
Real Time ◽  
Fourier Transforms ◽  
Pass Filter ◽  
Discrete Fourier Transforms ◽  
Real Time Mode ◽  
Asymptomatic Patients ◽  
St Segment ◽  
Coronary Syndromes ◽  
Clinically Significant ◽  
High Pass

Introduction. Artifactual variations in the ST segment may lead to confusion with acute coronary syndromes. Objective. To evaluate how the technical characteristics of the recording mode may distort the ST segment. Material and Method. We made a series of electrocardiograms using different filter configurations in 45 asymptomatic patients. A spectral analysis of the electrocardiograms was made by discrete Fourier transforms, and an accurate recomposition of the ECG signal was obtained from the addition of successive harmonics. Digital high-pass filters of 0.05 and 0.5 Hz were used, and the resulting shapes were compared with the originals. Results. In 42 patients (93%) clinically significant alterations in ST segment level were detected. These changes were only seen in “real time mode” with high-pass filter of 0.5 Hz. Conclusions. Interpretation of the ST segment in “real time mode” should only be carried out using high-pass filters of 0.05 Hz.

A New Stripline High Pass Filter Layout

2000 ◽  
Vol 14 (3) ◽  
pp. 423-439 ◽  
Author(s):  
F. Bilotti ◽  
L. Vegni ◽  
A. Toscano
Keyword(s):  
Pass Filter ◽  
High Pass Filter ◽  
High Pass

Ripple FPN reduced algorithm based on temporal high-pass filter and hardware implementation

2016 ◽  
Author(s):  
Yiyang Li ◽  
Shuo Li ◽  
Zhipeng Zhang ◽  
Weiqi Jin ◽  
Lei Wu ◽  
...  
Keyword(s):  
Hardware Implementation ◽  
Pass Filter ◽  
High Pass Filter ◽  
High Pass
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