scholarly journals Extraskeletal Osteosarcoma of the Thigh: An Autopsy Case Report

Sarcoma ◽  
2009 ◽  
Vol 2009 ◽  
pp. 1-5
Author(s):  
Akihito Nagano ◽  
Takatoshi Ohno ◽  
Yutaka Nishimoto ◽  
Kazunari Yamada ◽  
Katsuji Shimizu
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Primary Tumor ◽  
Left Lung ◽  
Definite Diagnosis ◽  
Autopsy Case ◽  
Extraskeletal Osteosarcoma ◽  
Secondary Tumors ◽  
Multiagent Chemotherapy ◽  
The Right

We report a case of extraskeletal osteosarcoma (ESOS) and autopsy findings. A 35-year-old man presented with an ossified tumor in the right thigh and lung metastasis. The lung tumors continued to develop despite multiagent chemotherapy and caused death within 8 months. Autopsy revealed many secondary lesions in the lungs, especially in the left lung. Histopathologically, the primary tumor and one of the secondary tumors showed proliferation of spindle-shaped tumor cells focally forming lace-like osteoid material. Therefore, we made a definite diagnosis of ESOS.

scholarly journals Absence of both fissures in a right lung: a case report

2015 ◽  
Vol 04 (02) ◽  
pp. 105-106
Author(s):  
S. Supadevi ◽  
Ramesh Kumar Subramanian ◽  
D. Kesavi
Keyword(s):  
Case Report ◽  
Left Lung ◽  
Segmental Resection ◽  
The Right ◽  
Oblique Fissure

AbstractThe right lung has two fissures which separate the lung into three lobes. They are the oblique fissure and the horizontal fissure and the lobes are superior, middle and the inferior lobes respectively arranged from the apex of the lung to the base. In the present case, during routine dissection the right lung was observed to have complete absence of both oblique fissure and horizontal fissure and there was no lobar pattern. The lung pleural membrane was continuous from the apex to the base. Hilum structures were arranged normally. Left lung was completely normal with no variation. Variation of anatomy of lung fissures is important in case of diagnosis of lung pathologies and in the modality of treatment for segmental resection of lung.

Prospective study with circulating tumor cells as potential prognosis biomarker in metastatic colorectal cancer.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 203-203 ◽  
Author(s):  
Virgilio Souza E Silva ◽  
Emne Ali Abdallah ◽  
Celso Abdon Lopes de Mello ◽  
Milena Shizue Tariki ◽  
Vinicius Fernando Calsavara ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prospective Study ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Primary Tumor ◽  
Progression Free Survival ◽  
Blood Collection ◽  
Multidrug Resistance Protein 1 ◽  
Promising Tool ◽  
The Right

203 Background: Colorectal cancer (CRC) is one of the most common cancer worldwide. Around 30% present metastatic disease at diagnosis and 50%–60% of patients develop metastasis. New prognostic markers are needed and circulating tumor cells (CTCs) are a promising tool. Methods: Prospective study conducted by blood collection from 75 patients (pts) with metastatic CRC (mCRC), twice, with 2 months interval, together with image exams for therapeutic response evaluation. CTCs were detected by ISET and identified by immunocytochemistry. Results: The mean age was 57.3 years old (24-81). RAS mutations in primary tumor was found in 38% (19/50) of patients (pts) and left colon topography in 41.3% (31/75). Comparing the baseline CTC level (CTC1) with the level at first follow-up (CTC 2), pts with CTC2 – CTC1 > 5.5 per ml demonstrated poor progression-free survival (PFS) (3.2 months) when compared to CTC 2 – CTC1 ≤ 5.5 (9.1 months) (p= 0.005). The median overall survival (OS) was 24.5 months for pts with CTC 1 > 1.5 per ml and 34.2 months for those with CTC1 ≤ 1.5 per (HR=1.89, 95% CI, 1.01 to 3.52; p= 0.041). Patients with RAS mutation (P= 0.001), primary tumor in the right colon (p= 0.014) and expression of Multidrug Resistance Protein 1 in CTCs (p= 0.044) had worse OS. By multivariable analyses, CTC 1 > 1.5/mL (p= 0.025) was an independent prognostic factor. Conclusions: This prospective study confirmed that counts of CTCs at baseline (CTC1) is an important prognostic marker for monitoring mCRC and correlates with other established prognostic factors. Clinical trial information: NCT02979470.

