Long-Term Effects of Metformin and Lifestyle Modification on Nonalcoholic Fatty Liver Disease Obese Adolescents

Objective. To assess the long-term effects of metformin in combination with lifestyle intervention and its association between insulin levels and the degree of steatosis at ultrasonography (US) in obese adolescents.Methods. Thirty-five postpubertal obese boys were randomized into two groups: one receiving metformin in combination with a multidisciplinary lifestyle intervention versus a placebo group, which also received the same intervention. The visceral, subcutaneous fat and degree of steatosis were measured by ultrasonography. Fasting blood samples were collected to analyze glucose, insulin, insulin resistance, and aminotransferases. Repeated ANOVA measures were used to compare changes over time and between groups, and Spearman's correlations were used to identify an association between insulin and the degree of steatosis at US.Results. There was a positive correlation between the degree of steatosis at US with insulin concentrations and HOMA-IR. Long-term therapy plus metformin significantly reduced body weight, body mass index, insulin, HOMA-IR, and visceral fat.Conclusions. Metformin was more effective than the placebo in improving clinical parameters associated with obesity and steatosis.

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Aspects of Long-Term Treatment with Neuroleptics Historical and Literature Review—Personal Experience with Fluspirilene and Penfluridol

Journal of International Medical Research ◽

10.1177/030006057500300210 ◽

1975 ◽

Vol 3 (2) ◽

pp. 114-124 ◽

Cited By ~ 1

Author(s):

Lucian Floru

Keyword(s):

Side Effects ◽

Literature Review ◽

Personal Experience ◽

Term Treatment ◽

Term Therapy ◽

Tabular Form ◽

Long Term Effects ◽

Long Term Treatment ◽

Long Term Therapy

The literature on neuroleptics with substance-specific long-term effects (fluspirilene, penfluridol) is reviewed in tabular form. This is followed by a report of personal investigations on 76 schizophrenics who were treated with fluspirilene initially within the hospital and later on an out-patient basis, on 86 patients who were treated with it exclusively at the out-patients' department, as well as on 123 schizophrenic psychoses treated with penfluridol in the out-patients' department. The side-effects caused by the two substances are compared. Pre-requisites for effective long-term therapy with a few complications are discussed.

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Serum myristic fatty acid negatively correlates with anti-inflammatory adiponectin/leptin ratio in obese adolescents: effects of long- term therapy

O Mundo da Saúde ◽

10.15343/0104-7809.201740a537554 ◽

2017 ◽

Vol 40 (A) ◽

pp. 537-554 ◽

Cited By ~ 1

Author(s):

Aline de Piano-Ganen ◽

Deborah Cristina Landi Masquio ◽

Ana R. Dâmaso ◽

Lila Missae Oyama ◽

Debora Estadella ◽

...

Keyword(s):

Fatty Acid ◽

Term Therapy ◽

Obese Adolescents ◽

Anti Inflammatory ◽

Long Term Therapy

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Long-term side effects of high-risk neuroblastoma survivors in a referral center in central Illinois.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.5_suppl.129 ◽

2017 ◽

Vol 35 (5_suppl) ◽

pp. 129-129

Author(s):

Beth Speckhart ◽

Reuben Antony ◽

Karen S. Fernandez

Keyword(s):

Side Effects ◽

High Risk ◽

Term Therapy ◽

Solid Organ ◽

Long Term Effects ◽

Improved Outcomes ◽

Risk Patients ◽

Central Illinois ◽

Long Term Therapy

129 Background: Neuroblastoma (NBL) is the most common extra-cranial solid organ malignancy in children. Although low and intermediate-risk patients have a survival of close to 90%, the same cannot be said for patients with high risk (HR) disease. In the last decade multi-modality treatment of HR NBL patients has been intensified to include chemotherapy, surgery, radiation, bone marrow transplantation and immunotherapy and has resulted in improved survival (Yu, 2009). Data regarding the medium to long-term side effects of this intensive multi-modality therapy is now being collected as the population of HR neuroblastoma survivors continues to grow. Methods: We retrospectively reviewed the clinical data of survivors of HR NBL treated at the Children’s Hospital of Illinois diagnosed since 2009 and evaluated the long-term side effects of survivors through 2015. Results: We found 14 NBL patients of whom 10 had HR disease. Four patients died of progressive disease. Therapy-related, long-term side effects occurred in 6 patients: hearing loss (n = 6), adrenal insufficiency (n = 2), focal nodular hyperplasia of the liver (n = 2), linear growth retardation (n = 1). No patient in our cohort developed thyroid or cardiac problems and no patient was diagnosed with a second malignancy in the 5 years of observation. Conclusions: While the improved outcomes seen in HR NBL patients is encouraging, we found in our small cohort hat survivors of multimodality therapy for high-risk neuroblastoma experience significant long-term effects of treatment which impact their quality of life as well as growth and development. As the number of NBL survivors increases our understanding of the long-term therapy related side effects will continue to improve. Larger longitudinal studies are needed to monitor for other possible side effects that may manifest overtime such as cardiomyopathy, disturbances in sexual development, fertility, intellectual function, learning problems and therapy related second malignancies later in life.

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Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0b013e32835793ac ◽

2012 ◽

pp. 1 ◽

Cited By ~ 10

Author(s):

Aline de Piano ◽

Marco T. de Mello ◽

Priscila de L. Sanches ◽

Patrícia L. da Silva ◽

Raquel M.S. Campos ◽

...

Keyword(s):

Liver Disease ◽

Resistance Training ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Long Term Effects ◽

Nonalcoholic Fatty Liver ◽

Obese Adolescents

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Therapy-Related Late Adverse Events in Hodgkin’s Lymphoma

Lymphoma ◽

10.1155/2013/952698 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Manuel Gotti ◽

Valeria Fiaccadori ◽

Elisa Bono ◽

Benedetta Landini ◽

Marzia Varettoni ◽

...

Keyword(s):

Hodgkin’S Lymphoma ◽

Chemotherapeutic Agents ◽

Hodgkin's Lymphoma ◽

Clinical Aspects ◽

Term Therapy ◽

Long Term Effects ◽

Chemotherapy Dose ◽

Long Term Therapy ◽

Made In

Hodgkin's lymphoma (HL) is one of the most curable hematologic diseases with an overall response rate over 80%. However, despite this therapeutic efficacy, HL survivors show a higher morbidity and mortality than other people of the same age because of long-term therapy-related events. In the last decades, many efforts have been made to reduce these effects through the reduction of chemotherapy dose, the use of less toxic chemotherapeutic agents, and the introduction of new radiation techniques. In this paper, we will describe the main long-term effects related to chemotherapy and radiotherapy for HL, the efforts to reduce toxicity made in the last years, and the clinical aspects which have to be taken into consideration in the followup of these patients.

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Antithrombotic Therapy for DVT/PE

Hämostaseologie ◽

10.1055/s-0038-1659983 ◽

1997 ◽

Vol 17 (03) ◽

pp. 161-162

Author(s):

Thomas Hyers

Keyword(s):

Molecular Weight ◽

Low Molecular Weight Heparin ◽

Oral Anticoagulants ◽

Cost Effective ◽

Therapeutic Agents ◽

Great Promise ◽

Term Therapy ◽

Low Molecular Weight ◽

Long Term Therapy

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.

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