scholarly journals Treatment of Chagas Cardiomyopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fernando A. Botoni ◽  
Antonio Luiz P. Ribeiro ◽  
Carolina Coimbra Marinho ◽  
Marcia Maria Oliveira Lima ◽  
Maria do Carmo Pereira Nunes ◽  
...  
Keyword(s):  
North America ◽  
South America ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Therapeutic Approach ◽  
Original Description ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Underdeveloped Countries ◽  
Chagas Cardiomyopathy

Chagas' disease (ChD), caused by the protozoaTrypanosoma cruzi(T. cruzi), was discovered and described by the Brazilian physician Carlos Chagas in 1909. After a century of original description, trypanosomiasis still brings much misery to humanity and is classified as a neglected tropical disease prevalent in underdeveloped countries, particularly in South America. It is an increasing worldwide problem due to the number of cases in endemic areas and the migration of infected subjects to more developed regions, mainly North America and Europe. Despite its importance, chronic chagas cardiomyopathy (CCC) pathophysiology is yet poorly understood, and independently of its social, clinical, and epidemiological importance, the therapeutic approach of CCC is still transposed from the knowledge acquired from other cardiomyopathies. Therefore, the objective of this review is to describe the treatment of Chagas cardiomyopathy with emphasis on its peculiarities.

Development of new dinuclear Fe(III) coordination compounds with in vitro nanomolar antitrypanosomal activity

2021 ◽  
Author(s):  
Felipe Figuerôa Moreira ◽  
Juliana de Araujo Portes ◽  
Nathalia Florencia Barros Azeredo ◽  
Christiane Fernandes ◽  
Adolfo Horn ◽  
...  
Keyword(s):  
Public Health ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Health Problem ◽  
Coordination Compounds ◽  
Public Health Problem ◽  
Neglected Tropical Disease ◽  
Major Public Health Problem ◽  
Protozoan Pathogen

Chagas disease is a neglected tropical disease caused by the protozoan pathogen Trypanosoma cruzi. The disease is the major public health problem affecting about 6 to 7 million people worldwide,...

scholarly journals Benznidazole Shortage Makes Chagas Disease a Neglected Tropical Disease in Developed Countries: Data from Spain

2012 ◽  
Vol 87 (3) ◽  
pp. 489-490 ◽  
Author(s):  
Miriam Navarro ◽  
Rogelio López-Vélez ◽  
José Antonio Pérez-Molina ◽  
Francesca F. Norman
Keyword(s):  
Chagas Disease ◽  
Developed Countries ◽  
Tropical Disease ◽  
Neglected Tropical Disease

Incidence and Predictors of Progression to Chagas Cardiomyopathy: Long-Term Follow-Up of Trypanosoma Cruzi Seropositive Individuals

Circulation ◽  
2021 ◽  
Author(s):  
Maria Carmo P. Nunes ◽  
Lewis F. Buss ◽  
Jose Luiz P. da Silva ◽  
Larissa Natany Almeida Martins ◽  
Claudia Di Lorenzo Oliveira ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Clinical Epidemiology ◽  
Outpatient Service ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Blood Collection ◽  
Ventricular Ejection Fraction ◽  
Chagas Cardiomyopathy

Background: There are few contemporary cohorts of Trypanosoma cruzi -seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with T. cruzi seropositivity. Methods: Participants were selected in blood banks at 2 Brazilian centers. Cases were defined as T. cruzi -seropositive blood donors. T. cruzi -seronegative controls were matched for age, sex, and period of donation. Patients with established Chagas cardiomyopathy were recruited from a tertiary outpatient service. Participants underwent medical examination, blood collection, electrocardiogram, and echocardiogram at enrollment (2008 to 2010) and at follow-up (2018 to 2019). The primary outcomes were all-cause mortality and development of cardiomyopathy, defined as the presence of a left ventricular ejection fraction <50% and/or QRS complex duration ≥ 120 ms. To handle loss to follow-up, a sensitivity analysis was performed using inverse probability weights for selection. Results: We enrolled 499 T. cruzi -seropositive donors (age 48 ± 10 years, 52% male), 488 T. cruzi -seronegative donors (age 49 ± 10 years, 49% male), and 101 patients with established Chagas cardiomyopathy (age 48 ± 8 years, 59% male). The mortality in patients with established cardiomyopathy was 80.9 deaths/1000 person-years (py) (54/101, 53%) and 15.1 deaths/1000py (17/114, 15%) in T. cruzi -seropositives with cardiomyopathy at baseline. Among T. cruzi -seropositive donors without cardiomyopathy at baseline mortality was 3.7 events/1000py (15/385, 4%), which was no different from T. cruzi -seronegative donors with 3.6 deaths/1000py (17/488, 3%). The incidence of cardiomyopathy in T. cruzi -seropositive donors was 13.8 (95% CI 9.5-19.6) events/1000py (32/262, 12%) compared with 4.6 (95% CI 2.3-8.3) events/1000 py (11/277, 4%) in seronegative controls, with an absolute incidence difference associated with T. cruzi seropositivity of 9.2 (95% CI 3.6 - 15.0) events/1000py. T. cruzi antibody level at baseline was associated with development of cardiomyopathy (adjusted OR of 1.4, 95% CI 1.1-1.8). Conclusions: We present a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population. The results highlight the central importance of anti- T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.

