scholarly journals Leishmania major Self-Limited Infection Increases Blood Cholesterol and Promotes Atherosclerosis Development

Cholesterol ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Luciana R. Fernandes ◽  
Ana Cecília C. Ribeiro ◽  
Marcela Segatto ◽  
Luís Felipe F. F. Santos ◽  
Joana Amaral ◽  
...  
Keyword(s):  
Macrophage Activation ◽  
Leishmania Major ◽  
Plasma Cholesterol ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Proinflammatory Response ◽  
Blood Lipid Profile ◽  
Atherosclerosis Development ◽  
Apoe Ko Mice ◽  
Apoe Ko

Leishmania major infection of resistant mice causes a self-limited lesion characterized by macrophage activation and a Th1 proinflammatory response. Atherosclerosis is an inflammatory disease involving hypercholesterolemia and macrophage activation. In this study, we evaluated the influence of L. major infection on the development of atherosclerosis using atherosclerosis-susceptible apolipoprotein E-deficient (apoE KO) mice. After 6 weeks of infection, apoE KO mice exhibited reduced footpad swelling and parasitemia similar to C57BL/6 controls, confirming that both strains are resistant to infection with L. major. L. major-infected mice had increased plasma cholesterol levels and reduced triacylglycerols. With regard to atherosclerosis, noninfected mice developed only fatty streak lesions, while the infected mice presented with advanced lesions containing a necrotic core and an abundant inflammatory infiltrate. CD36 expression was increased in the aortic valve of the infected mice, indicating increased macrophage activation. In conclusion, L. major infection, although localized and self-limited in resistant apoE KO mice, has a detrimental effect on the blood lipid profile, increases the inflammatory cell migration to atherosclerotic lesions, and promotes atherogenesis. These effects are consequences of the stimulation of the immune system by L. major, which promotes the inflammatory components of atherosclerosis, which are primarily the parasite-activated macrophages.

scholarly journals Effect of Basil Seed and Chia SeedExtracts on Blood Lipid Profile

2021 ◽  
Vol 15 (6) ◽  
pp. 1368-1371
Author(s):  
S. Munir ◽  
S. Khurshid ◽  
Q. J. Iqbal ◽  
N. Iqbal ◽  
Z. Masood
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Plasma Lipid ◽  
Blood Lipid ◽  
Histopathological Analysis ◽  
Omega 3 ◽  
Blood Lipid Profile ◽  
Cholesterol Levels ◽  
Maintain Body Weight

Background: Basil and Chia seeds contain higher nutritive values like vitamin, carbohydrates, Omega-3 oil and other dietary fibers. With all these rich dietary benefits these seeds regulate necessary health conditions and maintain body weight. Ocimumbasilicum (Basil) plant have been known to contain properties of weight loss, better digestion and other health benefits. Aim: To check the Basil seed against hyperlipidemia in mice with Chia seeds. Methodology: In this research, the effect of both seeds extract on body weight and plasma lipid profile were estimated in Albino mice after raising their cholesterol levels by high fatty diet. The experiments were performed in different groups like normal control, standard control, hyperlipidemia group and four groups of diet supplemented chia or basil seeds with two different doses. Results: The biochemical analysis revealed that the supplementation of Basil seeds (400mg/kg/day) significantly lowered the levels of total plasma cholesterol, lipoproteins and triacylglycerol. Moreover, histopathological analysis of vital organs like kidneys, heart reported no toxicity. Conclusion: Extracts of Chia and Basil seeds have shown controlling effects over the given parameters in the blood and weights of the animals and these may have potential to control high fat diet-induced hyperlipidemia when taken as dietary supplements. Keywords: Cholesterol, Hyperlipidemia, Ocimumbasilicum, Salvia hispanica

scholarly journals Effect of dietary fatty acid on blood lipid profile and induced bacterial infection in rat

2015 ◽  
Vol 1 (2) ◽  
pp. 235-243
Author(s):  
Most Sumona Akter ◽  
Md Abu Yousuf ◽  
Md Yousuf Ali ◽  
Most Mahfuja Khatun ◽  
Sukumar Saha ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Bacterial Colony ◽  
Group A ◽  
Group B

