Cortical Involvement in the Generation of Essential Tremor

2007 ◽  
Vol 97 (5) ◽  
pp. 3219-3228 ◽  
Author(s):  
Jan Raethjen ◽  
R. B. Govindan ◽  
Florian Kopper ◽  
M. Muthuraman ◽  
Günther Deuschl
Keyword(s):  
Essential Tremor ◽  
Hot Spot ◽  
Power Spectra ◽  
Emg Activity ◽  
Cortical Circuits ◽  
Coherent Signals ◽  
Cortical Motor ◽  
Tremor Frequency ◽  
Cortical Involvement

Conflicting results on the existence of tremor-related cortical activity in essential tremor (ET) have raised questions on the role of the cortex in tremor generation. Here we attempt to address these issues. We recorded 64 channel surface EEGs and EMGs from forearm muscles in 15 patients with definite ET. EEG and EMG power spectra, relative power of the rhythmic EMG activity, relative EEG power at the tremor frequency, and EEG–EMG and EEG–EEG coherence were calculated and their dynamics over time explored. Corticomuscular delay was studied using a new method for narrow-band coherent signals. Corticomuscular coherence in the contralateral central region at the tremor frequency was present in all patients in recordings with a relative tremor EMG power exceeding a certain level. However, the coherence was lost intermittently even with tremors far above this level. Physiological 15- to 30-Hz coherence was found consistently in 11 patients with significantly weaker EMG activity in this frequency range. A more frontal (mesial) hot spot was also intermittently coupled with the tremor and the central hot spot in five patients. Corticomuscular delays were compatible with transmission in fast corticospinal pathways and feedback of the tremor signal. Thus the tremor rhythm is intermittently relayed only in different cortical motor areas. We hypothesize that tremor oscillations build up in different subcortical and subcortico-cortical circuits only temporarily entraining each other.

Pulvino-cortical interaction: an integrative role in the control of attention

2019 ◽  
Author(s):  
Alexia Bourgeois ◽  
Carole Guedj ◽  
Emmanuel Carrera ◽  
Patrik Vuilleumier
Keyword(s):  
Executive Control ◽  
Sensory Information ◽  
Relevant Information ◽  
Cortical Circuits ◽  
Attention And Executive Control ◽  
Neural Communication ◽  
Subcortical Regions ◽  
Theoretical Proposal ◽  
Selection Of

Selective attention is a fundamental cognitive function that guides behavior by selecting and prioritizing salient or relevant sensory information of our environment. Despite early evidence and theoretical proposal pointing to an implication of thalamic control in attention, most studies in the past two decades focused on cortical substrates, largely ignoring the contribution of subcortical regions as well as cortico-subcortical interactions. Here, we suggest a key role of the pulvinar in the selection of salient and relevant information via its involvement in priority maps computation. Prioritization may be achieved through a pulvinar- mediated generation of alpha oscillations, which may then modulate neuronal gain in thalamo-cortical circuits. Such mechanism might orchestrate the synchrony of cortico-cortical interaction, by rendering neural communication more effective, precise and selective. We propose that this theoretical framework will support a timely shift from the prevailing cortico- centric view of cognition to a more integrative perspective of thalamic contributions to attention and executive control processes.

Tissue Ki67 proliferative index expression and pathological changes in hemodialysis arteriovenous fistulae: Preliminary single-center results

2021 ◽  
pp. 112972982110154
Author(s):  
Raffaella Mauro ◽  
Cristina Rocchi ◽  
Francesco Vasuri ◽  
Alessia Pini ◽  
Anna Laura Croci Chiocchini ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Hot Spot ◽  
Wall Thickening ◽  
Proliferating Cells ◽  
Ki 67 ◽  
Group A ◽  
The Mean ◽  
Set Up ◽  
Group B

