Efficacy of Physiotherapy for Urinary Incontinence following Prostate Cancer Surgery

The study enrolled 81 with urinary incontinence following radical prostate-only prostatectomy for prostatic carcinoma. The patients were divided into two groups. The patients in Group I were additionally subdivided into two subgroups with respect to the physiotherapeutic method used. The patients of subgroup IA received a rehabilitation program consisting of three parts. The patients of subgroup IB rehabilitation program consist of two parts. Group II, a control group, had reported for therapy for persistent urinary incontinence following radical prostatectomy but had not entered therapy for personal reasons. For estimating the level of incontinence, a 1-hour and 24-hour urinary pad tests, the miction diary, and incontinence questionnaire were used, and for recording the measurements of pelvic floor muscles tension, the sEMG (surface electromyography) was applied. The therapy duration depended on the level of incontinence and it continued for not longer than 12 months. Superior continence outcomes were obtained in Group I versus Group II and the difference was statistically significant. The odds ratio for regaining continence was greater in the rehabilitated Group I and smaller in the group II without the rehabilitation. A comparison of continence outcomes revealed a statistically significant difference between Subgroups IA versus IB. The physiotherapeutic procedures applied on patients with urine incontinence after prostatectomy, for most of them, proved to be an effective way of acting, which is supported by the obtained results.

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Aminoglycoside trough levels in neonates

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1002050p ◽

2010 ◽

Vol 138 (1-2) ◽

pp. 50-55 ◽

Cited By ~ 1

Author(s):

Biljana Pejovic ◽

Milica Rankovic-Janevski ◽

Niveska Bozinovic-Prekajski

Keyword(s):

Gestational Age ◽

Trough Level ◽

Inverse Correlation ◽

Risk Groups ◽

Target Range ◽

Group I ◽

Significant Difference ◽

Group Ii ◽

The Difference ◽

Trough Levels

Introduction. Drug safety depends on trough levels. Objective. Objective of the study was to measure gentamicin and amikacin trough levels in neonates and to identify risk groups by gestational and postnatal age. Methods. Gentamicin and amikacin were applied according to the clinical practice guidelines. Trough levels (mg/l) were deter- mined using fluorescence polarization immunoassay methodology. Target trough levels were <2 mg/l for gentamicin, and <10 mg/l for amikacin. Patients were divided in 3 groups by gestational age: I ?32, II 33-36, and III ?37 gestational weeks and, by postnatal age, in 2 groups: ?7 and >7 days. Results. Out of 163 neonates, 111 were receiving gentamicin and 52 amikacin. Mean amikacin trough level was 7.8?4.8 mg/l and, in group I 10.5?4.9 mg/l, which was above the target range and significantly higher than in group II (LSD, p<0.05). In the amikacin group, 26 patients were 7 and less, and 26 more than 7 days old, without significant differences in trough levels between the groups. In the gentamicin group, 52.3% of neonates had trough values within the target range. Gentamicin trough level in group I was above the trough range, 3.7?1.8, 2.3?1.5 in group II and, 1.8?1.4 mg/l in group III. The difference in trough levels among the groups was highly significant (F=9.015, p<0.001, ?2=17. 576, p<0.001). Further analysis revealed that differences between groups I and II (LSD, p=0.002) and between I and III (LSD, p=0.000) were highly significant. Conclusion. Obtained gentamicin and amikacin trough levels are high. Inverse correlation has been confirmed between trough level and gestational age, with highly significant difference, and the risk group has been identified. There is obviously a need to change the dosing regimen in terms of those with extended intervals, particularly for neonates of the lowest gestational age, along with pharmacokinetic measurements.

