scholarly journals A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zhao-min Liu ◽  
Suzanne C. Ho ◽  
Yu-ming Chen ◽  
Jean Woo
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Postmenopausal Women ◽  
Fat Mass ◽  
Controlled Trial ◽  
Milk Powder ◽  
Soy Flour ◽  
Low Fat ◽  
Double Blind ◽  
Good Compliance

Objectives. This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers.Methods. 270 eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention.Results. 253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass. Conclusion. Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.govNCT01270737.

scholarly journals Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

2011 ◽  
Vol 108 (6) ◽  
pp. 1017-1024 ◽  
Author(s):  
Marjo H. J. Knapen ◽  
Leon J. Schurgers ◽  
Martin J. Shearer ◽  
Paul Newman ◽  
Elke Theuwissen ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Postmenopausal Women ◽  
Vitamin K ◽  
Fat Mass ◽  
Controlled Trial ◽  
High Serum ◽  
Cross Sectional ◽  
Dependent Protein ◽  
Sectional Analysis

Osteocalcin (OC) is a vitamin K-dependent protein found in bone and in circulation. High serum γ-carboxylated OC reflects a high, and high uncarboxylated OC (ucOC) reflects a low vitamin K status. A revolutionary hypothesis is that ucOC acts as a hormone improving glucose handling and reducing fat mass. The objective was to test the logical extrapolation of the ucOC hormone hypothesis to humans that elevated ucOC is associated with higher body weight, BMI and fat mass. In a cross-sectional analysis, the associations of vitamin K status with circulating adiponectin and body composition were investigated in 244 postmenopausal women (study I). The effects of vitamin K treatment on adiponectin, body weight and BMI were investigated in archived samples from forty-two young men and women who received varying doses of menaquinone-7 during 12 weeks (study II) and from a cohort of 164 postmenopausal women who participated in a 3-year placebo-controlled trial on 45 mg menaquinone-4 (MK-4) (study III). No association was found between vitamin K status and circulating adiponectin before or after vitamin K supplementation. A higher carboxylation of OC was significantly correlated with lower body weight, BMI and fat mass of the trunk. Women taking MK-4 maintained their baseline body weight and BMI, whereas women taking placebo showed significant increases in both indices. These findings demonstrate that a high vitamin K status of bone has no effect on circulating adiponectin in healthy people and long-term vitamin K supplementation does not increase weight in healthy postmenopausal women.

scholarly journals The Effect of Foeniculum Vulgare (Fennel) on Body Composition in Postmenopausal Women with Excess Weight: A Double-blind Randomized Placebo-controlled Trial

2017 ◽  
Vol 23 (3) ◽  
pp. 166 ◽  
Author(s):  
Nafiseh Saghafi ◽  
Masumeh Ghazanfarpour ◽  
Talat Khadivzadeh ◽  
Masoudeh Babakhanian ◽  
Maliheh Afiat
Keyword(s):  
Body Composition ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Excess Weight ◽  
Foeniculum Vulgare ◽  
Double Blind

scholarly journals A multicenter, double-blind, randomized, placebo-controlled trial to evaluate the effect of consuming Growing Up Milk “Lite” on body composition in children aged 12–23 mo

2019 ◽  
Vol 109 (3) ◽  
pp. 576-585 ◽  
Author(s):  
Clare R Wall ◽  
Rebecca J Hill ◽  
Amy L Lovell ◽  
Misa Matsuyama ◽  
Tania Milne ◽  
...  
Keyword(s):  
Body Composition ◽  
Young Children ◽  
Body Fat ◽  
Fat Mass ◽  
Controlled Trial ◽  
Mean Difference ◽  
Cow Milk ◽  
Growing Up ◽  
Double Blind ◽  
Percentage Body Fat

