Upper Gastrointestinal Endoscopy Detection of Synchronous Multiple Primary Cancers in Esophagus and Stomach: Single Center Experience from China

The present study was undertaken to clarify the prevalence and clinicopathological features of synchronous multiple primary cancers (SMPCs) under upper gastrointestinal endoscopic examination. We enrolled 45,032 consecutive patients who underwent upper gastrointestinal endoscopic examination for digestive disease from January 2006 to December 2007 in our hospital and analyzed the clinicopathological features of SMPCs in esophagus and stomach. SMPCs are defined as two or over two different cancerous lesions developing in the same or other organs within 6 months. SMPCs were identified in 46 patients (0.1%). The gender ratio was 5.6 : 1 (male/female) and the mean age was 59.4 years. Synchronous esophageal and gastric cancers were the most frequent, being seen in 32 patients (0.07%). The most common histological types of SMPCs were squamous cell carcinoma in esophagus and adenocarcinoma in stomach, respectively. There were 27 (59%) SMPCs patients who had the history of simultaneous exposure to tobacco smoking and alcohol drinking. Additionally, 32 (78%) esophageal squamous cell cancers were associated with tobacco use. And 23 adenocarcinomas of the stomach were associated withHelicobacter pyloriinfection.

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Nivolumab Effective for Gastric and Lung Cancers but Not for Multiple Myeloma in a Multiple Primary Cancer Patient

Case Reports in Hematology ◽

10.1155/2021/9965371 ◽

2021 ◽

Vol 2021 ◽

pp. 1-4

Author(s):

Tsukasa Yasuda ◽

Junji Hiraga ◽

Michihiko Narita ◽

Yoshimasa Tanikawa ◽

Tomoyuki Tsuzuki

Keyword(s):

Multiple Myeloma ◽

Primary Lung Cancer ◽

Multiple Primary Cancers ◽

Upper Gastrointestinal Endoscopy ◽

Multiple Primary Cancer ◽

Lung Cancers ◽

Multiple Primary ◽

Third Line Therapy ◽

Third Line ◽

Upper Gastrointestinal

The case of a 76-year-old man with multiple primary cancers that were treated with nivolumab is presented. Six years earlier, he was diagnosed with multiple myeloma (MM) and was treated with several chemotherapies. He was also diagnosed with gastric cancer with liver metastasis and primary lung cancer by upper gastrointestinal endoscopy and computed tomography (CT). Nivolumab treatment was given as third-line therapy, and it was effective for gastric and lung cancers. But MM worsened, and the patient died. There is no standard treatment for multiple primary cancers, and the development of effective treatments for multiple primary cancers is important.

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MULTIPLE PRIMARY CANCERS IN PATIENTS WITH HEAD AND NECK CANCER AND HISTORY OF TOBACCO SMOKING AND DRINKING

Nippon Jibiinkoka Gakkai Kaiho ◽

10.3950/jibiinkoka.96.1501 ◽

1993 ◽

Vol 96 (9) ◽

pp. 1501-1509,1579 ◽

Cited By ~ 2

Author(s):

MUNENAGA NAKAMIZO ◽

SIN'ETSU KAMATA ◽

KAZUYOSHI KAWABATA ◽

HISAAKI TAKAHASHI ◽

TOMOHIKO NIGAURI ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Tobacco Smoking ◽

Multiple Primary Cancers ◽

Multiple Primary ◽

History Of

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Appropriateness of Upper Gastrointestinal Endoscopy in Patients With Gastroesophageal Reflux Disease (GERD): A Single-Center Experience

The American Journal of Gastroenterology ◽

10.14309/00000434-201410002-00056 ◽

2014 ◽

Vol 109 ◽

pp. S20

Author(s):

Nneoma Okoronkwo ◽

Leroy Floyd ◽

Xiangli Li ◽

Yucai Wang ◽

Aleksey Tentler ◽

...