Background: Arteriovenous fistula (AVF) for hemodialysis integrates outward remodeling with vessel wall thickening in response to drastic hemodynamic changes. Aim of this study is to determine the role of Ki67, a well-established proliferative marker, related to AVF, and its relationship with time-dependent histological morphologic changes. Materials and methods: All patients were enrolled in 1 year and stratified in two groups: (A) pre-dialysis patients submitted to first AVF and (B) patients submitted to revision of AVF. Morphological changes: neo-angiogenesis (NAG), myointimal thickening (MIT), inflammatory infiltrate (IT), and aneurysmatic fistula degeneration (AD). The time of AVF creation was recorded. A biopsy of native vein in Group A and of arterialized vein in Group B was submitted to histological and immunohistochemical (IHC) analysis. IHC for Ki67 was automatically performed in all specimens. Ki67 immunoreactivity was assessed as the mean number of positive cells on several high-power fields, counted in the hot spots. Results: A total of 138 patients were enrolled, 69 (50.0%) Group A and 69 (50.0%) Group B. No NAG or MIT were found in Group A. Seven (10.1%) Group A veins showed a mild MIT. Analyzing the Group B, a moderate-to-severe MIT was present in 35 (50.7%), IT in 19 (27.5%), NAG in 37 (53.6%); AD was present in 10 (14.5%). All AVF of Group B with the exception of one (1.4%) showed a positivity for Ki67, with a mean of 12.31 ± 13.79 positive cells/hot spot (range 0–65). Ki67-immunoreactive cells had a subendothelial localization in 23 (33.3%) cases, a myointimal localization in SMC in 35 (50.7%) cases. The number of positive cells was significantly correlated with subendothelial localization of Ki67 ( p = 0.001) and with NA ( p = 0.001). Conclusions: Native veins do not contain cycling cells. In contrast, vascular cell proliferation starts immediately after AVF creation and persists independently of the time the fistula is set up. The amount of proliferating cells is significantly associated with MIT and subendothelial localization of Ki67-immunoreactive cells, thus suggesting a role of Ki-67 index in predicting AVF failure.

scholarly journals Adaptive Integration in the Visual Cortex by Depressing Recurrent Cortical Circuits

2008 ◽  
Vol 20 (7) ◽  
pp. 1847-1872 ◽  
Author(s):  
Mark C. W. van Rossum ◽  
Matthijs A. A. van der Meer ◽  
Dengke Xiao ◽  
Mike W. Oram
Keyword(s):  
Visual Cortex ◽  
Physiological Data ◽  
High Contrast ◽  
Cortical Circuits ◽  
Response Latencies ◽  
Low Contrast ◽  
Visual Areas ◽  
Higher Visual Areas ◽  
Recurrent Connections

Neurons in the visual cortex receive a large amount of input from recurrent connections, yet the functional role of these connections remains unclear. Here we explore networks with strong recurrence in a computational model and show that short-term depression of the synapses in the recurrent loops implements an adaptive filter. This allows the visual system to respond reliably to deteriorated stimuli yet quickly to high-quality stimuli. For low-contrast stimuli, the model predicts long response latencies, whereas latencies are short for high-contrast stimuli. This is consistent with physiological data showing that in higher visual areas, latencies can increase more than 100 ms at low contrast compared to high contrast. Moreover, when presented with briefly flashed stimuli, the model predicts stereotypical responses that outlast the stimulus, again consistent with physiological findings. The adaptive properties of the model suggest that the abundant recurrent connections found in visual cortex serve to adapt the network's time constant in accordance with the stimulus and normalizes neuronal signals such that processing is as fast as possible while maintaining reliability.

scholarly journals Cholinergic systems are essential for late-stage maturation and refinement of motor cortical circuits

2015 ◽  
Vol 113 (5) ◽  
pp. 1585-1597 ◽  
Author(s):  
Dhakshin S. Ramanathan ◽  
James M. Conner ◽  
Arjun A. Anilkumar ◽  
Mark H. Tuszynski
Keyword(s):  
Late Onset ◽  
Adult Size ◽  
Cortical Circuits ◽  
Motor Tasks ◽  
Cholinergic Lesions ◽  
Cortical Motor ◽  
Cholinergic Systems ◽  
Temporal Course ◽  
Motor Cortical ◽  
Motor Representations

