scholarly journals Effect of dietary fatty acid on blood lipid profile and induced bacterial infection in rat

2015 ◽  
Vol 1 (2) ◽  
pp. 235-243
Author(s):  
Most Sumona Akter ◽  
Md Abu Yousuf ◽  
Md Yousuf Ali ◽  
Most Mahfuja Khatun ◽  
Sukumar Saha ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Bacterial Colony ◽  
Group A ◽  
Group B

Ground nut is one of the commonly used decorative nutritious relish seed around the world. Ground nut have hypocholesterolamic, hypoglycemic, hypolipidemic, anti-atherosclerotic, immune-modulatory and bacterial counting effects. In Bangladesh, limited research has so far been performed on the action of ground nut in biological system and its comparative efficacy with commercialized drugs that reduce blood cholesterol. The aim of this study was carried on the effects of PUFA on blood total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) and against artificial inoculation (I/N) Staphylococcus aureus infection of experimental rat by feeding of ground nut. A total of fifteen long Evans rats (Rattus norvegicus) were used for this study. The rats were randomly divided into three equal groups (n=5) and numbered as A, B and C. Group A (control), Group B (50gm ground nut/ day/group), group C (100 gm ground nut/day/group). All groups were supplied with standard broiler pellet and fresh drinking water throughout the experimental period (January to June /2012). The blood samples were collected directly from the heart at the 1st and 60th day for biochemical test (TC, LDL, HDL and TG) and test was performed as per Memorial Diagnostic Centre, Charpara, Mymensingh. Staphylococcus aureus was cultured in nutrient broth and 100 µl of their culture was inoculated into the rats through intranasal route. Among all the treated groups, the rats of group C exhibited the lowest TC value, TG and LDL and reduced blood cholesterol significantly than (control group A) followed by group B. In bacteriological examinations, it was found that the number of bacterial colony lowest in group C in comparison with the group of A and B. From the present experiment, it can be assumed that PUFA has significant effect on blood lipid profile and against bacterial infection.Asian J. Med. Biol. Res. June 2015, 1(2): 235-243

scholarly journals Plasma lipid profile of mice fed diet supplemented with broiler fat

2014 ◽  
Vol 43 (1) ◽  
pp. 21-24 ◽  
Author(s):  
GB Das ◽  
ME Hossain ◽  
MA Akbar
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Dietary Treatment ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile

This study was conducted with 180 female Swiss albino mice to examine the effects of supplementing broiler fat in the diets of mice on blood lipid profile. Twenty one days old mice were collected from ICDDRB, Mohakhali, Dhaka. They were randomly distributed in four groups having three replications each. Each replicate group had 15 mice. Results revealed that supplementation of broiler fat in mice diet significantly changed (p<0.05) triglyceride (TG) and low density lipoprotein (LDL) among groups. The control group (T0) had the highest level of cholesterol and LDL. Cholesterol, TG and LDL markedly increased (p<0.05) in all dietary treatment groups, while high density lipoprotein (HDL) significantly (p<0.01) decreased after supplementation of experimental diets. It was concluded that all the dietary treatments in general increased blood cholesterol, TG and LDL in mice fed broiler fat with different oil supplements. However, the soybean and palm oil group was comparatively better than other groups in respect of cholesterol, HDL and LDL at the blood lipid profile of mice. Therefore, it can be concluded that consumption of broiler fat with soybean and palm oil could be less harmful for mice.DOI: http://dx.doi.org/10.3329/bjas.v43i1.19380 Bang. J. Anim. Sci. 2014. 43 (1): 21-24

scholarly journals A Case-Control Study on Blood Lipid Profile in Patients with COVID-19

2021 ◽  
Author(s):  
Shahab Changaripour ◽  
Hosna Sarvazad ◽  
Maryam Barghi ◽  
Elham Sajadi ◽  
Mahdi Hashempour Sadeghian ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Severe Form ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Outpatient Group ◽  
Significant Difference ◽  
Patient Groups ◽  
The Mean

Abstract Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

scholarly journals Study of thyroid dysfunction and dyslipidemia in chronic kidney diseases