METASTATIC CHORIOCARCINOMA PRESENTING AS RENAL COLIC AND SKIN LESION – CASE REPORT

2021 ◽  
Vol 74 (7) ◽  
pp. 1763-1766
Author(s):  
Michał Pietrus ◽  
Adrian Czekaj ◽  
Dominik Dziadkowiak ◽  
Krzysztof Ratajczyk ◽  
Maciej Trzciniecki ◽  
...  
Keyword(s):  
Case Report ◽  
Skin Lesion ◽  
Renal Colic ◽  
Left Lung ◽  
Cutaneous Metastasis ◽  
Blood Levels ◽  
Surgical Removal ◽  
Β Hcg ◽  
The Right ◽  
Kidney Metastasis

Choriocarcinoma is a rare malignant disease that is usually associated with a gestational event. Kidney metastasis might be misdiagnosed as renal cell carcinoma or kidney abscess. To the best of our knowledge, only 13 cases of cutaneous metastasis of choriocarcinoma have been reported in the literature so far. We report a case of choriocarcinoma that manifested with multiple metastases to the lung, skin, kidney and brain. Case report: We reported a case of a 37-year-old woman with a history of hydatiform mole, with symptoms of renal colic and abnormal findings on the skin. Chest X-ray revealed visible focal change 80 mm in diameter, located in the left lung area. The CT exposed in both kidneys multiple hypodense foci, 32 mm in size, suggesting multifocal abscesses with disruptions and perforation to paranephric area. Due to the presence of and temporary loss of vision in the right eye head CT was performed revealing metastatic changes in the brain. The diferential diagnosis between renal cancer, lung carcinoma and choriocarcinoma was achieved only after surgical removal skin lesion. This was the first time in our experience with choriocarcinoma. Immunohistochemically, the analysis was positive for beta hCG, cytokeratin AE1/AE, CK 8/18, CD10, EMA, alfa 1-inhibin and negative for protein 63, CD30 and CD117. Serum hCG level was 394590,0 mIU/mL. Conclusions: Choriocarcinoma should be taken into consideration when associated symptoms and significantly elevated blood levels of β-hCG were identified.

scholarly journals Malign Recurrence of Primary Chest Wall Hemangiopericytoma in the Lung after Four Years: A Case Report and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Tulay Akman ◽  
Ahmet Alacacioglu ◽  
Devrim Dolek ◽  
Tugba Unek ◽  
Duygu Gurel ◽  
...  
Keyword(s):  
Case Report ◽  
Chest Wall ◽  
Lung Metastasis ◽  
Primary Tumor ◽  
Pathological Fracture ◽  
Review Of The Literature ◽  
Muscular System ◽  
The Right ◽  
Endothelial Tissue ◽  
Benign Course

Hemangiopericytoma (HPC) may develop in every site where the endothelial tissue exits and primarily develops in the skeletal-muscular system or the skin. Adult cases of HPC generally exhibit a benign course. 20–30% of the cases may show a malign course. The tumors that show more than four mitoses, a focal area of necrosis, and increased cellularity on a magnification ×10 are considered as malign. In our paper, we presented our case who showed a lung metastasis at the end of 4 years and who developed a pathological fracture of the right humerus at the end of approximately 2 years, because hemangiopericytoma is rarely seen in the chest wall as a primary tumor.

scholarly journals Unusual localizations of hydatid cysts: a rare case report from Syria

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Zain Douba ◽  
Judy A Sinno ◽  
Haya Jawish ◽  
Nour Hakim ◽  
Abdullah Mouselli ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
South America ◽  
Rare Case ◽  
Eastern Mediterranean ◽  
Left Lung ◽  
Hydatid Cysts ◽  
Rare Case Report ◽  
History Of ◽  
The Right

Abstract Hydatid disease (HD) is an infection with the metacestode stage of the tapeworm Echinococcus. It is commonly seen in South America, The Middle East, Eastern Mediterranean, Africa and China. Hydatid cysts usually affect the liver followed by the lungs. Involvement in other organs has been reported. However, in the majority of the cases, cysts are localized in one organ or one region. We report a rare case of a 36-year-old woman who presented to the hospital in Syria with long-standing history of non-specific abdominal pain. Computerized tomography showed several hydatid cysts in the liver, spleen, left lung, mediastinum (adjacent to the aortic arch), both breasts and above the right gluteal muscles.

scholarly journals Clinicopathological Characteristics and Prognostic Factors in Ovarian Metastases from Right- and Left-Sided Colorectal Cancer

2021 ◽  
Vol 28 (4) ◽  
pp. 2914-2927
Author(s):  
Ondřej Kubeček ◽  
Jan Laco ◽  
Jiří Špaček ◽  
Alena Kubečková ◽  
Jiří Petera ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Primary Tumor ◽  
Residual Disease ◽  
Menopausal Status ◽  
Clinicopathological Characteristics ◽  
Primary Tumors ◽  
Imaging Methods ◽  
Secondary Tumors ◽  
The Right