Ground nut is one of the commonly used decorative nutritious relish seed around the world. Ground nut have hypocholesterolamic, hypoglycemic, hypolipidemic, anti-atherosclerotic, immune-modulatory and bacterial counting effects. In Bangladesh, limited research has so far been performed on the action of ground nut in biological system and its comparative efficacy with commercialized drugs that reduce blood cholesterol. The aim of this study was carried on the effects of PUFA on blood total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) and against artificial inoculation (I/N) Staphylococcus aureus infection of experimental rat by feeding of ground nut. A total of fifteen long Evans rats (Rattus norvegicus) were used for this study. The rats were randomly divided into three equal groups (n=5) and numbered as A, B and C. Group A (control), Group B (50gm ground nut/ day/group), group C (100 gm ground nut/day/group). All groups were supplied with standard broiler pellet and fresh drinking water throughout the experimental period (January to June /2012). The blood samples were collected directly from the heart at the 1st and 60th day for biochemical test (TC, LDL, HDL and TG) and test was performed as per Memorial Diagnostic Centre, Charpara, Mymensingh. Staphylococcus aureus was cultured in nutrient broth and 100 µl of their culture was inoculated into the rats through intranasal route. Among all the treated groups, the rats of group C exhibited the lowest TC value, TG and LDL and reduced blood cholesterol significantly than (control group A) followed by group B. In bacteriological examinations, it was found that the number of bacterial colony lowest in group C in comparison with the group of A and B. From the present experiment, it can be assumed that PUFA has significant effect on blood lipid profile and against bacterial infection.Asian J. Med. Biol. Res. June 2015, 1(2): 235-243

SUN-LB037: Gluten-Free Diet Reduces Cardiovascular Risk Factors and Atherosclerosis Development in ApoE KO Mice

2015 ◽  
Vol 34 ◽  
pp. S248 ◽  
Author(s):  
E.C. Aguilar ◽  
F.L. Soares ◽  
L.C. Santos ◽  
L.S. Capettini ◽  
L.G. Teixeira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Atherosclerosis Development ◽  
Apoe Ko Mice ◽  
Apoe Ko

scholarly journals Plasma lipid profile of mice fed diet supplemented with broiler fat

2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Dietary Treatment ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24

Immunoenhancing property of dietary un-denatured whey protein derived from three camel breeds in mice

Biologia ◽  
2012 ◽  
Vol 67 (2) ◽  
Author(s):  
Hossam Ebaid ◽  
Gamal Badr ◽  
Ali Metwalli
Keyword(s):  
Whey Protein ◽  
Whey Proteins ◽  
Blood Lipid ◽  
Time Dependent ◽  
Blood Cholesterol ◽  
Control Group ◽  
Dependent Manner ◽  
Immune Functions ◽  
Blood Lipid Profile ◽  
Electrophoretic Patterns

AbstractData have demonstrated that whey protein (WP) enhances the immune system. The aim of this study was to investigate and compare the effects of WP from three camel breeds on oxidative stress, blood lipid profile and the cytokine levels. Seventy five male mice were randomly split into five groups. The first served as a control group. The second, the third and the fourth groups were orally administrated the WP from Majaheim, Maghateer and Soffer camel breeds, respectively, at a dose of 100 mg/kg mouse body weight. The fifth group was supplemented with bovine serum albumin (BSA). Results showed similar electrophoretic patterns of the three whey proteins. WP was found to significantly inhibit the hydroperoxide and the Reactive Oxygen Species (ROS) in leukocytes, liver and skin as well as the blood cholesterol level in a time dependent manner. A significant enhancement of glutathione was revealed in WP groups. Furthermore, WP was found to significantly elevate the IL-2 with a significant time dependent enhance of IL-8. On contrast, a significant lowering effect of whey proteins on the pro-inflammatory cytokines, IL-1α, IL-1β, IL-6 and IL-10 was detected. Moreover, a mitogenic activity of WP was observed on the lymphocytes. Non-significant changes were observed in AST, ALT, creatinine and glucose level. These findings suggest that WP significantly improved the levels of the oxidative markers and the immune functions without any difference in the bioactivities of the three studied whey proteins.