2017 ◽  
Vol 6 (1) ◽  
pp. 110
Author(s):  
S. K. Tripathy ◽  
N. Dhal ◽  
M. Kanungo ◽  
S. Das ◽  
S. K. Mishra ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Lipid Profile ◽  
Thyroid Function ◽  
Conservative Management ◽  
Thyroid Dysfunction ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Group A ◽  
Group B

Background: Though there are many studies on thyroid dysfunction and dyslipidemia in Chronic Kidney Disease (CKD), no study is conclusive. Aim of this study was to correlate abnormalities in thyroid function and lipid profile with the severity of renal failure and also to observe the difference of these abnormalities between patients on conservative management verses hemodialysis.Methods: Hundred consecutive CKD cases admitted to Medicine Department were taken up for the study. They were divided into two groups as Group-A [on conservative management] and Group-B [on regular Hemodialysis (HD)]. Hundred healthy persons were taken as control in Group-C. After evaluation of thyroid function and lipid profile statistical analysis was done by students t-test, chi-square and regression analysis.Results: Hundred CKD cases with 74% male (n=74) and 26% female (n=26) in a M: F ratio of 2.9:1 were found to be in different stages CKD (0, 2, 20, 28 and 50 in stage-1 to stage-5 respectively). In 50 cases of stage-5 CKD, 30 were on HD and 20 on conservative management. Diabetes Mellitus (DM) (40%) was the commonest etiology of CKD followed by Hypertension (HTN), obstructive uropathy, chronic glomerulonephritis (CGN) and polycystic kidney disease (PKD). Thyromegaly was not found in a single case. In all CKD cases (Group-A+B) TT3 (TT3) was significantly low (P =0.0011) when compared with control (Group-C) and no difference was found between Group-A and Group-B. Fall in TT3 worsened with increasing severity of CKD. Lipid profile study revealed Decreased High-Density Lipoprotein Cholesterol (HDLc) and increased Triglyceride (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDLc), TC/HDLc and LDLc/HDLc in Group-A than Group-B but only TG and TC increase was statistically significant. The levels of TG and TC and TC/HDLc increased as the stage of CKD progressed and was statistically significant (P= 0.035).Conclusions: There occurs a state of biochemical hypothyroidism without overt clinical hypothyroid state in CKD, the extent of which correlates with the severity of CKD. Increased cardiovascular complications occur due to accelerated atherosclerosis in CKD. This study confirmed that atherogenic lipid profile and thyroid dysfunction worsen with the progression of disease. Difference between patients on conservative management and HD was not found.

scholarly journals Effects of ethanolic extracts of Datura metel on blood lipid profile of male albino rats

2016 ◽  
Vol 2 (10) ◽  
pp. 248 ◽  
Author(s):  
Kayode A. Arowora ◽  
Chinedu Imo ◽  
Chukwuma S. Ezeonu ◽  
Zuhairah I. Muhammad
Keyword(s):  
Lipid Profile ◽  
Normal Control ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Normal Control Group ◽  
Control Group ◽  
Albino Rats ◽  
Blood Lipid Profile ◽  
Datura Metel ◽  
Ethanolic Extracts

<p class="abstract"><strong>Background:</strong> This study was carried out to investigate the effects of <em>Datura metel (</em>leaf, seed and fruit<em>)</em> on blood lipid profile of male albino rats.</p><p class="abstract"><strong>Methods:</strong> Thirty-five albino rats (8 weeks old) weighing between 66g and 84g were purchased and randomly allotted into 7 groups. The normal control (group 1) received normal saline, while groups 2 to 7 received extracts of <em>Datura metel</em> at low (300 mg/kg body weight) and high doses (600 mg/kg body weight). The extracts were administered orally for seven consecutive days, while the animals were sacrificed on the 8th day; blood samples were collected, allowed to stand for fifteen minutes and then centrifuged.  </p><p class="abstract"><strong>Results:</strong> There was a general decreasing trend in the mean values of low density lipoprotein levels across  the groups, however, group 7 (with lowest value) was found to be significantly lower (p &lt;0.05) than other groups when compared with the normal control. Also, there was a general decreasing trend in the values of high density lipoprotein compared with normal control group, however lowest value was recorded to be 1.35±0.06 mmol/l for group 5. There were no significant differences (p &gt;0.05) in triglyceride levels across the groups, while total cholesterol in groups 5 and 6 had significant differences with values of 2.05±0.06 mmol/l and 2.13±0.10 mmol/l respectively when compared with the normal control.</p><p><strong>Conclusions:</strong> This study suggests that ethanolic extracts of<em> Datura metel </em>have active ingredients that are capable of improving blood lipid profile and this might be useful in the management of cardiovascular diseases. </p>

scholarly journals Effect of Sumac (Rhus coriaria) Extract on Blood Lipid Profile in White Wistar Rat

