Vitamin D Supplementation for the Treatment of Acute Childhood Pneumonia: A Systematic Review

Background. Studies have found an increased incidence of vitamin D deficiency in children with pneumonia; however, there is no conclusive data regarding the direct effect of vitamin D supplementation in acute pneumonia. Methods. A comprehensive search was performed of the major electronic databases till September 2013. Randomized controlled trials (RCTs) comparing treatment with vitamin D3 versus placebo in children ≤5 years old with pneumonia were included. Results. Out of 32 full text articles, 2 RCTs including 653 children were eligible for inclusion. One trial used a single 100,000 unit of oral vitamin D3 at the onset of pneumonia. There was no significant difference in the mean (±SD) number of days to recovery between the vitamin D3 and placebo arms (P=0.17). Another trial used oral vitamin D3 (1000 IU for <1 year and 2000 IU for >1 year) for 5 days in children with severe pneumonia. Median duration of resolution of severe pneumonia was similar in the two groups (intervention, 72 hours; placebo, 64 hours). Duration of hospitalization and time to resolution of tachypnea, chest retractions, and inability to feed were also comparable between the two groups. Conclusions. Oral vitamin D supplementation does not help children under-five with acute pneumonia.

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The Clinical Effect of Oral Vitamin D2 Supplementation on Psoriasis: A Double-Blind, Randomized, Placebo-Controlled Study

Dermatology Research and Practice ◽

10.1155/2019/5237642 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9 ◽

Cited By ~ 9

Author(s):

Wareeporn Disphanurat ◽

Wongsiya Viarasilpa ◽

Panlop Chakkavittumrong ◽

Padcha Pongcharoen

Keyword(s):

Vitamin D ◽

Placebo Group ◽

Adverse Events ◽

Clinical Effect ◽

Vitamin D Supplementation ◽

P Value ◽

Vitamin D2 ◽

Oral Vitamin ◽

Pasi Score ◽

The Mean

Background. There are limited randomized controlled trials of oral vitamin D supplementation in psoriasis, especially in Asia, and the results are inconclusive. Objective. To investigate the clinical effect of oral vitamin D supplementation on psoriasis. Methods. Patients with psoriasis were randomized to receive vitamin D2 60,000 IU or similar-looking placebo pills once every 2 weeks for 6 months. The primary outcome was improvement of the Psoriasis Area and Severity Index (PASI) score at 3 and 6 months after treatment. Serum levels of 25(OH)D, calcium, phosphate, parathyroid hormone, and C-reactive protein and adverse events were monitored. The chi-square test, Fisher’s exact test, Student’s t-test, and Spearman’s correlation analysis were used in statistical analysis. Results. Of 50 subjects screened, 45 were eligible and randomized to the oral vitamin D2 group (n=23) or placebo group (n=22). At enrollment, the mean PASI score was 4.45, and 26.7% of patients had vitamin D deficiency. At 3 months, the oral vitamin D2 group had significantly higher PASI improvement than the placebo group (mean PASI improvement: 1.43 versus [vs.] -0.33, p-value=0.034; mean %PASI improvement: 34.21% vs. -1.85%, p-value=0.039). The mean serum 25(OH)D level was significantly higher in the oral vitamin D group than in the placebo group (27.4 vs. 22.4 ng/mL, p-value=0.029). Serum 25(OH)D concentrations were significantly inversely correlated with PASI scores at the 6-month follow-up. No major adverse event was observed overall. Conclusion. Oral vitamin D2 supplementation in patients with psoriasis increased the serum vitamin D level and significantly improved the treatment outcome without increasing adverse events. Trial Registration. This trial is registered with Thai Clinical Trials Registry TCTR20180613001.