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Value of Entheseal Ultrasonography and Serum Cartilage Oligomeric Matrix Protein in the Preclinical Diagnosis of Psoriatic Arthritis

Clinical Medicine Insights Arthritis and Musculoskeletal Disorders ◽

10.4137/cmamd.s4461 ◽

2010 ◽

Vol 3 ◽

pp. CMAMD.S4461 ◽

Cited By ~ 11

Author(s):

Hanan Mohamed Farouk ◽

Afaf Abdel Alim Mostafa ◽

Sahar S. Youssef ◽

Moataz Mohammed Samy Elbeblawy ◽

Naglaa Youssef Assaf ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Cartilage Oligomeric Matrix Protein ◽

Matrix Protein ◽

Serum Levels ◽

Lower Limbs ◽

Control Group ◽

Group I ◽

Significant Difference ◽

Preclinical Diagnosis ◽

Group Ii

Objective To evaluate the utility of entheseal ultrasonography and serum COMP in the preclinical diagnosis of psoriatic arthritis. Methods 60 psoriatic patients were divided into: 30 patients with psoriasis (group I) and 30 patients with psoriatic arthritis as control (group II). They underwent independent clinical and ultrasonographic examination of both lower limbs at the calcaneal insertions of Achilles tendons. Psoriatic arthritis disease activity and severity was assessed by modified DAS28 and Steinbrockers scores. Serum levels of COMP were measured for all patients by ELISA. Results On clinical examination, no entheseal abnormalities were detected in group I while they were present in 23.3% of group II with statistically significant difference between them ( P < 0.001). Ultrasonographic entheseal abnormalities were detected in 33.3% of group I and in 46.7% of group II with no significant difference between them ( P > 0.05). Serum COMP were significantly elevated in group I and II with no statistically significant difference between them (mean ± SD 5.9 ± 3 and 6.8 ± 12 respectively, P > 0.05). Entheseal ultrasound was more specific (67%) while serum COMP was more sensitive (87%) in the preclinical diagnosis of psoriatic arthritis. Serum COMP levels were significantly correlated with CRP in both groups and with DAS28 and Steinbrockers scores in group II ( P < 0.01). Conclusion Entheseal ultrasonography and serum COMP levels may be used complementary to each other for preclinical diagnosis of psoriatic arthritis. Serum COMP seems to be promising prognostic marker for psoriatic arthritis patients.

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The Role of sFas in the Immune Escape Mechanism and Progression of Cancer Larynx

Clinical medicine Ear nose and throat ◽

10.4137/cment.s2565 ◽

2009 ◽

Vol 2 ◽

pp. CMENT.S2565

Author(s):

Amr A El Badry ◽

Ismail Elmofty ◽

Amira Helmy

Keyword(s):

Serum Level ◽

Buffy Coat ◽

Control Group ◽

Group Iii ◽

Soluble Fas ◽

Group I ◽

Significant Difference ◽

Cancer Larynx ◽

The Mean ◽

Group Ii

This work assess serum levels of soluble Fas form (sFas) in patients with different stages of laryngeal squamous cell carcinoma(LSCC) to investigate its prognostic significance. We correlate its levels with the morphological changes of peripheral blood cells via buffy coat examinatin. The study population included 70 patients clinically diagnosed and pathohistologically confirmed LSCC in addition to 20 healthy controls. According to TNM classification 33(47.1%) patients were in stage I (group I) and 24(34.3%) in stage II (group II), 13(18.5%) in stage III (group III). The results revealed that the mean serum level of sFas (pg/ml) in the control group was 51.2, in group I was 66.33, in group II was 81.33 and in group III was 112.45. Statistical analysis of the mean of sFas by ELISA test in the patients' groups in comparison to the control revealed a significant increase of both group II and III in comparison to the control group (P < 0.01) but there was no significant difference (P > 0.05) between group I in comparison to either the control or group II. There was a significant difference (P < 0.05) between group I in comparison to group III. LM examination revealed massive extent of the apoptotic cells in group III when compared to both group I and group II. EM examination of the buffy coat revealed apoptotic changes, mainly in the peripheral blood mononuclear cells (PBMNCs), represented by surface membrane ruffles and blebs with clumped nuclear chromatin and vacuolated cytoplasm. In conclusion, this study may help us to better understand one of the escape mechanisms in cancer larynx. This mechanism is represented by the significant increase in both the serum level of sFas and the morphological apoptotic changes that detected in PBMNCs. Soluble Fas may contribute to the progression of laryngeal cancer. It can be used as an attractive target for anticancer therapy and may be considered as a marker of disease progression and poor prognosis in laryngeal cancer.