scholarly journals Nigrograna mackinnonii, NotTrematosphaeria grisea(syn.,Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America

2017 ◽  
Vol 56 (3) ◽  
Author(s):  
Sarah A. Ahmed ◽  
Gloria M. González ◽  
Andrés Tirado-Sánchez ◽  
Luis Miguel Moreno-López ◽  
Sybren de Hoog ◽  
...  
Keyword(s):  
Latin America ◽  
South America ◽  
Latin American ◽  
Tropical Disease ◽  
Human Diseases ◽  
Neglected Tropical Disease ◽  
Content Type ◽  
Subcutaneous Infection ◽  
Molecular Studies

ABSTRACTMycetoma, a chronic and mutilating subcutaneous infection recognized by the WHO as a neglected tropical disease, has been reported in >25 countries in Africa, Asia, and South America. In Latin America,Trematosphaeria griseais assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe, where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed toTrematosphaeria grisea. Three cases analyzed were caused byNigrograna mackinnonii. Data on an additional 21 strains in the literature revealed thatN. mackinnoniirather thanT. griseais responsible for most cases of black grain eumycetoma in Latin America.

scholarly journals A Brief View of the Surface Membrane Proteins fromTrypanosoma cruzi

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Ángel de la Cruz Pech-Canul ◽  
Victor Monteón ◽  
Rosa-Lidia Solís-Oviedo
Keyword(s):  
Life Cycle ◽  
Membrane Proteins ◽  
South America ◽  
Cell Surface ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Surface Membrane ◽  
Surface Molecules ◽  
The World ◽  
Large Families

Trypanosoma cruziis the causal agent of Chagas’ disease which affects millions of people around the world mostly in Central and South America.T. cruziexpresses a wide variety of proteins on its surface membrane which has an important role in the biology of these parasites. Surface molecules of the parasites are the result of the environment to which the parasites are exposed during their life cycle. Hence,T. cruzidisplays several modifications when they move from one host to another. Due to the complexity of this parasite’s cell surface, this review presents some membrane proteins organized as large families, as they are the most abundant and/or relevant throughout theT. cruzimembrane.

scholarly journals The Trypanosoma cruzi kinetoplast DNA minicircle sequences transfer biomarker of the multidrug treatment of Chagas disease

2021 ◽  
Author(s):  
Antonio R. L. Teixeira ◽  
Alessandro O Sousa ◽  
Clever C Gomes ◽  
Adriana A Sá ◽  
Rubens J Nascimento ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Nuclear Dna ◽  
Germ Line ◽  
Pcr Amplification ◽  
Dna Transfer ◽  
Heart Cells ◽  
Kinetoplast Dna ◽  
Chagas Cardiomyopathy ◽  
Primer Sets