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Effects of Stratified Vitamin D Supplementation in Middle-Aged and Elderly Individuals with Vitamin D Insufficiency

Hormone and Metabolic Research ◽

10.1055/a-0746-5031 ◽

2018 ◽

Vol 50 (10) ◽

pp. 747-753

Author(s):

Yanhui Lu ◽

Xiaomin Fu ◽

Lili Zhang ◽

Minyan Liu ◽

Xiaoling Cheng ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Intervention Group ◽

Vitamin D Insufficiency ◽

Vitamin D Supplementation ◽

Control Group ◽

Middle Aged ◽

Oral Vitamin ◽

Severe Vitamin

AbstractThe incidence of vitamin D deficiency is high globally, and vitamin D supplementation draws particular attention. The objective of this study was to investigate the effects of stratified vitamin D supplementation in middle-aged and elderly individuals with vitamin D insufficiency in Beijing. A total of 448 subjects aged over 40 years old were selected from a community in Beijing. Among them, 100 middle-aged and elderly people with vitamin D insufficiency were randomly selected on a voluntary basis. They were further divided into control group and intervention group. The control group received health education and lifestyle guidance, and the intervention group received lifestyle guidance and vitamin D supplementation for nine months. The doses were stratified as follows: for vitamin D insufficiency, oral vitamin D3 supplement was given at 5000 IU/w; for mild vitamin D deficiency, oral vitamin D3 supplement was given at 10 000 IU/w; for severe vitamin D deficiency, oral vitamin D3 supplement was given at 15 000 IU/w. Safety evaluation was conducted after three-month treatment. The intervention group consisted of 8%, 62%, and 30% of cases who had vitamin D insufficiency, mild vitamin D deficiency, and severe vitamin D deficiency, respectively, which were similar with the control group. It showed that the blood 25(OH)D level increased significantly in the intervention group, from 14.30±4.30 ng/ml to 33.62±6.99 ng/ml (p<0.001), in contrast to insignificant change in the control group. Stratified vitamin D supplementation effectively increased the blood 25(OH)D level, as well as the number of cases with corrected vitamin D insufficiency or deficiency.

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Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

10.21203/rs.3.rs-517022/v1 ◽

2021 ◽

Author(s):

Ying Lin ◽

Huanjun Su ◽

Jianbin Wu ◽

Muzhi Yuan ◽

Yong Zhang

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Vitamin D3 ◽

Serum Vitamin ◽

Control Group ◽

Oral Vitamin ◽

Serum Vitamin D ◽

The Mean ◽

Experimental Group ◽

Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

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Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

International Journal of Endocrinology ◽

10.1155/2010/235035 ◽

2010 ◽

Vol 2010 ◽

pp. 1-5 ◽

Cited By ~ 22

Author(s):

Carol L. Wagner ◽

Cindy Howard ◽

Thomas C. Hulsey ◽

Ruth A. Lawrence ◽

Sarah N. Taylor ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Vitamin Supplementation ◽

Oral Vitamin ◽

Oil Emulsion ◽

Hydroxyvitamin D ◽

Breastfed Infants ◽

25 Hydroxyvitamin D ◽

The Mean ◽

Nutritional Vitamin

Objective. To examine the effectiveness of oral vitamin (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.Design. As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin /day starting at one month of age. Infant 25(OH)D levels (mean S.D.) were measured by RIA at visits 1, 4, and 7.Results. The infant mean S.D. 25(OH)D at baseline was 16.0 9.3 ng/mL (range 1.0–40.8; ); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency). The mean levels increased to 43.6 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 12.1 ng/mL (range 18.9–67.2). The change in values between 1 and 4 months and 1 and 7 months was statistically significant , and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 .Conclusions. Oral vitamin supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.

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Effect of Vitamin-D supplementation in adults presenting with chronic lower back pain

Journal of Rawalpindi Medical College ◽

10.37939/jrmc.v24i2.1399 ◽

2020 ◽

Vol 24 (2) ◽

pp. 161-165

Author(s):

Rahman Rasool Akhtar ◽

Riaz Ahmed ◽

Sabeen Ashraf ◽

Omair Ashraf ◽

Umer Shafique ◽

...

