scholarly journals The Protective Effect of Aged Garlic Extract on Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Inflammations in Male Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Gehan Moustafa Badr ◽  
Jawaher Abdulaziz AL-Mulhim
Keyword(s):  
Mucosal Healing ◽  
Garlic Extract ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Aged Garlic Extract ◽  
Drug Induced ◽  
Potent Effect ◽  
Anti Inflammatory ◽  
Aged Garlic

Natural products have long gained wide acceptance among the public and scientific community in the gastrointestinal ulcerative field. The present study explore the potential effects of aged garlic extract (AGE) on indomethacin-(IN-) induced gastric inflammation in male rats. Animals were divided into six groups (n=8) control group, IN-induced gastric inflammation group via oral single dose (30 mg/kg to fasted rats) two AGE orally administered groups (100 and 200 mg/kg for 30 consecutive days) two AGE orally administered groups to rats pretreated with IN at the same aforementioned doses. The results declared the more potent effect of the higher AGE dose (200 mg/kg) as compared to that of the 100 mg/kg dose in the gastroprotective effects reflected by significant gastric mucosal healing of damage and reduction in the total microbial induced due to indomethacin administration. In addition to the significant effect to normalize the significant increase in malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-α(TNF-α) values, and the significant decrease in the total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) values induced by indomethacin. The results support AGE antioxidant, anti-inflammatory, and antimicrobial potency reflected by the healing of the gastric tissue damage induced by indomethacin.

scholarly journals UJI EFEK AGED GARLIC EXTRACT (Allium sativum L) TERHADAP WAKTU PERDARAHAN MENCIT PUTIH JANTAN

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Fajar Sartika Hadi
Keyword(s):  
Platelet Aggregation ◽  
Allium Sativum ◽  
Bleeding Time ◽  
Garlic Extract ◽  
Oral Suspension ◽  
Control Group ◽  
Aged Garlic Extract ◽  
Post Test ◽  
Mean Time ◽  
Aged Garlic

Abstrak. Bawang putih (Allium sativum L) telah digunakan untuk mengobati penyakit sejak ribuan tahun yang lalu seperti hipertensi, infeksi dan bekas gigitan ular.Saat ini, preparat bawang putih yang dikenal sebagai Aged Garlic Extract banyak diteliti dalam mengevaluasi efek kardioprotektif penyusunnya yaitu S-allylcysteine (SAC).Penelitian ini bertujuan untuk mengetahui potensi SAC dalam menghambat agregasi trombosit melalui pengamatan waktu perdarahan. Penelitian ini dirancang sebagai laboratorium eksperimental dengan rancangan kelompokPre Test-Post Test secara acak yang dilakukan pada 30 ekor tikus jantan yang terbagi dalam lima kelompok. Perlakuan diberikan pada hari ke 8 sampai hari ke 21, yaitu kelompok K1 (kontrol negatif), kelompok K2 (Clopidogrel Oral Suspension dosis 0,195 mg / 20 g BB), kelompok P1 (Aged Garlic Extract dosis 1 mg / 20 g BB) , kelompok P2 (AGE dosis 2 mg / 20 g BB), kelompok P3 (AGE dosis 4 mg / 20 g BB). Pengukuran waktu perdarahan dilakukan pada hari ke 0 dan 21.Analisis data menggunakan Uji Normalitas Saphiro-Wilk, Uji Kruskal-Wallis, dan Uji Mann-Whitney. Hasil penelitian ini dengan uji t-paired menunjukkan bahwa tidak ada perubahan signifikan dalam rerata waktu perdarahan pada kelompok K1 (p = 0,988), K2 (p = 0,096), P2 (0,053) dan P3 (0,335), sedangkan kelompok P1 menunjukkan perubahan waktu perdarahan dengan nilai signifikansi p = 0,034. Uji Kruskal-Wallis setelah perlakuan dan uji Mann-Whitney menunjukkan bahwa hanya ada perbedaan yang signifikan antara kelompok K2 dan kelompok P1, P2 (p 0,05). Berdasarkan hasil penelitian ini menunjukkan bahwa Aged Garlic Extract tidak memperpanjang waktu perdarahan.Kata kunci:  Abstract. Garlic (Allium sativum L) has been used for thousands of years to treat many conditions, including hypertension, infections, and snakebites. Currently, garlic preparation named Aged Garlic Extract is widely use to evaluates the cardioprotective effect of its constituent S-allylcysteine (SAC). This study aims to determine the potential of SAC in inhibiting platelet aggregation through observation time of bleeding. This research is designed as a laboratorium experimental with randomized Pre-Test Post Test Control Group Design that conducted on 30 male mice divided into five groups. The treatment was given on the 8th day until the 21st day, ie group K1 (negative control), group K2 (Clopidogrel Oral Suspension dose 0,195 mg/20 g BB), group P1 (Aged Garlic Extract dose 1 mg/ 20 g BB), group P2 (Aged Garlic Extract dose 2 mg/ 20 g BB), group P3 (Aged Garlic Extract dose 4 mg/20 g BB). The measurement of  bleeding time on day 0 and 21. Data analysis used Saphiro-Wilk Normality Test, t-paired, Kruskal-Wallis Test, and Mann-Whitney Test.The results of this study with t-paired test showed that there was no significant change in mean time of bleeding in groups K1 (p=0,988), K2 (p=0,096), P2 (0,053) and P3 (0,335) , while P1 group showed a significant mean time change in bleeding time with value of significance is p= 0,034. Kruskal-Wallis test after treatment and Mann-Whitney test showed that there were only significant differences between group K2 and group P1,P2 (p0,05). Based on the result of this study show that Aged Garlic Extract doesn’t prolong the bleeding time. Key words : Aged Garlic Extract, bleeding time, platelet aggregation

Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity

2009 ◽  
Vol 87 (8) ◽  
pp. 633-640 ◽  
Author(s):  
Erkan Demirkaya ◽  
Aslıhan Avci ◽  
Vural Kesik ◽  
Yıldırım Karslioglu ◽  
Emin Oztas ◽  
...  
Keyword(s):  
Grape Seed ◽  
Garlic Extract ◽  
Natural Antioxidant ◽  
Male Rats ◽  
Free Oxygen Radicals ◽  
Protective Effects ◽  
Aged Garlic Extract ◽  
Positive Effects ◽  
Grape Seed Proanthocyanidin ◽  
Aged Garlic

Doxorubicin (DXR) is a chemotherapeutic agent used effectively in the treatment of several childhood malignancies. During treatment, cardiotoxicity caused by cell damage due to the free oxygen radicals that are generated is a major limiting factor. This study was undertaken to determine whether DXR-induced cardiotoxicity could be prevented by natural foods with antioxidant properties such as aged garlic extract (AGEX), grape seed proanthocyanidin (PA), and hazelnut. Wistar albino male rats were assigned randomly to 9 groups each consisting of 15 rats. AGEX, PA, and hazelnut groups received these antioxidants in addition to their standard rat diet. They were also treated with cumulative intraperitoneal (i.p.) injections according to 2 different regimens: either a high-dose of 15 mg/kg DXR (3.75 mg/kg per week for 4 weeks) or a low-dose of 7.5 mg/kg DXR (1.875 mg/kg per week for 4 weeks). The control group received i.p. 0.9% saline. AGEX, PA, or hazelnut supplements were given orally to the groups for a 6-week period starting 1 week before the DXR treatment and ending 1 week after the treatment. One week after the last DXR injection, heart tissue samples were analyzed to determine malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and xanthine oxidase (XO) levels, and serum samples were taken for creatine kinase (CK). There were no significant changes in MDA levels among the control, DXR-treated groups, or supplemented groups that received additional natural antioxidant foods. SOD enzyme levels were decreased in rats treated with DXR. PA prevented the decrease at low doses of DXR. DXR treatment decreased CAT enzyme levels, but additional PA and hazelnut consumption increased these levels at low cumulative doses. XO enzyme levels were decreased in AGEX and hazelnut groups, but PA prevented the decrease. CK levels were elevated after DXR administration, indicating myocardial injury, but PA significantly reversed this. Although there were no differences histopathologically between AGEX, PA, and hazelnut groups, the protective effects of AGEX and PA were evident in electron microscopy. In conclusion, the positive effects of natural antioxidant foods on the prevention of DXR-induced cardiac injury could not be clearly shown on the basis of antioxidant enzymes. However, the electron microscopic changes clearly demonstrated the protective effects of AGEX and PA. The supplementation of these antioxidant foods over longer periods may show more definitive results. Human studies with different doses are needed to evaluate the effects of these foods on the human heart.

Aged Garlic Extract Inhibits CD36 Expression and Foam Cell Formation in Human Macrophages

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
N Ide ◽  
N Morihara ◽  
L Paptheodorou ◽  
R Stirner ◽  
N Weiss
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Garlic Extract ◽  
Foam Cell Formation ◽  
Aged Garlic Extract ◽  
Human Macrophages ◽  
Cd36 Expression ◽  
Aged Garlic

scholarly journals Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3203
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Obulesu Challa ◽  
Abdulhakeem S. Alamri ◽  
Walaa F. Alsanie ◽  
Majid Alhomrani ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Combined Therapy ◽  
Myocardial Damage ◽  
Thiobarbituric Acid ◽  
Significant Rise ◽  
Garlic Extract ◽  
High Dose ◽  
Aged Garlic Extract ◽  
Active Constituent ◽  
Aged Garlic

This study was conducted to determine the potential interaction of aged garlic extract (AGE) with carvedilol (CAR), as well as to investigate the role of S-allyl-l-cysteine (SAC), an active constituent of AGE, in rats with isoproterenol (ISO)-induced myocardial dysfunction. At the end of three weeks of treatment with AGE (2 and 5 mL/kg) or SAC (13.1 and 32.76 mg/kg), either alone or along with CAR (10 mg/kg) in the respective groups of animals, ISO was administered subcutaneously to induce myocardial damage. Myocardial infarction (MI) diagnostic predictor enzymes, lactate dehydrogenase (LDH) and creatinine kinase (CK-MB), were measured in both serum and heart tissue homogenates (HTH). Superoxide dismutase (SOD), catalase, and thiobarbituric acid reactive species (TBARS) were estimated in HTH. When compared with other groups, the combined therapy of high doses of AGE and SAC given alone or together with CAR caused a significant decrease in serum LDH and CK-MB activities. Further, significant rise in the LDH and CK-MB activities in HTH was noticed in the combined groups of AGE and SAC with CAR. It was also observed that both doses of AGE and SAC significantly increased endogenous antioxidants in HTH. Furthermore, histopathological observations corroborated the biochemical findings. The cytoprotective potential of SAC and AGE were dose-dependent, and SAC was more potent than AGE. The protection offered by aged garlic may be attributed to SAC. Overall, the results indicated that a high dose of AGE and its constituent SAC, when combined with carvedilol, has a synergistic effect in preventing morphological and physiological changes in the myocardium during ISO-induced myocardial damage.

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