Design, Synthesis, Antibacterial and Antifungal Activity of Novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones

The novel 2-[(E)-2-aryl-1-ethenyl]-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4- dihydro-4-quinolinones (4a-j) analogs were synthesized by Knoevenagel condensation of a solution of 2-methyl-3-(2-sulfanyl-1H-benzo[d]imidazole-5-yl)-3,4-dihydro-4-quinazolinone (3) with aromatic aldehyde in presence of catalytic amount of piperidine. Compounds (4a-j) showed significant biological activity against all the standard strains. All the synthesized compounds were characterized on the basis of their IR,1H NMR, MASS spectroscopic data and elemental analyses. All the compounds have been tested for antimicrobial and antifungal activity by the cup-plate method.

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Design, synthesis and antimicrobial activity of new biquinoline derivatives

Journal of the Serbian Chemical Society ◽

10.2298/jsc110630197s ◽

2012 ◽

Vol 77 (3) ◽

pp. 279-286 ◽

Cited By ~ 10

Author(s):

Nirav Shah ◽

Nimesh Shah ◽

Manish Patel ◽

Ranjan Patel

Keyword(s):

Antimicrobial Activity ◽

Antifungal Activity ◽

Efficient Method ◽

Ethyl Cyanoacetate ◽

Catalytic Amount ◽

Antibacterial And Antifungal Activity ◽

Design Synthesis ◽

Antibacterial And Antifungal

A simple and efficient method has been developed for the synthesis of some novel biquinoline derivatives bearing a thiazole moiety through a onepot three-component condensation of 2-chlro-3-formylquinolines, ethyl cyanoacetate and ?-enaminone using catalytic amount of piperidine in refluxing ethanol. These molecules were evaluated in vitro for their antibacterial and antifungal activity. Most of the compounds exhibited moderate antibacterial and antifungal activity against all the tested strains.

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Synthesis of new condensed coumarin derivatives

Facta universitatis - series Physics Chemistry and Technology ◽

10.2298/fupct0701085d ◽

2007 ◽

Vol 5 (1) ◽

pp. 85-88 ◽

Cited By ~ 4

Author(s):

Stojadin Dekic ◽

Vidoslav Dekic ◽

Branimirka Vucic ◽

Biljana Dekic ◽

Milan Dekic

Keyword(s):

Acid Hydrolysis ◽

Nmr Spectra ◽

Proton Nmr ◽

Catalytic Amount ◽

The Novel ◽

Coumarin Derivatives ◽

Elemental Analyses

Reactions of 4-chloro-2-oxo-2H-chromene-3-carbonitrile (1) with 4-methylpyridin- 2-ylamine (2) and 6-methoxy-benzothiazol-2-ylamine (3) in acetonitrile containing a catalytic amount of triethylamine gave the new coumarin derivatives 7-imino-10-methyl-7H- 5-oxa-7a,12-diaza-benzo[a]anthracen-6-one (4) and 7-imino-10-methoxy-7H-5-oxa-12- thia-7a,13-diaza-indeno[1,2-b]phenanthren-6-one (5) in 52 and 39% yields, respectively. The novel compounds were subjected to acid hydrolysis giving the corresponding oxoderivatives 10-methyl-5-oxa-7a,12-diaza-benzo[a]anthracene-6,7-dione (6) and 10- methoxy-5-oxa-12-thia-7a,13-diaza-indeno[1,2-b]phenanthrene-6,7-dione (7) in 64 and 58% yields, respectively. The structural assignments of the synthesized compounds were based on elemental analyses, IR and proton NMR spectra. .