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Effects of Electroacupuncture on Intraoperative and Postoperative Analgesic Requirement

Acupuncture in Medicine ◽

10.1136/aim.20.2-3.56 ◽

2002 ◽

Vol 20 (2-3) ◽

pp. 56-65 ◽

Cited By ~ 65

Author(s):

Chin-Keng Sim ◽

Pei-Chang Xu ◽

Hwee-Leng Pua ◽

Guojing Zhang ◽

Tat-Leang Lee

Keyword(s):

Early Postoperative Period ◽

Morphine Consumption ◽

Control Group ◽

Analgesic Requirement ◽

Group Iii ◽

Group I ◽

Group Ii ◽

The Difference ◽

Sparing Effect ◽

Postoperative Morphine

Acupuncture has been shown to be effective in experimental and clinical acute pain settings. This study aims to evaluate the effect of preoperative electroacupuncture (EA) on intraoperative and postoperative analgesic (alfentanil and morphine) requirement in patients scheduled for gynaecologic lower abdominal surgery. Ninety patients were randomly assigned to one of three groups: Group I (control group) –received placebo EA for 45 minutes before induction of general anaesthesia (GA); Group II –preoperative EA instituted 45 minutes before induction of GA; Group III – 45 minutes of postoperative EA. The Bispectral Index monitor was used intraoperatively to monitor the hypnotic effect of anaesthetic drugs, and alfentanil was titrated to maintain the blood pressure and pulse rate within ±15% of basal values. Postoperative pain was managed by intravenous morphine via a patient-controlled analgesia (PCA) device. Patients in Group II (0.44 ± 0.15μg/kg/min) received less alfentanil than those in Group III (0.58 ± 0.22μg/kg/min) (p=0.024), but not significantly less than those in Group I (0.51 ± 0.21μg/kg/min) (p=0.472). Postoperative morphine consumption was numerically lower in Group II compared with the other groups; however, the difference was statistically significant only during the period of 6–12 hours between Group II [0.03 (0.05) mg/kg] and Group I [0.10 (0.11) mg/kg] (p=0.015), and Group II and Group III [0.08 (0.10) mg/kg] (p=0.010). The 24-hour cumulative morphine consumption for Group II (0.52 ± 0.19mg/kg) was less than that for either Group I (0.68 ± 0.38mg/kg) or Group III (0.58 ± 0.27mg/kg), but the difference did not reach significance. In conclusion, preoperative EA leads to a reduced intraoperative alfentanil consumption, though this effect may not be specific, and has a morphine sparing effect during the early postoperative period.

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EFFECTS OF TRAINING SIDE HOP OVER BARRIER WITH DUMBELL AND HEXAGON WITH DUMBELL ON LEG STRENGTH AND LEG POWER

JOSSAE Journal of Sport Science and Education ◽

10.26740/jossae.v2n2.p46-50 ◽

2018 ◽

Vol 2 (2) ◽

pp. 46

Author(s):

Nur Akbari ◽

Oce Wiriawan ◽

Nining Widyah Kusnanik

Keyword(s):