Keyword(s):

Vitamin D ◽

Back Pain ◽

Pain Score ◽

Lower Back Pain ◽

Vitamin D3 ◽

Vitamin D Supplementation ◽

Chronic Lower Back Pain ◽

Oral Vitamin ◽

Lower Back ◽

Vitamin D Levels

Background: Chronic pain in the lower back of adults is a common problem and mostly associated with Vitamin D deficiency. Along with standard treatment, vitamin D supplementation can help in early and better relief from back pain. Objective: To assess the effectiveness of vitamin D supplementation in patients with chronic lower back pain. Study Design & Methods: This Quasi-experimental trial was conducted at Department of Orthopaedics, Benazir Bhutto Hospital for 6 months. The patients aged between 15 to 55 years with chronic low back pain were included and pain score was noted by using a visual analogue scale (VAS). Patients were prescribed with oral vitamin D3 with a dose of 50,000 IU weekly for eight weeks (induction phase) and oral vitamin D3 with a dose of 50,000 IU once monthly for 6 months (maintenance phase). Outcome parameters included pain measured by VAS, functional disability by modified Oswestry disability questionnaire scores, and Vitamin-D3 levels at baseline,2, 3 and 6 months post-supplementation. Results: Mean age of patients was 44.21± 11.92 years.There were 337 (56.2%) male patients while 263 (43.8%) female patients. Baseline mean vitamin-D levels were 13.32 ± 6.10 ng/mL and increased to 37.18 ± 11.72 post supplementation (P < 0.0001). There was a significant decrease in the pain score after 2nd, 3rd& 6th months (61.7 ± 4.8, 45.2 ± 4.6 & 36.9 ± 7.9, respectively) than 81.2 ± 2.4 before supplementation (P < 0.001). The modified Oswestry disability score also showed significant improvement after 2nd, 3rd& 6thmonths (35.5 ± 11.4, 30.2 ± 9.4 & 25.8 ± 10.6, respectively) as compared to baseline 46.4 ± 13.2 (P < 0.001). About 418 (69.7%) patients attained normal levels after 6 months. Conclusion: Prescription of Vitamin D in addition to standard therapy for chronic lower back pain can be beneficial in getting relief from pain and improving the functional ability of the patient.

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The efficacy of vitamin D3 supplementation in increasing 25-hydroxyvitamin D levels in childhood vitiligo patients receiving 308-nm-excimer light phototherapy

Dermatology Reports ◽

10.4081/dr.2019.8049 ◽

2019 ◽

Author(s):

Reiva Farah Dwiyana ◽

Pramita K.C. Nugrahaini ◽

D.P. Larasati ◽

Inne Arline Diana ◽

Reti Hindritiani ◽

...

Keyword(s):

Vitamin D ◽

Combination Therapy ◽

Vitamin D3 ◽

Vitamin D Supplementation ◽

Oral Vitamin ◽

Once Daily ◽

Hydroxyvitamin D ◽

Group I ◽

Vitamin D3 Supplementation ◽

25 Hydroxyvitamin D

Vitamin D deficiency is a condition often found in various autoimmune diseases, including vitiligo. There were clinical improvements in autoimmune patients who had been given oral vitamin D supplementation, as well as vitiligo patients. This study aimed to analyze the comparison effect of a combination therapy of 308-nmexcimer light phototherapy and vitamin D3 supplementation toward 308-nm-excimer light phototherapy alone to increase of serum 25-(OH)D levels in childhood vitiligo patients. Subjects consisted of 16 childhood vitiligo patients that divided into two groups; group I was given a combination of 308-nm-excimer light phototherapy and 5000 IU of vitamin D3 supplement once daily, while group II was given monotherapy of excimer light. There were highly significant increase of 25-(OH)D serum in both groups which were 324.00±119.066% and 29.84±36.106%, respectively. The very significant result was seen in a comparison of average increased of serum 25-(OH)D levels between both groups. The study concluded that combination of 308-nm-excimer light phototherapy and vitamin D3 supplementation gave a better effect than phototherapy only to increase of serum 25- (OH)D levels in childhood vitiligo patients.