2017 ◽  
Vol 2 (3) ◽  
pp. 97
Author(s):  
HamidReza Soltani ◽  
Alireza Vahidi ◽  
Mohammad Dehghan Tezerjani ◽  
Mohammad Javaherchian ◽  
SeyedAli Shiryazdi
Keyword(s):  
Lipid Profile ◽  
Blood Lipid ◽  
Wistar Rat ◽  
Normal Diet ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Significant Difference ◽  
Rhus Coriaria ◽  
The Mean

Background: Hyperlipidemia is one of the chronic diseases whose current solutions are the proper diet and chemical drugs. Evaluation of accessible medicinal plant recourses has an important role to prevent and treat the hyperlipidemia. The present study aimed to investigate the effect of sumac (Rhus coriaria) extract on blood lipid profile in white Wistar rat.Methods: This laboratory animal experiment was conducted on 21 white Wistar rats during four weeks. The research units divided into three groups separately were fed by normal diet, fatty diet without sumac extract and fatty diet with sumac extract. The samples were excluded after appearing sick-like behaviors. Finally, data were analyzed in SPSS ver. 16 software using ANOVA and LSD tests.Results: The mean weight of rats was 310±26 gram. The mean blood cholesterol had significant difference in fatty diet with sumac group in compared with control group from the second week to the end of study (P<0.001), also the mean triglyceride was increased significantly during the study in fatty diet with sumac extract group (P=0.47). The mean HDL and LDL had no significant change during the study (P>0.05).Conclusion: According to the findings of this study, the use of sumac with fatty diet can be effective to reduce blood cholesterol in prevention and treatment of hyperlipidemia.

scholarly journals A case-control Study on Blood Lipid Profile in Patients with COVID-19

2021 ◽  
Author(s):  
Shahab Changaripour ◽  
Hosna Sarvazad ◽  
Maryam Barghi ◽  
Elham Sajadi ◽  
Mahdi Hashempour Sadeghian ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Severe Form ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Outpatient Group ◽  
Significant Difference ◽  
Patient Groups ◽  
The Mean

Abstract Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

scholarly journals DIETARY EFFECTS ON HEMO-LIPID PROFILE

2006 ◽  
Vol 13 (04) ◽  
pp. 621-626
Author(s):  
FAIQA FAYYAZ ◽  
Miss. Saman Batool ◽  
MUHAMMAD NAWAZ ◽  
Asma Lodhi ◽  
MISS. FATIMA ARIF
Keyword(s):  
Lipid Profile ◽  
Heart Diseases ◽  
Saturated Fatty Acids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Young Male ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Blood Lipid Profile ◽  
Male Volunteers

A study had been being undertaken to estimate the dietaryeffects on blood lipid profile of young male and female university students. Lipid profile is a group of teststhat are often ordered together to determine risk of coronary heart diseases by estimating blood cholesterol,low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides. For the estimation, bloodsamples of each 30 female and male volunteers had been centrifuged and plasma had been separated foranalysis. Levels of lipid profile parameters had been measured by recommended kit method and colordeveloped had been measured by spectrophotomer. The results had been presented as mean±SD. Femalevolunteers had an average±SD value for cholesterol 183.1±14.8, for triglycerides 183.2±22.5, for HDL51±6.2 and for LDL 95.5±15.7, whereas male volunteers had an average ±SD value for cholesterol190±14.9, for triglycerides 222.5±18.2, for HDL 41.4±5.8 and for LDL 104.2±17.1. It had been concludedthat values of triglycerides and cholesterol were higher than the normal values for both female and malevolunteers because the content of saturated fatty acids was higher in their diets, use of vegetables, fruitsand fruit juices was very low, in some cases the number of meals taken per day was more than 5 which isnot desirable in adult people especially when their lifestyle is sedentary and in some cases smoking alteredthe levels of cholesterol and triglycerides.