High Cholesterol Level As A Marker of Allergic Rhinitis Severity

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Dina S Sheha ◽  
Lobna A El-Korashi ◽  
Marwa M El-Begermy ◽  
Amira R Elmahdi
Keyword(s):  
Allergic Rhinitis ◽  
Cholesterol Level ◽  
Blood Lipid ◽  
Cross Sectional Study ◽  
Blood Cholesterol ◽  
Sectional Study ◽  
High Cholesterol ◽  
Blood Lipid Profile ◽  
Cross Sectional ◽  
High Cholesterol Level

Abstract Background There is some evidences illustrated the relation between abnormal blood lipid profile and atopy. But, the evidence about relation between allergic rhinitis (AR) and cholesterol level is conflicting. We aimed to assess correlation between Cholesterol level and severity of AR. Methods 50 AR patients were recruited in this cross-sectional study. Blood samples for blood cholesterol level were drawn from all patients. Results There was a statistically significant positive correlation between TC and visual analogue scale (VAS) score. Conclusion High cholesterol level in AR patients can be a marker of disease severity.

scholarly journals Profil Glukosa Darah, Lipid dan Visualisasi Pulau Langerhans sebagai Imunoreaktor Insulin dan Glukagon pada Pankreas Tikus (rattus norvegicus) Obesitas Menggunakan Teknik Imunohistokimia

2017 ◽  
Vol 1 (1) ◽  
pp. 24
Author(s):  
Dela Ria Nesti ◽  
Ahmad Baidlowi
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cholesterol Level ◽  
Glucose Level ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Blood Capillary ◽  
Blood Lipid Profile ◽  
Lipid Metabolism Disorder

Obesity is not concerned as specific congenital disorder or derived lipid metabolism disorder recently, but more to bod yinability to handle the increase of nutrition intake caused by behavioral changes. Langerhans Islet is a section in the pancreas which play crucial role in producing and regulating metabolism hormones, insulin and glucagon. This research was conducted to observe blood glucose and lipid profile and to visualize Langerhans Islet in rat pancreas which were induced obesity and compared it with normal ones. Ten of male non-genetic obese four weeks old Winstar rats were divided into two groups, normal (K) and induced with obesity (O). Blood plasma samples were collected to determine blood glucose and blood lipid profile. Pancreas (regio splenic) samples were collected and fixated with Bouin solution, blocked by paraffin and cut with 5 μm thickness. Histology preparats were stained with Hematoxylin-Eosin and Immunohistochemistry (IHC) is determined with Labeled Sterptavidin-Biotin (LSAB) method. Staining is act as visual detector with will be analyzed descriptively and quantitatively. The data of Obesity group showed that blood glucose level is 88.59 ± 1.77 mg/dl, blood cholesterol level is 160.62±3.52 mg/dl, triglycerides level is 98.61±2.66 mg/dl, HDL level is 44.68±2.25 mg/dl and LDL level is 67.51±1.81. Pancreas’s topography in obese group spread into three regions, which are: gastrium, duodenum and lien. Langerhans Islet morphology shaped oval and polygonal also surrounded by fine filaments and blood capillary. Insulin and glucagon immunoreactive cell’s morphology in obesity group shaped irregular polygonal with round/oval nucleus placed in central/peripheral. Langerhans Islet’s in obesity group has diameter (154.38±65.56) μm, circumference (373,51±146,69) μm and volume 3241105.96 μm3. Obesity induced rat showed the increase in cholesterol level, triglycerides level, LDL level, blood glucose level and Langerhans Islet’s diameter, volume and circumference compared to normal ones (P<0.05). Decrease of HDL, topography and morphology of pancreas in obesity induced rat did’t showed significant changes compared to normal ones.

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