scholarly journals GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Florence Delie ◽  
Patrick Petignat ◽  
Marie Cohen
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Ovarian Cancer Cell ◽  
Glucose Deprivation ◽  
Chaperone Protein ◽  
Low Levels ◽  
Potential Use ◽  
Glucose Regulated Protein

Glucose-regulated protein of 78 kD (GRP78) is a chaperone protein mainly located in the endoplasmic reticulum (ER). This protein is normally present at low levels in adult cells but its expression is triggered by ER stress including glucose deprivation and hypoxia. In tumor cells, it is overexpressed with fraction of protein found at the cell surface. This paper presents the physiology of GRP78 in the context of ovarian cancer and its potential use as drug delivery systems targeting ovarian cancer cell.

scholarly journals Nanoparticulate targeted drug delivery systems - A Review

2020 ◽  
Vol 11 (2) ◽  
pp. 2505-2518
Author(s):  
Sindhuja Devaraj ◽  
Ganesh GNK
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Developing System ◽  
General Method

Nanoparticulate drug delivery system are the rapidly developing system, and nanoparticles are present in the size range of 1-100nm. Nanoparticles composed of various thermal, electrical, and optical property. Nanoparticles offers the potential advantages over the traditional dosage forms it is ascribable to the properties of nanoparticles. Nanoparticulate drug delivery system ensures the site-specific delivery of a drug(Targeting drug delivery) and aids in improving the efficacy of the new as well as old drugs and has the potential in crossing the various physiological barriers and also improves the therapeutic index of the drugs and increases the patient compliance. The objectives of this review is to classify the nanoparticles based on the different groups, surface properties of nanoparticles, describe the strategies of drug targeting, the necessity of nanoparticles their general method of preparation, different methods used in characterization, self- assembly and mechanism of drug release in a systemic manner. The potential advantages and limitations of various nanoparticulate drug delivery systems are also discussed elaborately.

scholarly journals RECENT APPROACHES INVOLVED IN COLONIC DRUG TARGETING FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE: A REVIEW

2021 ◽  
pp. 40-46
Author(s):  
SWAMINATHAN V. ◽  
VAIYANA RAJESH C.
Keyword(s):  
Drug Delivery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Adverse Reactions ◽  
Delivery Systems ◽  
Systemic Absorption ◽  
Conventional Drug ◽  
Inflammatory Bowel

The objective of the review is to present the contemporary approaches involved in colonic drug targeting for the therapy of inflammatory bowel disease (IBD). The adverse reactions and side-effects of the conventional drug delivery systems are largely on account of the systemic absorption of the drugs from the small intestine. Moreover, in current drug delivery systems, the drug has to be frequently administered and also in larger doses which greatly reduces patient compliance. Various approaches which are being described here mainly target the colonic region specifically for improved therapy of IBD, by increasing localization and accessibility of the drug to the target site. Also, these approaches will result in the reduction of dose and minimization of adverse effects combined with the use of conventional drug delivery systems.

Development of Drug Targeting and Delivery in Cervical Cancer

2018 ◽  
Vol 18 (8) ◽  
pp. 792-806 ◽  
Author(s):  
Urvashi Aggarwal ◽  
Amit Kumar Goyal ◽  
Goutam Rath
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Side Effects ◽  
Targeted Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Treatment Options ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Delivery Strategies

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.

Preparation and characterization of magnetic nanoparticles and their impact on anticancer drug binding and release processes moderated through a 1sttier dendrimer

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37391-37402 ◽  
Author(s):  
Shivani R. Pandya ◽  
Man Singh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Binding ◽  
Potential Use ◽  
Release Processes

MNPs show superparamagnetic character which moderates the structural ability of TTDMM to bind silibinin (SB) and methotrexate (MTX) anticancer drugs for their potential use in drug delivery systems.

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