scholarly journals Effect of Whole Quail (Coturnix japonica) Egg Consumption on some Reproductive Parameters and Lipid Profile of Male Albino Rat (Rattus norvegicus)

2017 ◽  
Vol 9 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Samuel O. EKERE ◽  
Onyinyechukwu A. AGINA ◽  
Ikechukwu J. UDEANI ◽  
Chukwunonso K. EZEASOR
Keyword(s):  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Epididymal Sperm ◽  
Treatment Groups ◽  
Egg Consumption ◽  
Group A ◽  
The Mean

The present study evaluated the effect of whole egg consumption on the liver, testes, cauda epididymal sperm reserve and lipid profile of male rats. These evaluations were carried out on adult twenty (20) male albino rats, which were randomly selected into four groups of 5 rats each, designated groups A, B, C and D. Group A was the control group and received only equivalent volume of distilled water, while groups B, C and D received 0.25mg/kg, 0.5mg/kg; and 1.0mg/kg body weight of the quail egg respectively. Standard procedures were carried out in the tissue processing, cauda epididymal sperm reserve and in lipid profile determinations. On days 35 and 49, the mean serum total cholesterol value of group D was significantly lower than that of the control group. On day 35, the mean serum low density lipoprotein and high density lipoprotein (LDL and HDL cholesterol) values of all the treatment groups were significantly lower and higher than that of the control group, respectively. However, on days 49 and 63, the mean serum very low density lipoprotein (VLDL cholesterol) and triglyceride values of all the treatment groups were significantly higher than that of the control group. A significant increase in cadual epididymal sperm count (CESR) was recorded on day 63 at the mid and high doses. No obvious pathological lesions were observed in the histomorphology of the testes and liver when compared to the control. Therefore, whole quail egg consumption caused an increase in serum triglyceride and very low density lipoprotein concentration, and also improved fertility. In other words, prolonged consumption of quail egg should be done with caution as it may predispose one to cardiovascular disease.

Influence of Moderate, Daily Physical Activity On Body Composition and Blood Lipid Profile in Swedish Adults

2012 ◽  
Vol 9 (6) ◽  
pp. 867-874 ◽  
Author(s):  
Peter Pagels ◽  
Anders Raustorp ◽  
Trevor Archer ◽  
Ulf Lidman ◽  
Marie Alricsson
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Lipid Profile ◽  
Inverse Correlation ◽  
Blood Lipid ◽  
Daily Physical Activity ◽  
Moderate Intensity ◽  
Control Group ◽  
Brisk Walking ◽  
Blood Lipid Profile

Background:Health organizations suggest that adults ought to engage in at least 30 minutes of moderate-intensity daily physical activity. This study investigated the effects of a 30-minute single daily bout of brisk walking upon risk factors for coronary heart disease with blood lipid profile in particular.Methods:Thirty-three (25–45 y) adults, were randomly assigned into an exercise group (EG; n = 16, 9w) and a control group (CG; n = 17, 6w). The EG walked briskly 30 minutes daily during the 3-week test period. Compliance/adherence was maximal throughout the 3-week intervention due to stringent daily monitoring.Results:The EG showed a significant decrease in concentrations of low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) during the intervention period. A significant inverse correlation between Δ energy expenditure/day and Δ LDL-C (r = –0.39, P < .05) and an improvement in weight and BMI in the EG was found. Average steps during 30 minutes brisk walking bout was 3669 steps/bout generating a mean energy expenditure of 191 kcal/ bout.Conclusions:The most unique findings were that daily single bouts of moderate-intensity physical activity for 30 minutes, during 3 weeks, induced favorable effects upon body weight, BMI, and blood concentration of LDL-C and TC in healthy adults.

scholarly journals ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

2013 ◽  
Vol 12 (5) ◽  
pp. 29-33
Author(s):  
S. A. Matveeva
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Blood Lipid Profile ◽  
Glucose Levels ◽  
Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology. 

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