Previous studies reported that early postnatal cholinergic lesions severely perturb early cortical development, impairing neuronal cortical migration and the formation of cortical dendrites and synapses. These severe effects of early postnatal cholinergic lesions preclude our ability to understand the contribution of cholinergic systems to the later-stage maturation of topographic cortical representations. To study cholinergic mechanisms contributing to the later maturation of motor cortical circuits, we first characterized the temporal course of cortical motor map development and maturation in rats. In this study, we focused our attention on the maturation of cortical motor representations after postnatal day 25 (PND 25), a time after neuronal migration has been accomplished and cortical volume has reached adult size. We found significant maturation of cortical motor representations after this time, including both an expansion of forelimb representations in motor cortex and a shift from proximal to distal forelimb representations to an extent unexplainable by simple volume enlargement of the neocortex. Specific cholinergic lesions placed at PND 24 impaired enlargement of distal forelimb representations in particular and markedly reduced the ability to learn skilled motor tasks as adults. These results identify a novel and essential role for cholinergic systems in the late refinement and maturation of cortical circuits. Dysfunctions in this system may constitute a mechanism of late-onset neurodevelopmental disorders such as Rett syndrome and schizophrenia.

scholarly journals Extending the Definition of the GyrB Quinolone Resistance-Determining Region in Mycobacterium tuberculosis DNA Gyrase for Assessing Fluoroquinolone Resistance in M. tuberculosis

2012 ◽  
Vol 56 (4) ◽  
pp. 1990-1996 ◽  
Author(s):  
Alix Pantel ◽  
Stéphanie Petrella ◽  
Nicolas Veziris ◽  
Florence Brossier ◽  
Sylvaine Bastian ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Hot Spot ◽  
Dna Gyrase ◽  
Quinolone Resistance ◽  
Fluoroquinolone Resistance ◽  
Wild Type ◽  
Content Type ◽  
Highly Active ◽  
Definition Of

ABSTRACTFluoroquinolone (FQ) resistance is emerging inMycobacterium tuberculosis. The main mechanism of FQ resistance is amino acid substitution within the quinolone resistance-determining region (QRDR) of the GyrA subunit of DNA gyrase, the sole FQ target inM. tuberculosis. However, substitutions in GyrB whose implication in FQ resistance is unknown are increasingly being reported. The present study clarified the role of four GyrB substitutions identified inM. tuberculosisclinical strains, two located in the QRDR (D500A and N538T) and two outside the QRDR (T539P and E540V), in FQ resistance. We measured FQ MICs and also DNA gyrase inhibition by FQs in order to unequivocally clarify the role of these mutations in FQ resistance. Wild-type GyrA, wild-type GyrB, and mutant GyrB subunits produced from engineeredgyrBalleles by mutagenesis were overexpressed inEscherichia coli, purified to homogeneity, and used to reconstitute highly active gyrase complexes. MICs and DNA gyrase inhibition were determined for moxifloxacin, gatifloxacin, ofloxacin, levofloxacin, and enoxacin. All these substitutions are clearly implicated in FQ resistance, underlining the presence of a hot spot region housing most of the GyrB substitutions implicated in FQ resistance (residues NTE, 538 to 540). These findings help us to refine the definition of GyrB QRDR, which is extended to positions 500 to 540.

scholarly journals Extreme value theory in the solar wind: the role of current sheets

2019 ◽  
Vol 490 (2) ◽  
pp. 1879-1893
Author(s):  
Tiago F P Gomes ◽  
Erico L Rempel ◽  
Fernando M Ramos ◽  
Suzana S A Silva ◽  
Pablo R Muñoz
Keyword(s):  
Solar Wind ◽  
Power Spectra ◽  
Value Theory ◽  
Extreme Value ◽  
Extreme Value Statistics ◽  
Intermittent Turbulence ◽  
Current Sheets ◽  
Developed Turbulence ◽  
The Right

ABSTRACT This article provides observational evidence for the direct relation between current sheets, multifractality and fully developed turbulence in the solar wind. In order to study the role of current sheets in extreme-value statistics in the solar wind, the use of magnetic volatility is proposed. The statistical fits of extreme events are based on the peaks-over-threshold (POT) modelling of Cluster 1 magnetic field data. The results reveal that current sheets are the main factor responsible for the behaviour of the tail of the magnetic volatility distributions. In the presence of current sheets, the distributions display a positive shape parameter, which means that the distribution is unbounded in the right tail. Thus the appearance of larger current sheets is to be expected and magnetic reconnection events are more likely to occur. The volatility analysis confirms that current sheets are responsible for the −5/3 Kolmogorov power spectra and the increase in multifractality and non-Gaussianity in solar wind statistics. In the absence of current sheets, the power spectra display a −3/2 Iroshnikov–Kraichnan law. The implications of these findings for the understanding of intermittent turbulence in the solar wind are discussed.

