scholarly journals Biomaterials in Cardiovascular Research: Applications and Clinical Implications

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Saravana Kumar Jaganathan ◽  
Eko Supriyanto ◽  
Selvakumar Murugesan ◽  
Arunpandian Balaji ◽  
Manjeesh Kumar Asokan
Keyword(s):  
Surface Modification ◽  
Pluripotent Stem Cells ◽  
Blood Compatibility ◽  
Current Trend ◽  
Basic Research ◽  
Clinical Implications ◽  
Cardiovascular Research ◽  
Cardiovascular Devices ◽  
One Stop ◽  
Cardiac Implants

Cardiovascular biomaterials (CB) dominate the category of biomaterials based on the demand and investments in this field. This review article classifies the CB into three major classes, namely, metals, polymers, and biological materials and collates the information about the CB. Blood compatibility is one of the major criteria which limit the use of biomaterials for cardiovascular application. Several key players are associated with blood compatibility and they are discussed in this paper. To enhance the compatibility of the CB, several surface modification strategies were in use currently. Some recent applications of surface modification technology on the materials for cardiovascular devices were also discussed for better understanding. Finally, the current trend of the CB, endothelization of the cardiac implants and utilization of induced human pluripotent stem cells (ihPSCs), is also presented in this review. The field of CB is growing constantly and many new investigators and researchers are developing interest in this domain. This review will serve as a one stop arrangement to quickly grasp the basic research in the field of CB.

Improving Blood Compatibility of Cardiovascular Devices by Surface Modification

2007 ◽  
pp. 801-804
Author(s):  
Nan Huang ◽  
Ping Yang ◽  
Yong Xiang Leng ◽  
Jun Ying Chen ◽  
Jin Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Blood Compatibility ◽  
Cardiovascular Devices

Improving Blood Compatibility of Cardiovascular Devices by Surface Modification

2007 ◽  
Vol 342-343 ◽  
pp. 801-804 ◽  
Author(s):  
Nan Huang ◽  
Ping Yang ◽  
Yong Xiang Leng ◽  
Jun Ying Chen ◽  
Jin Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Artificial Heart ◽  
Heart Valves ◽  
Blood Compatibility ◽  
Artificial Heart Valve ◽  
Cardiovascular Devices ◽  
Inorganic Films ◽  
Artificial Heart Valves ◽  
Plasma Grafting ◽  
Circulation Tube

This paper presents recent activities on the surface modification of blood contacting biomaterials and devices in the author’s laboratory. Surface coating of inorganic films on materials for artificial heart valves, ventricular pumps and coronary stents, such as titanium, stainless steel and low temperature isotropic pryolitc carbon, etc, shows a significant improvement in the anticoagulation behavior. Further, the formation of functional groups such as hydroxyl or amino groups and the binding of biomolecules as well as seeding of endothelial cell shows the promise of biomimetic surface formation. Plasma grafting on materials for artificial heart valve sewing cuff, extracorporeal circulation tube, etc, such as PET, PU, PVC polymers, revealed a significant improvement of anti-platelet adhesion as well as anti-bacterial properties.

scholarly journals Venous and Arterial Endothelial Cells from Human Umbilical Cords: Potential Cell Sources for Cardiovascular Research

2021 ◽  
Vol 22 (2) ◽  
pp. 978
Author(s):  
Skadi Lau ◽  
Manfred Gossen ◽  
Andreas Lendlein ◽  
Friedrich Jung
Keyword(s):  
Endothelial Cells ◽  
Umbilical Cord ◽  
Membrane Integrity ◽  
Cell Types ◽  
Cell Number ◽  
Human Umbilical Cord ◽  
Cardiovascular Research ◽  
Cardiovascular Devices ◽  
Arterial Endothelial Cells