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Gastrointestinal Endoscopy ◽

Upper Gastrointestinal Endoscopy ◽

Single Center ◽

Single Center Experience ◽

Upper Gastrointestinal

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Palliation with Oesophageal Metal Stent of Pseudoachalasia from Gastric Carcinoma at the Cardia: A Case Report

Diagnostic and Therapeutic Endoscopy ◽

10.1155/2009/791627 ◽

2009 ◽

Vol 2009 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Salvatore Maria Antonio Campo ◽

Roberto Lorenzetti ◽

Marina de Matthaeis ◽

Cesare Hassan ◽

Angelo Zullo ◽

...

Keyword(s):

Old Age ◽

Iron Deficiency Anaemia ◽

Gastrointestinal Endoscopy ◽

Barium Swallow ◽

Upper Gastrointestinal Endoscopy ◽

Metal Stent ◽

History Of ◽

Upper Gastrointestinal ◽

Progressive Dysphagia

We present an 82-year-old woman with a 3-month history of progressive dysphagia and a normal initial upper gastrointestinal endoscopy. The diagnosis of pseudoachalasia was suspected by oesophageal manometric and barium swallow studies, and confirmed by biopsies revealing an intestinal type carcinoma of the stomach at a repeated endoscopy. In view of the history of heart disease, diabetes, and old age, this patient was treated by a partially covered Ultraflex self-expanding metal stent (Boston Scientific, Natick, MA, USA) placed into the oesophageal body with no direct complications and obtaining the relief from dysphagia. During the 11-month follow-up she was treated for an iron deficiency anaemia due to reflux oesophagitis with ulcerations in the oesophageal body and died from myocardial infarction. According to the localization of the cancer, the old age, and the presence of comorbidities, we should recommend the insertion of a partially covered self-expanding metal stent as a reasonable palliative treatment in selected subjects with pseudoachalasia.

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A rare cause of abdominal pain with fever

BMJ Case Reports ◽

10.1136/bcr-2018-228401 ◽

2019 ◽

Vol 12 (3) ◽

pp. e228401

Author(s):

Diana Martins Oliveira ◽

Catarina Correia ◽

Flávia Cunha ◽

Patrícia Dias

Keyword(s):

Gastrointestinal Endoscopy ◽

Acute Cholangitis ◽

Magnetic Resonance Cholangiopancreatography ◽

Upper Gastrointestinal Endoscopy ◽

Laboratory Findings ◽

Reactive Protein ◽

Elevated Liver Enzymes ◽

History Of ◽

Lemmel’S Syndrome ◽

Upper Gastrointestinal

An 89-year-old man presented to the emergency department with a 1-month history of upper right quadrant pain, worsened in the last 3 days and accompanied by fever and chills. On physical examination, he had scleral icterus and right upper quadrant tenderness. Laboratory findings showed hyperbilirubinemia, elevated liver enzymes and C reactive protein. The patient was admitted, suspecting of an acute cholangitis and started on antibiotics. An upper gastrointestinal endoscopy revealed the presence of a juxtapapillary diverticulum in the second portion of the duodenum, which was confirmed by a magnetic resonance cholangiopancreatography, along with upstream biliary tract ectasia. The imaging findings allowed us to diagnose a Lemmel’s syndrome. Due to potential surgical risk, we decided for a conservative approach. The patient had a favourable course and was discharged home.

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A Retrospective Analysis of Cyanoacrylate Injection versus Hemoclip Placement for Bleeding Dieulafoy’s Lesion in Duodenum

Gastroenterology Research and Practice ◽

10.1155/2018/3208690 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Yu Jiang ◽

Julong Hu ◽

Ping Li ◽

Wen Jiang ◽

Wenyan Liang ◽

...

Keyword(s):