ABSTRACT Background Growing Up Milk (GUM) was developed to assist young children in meeting their nutritional requirements during the second year of life. However, there is limited evidence that GUM improves nutritional status and growth in young children. Objectives To evaluate the effect of consuming Growing Up Milk “Lite” (GUMLi) (reduced protein with synbiotics and micronutrients added) compared with standard cow milk as part of a whole diet for 1 y on body composition at 2 y of age. Methods GUMLi Trial was a multicenter, double-blind, randomized placebo-controlled trial conducted in Auckland and Brisbane. Healthy 1-y-olds were recruited and randomly assigned to receive either GUMLi or standard cow milk for 12 mo as part of a whole diet. The primary outcome was percentage body fat at 2 y of age measured by bioelectrical impedance. All regression models adjusted for baseline outcome and study center. Results 160 children (80 per arm) were randomly assigned, and 134 (67 per arm) were included in the modified intention-to-treat analyses. The mean percentage body fat at 12 mo was 23.3% (SD 7.9) in the GUMLi group and 25.7% (SD 7.2) in the cow milk group. After adjusting for baseline outcome and study location, the estimated mean difference in percentage body fat between the intervention and control at 12 mo was −2.19% (95% CI: −4.24, −0.15; P = 0.036). Per-protocol analysis showed a similar effect (mean difference: −2.09%; 95% CI: −4.16, −0.03; P = 0.047). Both fat mass and the fat mass index were significantly lower in the GUMLi group at 12 mo than in the cow milk group. Conclusions At 2 y of age, children who consumed a GUM with a lower protein content than cow milk over 12 mo had a lower percentage of body fat. This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12614000918628.

scholarly journals Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial

2010 ◽  
Vol 162 (2) ◽  
pp. 371-376 ◽  
Author(s):  
Didy E Jacobsen ◽  
Monique M Samson ◽  
Marielle H Emmelot-Vonk ◽  
Harald J J Verhaar
Keyword(s):  
Body Composition ◽  
Placebo Group ◽  
Muscle Strength ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Group Versus ◽  
The Body ◽  
Fat Free Mass ◽  
Double Blind ◽  
Double Blind Placebo

ObjectiveTo compare the effects of raloxifene and placebo on body composition and muscle strength.DesignRandomized, double-blind, placebo-controlled trial involving 198 healthy women aged 70 years or older conducted between July 2003 and January 2008 at the University Medical Centre, Utrecht, The Netherlands.MethodsParticipants were randomly assigned to receive raloxifene 60 mg or placebo daily for 12 months. Measurements were taken at baseline, 3, 6, and 12 months, and change from baseline was calculated. Main outcome measures were body composition (bioelectrical impedance analysis), muscle strength, and muscle power (maximum voluntary isometric knee extension strength, explosive leg extensor power, and handgrip strength).ResultsAt 12 months, the body composition of women taking raloxifene was significantly different from that of women taking placebo: fat-free mass (FFM) had increased by a mean of 0.83 (2.4) kg in the raloxifene group versus 0.03 (1.5) kg in the placebo group (P=0.05), and total body water had increased by a mean of 0.6 (1.8) litres in the raloxifene group versus a decrease of 0.06 (1.1) litres in the placebo group (P=0.02). Muscle strength and power were not significantly different.ConclusionRaloxifene significantly changed body composition (increased FFM; increased water content) compared with placebo in postmenopausal women.

scholarly journals Helianthus annuus Seed Extract Affects Weight and Body Composition of Healthy Obese Adults during 12 Weeks of Consumption: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1080 ◽  
Author(s):  
Aurélie Leverrier ◽  
David Daguet ◽  
Wim Calame ◽  
Pierre Dhoye ◽  
Shyam Prasad Kodimule
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Pilot Study ◽  
Helianthus Annuus ◽  
Fat Mass ◽  
Seed Extract ◽  
Herbal Extract ◽  
Blood Cholesterol ◽  
Obese Adults ◽  
Double Blind

The aim of this pilot study was to evaluate the effects of a sunflower (Helianthus annuus) seed extract, standardized for 40% chlorogenic acids on weight and body composition of obese adults. Fifty subjects were randomly assigned to sunflower extract or isocaloric placebo groups, receiving respectively 500 mg/day of treatment for 12 weeks. At the end of the intervention, a significant decrease in body weight, Body Mass Index (BMI), and waist circumference was observed, especially for obese female subjects above 30 years. Those changes were associated with modified body composition related to fat mass loss. A decrease in blood cholesterol was also observed, supporting the potential action of sunflower extract on lipid metabolism. It was concluded that consumption of sunflower extract has a beneficial effect on body weight, fat mass, and lipid profile, providing evidence for its use as a natural anti-obesity herbal extract.