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Friedel-Crafts Polyketones: Synthesis, Characterization and Antimicrobial Properties of Unsaturated Polyketones and Copolyketones Based on Difurfurylidene Cycloheptanone

International Journal of Polymer Science ◽

10.1155/2011/810628 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Nayef S. Al-Muaikel

Keyword(s):

Model Compound ◽

Antimicrobial Properties ◽

Morphological Properties ◽

H Nmr ◽

Dsc Measurements ◽

Protic Solvents ◽

Elemental Analyses ◽

New Type ◽

Antibacterial And Antifungal ◽

Tga And Dsc

A new type of unsaturated polyketones and copolyketones having cycloheptanone moiety in a p-conjugated main chain were synthesized via Friedel-Crafts reaction through the polymerization of the monomer: 2,7-bis furfurylidene cycloheptanoneIwith different diacid chlorides. The model compound was synthesized by reactingIwith benzoyl chloride and characterized by1H-NMR, IR, and elemental analyses. The polyketones and copolyketones were soluble easily in protic solvents like H2SO4and trifluoroacetic acid. The thermal properties of these polyketones and copolyketones were evaluated and correlated to their structural units by TGA and DSC measurements. The crystallinity of some polymers was tested by X-ray analyses; also the morphological properties of selected examples of poly and copolyketones were detected by SEM. All the polyketones were tested for their biological activity against bacteria, fungi, and yeast. It was observed that the majority of the polyketones and its copolymers synthesized can be used as antibacterial and antifungal agents.

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SYNTHESIS AND EVALUATION OF SOME SUBSTITUTED 2-AMINOTHIAZOLE DERIVATIVES FOR THEIR ANTITUBERCULAR, ANTIMICROBIAL & ANTIFUNGAL ACTIVITY

INDIAN DRUGS ◽

10.53879/id.49.01.p0024 ◽

2012 ◽

Vol 49 (01) ◽

pp. 24-32

Author(s):

S. R. Pattan ◽

◽

S. H Kale ◽

R. A. Mali ◽

S. S. Dengale ◽

...

Keyword(s):

Antifungal Activity ◽

Antifungal Agents ◽

Antitubercular Activity ◽

Diffusion Method ◽

Zone Of Inhibition ◽

Standard Drug ◽

E Coli ◽

H Nmr ◽

Antimicrobial And Antifungal Activity ◽

Micro Organisms

Millions of people are affected by infectious diseases caused by micro-organisms. Further the widespread microbial resistance had renewed the interest in quest for new antitubercular, antimicrobial & antifungal agents. The present study deals with synthesis & evaluation of some substituted 2-aminothiazole derivatives for their antitubercular, antimicrobial and antifungal activity. 2-aminothiazole derivatives were synthesized by treating substituted acetophenones with thiourea in presence of bromine to give 2-amino 4-substituted phenylthizole and then further treated with chloracetyl chloride to give 2-chloro-N-(4-substituted phenylthizole-2-yl)-acetamide which on refluxing with primary amine gives 15 derivatives. All the synthesized compounds were characterized by IR, H-NMR and elemental analysis.All the synthesized compounds were screened for their antibacterial activity against S. aureus and E. coli by using cup plate agar diffusion method. The activity was measured in terms of zone of inhibition and compared with standard drug ciprofloxacin, sulfonamide. The aminothiazole derivatives were evaluated for antitubercular activity and their result were compared with standard streptomycin.

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Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones

International Scholarly Research Notices ◽

10.1155/2014/439243 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Namratha Bhandari ◽

Santosh L. Gaonkar

Keyword(s):

Convenient Method ◽

Nmr Spectra ◽

Spectral Studies ◽

Antimicrobial Screening ◽

Antifungal Activities ◽

H Nmr ◽

Antibacterial And Antifungal Activities ◽

Elemental Analyses ◽

Antibacterial And Antifungal ◽

C Nmr

The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1H NMR, 13C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by 1H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral studies, formation of 2-amino-1,3,4-thiadiazoles from the isobenzofuran acyl thiosemicarbazides 11(a–h) is ruled out.