Control Group ◽

Percentage Increase ◽

Design Data ◽

Group Iii ◽

Strength Group ◽

Leg Strength ◽

Group I ◽

Significant Difference ◽

Quasi Experimental ◽

Group Ii

This study was conducted at 45 students of SMAN 1 Cerme with aged between 15-16 years old. Students were divided into 3 groups. the type of research used quantitative with quasi-experimental approach. Instruments of this study were test of leg strength and leg power using Leg Dynamometer and Jump MD. The research design used matching only design. Data was anlyzed using ANOVA. The results of the research was found that training program side hop over barrier with dumbell and hexagon with dumbbell significantly increase at leg strength and leg power (Sig. 0.000 <α = 0.05). Group I, Group II and Group III had significant difference (Sig. 0.000 α = 0.005). Percentage increase in leg strength group 1 of 1,80% and leg power of 15,49%. Percentage increase in leg strength group II of 1,68% and a power of 14,27% and whereas in the control group increase in leg strength was 1.67% power at 12.32%.It can be concluded that There was an increase in leg strength and leg power in each group after the training was given. In addition, there were differences among the three groups effects seen improved in leg strength and leg power through ANOVA, where the training side hop over barrier with dumbbell and hexagon with dumbell had increased in leg strength and leg power. But side hop over barrier with dumbbell had more significant increased than hexagon with dumbbell. Key words: Side hop over with barrier dumbell, hexagon with dumbell, leg strength and leg power.

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EFFECTIVENESS OF TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION AND INTERFERENTIAL CURRENT IN PATIENTS WITH NON-SPECIFIC CHRONIC LOW BACK PAIN

Journal of Medical Sciences ◽

10.52764/jms.20.28.4.7 ◽

2020 ◽

Vol 28 (4) ◽

pp. 341-344

Author(s):

Muhammad Adnan ◽

Babar Ali ◽

Muhammad Mohsin Sajjad ◽

Ali Rahman ◽

Omair Rafiq Qurashi ◽

...

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Post Treatment ◽

Low Back ◽

Electrical Nerve Stimulation ◽

Group I ◽

Significant Difference ◽

Interferential Current ◽

Group Ii ◽

The Difference

ABSTRACT: Objectives: To compare the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) and Interferential Current (IF) in patients with nonspecific chronic low back pain. Material and Methods: This quasi experimental study was performed in Khyber Teaching Hospital and Khyber Medical University Peshawar from August 2015 to January 2016. All patients were assessed before and after TENS and IF therapy using Visual Analogue Scale 0-10 (VAS) and Oswestry Disability Index (ODI). Thirty patients were divided into two groups. TENS (group I) & IF (group II). In group I, patients received 10 minutes session with heat therapy (hot pack) and 20 minutes session with TENS. In group II, the patients received 10 minutes session with heat therapy (hot pack) and 20 minutes session with IF current. Results: Mean age of participants was 34.85±4.80 and 33.50±5.20 years in group I and group II. The mean of pain before treatment in group I was 6.47±.29 and that of group II was 5.60±.33 in which the minimum pain on VAS was 4 and maximum pain was 8. A pair T test was done to identify the difference between pre and post treatment score on VAS in the intervention. The p values shows .000 which is less than .05 indicate that there is significant difference present between pre and post treatment pain on VAS. The pair T test for disability percentage on ODI was done to identify the difference between pre and post treatment in the interventions. The p value was less than .05 which shows that there is significant difference and reduction of disability percentage on ODI. Conclusion: The study concluded that both the treatment methods TENS and IF are effective in decreasing pain intensity and disability in low back pain patients.

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Patient Reported Urinary Incontinence and Sexual Impotency Following Multimodality Radical Therapy for Prostate Cancer: An Untold Story of Compound Toxicity?

10.21203/rs.3.rs-633279/v1 ◽

2021 ◽

Author(s):

Ori Haisraely ◽

Yaacov Richard Lawrence ◽

Ron Lewin ◽

Orit Kaidar-Person ◽

Ilana Weiss ◽

...