Background: The Trypanosoma cruzi infection renders the transfer of the mitochondrion kinetoplast DNA minicircle sequences into the host’s genome. The Aves are refractory to the infection, but chicks hatched from the T. cruzi inoculated eggs integrate the DNA minicircle sequences into the germ line cells. Rabbits, mice and chickens with the minicircle sequences mutations develop the Chagas cardiomyopathy and the DNA transfer underpins the heart disease. Methodology: The PCR with the specific primer sets revealed the Protist nuclear DNA and the kinetoplast DNA in the agarose gels bands probed with the radiolabel specific sequences from tissues of the T. cruzi-infected rabbits and of the mice. A targetprimer TAIL-PCR amplification employing primer sets from the chickens, rabbits and mice, in combination with primer sets from the the T. cruzi kinetoplast minicircle sequences was used. This approach led us to disclose the integration sites of the kinetoplast DNA biomarker, then, used to monitor the effect of multidrug treatment of the T. cruzi infected mice. Principal findings: The Southern hybridization, clone and sequence of the amplification products revealed the DNA minicircle sequences integrations sites in the LINE transposable elements. An array of inhibitors of eukaryote cells division was used to arrest the DNA transfer. It was shown that nine out of 12 inhibitors prevented the kinetoplast DNA integration into the macrophage genome. The multidrug treatment of the acutely T. cruzi-infected mice with Benznidazole, Azidothymidine and Ofloxacin lessened circa 2.5-fold the rate of the minicircle sequences integrations in the mouse genome and inhibited the rejection of the target heart cells. Conclusion and significance: The T. cruzi mitochondrion kinetoplast minicircle sequences transfer driven pathogenesis of Chagas disease is an ancient Cross-Kingdom DNA phenomenon of evolution and, therefore, paradigm research with effective purposing inhibitors is needed.

scholarly journals Eastern Bloodsucking Conenose, Triatoma sanguisuga (LeConte) (Hemiptera: Reduviidae: Triatominae)

EDIS ◽  
2013 ◽  
Vol 2013 (10) ◽  
Author(s):  
John L. Capinera
Keyword(s):  
United States ◽  
South America ◽  
Trypanosoma Cruzi ◽  
Central America ◽  
Chagas Disease ◽  
The United States ◽  
American Trypanosomiasis ◽  
Fact Sheet ◽  
Blood Meals

The eastern bloodsucking conenose belongs to the subfamily Triatominae, known as the kissing bugs. Despite their affectionate vernacular name, they are particularly threatening “assassin bugs” who require blood meals to survive and reproduce. They are a known vector of American trypanosomiasis (or Chagas Disease) in South America, a debilitating illness caused by the parasite Trypanosoma cruzi. This disease is a problem in South and Central America and has been detected in the United States, but has not been found in Florida. This 4-page fact sheet was written by John L. Capinera, and published by the UF Department of Entomology and Nematology, November 2013. http://edis.ifas.ufl.edu/in1018

The genus Cosmocercella Steiner, 1924 (Nematoda: Cosmocercoidea)

1977 ◽  
Vol 55 (10) ◽  
pp. 1644-1649 ◽  
Author(s):  
M. R. Baker ◽  
M. L. Adamson
Keyword(s):  
North America ◽  
South America ◽  
Original Description ◽  
Eastern North America

Cosmocercella anothecae n.sp. from Anotheca spinosa (Hylidae) of Mexico and the generotype C. haberi Steiner. 1924, from Hyla spp. (Hylidae) of eastern North America are described. Cosmocercella anothecae n.sp. most closely resembles C. haberi. These species differ in the number and arrangement of digitiform caudal papillae, shape of the gubernaculum, and size of spicules in males. Cosmocercella haberi lacks the vesiculated 'bursa' mentioned in the original description and this character cannot be used to distinguish this genus. Cosmocercella is characterized, however, by vesiculated rosette male caudal papillae not present in other genera of Cosmocercidae. Raillietnema minor Freitas and Dobbin, 1961, from Phyllomedusa (Hylidae) of South America is reclassified as Cosmocercella minor (Freitas and Dobbin, 1961) n.comb. The genus also includes C. neveri Hsü and Hoeppli, 1933.

World Chagas Disease Day and the New Road Map for Neglected Tropical Diseases

2020 ◽  
Vol 20 (17) ◽  
pp. 1518-1520
Author(s):  
Leonardo L.G. Ferreira ◽  
Adriano D. Andricopulo
Keyword(s):  
Chagas Disease ◽  
Neglected Tropical Diseases ◽  
Tropical Disease ◽  
Neglected Tropical Disease ◽  
Tropical Diseases ◽  
Road Map ◽  
The Impact ◽  
First World

The first-ever World Chagas Disease Day, celebrated in April 14, 2020, is a key initiative to raise awareness of the impact of this neglected tropical disease (NTD). This landmark comes along with the first World NTD Day and the new WHO Road Map on NTDs for 2021-2030.

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