Retrospective Analysis ◽

Gastrointestinal Endoscopy ◽

Endoscopic Examination ◽

Upper Gastrointestinal Endoscopy ◽

Recurrent Hemorrhage ◽

Dieulafoy’S Lesion ◽

Endoscopic Intervention ◽

Primary Hemostasis ◽

Medical Centers ◽

Upper Gastrointestinal

Background. Duodenal Dieulafoy’s lesion (DL) is a rare disease that may lead to lethal hemorrhage in the upper gastrointestinal tract. The best technique for endoscopic intervention still remains unclear. In the present study, we performed a retrospective analysis of cyanoacrylate injection versus hemoclip placement for treating bleeding DLs. Materials and Methods. We retrospectively analyzed eighteen patients from three medical centers between October 2008 and February 2016; six patients received cyanoacrylate injection, while hemoclips were placed in 12 patients during the upper gastrointestinal endoscopy. Results. All patients received first endoscopic examination and/or endotherapy within 12 hours of admission to hospital. No difference was observed in the primary hemostasis rate or the recurrent hemorrhage rate between the cyanoacrylate injection (CI) group and the hemoclip placement (HP) group, except that in one patient from the HP group melena was found three days after the first endotherapy. This patient received cyanoacrylate injection once again. Conclusion. Both cyanoacrylate injection and hemoclip placement are effective in treating duodenal DL, and neither of them causes significant side effects.

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Periesophageal Pseudoaneurysms: Rare Cause of Refractory Bleeding Treated with Transarterial Embolization

Case Reports in Gastrointestinal Medicine ◽

10.1155/2016/1456949 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3

Author(s):

Divyanshoo R. Kohli ◽

Rachit D. Shah ◽

Daniel J. Komorowski ◽

George B. Smallfield

Keyword(s):

Lupus Erythematosus ◽

Transarterial Embolization ◽

Left Gastric Artery ◽

Massive Bleeding ◽

Upper Gastrointestinal Endoscopy ◽

Angiographic Embolization ◽

First Case ◽

Arterial Bleeding ◽

History Of ◽

Upper Gastrointestinal

A 43-year-old female with history of systemic lupus erythematosus, prior cytomegalovirus esophagitis treated with ganciclovir, and long segment Barrett’s esophagus (Prague class C8 M9) with high grade dysplasia treated with radiofrequency ablation presented to the hospital with hematemesis. An upper gastrointestinal endoscopy showed multiple esophageal ulcers with active arterial spurting which could not be controlled with endoscopic interventions including placement of hemostatic clips. An emergent angiogram demonstrated actively bleeding saccular dilations (pseudoaneurysms) in the esophageal branches of the lower thoracic aorta as well as left gastric artery for which gelfoam and coil embolization was initially successful. Due to recurrence of massive bleeding, she subsequently underwent emergent esophagectomy and bipolar exclusion. Pathology demonstrated submucosal hemorrhage, esophagitis with dysplastic Barrett’s mucosa, and an ulcer containing cytomegaloviral inclusions. We report the first case of arterial bleeding from periesophageal pseudoaneurysms as well as use of angiographic embolization for arterial bleeding in the esophagus.

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Medication Bezoar Causing acute Gastric Outlet Obstruction: A Case Report

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v33i3.28063 ◽

2016 ◽

Vol 33 (3) ◽

pp. 177-180 ◽

Cited By ~ 1

Author(s):

Md Abdul Mazid

Keyword(s):

Gastric Outlet Obstruction ◽

Epigastric Pain ◽

Outlet Obstruction ◽

Uneventful Recovery ◽

Upper Gastrointestinal Endoscopy ◽

Abdominal Ultrasonography ◽

Life Threatening ◽

History Of ◽

Upper Gastrointestinal ◽

Made In

Medication bezoars are rare and are composed of medications and/or medication vehicles. Rarely, medication bezoars can cause serious problems due to complications such as perforation, obstruction, haemorrhage. A 60 years old woman presented with 10 days history of epigastric pain, weakness and postprandial non-bilious vomiting. Her abdominal ultrasonography showed strong post acoustic shadow noted within 1st part of duodenum possibly foreign body. Upper gastrointestinal endoscopy was performed and a bezoar of tablet of aluminum hydroxide was extracted. The patient had uneventful recovery. Acute gastric outlet obstruction is relatively uncommon and mostly due to foreign bodies related to food impaction, with meat being the most frequent culprit. The diagnostic approach to acute gastric outlet obstruction is similar to other cause of GOO. However, therapeutic options differ for each patient. The diagnosis should be made in prompt time to prevent life threatening complications due obstruction and/or effect of medication forming bezoar.J Bangladesh Coll Phys Surg 2015; 33(3): 177-180

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