Keyword(s):

Prostate Cancer ◽

Urinary Incontinence ◽

Odds Ratio ◽

Smoking Status ◽

Urinary Continence ◽

Sexual Performance ◽

Cross Sectional ◽

Significant Difference ◽

Patient Reported ◽

Primary Radiotherapy

Abstract Purpose: To evaluate urinary continence and sexual potency following radical prostatectomy and adjuvant radiotherapy. Materials/Methods: Expanded Prostate Cancer Index Composite (EPIC) surveys of patients with localized prostate cancer treated with surgery followed by adjuvant/salvage pelvic radiotherapy (S+RT) were analyzed. A control cohort was primary radiotherapy (RT). Results: Surveys at least 1 year after treatment were available for 130 S+RT and 374 RT patients. For S+RT vs. RT, the mean urinary incontinence score was 68 [6.25 -100] versus 86.4 [CI-95 39.5-100] (p<0.001), confirming 6.5 points of clinically significant difference. The adjusted odds ratio for superior urinary function was 2.67 (1.7-4.1, p<0.001) for primary radiotherapy. The odds ratio of having both poor urinary and sexual performance was 0.29 in RT arm (0.14-0.58, p<0.001) when adjusted to age and ADT use, group risk stratification, co morbidities and smoking status. Conclusion: In this cross sectional study, Surgery with adjuvant/salvage RT was associated with significantly worse patient reported urinary continence outcomes at 1-year post treatment, lower odds of achieving perfect urinary continence and a threefold risk of reverse ‘bifecta’ with inferior urinary continence and sexual performance. Longitudinal studies of evolving toxicity are required to validate these findings.

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Patient Reported Urinary Incontinence and Sexual Impotency Following Multimodality Radical Therapy for Prostate Cancer: An Untold Story of Compound Toxicity?

10.21203/rs.3.rs-633279/v2 ◽

2021 ◽

Author(s):

Ori Haisraely ◽

Yaacov Richard Lawrence ◽

Ron Lewin ◽

Orit Kaidar-Person ◽

Ilana Weiss ◽

...

Keyword(s):

Prostate Cancer ◽

Urinary Incontinence ◽

Odds Ratio ◽

Smoking Status ◽

Urinary Continence ◽

Sexual Performance ◽

Urinary Function ◽

Significant Difference ◽

Patient Reported ◽

Primary Radiotherapy

Abstract Purpose: To evaluate urinary continence and sexual potency following radical prostatectomy and adjuvant radiotherapy.Materials/Methods: Expanded Prostate Cancer Index Composite (EPIC) surveys of patients with localized prostate cancer treated with surgery followed by adjuvant/salvage pelvic radiotherapy (S+RT) were analyzed. A control cohort was primary radiotherapy (RT). Reverse "bifecta" was defined as a score less than 60 in both incontinence and sexual domains. Superior urinary function was defined as a score above 90. The clinically important difference was calculated using a distribution approach.Results: Surveys at least 1 year after treatment were available for 130 S+RT and 374 RT patients. For S+RT vs. RT, the mean urinary incontinence score was 68 [6.25 -100] versus 86.4 [CI-95 39.5-100] (p<0.001), confirming 6.5 points of clinically significant difference. The adjusted odds ratio for superior urinary function was 2.67 (1.7-4.1, p<0.001) for primary radiotherapy. The odds ratio of having both poor urinary and sexual performance (reverse " bifecta") was 0.29 in RT arm (0.14-0.58, p<0.001) when adjusted for age and Androgen Deprivation Therapy (ADT) , group risk stratification, comorbidities and smoking status.Conclusion: In this cross sectional study, Surgery with adjuvant/salvage RT was associated with significantly worse patient reported urinary continence outcomes at 1-year post treatment, lower odds of achieving perfect urinary continence and a threefold risk of reverse ‘bifecta’ with inferior urinary continence and sexual performance. Longitudinal studies of evolving toxicity are required to validate these findings. Patients referred for surgery with a high probability of requiring adjuvant or salvage radiotherapy should be informed regarding the potential composite toxicity of both surgery and radiotherapy.