scholarly journals Effects of Resistance Training and Soy Isoflavone on Body Composition in Postmenopausal Women

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Fábio Lera Orsatti ◽  
Eliana Aguiar Petri Nahas ◽  
Jorge Nahas-Neto ◽  
Nailza Maesta ◽  
Cláudio Lera Orsatti ◽  
...  
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Muscle Strength ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Fat Mass ◽  
Whole Body ◽  
Additive Effects ◽  
Double Blind ◽  
Soy Isoflavone

Objective. To investigate the independent and additive effects of resistance training (RT) and soy isoflavone (ISO) on body composition in postmenopausal women (PW).Method. This study used a placebo-controlled, double-blind (soy), randomized (ISO versus placebo) × (RT versus No RT) design. A total of 80 PW, aged 45–70 years, were randomly (71 completed 9-months intervention): RT + ISO (n=15), No RT + ISO (n=20), RT + placebo (n=18), and No RT + placebo (n=18). ISO received 100 mg a day of isoflavone; and to RT attended supervised resistance training sessions. At baseline and 9-months, fat and muscle mass were estimated by DXA. ANOVA and testtwere used.Results. RT groups showed significantly increased muscle strength (35.2%) and muscle mass (1.4%). Exercising attenuated gains in fat trunk and % body fat (P<.05). Significant decreases in muscle mass (−1.8%) and increases in fat mass of the whole-body (1.6%) and trunk (9.7%) was found in no-RT groups (P<.05). In ISO groups, there were no differences in body composition and muscle strength. ISO and RT had no additive effects.Conclusion. In PW: RT improved muscle mass and strength and attenuated gain of fat mass; ISO did not alter body composition and muscle strength; there were no additive effects of RT and ISO.

scholarly journals Effect of whole soy and isoflavones daidzein on bone turnover and inflammatory markers: a 6-month double-blind, randomized controlled trial in Chinese postmenopausal women who are equol producers

2020 ◽  
Vol 11 ◽  
pp. 204201882092055
Author(s):  
Zhao-min Liu ◽  
Bailing Chen ◽  
Shuyi Li ◽  
Guoyi Li ◽  
Di Zhang ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Inflammatory Markers ◽  
Controlled Trial ◽  
Milk Powder ◽  
Soy Flour ◽  
Type I ◽  
Randomized Controlled ◽  
Chinese Postmenopausal Women

Background: Human studies have demonstrated the beneficial effects of soy or isoflavones on bone metabolism. However, conflicting data remain. Equol is the intestinal metabolite of the isoflavone daidzein. The health benefits of soy are more pronounced in equol producers than those not producing equol. This 6-month randomized controlled trial aimed to examine the effect of whole soy (soy flour) and purified daidzein on bone turnover markers (BTMs) in Chinese postmenopausal women who are equol producers. Methods: A total of 270 eligible women were randomized to either one of the three isocaloric supplements as follows: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) given as a solid beverage daily for 6 months. The following fasting venous samples were collected at the baseline and end of the trial to analyze BTMs: serum cross-linked C-telopeptides of type I collagen, bone-specific alkaline phosphatase, osteocalcin, procollagen type I N-terminal propeptide, and 25(OH)D3. Inflammation-related biomarkers, such as serum interleukin-6, tumor necrosis factor-alpha, C-reactive protein, transferrin, and homocysteine, were also tested to explore potential mechanisms. Results: A total of 253 subjects validly completed the study protocol. Urinary isoflavones suggested a good compliance to the treatments. Intention-to-treat and per-protocol analyses indicated no significant difference in the 6-month or percentage changes in the parameters of bone metabolism and inflammatory markers among the three treatment groups. Conclusions: Whole soy and purified daidzein at provided dosages exhibited no significant effect on the bone metabolism and inflammation levels among Chinese equol-producing postmenopausal women. Trial registration: ClinicalTrials.gov identifier NCT01270737.