scholarly journals Controlling Complexity of Cerebral Cortex Simulations—II: Streamlined Microcircuits

2019 ◽  
Vol 31 (6) ◽  
pp. 1066-1084 ◽  
Author(s):  
Henri Hokkanen ◽  
Vafa Andalibi ◽  
Simo Vanni
Keyword(s):  
Reference Model ◽  
Computation Time ◽  
Cell Types ◽  
Oscillatory Behavior ◽  
Morphological Data ◽  
Attractive Alternative ◽  
Cortical Circuits ◽  
Neuron Models ◽  
High Calcium

Recently, Markram et al. (2015) presented a model of the rat somatosensory microcircuit (Markram model). Their model is high in anatomical and physiological detail, and its simulation requires supercomputers. The lack of neuroinformatics and computing power is an obstacle for using a similar approach to build models of other cortical areas or larger cortical systems. Simplified neuron models offer an attractive alternative to high-fidelity Hodgkin-Huxley-type neuron models, but their validity in modeling cortical circuits is unclear. We simplified the Markram model to a network of exponential integrate-and-fire (EIF) neurons that runs on a single CPU core in reasonable time. We analyzed the electrophysiology and the morphology of the Markram model neurons with eFel and NeuroM tools, provided by the Blue Brain Project. We then constructed neurons with few compartments and averaged parameters from the reference model. We used the CxSystem simulation framework to explore the role of short-term plasticity and GABA[Formula: see text] and NMDA synaptic conductances in replicating oscillatory phenomena in the Markram model. We show that having a slow inhibitory synaptic conductance (GABA[Formula: see text] allows replication of oscillatory behavior in the high-calcium state. Furthermore, we show that qualitatively similar dynamics are seen even with a reduced number of cell types (from 55 to 17 types). This reduction halved the computation time. Our results suggest that qualitative dynamics of cortical microcircuits can be studied using limited neuroinformatics and computing resources supporting parameter exploration and simulation of cortical systems. The simplification procedure can easily be adapted to studying other microcircuits for which sparse electrophysiological and morphological data are available.

scholarly journals The effect of posture on the role of pectoralis major and latissimus dorsi muscles in expiration in tetraplegia

1993 ◽  
Vol 49 (2) ◽  
pp. 25-27
Author(s):  
Poobalam Gounden
Keyword(s):  
Latissimus Dorsi ◽  
Pectoralis Major Muscle ◽  
Latissimus Dorsi Muscle ◽  
Pectoralis Major ◽  
Emg Activity ◽  
Electromyographic Activity ◽  
Forced Expiration ◽  
Dorsi Muscle ◽  
Postural Changes

This study was designed to. examine the effect of posture on forced expiration as reflected in phasic electromyographic activity in accessory expiratory muscles in tetraplegic subjects with complete lesions between the fifth and eight cervical segments. In order to determine the effect of posture on the action of the clavicular head of the pectoralis major muscle and the latissimus dorsi muscle during forced expiration, the subjects were studied in two test positions, support sitting and supine lying.Electromyographic examination of the above mentioned muscles in eight tetraplegic subjects showed changes in electrical activity in the clavicular portion of the pectoralis major muscle when the subjects were studied in the supine position. Four out of eight subjects showed evidence of an increase in EMG activity in the supine lying position. When the muscle was tested with the patient in the supported sitting position it failed to demonstrate a significant increase in electromyographic activity during forced expiration.We concluded therefore that the role of the clavicular portion of the pectoralis major muscle during expiration in tetraplegia is posture dependent. These findings have important therapeutic implications: specific training programmes to increase the strength and endurance of this muscle should be conducted with the subject in the correct position. The action of the latissimus dorsi muscle was not significantly influenced by the postural changes during forced expiration.

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