Although cardiovascular devices are mostly implanted in arteries or to replace arteries, in vitro studies on implant endothelialization are commonly performed with human umbilical cord-derived venous endothelial cells (HUVEC). In light of considerable differences, both morphologically and functionally, between arterial and venous endothelial cells, we here compare HUVEC and human umbilical cord-derived arterial endothelial cells (HUAEC) regarding their equivalence as an endothelial cell in vitro model for cardiovascular research. No differences were found in either for the tested parameters. The metabolic activity and lactate dehydrogenase, an indicator for the membrane integrity, slightly decreased over seven days of cultivation upon normalization to the cell number. The amount of secreted nitrite and nitrate, as well as prostacyclin per cell, also decreased slightly over time. Thromboxane B2 was secreted in constant amounts per cell at all time points. The Von Willebrand factor remained mainly intracellularly up to seven days of cultivation. In contrast, collagen and laminin were secreted into the extracellular space with increasing cell density. Based on these results one might argue that both cell types are equally suited for cardiovascular research. However, future studies should investigate further cell functionalities, and whether arterial endothelial cells from implantation-relevant areas, such as coronary arteries in the heart, are superior to umbilical cord-derived endothelial cells.

scholarly journals Erratum to “Clinical implications of basic research in hepatocellular carcinoma” [J Hepatol 2016;64:736–745]

2016 ◽  
Vol 64 (6) ◽  
pp. 1462
Author(s):  
Renumathy Dhanasekaran ◽  
Sudhakar K. Venkatesh ◽  
Michael S. Torbenson ◽  
Lewis R. Roberts
Keyword(s):  
Hepatocellular Carcinoma ◽  
Basic Research ◽  
Clinical Implications

scholarly journals A Mini Review: Recent Advances in Surface Modification of Porous Silicon

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2557 ◽  
Author(s):  
Seo Lee ◽  
Jae Kang ◽  
Dokyoung Kim
Keyword(s):  
Surface Modification ◽  
Porous Silicon ◽  
Wide Spectrum ◽  
Basic Research ◽  
Recent Advances ◽  
Developed Surface ◽  
The Many ◽  
Insight Into ◽  
Biomedical Fields

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.

Fibroblast Growth Factors and Their Receptors in Urological Cancers: Basic Research and Clinical Implications

2003 ◽  
Vol 43 (3) ◽  
pp. 309-319 ◽  
Author(s):  
M.V Cronauer ◽  
W.A Schulz ◽  
H.-H Seifert ◽  
R Ackermann ◽  
M Burchardt
Keyword(s):  
Growth Factors ◽  
Fibroblast Growth Factors ◽  
Basic Research ◽  
Clinical Implications ◽  
Fibroblast Growth ◽  
Urological Cancers

scholarly journals Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research—What We Have Learnt and Not Learnt until Now

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3112
Author(s):  
Michael Simeon ◽  
Seema Dangwal ◽  
Agapios Sachinidis ◽  
Michael Xavier Doss
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Pluripotent Stem Cells ◽  
Pluripotent Stem Cell ◽  
Genome Engineering ◽  
Tourism Industry ◽  
Full Potential ◽  
Cardiovascular Research ◽  
Global Pandemic

Personalized regenerative medicine and biomedical research have been galvanized and revolutionized by human pluripotent stem cells in combination with recent advances in genomics, artificial intelligence, and genome engineering. More recently, we have witnessed the unprecedented breakthrough life-saving translation of mRNA-based vaccines for COVID-19 to contain the global pandemic and the investment in billions of US dollars in space exploration projects and the blooming space-tourism industry fueled by the latest reusable space vessels. Now, it is time to examine where the translation of pluripotent stem cell research stands currently, which has been touted for more than the last two decades to cure and treat millions of patients with severe debilitating degenerative diseases and tissue injuries. This review attempts to highlight the accomplishments of pluripotent stem cell research together with cutting-edge genomics and genome editing tools and, also, the promises that have still not been transformed into clinical applications, with cardiovascular research as a case example. This review also brings to our attention the scientific and socioeconomic challenges that need to be effectively addressed to see the full potential of pluripotent stem cells at the clinical bedside.

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