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An in vitro comparative Evaluation of Fracture Strength of Roots Instrumentated with Self-adjusting File and Reciproc Reciprocating File, with and without Obturation

10.5005/jp-journals-10060-0005 ◽

2017 ◽

Vol 1 (1) ◽

pp. 20-25

Author(s):

Pooja Kabra

Keyword(s):

Fracture Strength ◽

Comparative Evaluation ◽

Group Iv ◽

Control Group ◽

Group V ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Group Ii

ABSTRACT Aim The purpose of this study was to evaluate the fracture strength of roots instrumented with the self-adjusting file (SAF; ReDent-Nova, Ra'anana, Israel) and the Reciproc reciprocating file and that were and were not obturated using the warm vertical lateral compaction technique. Materials and methods In total, 75 mandibular premolar teeth were sectioned at or below the cementoenamel junction to obtain roots 13 mm in length. The roots were balanced with respect to buccolingual and mesiodistal diameters and weight. They were distributed into four experimental groups and one control group (n = 15): No instrumentation (group I), instrumentation with SAF files but no obturation (group II), instrumentation with SAF files and obturated with warm vertical lateral compaction (group III), instrumentation with Reciproc File but no obturation (group IV), and instrumentation with Reciproc File and obturated with warm vertical lateral compaction (group V). AH Plus sealer (Dentsply DeTrey, Konstanz, Germany) was used along with gutta-percha points. One week later, a vertical load was applied to the specimen's canal until fracture occurred. Data were statistically analyzed using one-way analysis of variance (p = 0.05). Results The mean fracture load was 312.83 N for group I, 297.35 N for group II, 359.15 N for group III, 231.51 N for group IV, and 275.81 N for group V. Conclusion The fracture resistances exhibited a statistically significant difference between all the groups. Teeth instrumented by SAF exhibited a better fracture resistance. How to cite this article Tyagi S, Choudhary E, Kabra P, Chauhan R. An in vitro comparative Evaluation of Fracture Strength of Roots Instrumentated with Self-adjusting File and Reciproc Reciprocating File, with and without Obturation. Int J Clin Dent Res 2017;1(1):20-25.

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Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1434 ◽

2017 ◽

Vol 8 (3) ◽

pp. 177-182

Author(s):

Umesh P Verma

Keyword(s):

Growth Factor ◽

Bone Graft ◽

Dental Implants ◽

Synergistic Effects ◽

Test Group ◽

Control Group ◽

Barrier Membrane ◽

Group I ◽

Significant Difference ◽

Group Ii

ABSTRACT Aim The present study was primarily designed to evaluate the outcome of guided bone graft regeneration in peri-implant defects by combining recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and granules of beta-tricalcium phosphate (B-TCP) mounted by resorbable biomesh membrane. Secondary objective was to determine the value of resorbable barrier membrane to improve the efficacy of the growth factormediated regeneration. Materials and methods A randomized controlled study comprised 14 participants (8 males and 6 females, mean age 37 years, range 19—55 years), in which a total of 15 implants (10 in maxilla and 5 in the mandible) were placed. Fifteen implant sites were randomly divided by picking a code into three groups: Test group I (n = 5) ß-TCP + rhPDGF (0.3 mg/mL) + biomesh, test group II (n = 5) ß-TCP + rhPDGF, and control (n = 5) ß-TCP + biomesh. The experimental site was examined clinically for the gingival status and radiographically for the bone status. Results Statistically significant difference in preoperative and postoperative measurements was observed for test groups I and II in all the parameters except width; in contrast, there was no significant difference observed for the control group from baseline to 5 months postoperatively. On intergroup comparison, statistically significant difference was observed between test group I vs control group and test group II vs control group, but it was not significant between test groups I and II, which was further confirmed using global performance scale score. Conclusion It concluded that rhPDGF-BB and ß-TCP mounted by resorbable biomesh membrane played a synergistic role in the management of peri-implant defects. Clinical significance Bone regenerated using ß-TCP with rhPDGF-BB in the reversal of peri-implant defects. How to cite this article Arora R, Verma UP, Dixit J, Lal N. Synergistic Effects of Growth Factor, Bone Graft, and Resorbable Barrier Membrane in Management of Dehiscence and Fenestration of Dental Implants. World J Dent 2017;8(3):177-182.

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