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Investigation of the outcome of patients with hip fractures using vitamin D3

European Journal of Translational Myology ◽

10.4081/ejtm.2018.7372 ◽

2018 ◽

Vol 28 (3) ◽

Cited By ~ 1

Author(s):

Ahmadreza Behrouzi ◽

Hojat Hejazi ◽

Alireza Kamali ◽

Hoseinali Hadi

Keyword(s):

Vitamin D ◽

Hip Fractures ◽

Vitamin D3 ◽

Vitamin D Supplementation ◽

Radiographic Examination ◽

Fracture Union ◽

Double Blind ◽

Significant Difference ◽

Important Health ◽

Group B

Hip fracture is one of the important health problems of human societies. The aim of this study was to investigate the outcome of patients with this fracture using vitamin D3. This double-blind clinical trial was performed on 100 patients with hip fractures who referred to Valiasr Hospital. All specimens were evaluated for vitamin D3. Group A have had vitamin D3 in the normal range and received a dose of 50,000 vitamin D3 as blouse. Group B included individuals with hip fractures that did not have normal vitamin D3 levels. In this group, individuals received a dose of 50,000 units vitamin D3 in the form of muscular blouse, and then 50,000 units of vitamin D3 were given orally each week up to 12 weeks after surgery. After surgery, both groups were examined clinically and radiologically for ulcer and fracture healing. Moreover, mortality was checked 2 weeks after surgery and each month until healing. There was no significant difference in radiographic examination in the two groups in the term of adhesion and fracture union (P < 0.05). The formation of the union in the clinical examination 4 and 8 weeks after treatment in two groups showed significant difference. The formation of union in clinical presentation 4 weeks and 8 weeks after treatment in two groups showed significant difference (P = 0.005; P = 0.036). The results showed that a group with low vitamin D, but with supplementation, had more fracture union after 4 and 8 weeks after starting treatment. Vitamin D supplementation could improve patients' condition 4 and 8 weeks after treatment.

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Effect of Vitamin D Supplement on Vulvovaginal Atrophy of the Menopause

Nutrients ◽

10.3390/nu12092876 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2876 ◽

Cited By ~ 1

Author(s):

Thawinee Kamronrithisorn ◽

Jittima Manonai ◽

Sakda Arj-Ong Vallibhakara ◽

Areepan Sophonsritsuk ◽

Orawin Vallibhakara

Keyword(s):

Vitamin D ◽

Postmenopausal Women ◽

Controlled Trial ◽

Placebo Treatment ◽

Vitamin D Supplementation ◽

Oral Vitamin ◽

Vulvovaginal Atrophy ◽

Vaginal Ph ◽

Vaginal Health ◽

The Mean

The effects of oral vitamin D supplements on vaginal health in postmenopausal women with vulvovaginal atrophy (VVA) was evaluated. A double-blinded, randomized placebo-controlled trial was conducted for 12 weeks to investigate changes on vaginal maturation index (VMI), vaginal pH, and the visual analog scale (VAS) of VVA symptoms. The vitamin D group received oral ergocalciferol, at 40,000 IU per week, while the placebo group received an identical placebo capsule. Eighty postmenopausal women were enrolled. There were no significant differences in baseline characteristics between both groups. In an intention-to-treat analysis, VMI, vaginal pH, and VAS of VVA symptoms showed no significant differences between both groups at the six and 12 weeks. However, the mean difference of VMI in the vitamin D group between baseline and at six weeks showed significant improvement (5.5 + 16.27, p <0.05). Moreover, the mean vaginal pH and VAS of VVA patients in the vitamin D group were significantly improved at both six and 12 weeks compared to baseline. The oral vitamin D supplementation for 12 weeks potentially improves vaginal health outcomes in postmenopausal women with VVA symptoms, demonstrated by the improved mean VMI, vaginal pH, and VAS at six and 12 weeks between baseline, however, no significant differences were observed from the placebo treatment.

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Evaluation of role of vitamin-D levels in osteoporosis

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20172110 ◽

2017 ◽

Vol 4 (3) ◽

pp. 701

Author(s):

Shambhu Prasad ◽

Sharma B. P. ◽

. Saurabh

Keyword(s):