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Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

E-Journal of Chemistry ◽

10.1155/2008/876257 ◽

2008 ◽

Vol 5 (3) ◽

pp. 461-466 ◽

Cited By ~ 24

Author(s):

Y. Rajendra Prasad ◽

A. Lakshmana Rao ◽

R. Rambabu

Keyword(s):

Aqueous Solution ◽

Antimicrobial Activity ◽

Potassium Hydroxide ◽

Room Temperature ◽

Antimicrobial Agents ◽

Aromatic Aldehydes ◽

Plate Method ◽

H Nmr ◽

Antibacterial And Antifungal Activities ◽

Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

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Microwave Assisted Synthesis of Novel Imidazolopyridinyl Indoles as Potent Antioxidant and Antimicrobial Agents

Journal of Chemistry ◽

10.1155/2014/579612 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Jaiprakash S. Biradar ◽

Parveen Rajesab ◽

Sasidhar B. Somappa

Keyword(s):

Antimicrobial Agents ◽

Analytical Data ◽

Antimicrobial Activities ◽

Microwave Assisted Synthesis ◽

The Novel ◽

Design Synthesis ◽

Mass Spectral ◽

H Nmr ◽

Total Antioxidant ◽

Indole Analogues

We describe herein the design, synthesis, and pharmacological evaluation of novel series of imidazolopyridinyl indole analogues as potent antioxidants and antimicrobials. These novel compounds (3a–i) were synthesized by reacting 3,5-disubstituted-indole-2-carboxylic acid (1a–i) with 2,3-diamino pyridine (2) in excellent yield. The novel products were confirmed by their IR,1H NMR,13C NMR, mass spectral, and analytical data. These compounds were screened for their antioxidant and antimicrobial activities. Among the compounds tested,3a–dshowed the highest total antioxidant capacity, scavenging, and antimicrobial activities. Compounds3c-dand3g-hhave shown excellent ferric reducing activity.

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Synthesis, Antibacterial and Antifungal Activity of 5-Aryl Amido-6-Isopropyl-2-(Mercapto/Hydroxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl]-1,4-Dihydro Pyrimidine

International Letters of Chemistry Physics and Astronomy ◽

10.18052/www.scipress.com/ilcpa.51.54 ◽

2015 ◽

Vol 51 ◽

pp. 54-60

Author(s):

Vijay N. Bhadani ◽

Piyush A. Patel ◽

Heta D. Purohit ◽

Dipak M. Purohit

Keyword(s):

Antifungal Activity ◽

Ir Spectrum ◽

Acid Catalyst ◽

Antibacterial And Antifungal Activity ◽

Fungal Strains ◽

H Nmr ◽

Antibacterial And Antifungal

Various isopropylacetoacetanilides were treated with 4-(difluoromethoxy)-3-hydroxy benzaldehyde and thiourea/urea in the presence of acid catalyst to produce the 1,4-dihydropyrimidine derivatives (4a-5i and 5a-5i) with good yields. All the synthesized compounds were characterized by mass, 1H-NMR and IR spectrum, also evaluated for antibacterial and antifungal activity against two Gram +ve and two Gram-ve bacterial and fungi strains. The compounds 4e, 4g and 5d were found comparatively promising active against all the bacterial and fungal strains.

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Chemistry and Biological Evaluation of Some New Triazolopyrimidine Derivatives Containing Isopropyl Group

International Journal of Scientific Research in Science Engineering and Technology ◽

10.32628/ijsrset207266 ◽

2019 ◽

pp. 390-396

Author(s):

Janaki H. Chauhan ◽

Haresh K. Ram

Keyword(s):

Antifungal Activity ◽

1H Nmr ◽

Biological Evaluation ◽

Spectroscopic Techniques ◽

Efficient Synthesis ◽

Antibacterial And Antifungal Activity ◽

Isopropyl Group ◽

Elemental Analyses ◽

Antibacterial And Antifungal

An efficient Synthesis of a novel series of N,7-bis(substitutedphenyl)-4,7-dihydro-5-isopropyl-[1,2,4]triazolo-[1,5-a]pyrimidine-6-carboxamide (4a-j) was accomplished from N-(substituedphenyl)-4-methyl-3-oxopentanamide, 3-amino-1,2,4-triazole and different aldehyde reflex 20 min with DMF and then after the cooling product was obtained. All the recently synthesized compounds were characterized by the Mass, IR, 1H-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were assessed for their antibacterial and antifungal activity.

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