The effects of pre-sleep consumption of casein protein on next-morning measures of RMR and appetite compared between sedentary pre- and postmenopausal women

2020 ◽  
Vol 125 (2) ◽  
pp. 121-128
Author(s):  
Christopher M. Schattinger ◽  
J. T. Leonard ◽  
C. L. Pappas ◽  
M. J. Ormsbee ◽  
L. B. Panton
Keyword(s):  
Body Composition ◽  
Postmenopausal Women ◽  
Repeated Measures ◽  
Analogue Scale ◽  
Controlled Trial ◽  
Premenopausal Women ◽  
Double Blind ◽  
Repeated Measures Anova ◽  
Casein Protein ◽  
One Way Anova

AbstractThe purpose of the present study was to compare next-morning responses of RMR and appetite to pre-sleep consumption of casein protein (CP) in pre- and postmenopausal women. The study was a randomised, crossover, double-blind, placebo-controlled trial. Seven sedentary premenopausal (age: 19·9 (sd 1·2) years; BMI: 23·1 (sd 2·6) kg/m2) and seven sedentary postmenopausal (age: 56·4 (sd 4·9) years; BMI: 26·3 (sd 3·5) kg/m2) women participated. During visit one, anthropometrics and body composition were measured. Following visit one, subjects consumed either CP (25 g) or placebo (PL) ≥2 h after their last meal and ≤30 min prior to sleep on the night before visits two and three. Visits two and three occurred ≥1 week after visit one and were 48 h apart. During visits two and three, RMR (VO2), RER and appetite were measured via indirect calorimetry and visual analogue scale, respectively. Anthropometrics and body composition were analysed by one-way ANOVA. RMR and measures of appetite were analysed using a 2 × 2 (menopause status × CP/PL) repeated-measures ANOVA. Significance was accepted at P ≤ 0·05. RMR was significantly lower in postmenopausal compared with premenopausal women under both conditions (P = 0·003). When consumed pre-sleep CP did not alter RMR, RER or appetite compared with PL when assessed next morning in pre- and postmenopausal women. These data contribute to growing evidence that pre-sleep consumption of protein is not harmful to next-morning metabolism or appetite. In addition, these data demonstrate that menopause may not alter next-morning RMR, RER or appetite after pre-sleep consumption of CP.

scholarly journals Once/Day Provision of Essential Amino Acid Enriched Meal Replacement Improves Body Composition and Physical Function in Obese Elderly

2021 ◽  
Author(s):  
Melynda Coker ◽  
Kaylee Ladd ◽  
Zeinab Barati ◽  
Carl Murphy ◽  
Terry Bateman ◽  
...  
Keyword(s):  
Amino Acids ◽  
Body Composition ◽  
Physical Function ◽  
Body Mass ◽  
Fat Mass ◽  
Controlled Trial ◽  
Essential Amino Acids ◽  
Thigh Muscle ◽  
Meal Replacement ◽  
Double Blind

We have previously demonstrated that the acute ingestion of essential amino acids may augment net protein balance in the elderly. Using a double blind, randomized controlled trial, our objective was to compare an experimental meal replacement enriched with essential amino acids (EMR) compared to a commercial meal replacement (Optifast&reg;) provided once/day (q.d.) for four weeks on body composition and physical function in older, obese participants. Twenty-seven individuals (69&plusmn;5 yrs; body mass index of 32&plusmn;4 kg/m2) were randomly assigned to EMR (n=13) or Optifast&reg; (n=15) supplementation. Measurements of body composition, skeletal muscle cross-sectional area (CSA), intrahepatic lipid and physical function were completed pre- and post-supplementation. Body mass, fat mass, and visceral fat mass were reduced with EMR but not altered with Optifast&reg;. Thigh muscle CSA increased ( 4.1 &plusmn; 1.9 cm2, P = 0.03) with EMR but not Optifast&reg;. There was a significant increase in the distance covered during the six-minute walk test with EMR ( 21&plusmn;26 m) but no change in Optifast&reg; ( 22&plusmn;54 m). Improvements in body composition and physical function support the efficacious use of EMR-based meal replacements in the obese elderly.

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