Vitamin D ◽

Standard Deviation ◽

Bone Strength ◽

Vitamin D3 ◽

Serum Vitamin ◽

Vitamin D Supplementation ◽

Control Group ◽

T Score ◽

Vitamin D Levels ◽

The Mean

Background: Osteoporosis is a serious, worldwide, and growing health problem; WHO has estimated the 30% of all women, older than 50 years (post-menopausal) has osteoporosis. Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Bone strength reflects the integration of two main features: bone density and bone quality.Methods: After clinical examination, patients were subjected to lab and radiological investigation as under: complete hemogram with ESR, serum calcium, phosphate, alkaline phosphatase, parathyroid hormone, 25 (OH) vitamin-D, KFT, LFT, DEXA scan. From above data, vitamin-D levels DEXA scan (t-score) was collected and statistically analysed.Results: 53 radiologically established cases by DEXA score (spine) of osteoporosis/osteopenia and 50 persons in control group of the age and sex match with normal DEXA score, presenting to OPD of central institute of orthopaedics, VMMC and Safdarjung Hospital were selected. The mean vitamin D3 level in cases was 19.37ng/ml with standard deviation of 10.2. Range of serum vitamin D3 levels in cases was from 7 to 51.2. Whereas mean vitamin D3 level in control group was 25.92 ng/ml with standard deviation of 7.24. Range of serum vitamin D3 levels in controls was from 10 to 35.5. The mean vitamin D levels of cases and control was 19.735±10.2 and 25.92±7.2 ng/ml respectively, these values were compared by using student t test and results were found to be statistically significant (P= 0.0001). The mean T score in spine cases was -2.59 with standard deviation of 0.92. Range of T score in cases was from -5.1 to -1. Whereas, mean T score in control group was -0.26 with standard deviation of 0.68. Range of T score in controls was from -0.9 to 1.4. The mean T score spine of cases and controls was -2.59±0.92 and -0.264±0.68 respectively, these values were compared by using student t test and results were found to be statistically significant (P = 0.0001).Conclusions: Study recommend that, vitamin D supplementation should be given to patients with osteopenia/osteoporosis. Further prospective studies to firmly establish the relationship between vitamin D and osteoporosis as well as evaluation of vitamin D supplementation in osteoporosis are needed.

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Effect of Vitamin D Supplementation on Lipid Profile in Vitamin D-Deficient Children with Type 1 Diabetes and Dyslipidemia

Hormone Research in Paediatrics ◽

10.1159/000500829 ◽

2019 ◽

Vol 91 (5) ◽

pp. 311-318 ◽

Cited By ~ 4

Author(s):

Mona Hafez ◽

Noha Musa ◽

Sahar Abdel Atty ◽

Mohamed Ibrahem ◽

Nehal Abdel Wahab

Keyword(s):

Vitamin D ◽

Lipid Profile ◽

Vitamin D Supplementation ◽

Lipid Profiles ◽

Mean Difference ◽

Hydroxyvitamin D ◽

Significant Difference ◽

Patients With Diabetes ◽

History Of ◽

The Mean

Background: Vitamin D (VD) was suggested to have both direct and indirect effects on modifying lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity. Objectives: To detect the relationship between serum 25-hydroxyvitamin D (25OHD) and lipid profiles in dyslipidemic T1D patients and study the effect of VD supplementation on lipid profiles of VD-deficient T1D patients. Methods: Fifty patients with T1D (for >2 years) and dyslipidemia were included. 25OHD was assessed and patients were divided accordingly into 2 groups: VD sufficiency (>30 ng/mL) and VD deficiency (VDD) or insufficiency (<29 ng/mL) who were allocated to VD3 supplementation for 4 months, then lipid profile was reevaluated in both groups. Results: Thirty patients had VDD, while 20 patients had VD sufficiency. There was no significant correlation between 25OHD and different study parameters (p > 0.05). A significant difference was found among both groups in the family history of coronary heart disease (p = 0.036) and free tetraiodothyronine 4 (p = 0.035). After 4 months of VD supplementation in VDD group, the mean difference (at 0 and 4 months) in low-density lipoproteins (LDL) and hemoglobin A1c (HbA1c) was statistically significant (p = 0.02 and 0.04 respectively) between both groups. The mean basal LDL was 126.91 mg/dL in VDD group that improved to 117.13 mg/dL after 4 months of VD therapy with a mean difference of –9.7 mg/dL compared to a mean difference of –2 mg/dL in VD sufficiency group. Conclusions: VDD was highly prevalent in patients with T1D. There was no significant correlation between 25OHD levels and lipid profile in patients with T1D. VD supplementation for 4 months had a significant lowering effect on LDL and HbA1c.

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