Background: Secondary tumors of the ovary (STOs) account for 10–25% of all ovarian malignancies, including metastases from primary gynecological tumors. Colorectal cancer (CRC) has been recognized as one of the most common causes of STOs in Western countries. Despite it being well-known that CRC originating from the right versus left side of the colon/rectum differ substantially, there is a paucity of information regarding the effect of the primary tumor sidedness on the clinicopathological characteristics of STOs. Methods: This retrospective, observational chart review study included patients with histologically confirmed STOs of CRC origin diagnosed between January 2000 and December 2019. The clinicopathological characteristics of STOs originating from left-sided and right-sided CRC were compared. Univariable and multivariable analyses employing elastic net Cox proportional hazard models were used to evaluate potential prognostic factors. Further, the role of imaging methods in STOs diagnostics was evaluated. Results: Fifty-one patients with STOs of colorectal origin were identified. The primary tumor originated in the right and left colon/rectum in 39% and 61% of the cases, respectively. STOs originating from right-sided primary tumors were more frequently bilateral, associated with peritoneal carcinomatosis, had the ovarian surface affected by the tumor, and contained a mucinous component. The independent prognostic factors for overall survival in the whole cohort included: the presence of macroscopic residual disease after cytoreductive surgery, menopausal status, the application of systemic therapy, and the application of targeted therapy. In 54% of cases, the imaging methods failed to determine the laterality of the STOs correctly as compared to pathological reports and/or intraoperative findings. Conclusion: STOs originating from left-sided and right-sided CRC show distinct clinicopathological characteristics. Moreover, different metastatic pathways might be employed according to the primary tumor sidedness. Considering the discrepancies between radiological assessment and histopathological findings regarding the laterality of STOs, bilateral adnexectomy should be advised whenever feasible.

scholarly journals Granular cell tumor of the bronchus coexisting with a bronchogenic adenocarcinoma: Case report

2011 ◽  
Vol 19 (1-2) ◽  
pp. 31-33
Author(s):  
Nenad Solajic ◽  
Jelena Krcedinac ◽  
Golub Samardzija ◽  
Miljan Milic ◽  
Aleksandra Lovrenski
Keyword(s):  
Tumor Cells ◽  
Radiation Treatment ◽  
Main Bronchus ◽  
Left Lung ◽  
Granular Cell ◽  
Large Tumor ◽  
S 100 ◽  
Bronchogenic Adenocarcinoma ◽  
The Right ◽  
Contrast Ct

Pulmonary granular cell tumors (GCTs) are uncommon and usually benign and their coexistence with bronchogenic adenocarcinoma is rare. We report the case of 50-year-old woman with GCT located in the left lung hilum, which occurred simultaneously with a primary bronchogenic adenocarcinoma in the same area. Contrast CT scan of the head revealed secondary deposits in the right cerebellum, presumably of adenocarcinomas origin. Bronchoscopy revealed narrowing on the beginning of the left lingular bronchus and infiltration of the medial distal wall of the left main bronchus. Large tumor cells with eosinophilic granular cytoplasm were seen on light microscopic examination. Tumor cells fully occupied submucosa and had small, round nuclei with no signs of pleomorphism. Immunohistochemically, these cells were S-100 positive. In small area, groups of atypical oval-shaped cells of adenocarcinomas origin were noticed. This confirmed the diagnosis of GCT coexisting with adenocarcinoma. After consultation with oncologists, the patient was scheduled for further polychemotherapy and radiation treatment.

2. An Autopsy Case of a Stunt Man Who Jumped into Seawater Riding a Motorcycle: A Case Report

2002 ◽  
Vol 42 (4) ◽  
pp. 355-357
Author(s):  
Kanako Watanabe-Suzuki ◽  
Osamu Suzuki ◽  
Hideki Nozawa ◽  
Akira Ishii
Keyword(s):  
Case Report ◽  
Cause Of Death ◽  
Water Surface ◽  
Rare Case ◽  
Bone Fractures ◽  
Axillary Artery ◽  
Autopsy Case ◽  
Visceral Organs ◽  
Complete Rupture ◽  
The Right

We report a rare case of the death of a stunt man who jumped into the sea driving a motorcycle on location for a TV drama. A special ramp had been constructed for the jump. The stunt man and a passenger drove up the ramp at a speed of 60–70 km/h and jumped into the sea from a height of about five metres. Both men swam up, but the driver fell unconscious at the surface. He was sent to hospital, but did not recover. The autopsy revealed a deep laceration of the right axilla with complete rupture of the axillary artery, bone fractures of the right ribs and the right pelvis, and a small laceration of the upper lobe of the right lung. Other visceral organs were not injured. We finally judged that his cause of death was exsanguination due to rupture of the right axillary artery on the basis of the presence of a small amount of blood inside the heart and ischemic organs. All injuries were probably inflicted by a collision with the motorcycle upon reaching the water surface; the axillary injury might be due to the left handlebar piercing into the part.

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