scholarly journals Magnetic Resonance-Guided Laser Induced Thermal Therapy for Glioblastoma Multiforme: A Review

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Sarah E. Norred ◽  
Jacqueline Anne Johnson
Keyword(s):  
Glioblastoma Multiforme ◽  
Magnetic Resonance ◽  
Tumor Tissue ◽  
State Of The Art ◽  
Invasive Approach ◽  
Temperature Imaging ◽  
Current State ◽  
Clinical Challenge ◽  
Potential Applications ◽  
Magnetic Resonance Temperature Imaging

Magnetic resonance-guided laser induced thermotherapy (MRgLITT) has become an increasingly relevant therapy for tumor ablation due to its minimally invasive approach and broad applicability across many tissue types. The current state of the art applies laser irradiation via cooled optical fiber applicators in order to generate ablative heat and necrosis in tumor tissue. Magnetic resonance temperature imaging (MRTI) is used concurrently with this therapy to plan treatments and visualize tumor necrosis. Though application in neurosurgery remains in its infancy, MRgLITT has been found to be a promising therapy for many types of brain tumors. This review examines the current use of MRgLITT with regard to the special clinical challenge of glioblastoma multiforme and examines the potential applications of next-generation nanotherapy specific to the treatment of glioblastoma.

scholarly journals In vivo interactome profiling by enzyme‐catalyzed proximity labeling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yangfan Xu ◽  
Xianqun Fan ◽  
Yang Hu
Keyword(s):  
State Of The Art ◽  
Catalytic Efficiency ◽  
Biological Processes ◽  
Protein Protein Interaction ◽  
Current State ◽  
Protein Interactome ◽  
Potential Applications ◽  
Protein Protein Interaction Networks ◽  
Temporal And Spatial

AbstractEnzyme-catalyzed proximity labeling (PL) combined with mass spectrometry (MS) has emerged as a revolutionary approach to reveal the protein-protein interaction networks, dissect complex biological processes, and characterize the subcellular proteome in a more physiological setting than before. The enzymatic tags are being upgraded to improve temporal and spatial resolution and obtain faster catalytic dynamics and higher catalytic efficiency. In vivo application of PL integrated with other state of the art techniques has recently been adapted in live animals and plants, allowing questions to be addressed that were previously inaccessible. It is timely to summarize the current state of PL-dependent interactome studies and their potential applications. We will focus on in vivo uses of newer versions of PL and highlight critical considerations for successful in vivo PL experiments that will provide novel insights into the protein interactome in the context of human diseases.

scholarly journals Hydrothermal Carbonization of Organic Waste and Biomass: A Review on Process, Reactor, and Plant Modeling

2020 ◽  
Author(s):  
Giulia Ischia ◽  
Luca Fiori
Keyword(s):  
Organic Waste ◽  
Review Paper ◽  
Recent Literature ◽  
State Of The Art ◽  
Hydrothermal Carbonization ◽  
Residual Biomass ◽  
Current State ◽  
Potential Applications ◽  
Intrinsic Complexity ◽  
Context Models

Abstract Hydrothermal carbonization (HTC) is an emerging path to give a new life to organic waste and residual biomass. Fulfilling the principles of the circular economy, through HTC “unpleasant” organics can be transformed into useful materials and possibly energy carriers. The potential applications of HTC are tremendous and the recent literature is full of investigations. In this context, models capable to predict, simulate and optimize the HTC process, reactors, and plants are engineering tools that can significantly shift HTC research towards innovation by boosting the development of novel enterprises based on HTC technology. This review paper addresses such key-issue: where do we stand regarding the development of these tools? The literature presents many and simplified models to describe the reaction kinetics, some dealing with the process simulation, while few focused on the heart of an HTC system, the reactor. Statistical investigations and some life cycle assessment analyses also appear in the current state of the art. This work examines and analyzes these predicting tools, highlighting their potentialities and limits. Overall, the current models suffer from many aspects, from the lack of data to the intrinsic complexity of HTC reactions and HTC systems. Therefore, the emphasis is given to what is still necessary to make the HTC process duly simulated and therefore implementable on an industrial scale with sufficient predictive margins. Graphic Abstract

Referenceless magnetic resonance temperature imaging using Gaussian process modeling

2017 ◽  
Vol 44 (7) ◽  
pp. 3545-3555 ◽  
Author(s):  
Joshua P. Yung ◽  
David Fuentes ◽  
Christopher J MacLellan ◽  
Florian Maier ◽  
Yannis Liapis ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Gaussian Process ◽  
Process Modeling ◽  
Temperature Imaging ◽  
Magnetic Resonance Temperature Imaging ◽  
Gaussian Process Modeling

scholarly journals Interleaved echo-planar imaging for fast multiplanar magnetic resonance temperature imaging of ultrasound thermal ablation therapy

2004 ◽  
Vol 20 (4) ◽  
pp. 706-714 ◽  
Author(s):  
R. Jason Stafford ◽  
Roger E. Price DVM ◽  
Chris J. Diederich ◽  
Marko Kangasniemi ◽  
Lars E. Olsson ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Thermal Ablation ◽  
Echo Planar Imaging ◽  
Planar Imaging ◽  
Temperature Imaging ◽  
Ablation Therapy ◽  
Thermal Ablation Therapy ◽  
Magnetic Resonance Temperature Imaging ◽  
Echo Planar

scholarly journals Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors

Neurosurgery ◽  
2010 ◽  
Vol 66 (2) ◽  
pp. 323-332 ◽  
Author(s):  
Nathan McDannold ◽  
Greg T. Clement ◽  
Peter Black ◽  
Ferenc Jolesz ◽  
Kullervo Hynynen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Resonance Imaging ◽  
Ultrasound Surgery ◽  
Temperature Imaging ◽  
Focused Ultrasound Surgery ◽  
Brain Surface ◽  
Magnetic Resonance Temperature Imaging ◽  
The Brain

Abstract OBJECTIVE This work evaluated the clinical feasibility of transcranial magnetic resonance imaging–guided focused ultrasound surgery. METHODS Transcranial magnetic resonance imaging–guided focused ultrasound surgery offers a potential noninvasive alternative to surgical resection. The method combines a hemispherical phased-array transducer and patient-specific treatment planning based on acoustic models with feedback control based on magnetic resonance temperature imaging to overcome the effects of the cranium and allow for controlled and precise thermal ablation in the brain. In initial trials in 3 glioblastoma patients, multiple focused ultrasound exposures were applied up to the maximum acoustic power available. Offline analysis of the magnetic resonance temperature images evaluated the temperature changes at the focus and brain surface. RESULTS We found that it was possible to focus an ultrasound beam transcranially into the brain and to visualize the heating with magnetic resonance temperature imaging. Although we were limited by the device power available at the time and thus seemed to not achieve thermal coagulation, extrapolation of the temperature measurements at the focus and on the brain surface suggests that thermal ablation will be possible with this device without overheating the brain surface, with some possible limitation on the treatment envelope. CONCLUSION Although significant hurdles remain, these findings are a major step forward in producing a completely noninvasive alternative to surgical resection for brain disorders.

TU-A-9A-04: Development of a Thermally Stable Phantom for Photoacoustic and Magnetic Resonance Temperature Imaging

2014 ◽  
Vol 41 (6Part26) ◽  
pp. 447-448
Author(s):  
K Dextraze ◽  
C MacLellan ◽  
T Mitcham ◽  
M Melancon ◽  
R Bouchard
Keyword(s):  
Magnetic Resonance ◽  
Thermally Stable ◽  
Temperature Imaging ◽  
Magnetic Resonance Temperature Imaging
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